Cited by 76Gastrointestinal motility and disordersGut microbiota and healthDigestive system and related health

Interdigestive myoelectric complex in germ-free rats

Caenepeel, Ph., Janssens, J., Vantrappen, G., Eyssen, H., Coremans, G.·1989·Digestive Diseases and Sciences

Abstract

The effect of intestinal bacteria on the interdigestive myoelectric complex (IDMEC) was studied by recordings of the electrical activity of the proximal and distal small bowel in fasting germ-free (n = 6), gnotobiotic (n = 7), and conventional (n = 6) rats in vivo. Germ-free and gnotobiotic rats were operated and studied in germ-free or gnotobiotic conditions. The IDMEC period (mean +/- SD) in the proximal and distal small bowel was significantly longer in germ-free rats (20 +/- 2 min and 102 +/- 14 min) as compared to conventional rats (13 +/- 1 min and 58 +/- 5 min). Association of germ-free rats with a limited flora (gnotobiotic rats) decreased the IDMEC period significantly (15 +/- 1.5 min and 75 +/- 14 min). The migration velocity of the IDMEC was inversely related to the IDMEC period. These observations confirm previous data suggesting that the interdigestive motor complex has a role in the homeostasis of the bacterial content of the small bowel.

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Crossref · 10.1007/bf01537265

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Authors
Caenepeel, P., Janssens, J., Vantrappen, G., Eyssen, H., & Coremans, G.
Affiliations
Rega Institute for Medical Research (BE)
Venue
Digestive Diseases and Sciences
Published
1989-08
Volume
34
Issue
8
Pages
1180-1184
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
OpenAlex
W2002195228
Cited by
76
References
15
Citations by year
2025: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 2
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
Keywords
germ-free rats, gnotobiotic rats, intestinal bacteria, small intestine motility, migrating motor complex
MeSH terms
Animals, Bacteria, Digestion, Electromyography, Electrophysiology, Gastrointestinal Transit, Germ-Free Life, Ileum, Intestine, Small, Jejunum, Male, Rats

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