Interdigestive myoelectric complex in germ-free rats
Abstract
The effect of intestinal bacteria on the interdigestive myoelectric complex (IDMEC) was studied by recordings of the electrical activity of the proximal and distal small bowel in fasting germ-free (n = 6), gnotobiotic (n = 7), and conventional (n = 6) rats in vivo. Germ-free and gnotobiotic rats were operated and studied in germ-free or gnotobiotic conditions. The IDMEC period (mean +/- SD) in the proximal and distal small bowel was significantly longer in germ-free rats (20 +/- 2 min and 102 +/- 14 min) as compared to conventional rats (13 +/- 1 min and 58 +/- 5 min). Association of germ-free rats with a limited flora (gnotobiotic rats) decreased the IDMEC period significantly (15 +/- 1.5 min and 75 +/- 14 min). The migration velocity of the IDMEC was inversely related to the IDMEC period. These observations confirm previous data suggesting that the interdigestive motor complex has a role in the homeostasis of the bacterial content of the small bowel.
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Gut microbiota modulates gut motor function, which in turn can alter intestinal microbiota composition.
“Nonetheless gut microbiota modulates gut motor function, which in turn can alter the intestinal microbiota composition.”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [93]
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Multidisipliner Yaklaşımlarla Ağrı
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- Authors
- Caenepeel, P., Janssens, J., Vantrappen, G., Eyssen, H., & Coremans, G.
- Affiliations
- Rega Institute for Medical Research (BE)
- ORCID
- Janssens, J.
- Venue
- Digestive Diseases and Sciences
- Published
- 1989-08
- Volume
- 34
- Issue
- 8
- Pages
- 1180-1184
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2002195228
- Cited by
- 76
- References
- 15
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Keywords
- germ-free rats, gnotobiotic rats, intestinal bacteria, small intestine motility, migrating motor complex
- MeSH terms
- Animals, Bacteria, Digestion, Electromyography, Electrophysiology, Gastrointestinal Transit, Germ-Free Life, Ileum, Intestine, Small, Jejunum, Male, Rats
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