Impact of stressor exposure on the interplay between commensal microbiota and host inflammation
Open accessAbstract
Exposure to stressful stimuli results in the activation of multiple physiological processes aimed at maintaining homeostasis within the body. These physiological processes also have the capacity to influence the composition of microbial communities, and research now indicates that exposure to stressful stimuli leads to gut microbiota dysbiosis. While the relative abundance of many different bacterial types can be altered during stressor exposure, findings in nonhuman primates and laboratory rodents, as well as humans, indicate that bacteria in the genus Lactobacillus are consistently reduced in the gut during stress. The gut microbiota, including the lactobacilli, have many functions that enhance the health of the host. This review presents studies involving germfree and antibiotic treated mice, as well as mice given Lactobacillus spp. to prevent stressor-induced reductions in lactobacilli, to provide evidence that the microbiota contribute to stressor-induced immunomodulation, both in gut mucosa as well as in systemic compartments. This review will also discuss the evidence that commensal gut microbes have bidirectional effects on gastrointestinal physiology during stressor exposure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stress-induced flora disturbance has a vital impact on IBD by influencing host-microbiota crosstalk and regulating the neuro-immune-endocrine system.
“It has been shown that stress-induced flora disturbance has a vital impact on IBD by influencing host-microbiota crosstalk and regulating the neuro-immune-endocrine system (49–51).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works
Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., Eeckhaut, V., Ballet, V., Claes, K., Van Immerseel, F., Verbeke, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304833 · Cited by 1,904 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works
Low counts of Faecalibacterium prausnitzii in colitis microbiota
Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275 · see citing works
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123 · see citing works
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
How stress influences the immune response
Padgett, D. A., & Glaser, R. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00173-x · Cited by 1,059 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works
Studies on the Intestinal Flora
Drašar, B. S., Shiner, M., & McLeod, G. M. (1969) · Gastroenterology · doi:10.1016/s0016-5085(69)80067-3 · Cited by 564 · see citing works
Thomas, C. M., Hong, T., van Pijkeren, J. P., Hemarajata, P., Trinh, D. V., Hu, W., Britton, R. A., Kalkum, M., & Versalovic, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031951 · Cited by 491 · see citing works
A prospective population-based study of triggers of symptomatic flares in IBD
Bernstein, C. N., Singh, S., Graff, L. A., Walker, J. R., Miller, N., & Cheang, M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.140 · Cited by 400 · see citing works
Galley, J. D., Nelson, M. C., Yu, Z., Dowd, S. E., Walter, J., Kumar, P., Lyte, M., & Bailey, M. T. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-189 · Cited by 398 · see citing works
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling
Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397 · see citing works
Importance and regulation of the colonic mucus barrier in a mouse model of colitis
Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L., & Phillipson, M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00422.2010 · Cited by 384 · see citing works
Tannock, G. W., & Savage, D. C. (1974) · Infection and Immunity · doi:10.1128/iai.9.3.591-598.1974 · Cited by 349 · see citing works
Prenatal Stress Alters Bacterial Colonization of the Gut in Infant Monkeys
Bailey, M. T., Lubach, G. R., & Coe, C. L. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00009 · Cited by 339 · see citing works
Bailey, M. T., Dowd, S. E., Parry, N. M. A., Galley, J. D., Schauer, D. B., & Lyte, M. (2010) · Infection and Immunity · doi:10.1128/iai.00862-09 · Cited by 335 · see citing works
Self-citationPatterns of Early Gut Colonization Shape Future Immune Responses of the Host
Hansen, C. H. F., Nielsen, D. S., Kverka, M., Zakostelska, Z. J., Kostovcikova, K., Hudcovic, T., Tlaskalová‐Hogenová, H., & Hansen, A. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034043 · Cited by 310 · see citing works
CRF antagonist partially reverses CRF- and stress-induced effects on feeding
Krahn, D. D., Gosnell, B. A., Grace, M. K., & Levine, A. S. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90233-9 · Cited by 301 · see citing works
Commensal microbiota is fundamental for the development of inflammatory pain
Amaral, F. A., Sachs, D., Costa, V. V., Fagundes, C. T., Cisalpino, D., Cunha, T. M., Ferreira, S. H., Cunha, F. Q., Silva, T. A., Nicoli, J. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711891105 · Cited by 289 · see citing works
Martín, R., Chain, F., Miquel, S., Lu, J., Gratadoux, J.-J., Sokol, H., Verdu, E. F., Bercik, P., Bermúdez-Humarán, L. G., & Langella, P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000440815.76627.64 · Cited by 284 · see citing works
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
Reinhardt, C., Bergentall, M., Greiner, T. U., Schaffner, F., Östergren‐Lundén, G., Petersen, L. C., Ruf, W., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature10893 · Cited by 282 · see citing works
Crouzet, L., Gaultier, E., Del'Homme, C., Cartier, C., Delmas, E., Dapoigny, M., Fioramonti, J., & Bernalier‐Donadille, A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12103 · Cited by 280 · see citing works
Castagliuolo, I., LaMont, J. T., Qiu, B., Fleming, S. M., Bhaskar, K. R., Nikulásson, S. Þ., Kornetsky, C. H., & Pothoulakis, C. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.5.g884 · Cited by 251 · see citing works
Aidy, S. E., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G. J. E. J., Levenez, F., Dore, J. M., Dekker, J. P., Samsom, J. N., Nieuwenhuis, E. E. S., et al. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.32 · Cited by 247 · see citing works
Söderholm, J. D., Yates, D. A., Gareau, M. G., Yang, P.-C., MacQueen, G., & Perdue, M. H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00314.2002 · Cited by 243 · see citing works
Effect of the Normal Microbial Flora on Gastrointestinal Motility.
Abrams, G. D., & Bishop, J. E. (1967) · Experimental Biology and Medicine · doi:10.3181/00379727-126-32430 · Cited by 242 · see citing works
Reber, S. O., Birkeneder, L., Veenema, A. H., Obermeier, F., Falk, W., Straub, R. H., & Neumann, I. (2006) · Endocrinology · doi:10.1210/en.2006-0983 · Cited by 212 · see citing works
Knowles, S. R., Nelson, E. A., & Palombo, E. A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.010 · Cited by 192 · see citing works
Nieuwenhuijs, V. B., Verheem, A., van Duijvenbode-Beumer, H., Visser, M. R., Verhoef, J., Gooszen, H. G., & Akkermans, L. M. A. (1998) · Annals of Surgery · doi:10.1097/00000658-199808000-00007 · Cited by 186 · see citing works
Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat
Uribe, A., Alam, M., Johansson, O., Midtvedt, T., & Theodorsson, E. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90526-6 · Cited by 171 · see citing works
Resta, S. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176370 · Cited by 134 · see citing works
Nakade, Y., Tsuchida, D., Fukuda, H., Iwa, M., Pappas, T. N., & Takahashi, T. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00499.2004 · Cited by 128 · see citing works
Nakade, Y., Fukuda, H., Iwa, M., Tsukamoto, K., Yanagi, H., Yamamura, T., Mantyh, C. R., Pappas, T. N., & Takahashi, T. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00419.2006 · Cited by 114 · see citing works
The Microbiota and Allergies/Asthma
Huffnagle, G. B. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000549 · Cited by 104 · see citing works
Roberts, C., Campbell, I. C., & Troop, N. (2013) · European Eating Disorders Review · doi:10.1002/erv.2264 · Cited by 101 · see citing works
Barouei, J., Moussavi, M., & Hodgson, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046051 · Cited by 99 · see citing works
Adrenergic modulation of Escherichia coli O157:H7 adherence to the colonic mucosa
Green, B. T., Lyte, M., Chen, C., Xie, Y., Casey, M. A., Kulkarni, A. P., Vulchanova, L., & Brown, D. R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00471.2003 · Cited by 90 · see citing works
Primocolonization is associated with colonic epithelial maturation during conventionalization
Tomas, J., Wrzosek, L., Bouznad, N., Bouet, S., Mayeur, C., Noordine, M.-L., Honvo‐Houeto, E., Langella, P., Thomas, M., & Cherbuy, C. (2012) · The FASEB Journal · doi:10.1096/fj.12-216861 · Cited by 86 · see citing works
Early maternal separation: Neurobehavioral consequences in mother rats
Aguggia, J. P., Suárez, M. M., & Rivarola, M. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.040 · Cited by 80 · see citing works
Mackos, A. R., Eubank, T. D., Parry, N. M. A., & Bailey, M. T. (2013) · Infection and Immunity · doi:10.1128/iai.00278-13 · Cited by 78 · see citing works
Maslanik, T., Tannura, K., Mahaffey, L., Loughridge, A. B., Benninson, L., Ursell, L., Greenwood, B. N., Knight, R., & Fleshner, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050636 · Cited by 77 · see citing works
Interdigestive myoelectric complex in germ-free rats
Caenepeel, P., Janssens, J., Vantrappen, G., Eyssen, H., & Coremans, G. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01537265 · Cited by 76 · see citing works
Effect of repeated restraint stress on the levels of intestinal IgA in mice
Jarillo‐Luna, A., Rivera‐Aguilar, V., Reyna-Garfias, H., Lara‐Padilla, E., Kormanovski, A., & Campos-Rodrı́guez, R. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.04.009 · Cited by 74 · see citing works
Pullinger, G. D., Carnell, S. C., Sharaff, F., van Diemen, P. M., Dziva, F., Morgan, E., Lyte, M., Freestone, P. P. E., & Stevens, M. P. (2009) · Infection and Immunity · doi:10.1128/iai.01203-09 · Cited by 71 · see citing works
Sanghez, V., Razzoli, M., Carobbio, S., Campbell, M., McCallum, J., Cero, C., Ceresini, G., Cabassi, A., Govoni, P., Franceschini, P., et al. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.07.022 · Cited by 70 · see citing works
Gastric mucosal damage in water immersion stress: Mechanism and prevention with GHRP-6
Guo, S. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i24.3145 · Cited by 57 · see citing works
Allen, R. G., Lafuse, W. P., Galley, J. D., Ali, M. M., Ahmer, B. M. M., & Bailey, M. T. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.002 · Cited by 55 · see citing works
Goyal, N., & Shukla, G. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2503-y · Cited by 55 · see citing works
Effects of psychological stress on small intestinal motility and bacteria and mucosa in mice
Wang, S.-X. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i13.2016 · Cited by 55 · see citing works
Allen, R. G., Lafuse, W. P., Powell, N. D., Marketon, J. I. W., Stiner, L., Sheridan, J. F., & Bailey, M. T. (2012) · Infection and Immunity · doi:10.1128/iai.00714-12 · Cited by 53 · see citing works
Repeated restraint stress increases IgA concentration in rat small intestine
Reyna-Garfias, H., Miliar, A., Jarillo‐Luna, A., Rivera‐Aguilar, V., Pacheco‐Yépez, J., Baeza, I., & Campos‐Rodríguez, R. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.005 · Cited by 49 · see citing works
Yang, H., Yuan, P. Q., Wang, L., & Taché, Y. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00490-x · Cited by 43 · see citing works
Lewis, K. J., Caldwell, J., Phan, V., Prescott, D., Nazli, A., Wang, A., Söderholm, J. D., Perdue, M. H., Sherman, P. M., & McKay, D. M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00382.2007 · Cited by 40 · see citing works
Animal models for the study of the effect of prolonged stress on lactation in rats
Lau, C., & SIMPSON, C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.05.004 · Cited by 36 · see citing works
Bailey, M. T., Karaszewski, J. W., Lubach, G. R., Coe, C. L., & Lyte, M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00087-6 · Cited by 31 · see citing works
The role of sympathetic neurons for low susceptibility to stress in gastric lesions
Shichijo, K., Ito, M., Taniyama, K., & Sekine, I. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90677-u · Cited by 22 · see citing works
Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2
Flagged first, then by citations
Cited by
Sorted by citations
Integrating neuroimmune systems in the neurobiology of depression
Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573 · see citing works
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 535 · see citing works
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease
Buford, T. W. (2017) · Microbiome · doi:10.1186/s40168-017-0296-0 · Cited by 409 · see citing works
Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385 · see citing works
“The other way around, the CNS can also modulate the composition and balance of the intestinal microbial community (and mostly Gram-negative bacteria) through the stress system (ANS, HPA axis), (230).”
BackgroundThe mucosal immune system: master regulator of bidirectional gut-brain communications
Powell, N., Walker, M. M., & Talley, N. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.191 · Cited by 379 · see citing works
Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works
Kang, S. S., Jeraldo, P., Kurti, A., Miller, M. E. B., Cook, M. D., Whitlock, K. G., Goldenfeld, N. D., Woods, J. A., White, B. A., Chia, N., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-36 · Cited by 322 · see citing works
The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors
Lobionda, S., Sittipo, P., Kwon, H. Y., & Lee, Y. K. (2019) · Microorganisms · doi:10.3390/microorganisms7080271 · Cited by 319 · see citing works
Morris, G., Berk, M., Carvalho, A. F., Caso, J. R., Sanz, Y., Walder, K. R., & Maes, M. H. J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0004-2 · Cited by 307 · see citing works
Why do lactobacilli dominate the human vaginal microbiota?
Witkin, S. S., & Linhares, I. M. (2016) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14390 · Cited by 289 · see citing works
Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms
Godos, J., Currenti, W., Angelino, D., Mena, P. R., Castellano, S., Caraci, F., Galvano, F., Rio, D. D., Ferri, R., & Grosso, G. (2020) · Antioxidants · doi:10.3390/antiox9040346 · Cited by 263 · see citing works
Effects of heat stress on the gut health of poultry
Rostagno, M. H. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa090 · Cited by 266 · see citing works
Cerdá, B., Pérez, M., Pérez-Santiago, J. D., Tornero-Aguilera, J. F., González-Soltero, R., & Larrosa, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00051 · Cited by 247 · see citing works
Gut Microbiota: The Brain Peacekeeper
Mu, C., Yang, Y., & Zhu, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00345 · Cited by 188 · see citing works
Do bacteria shape our development? Crosstalk between intestinal microbiota and HPA axis
de Weerth, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.016 · Cited by 181 · see citing works
Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works
Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors
Pearce, S., Coia, H. G., Karl, J. P., Pantoja-Feliciano, I. G., Zachos, N. C., & Racicot, K. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01584 · Cited by 159 · see citing works
Gut microbiota, the immune system, and diet influence the neonatal gut–brain axis
Sherman, M. P., Zaghouani, H., & Niklas, V. (2014) · Pediatric Research · doi:10.1038/pr.2014.161 · Cited by 161 · see citing works
Environmental factors in autoimmune diseases and their role in multiple sclerosis
Haase, S., Grohme, D. A., Erzler, M., Binsfeld, M., Haghikia, A., Müller, D. N., Linker, R. A., & Kleinewietfeld, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2311-1 · Cited by 152 · see citing works
Gut Microbiota: A Perspective for Psychiatrists
Rea, K., Dinan, T. G., & Cryan, J. F. (2019) · Neuropsychobiology · doi:10.1159/000504495 · Cited by 142 · see citing works
The Immunopathogenesis of Alzheimer’s Disease Is Related to the Composition of Gut Microbiota
Leblhuber, F., Ehrlich, D., Steiner, K., Geisler, S., Fuchs, D., Lanser, L., & Kurz, K. (2021) · Nutrients · doi:10.3390/nu13020361 · Cited by 145 · see citing works
Effects of chronic exercise on gut microbiota and intestinal barrier in human with type 2 diabetes
Pasini, E., Corsetti, G., Assanelli, D., Testa, C., Romano, C., Dioguardi, F. S., & Aquilani, R. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05589-1 · Cited by 133 · see citing works
Dunphy-Doherty, F., O'Mahony, S. M., Peterson, V. L., O'Sullivan, O., Crispie, F., Cotter, P. D., Wigmore, P., King, M. V., Cryan, J. F., & Fone, K. C. F. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.10.024 · Cited by 124 · see citing works
Sun, L., Zhang, H., Cao, Y., Wang, C., Zhao, C., Wang, H., Cui, G., Wang, M., Pan, Y., Shi, Y., et al. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.37322 · Cited by 127 · see citing works
Stress-sensitive neural circuits change the gut microbiome via duodenal glands
Chang, H., Perkins, M. H., Novaes, L. S., Qian, F., Zhang, T., Neckel, P. H., Scherer, S., Ley, R. E., Han, W., & de Araújo, I. E. (2024) · Cell · doi:10.1016/j.cell.2024.07.019 · Cited by 133 · see citing works
Baxter, M. F. A., Merino-Guzmán, R., Latorre, J. D., Mahaffey, B. D., Yang, Y., Teague, K. D., Graham, L. E., Wolfenden, A. D., Hernández-Velasco, X., Bielke, L. R., et al. (2017) · Frontiers in Veterinary Science · doi:10.3389/fvets.2017.00056 · Cited by 113 · see citing works
Tooley, K. L. (2020) · Nutrients · doi:10.3390/nu12103009 · Cited by 111 · see citing works
Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
Sharma, V., Singh, T. G., Garg, N., Dhiman, S., Gupta, S., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomolecules · doi:10.3390/biom11050678 · Cited by 111 · see citing works
Donovan, M., Mackey, C. S., Platt, G. N., Rounds, J., Brown, A. N., Trickey, D. J., Liu, Y., Jones, K. M., & Wang, Z. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100278 · Cited by 85 · see citing works
The Potential Influence of the Bacterial Microbiome on the Development and Progression of ADHD
Bull-Larsen, S., & Mohajeri, M. H. (2019) · Nutrients · doi:10.3390/nu11112805 · Cited by 107 · see citing works
Early Life Experience and Gut Microbiome
Cong, X. S., Henderson, W. A., Graf, J., & McGrath, J. M. (2015) · Advances in Neonatal Care · doi:10.1097/anc.0000000000000191 · Cited by 100 · see citing works
The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review
Cao, C., Chowdhury, V. S., Cline, M. A., & Gilbert, E. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752265 · Cited by 104 · see citing works
Gut microbiota and central nervous system development
Principi, N., & Esposito, S. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.09.010 · Cited by 92 · see citing works
Intestinal microbiome-gut-brain axis and irritable bowel syndrome
Moser, G., Fournier, C., & Peter, J. (2017) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-017-0592-0 · Cited by 90 · see citing works
The microbiome as a novel paradigm in studying stress and mental health.
Liu, R. T. (2017) · American Psychologist · doi:10.1037/amp0000058 · Cited by 89 · see citing works
Stress gets into the belly: Early life stress and the gut microbiome
Hantsoo, L. V., & Zemel, B. S. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113474 · Cited by 91 · see citing works
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Nakhal, M. M., Yassin, L. K., Alyaqoubi, R., Saeed, S., Alderei, A., Alhammadi, A., Alshehhi, M., Almehairbi, A., Houqani, S. A., BaniYas, S., et al. (2024) · Life · doi:10.3390/life14101234 · Cited by 134 · see citing works
Low-level inflammation, immunity, and brain-gut axis in IBS: unraveling the complex relationships
Yuan, Y., Wang, X., Huang, S., Wang, H., & Shen, G.-M. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2263209 · Cited by 92 · see citing works
Chen, T., Wang, R., Duan, Z., Yuan, X., Ding, Y., Feng, Z., Bu, F., Liu, L., Wang, Q., Zhou, J., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.723856 · Cited by 85 · see citing works
Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues
Bhatt, S., Kanoujia, J., Lakshmi, S. M., Patil, C., Gupta, G., Chellappan, D. K., & Dua, K. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220329140804 · Cited by 81 · see citing works
Sawada, D., Kuwano, Y., Tanaka, H., Hara, S., Uchiyama, Y., Sugawara, T., Fujiwara, S., Rokutan, K., & Nishida, K. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.022 · Cited by 76 · see citing works
Staude, B., Oehmke, F., Lauer, T., Behnke, J., Göpel, W., Schloter, M., Schulz, H., Krauss‐Etschmann, S., & Ehrhardt, H. (2018) · BioMed Research International · doi:10.1155/2018/7218187 · Cited by 75 · see citing works
Omics Studies of the Murine Intestinal Ecosystem Exposed to Subchronic and Mild Social Defeat Stress
AOKI-YOSHIDA, A., Aoki, R., Moriya, N., Goto, T., Kubota, Y., Toyoda, A., Takayama, Y., & Suzuki, C. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00262 · Cited by 74 · see citing works
Intrauterine Microbiota: Missing, or the Missing Link?
Chen, H. J., & Gur, T. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.008 · Cited by 70 · see citing works
Gautam, A., Kumar, R., Chakraborty, N., Muhie, S. Y., Hoke, A. V., Hammamieh, R., & Jett, M. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24229 · Cited by 65 · see citing works
Madison, A. A., & Bailey, M. T. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.014 · Cited by 67 · see citing works
Ibrahim, N., Rahman, M. Z., Ad-Dab’bagh, Y., & Akhtar, M. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12804 · Cited by 62 · see citing works
Bi, C., Guo, S., Hu, S., Chen, J., Ye, M., & Liu, Z. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106372 · Cited by 61 · see citing works
Gautam, A., D’Arpa, P., Donohue, D. E., Muhie, S. Y., Chakraborty, N., Luke, B. T., Grapov, D., Carroll, E. E., Meyerhoff, J. L., Hammamieh, R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117092 · Cited by 51 · see citing works
Carson, T. L., Wang, F., Cui, X., Jackson, B. E., Pol, W. J. V. D., Lefkowitz, E. J., Morrow, C. D., & Baskin, M. L. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000614 · Cited by 49 · see citing works
The microbiome and cognitive aging: a review of mechanisms
Komanduri, M., Gondalia, S. V., Scholey, A. B., & Stough, C. K. K. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05231-1 · Cited by 48 · see citing works
The Timing Effects of Soy Protein Intake on Mice Gut Microbiota
Tamura, K., Sasaki, H., Shiga, K., Miyakawa, H., & Shibata, S. (2019) · Nutrients · doi:10.3390/nu12010087 · Cited by 48 · see citing works
Abedpoor, N., Taghian, F., & Hajibabaie, F. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02835-1 · Cited by 45 · see citing works
Maternal depressive symptoms linked to reduced fecal Immunoglobulin A concentrations in infants
Kang, L. J., Koleva, P. T., Field, C. J., Giesbrecht, G. F., Wine, E., Becker, A. B., Mandhane, P. J., Turvey, S. E., Subbarao, P., Sears, M. R., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.007 · Cited by 43 · see citing works
Yan, L., Li, H., Qian, Y., Zhang, J., Cong, S., Zhang, X., Wu, L., Wang, Y., Wang, M., & Yu, T. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1334887 · Cited by 41 · see citing works
Stress, inflammation, microbiome and depression
Medina-Rodriguez, E. M., Cruz, A. A., Abreu, J. C. D., & Beurel, E. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173561 · Cited by 37 · see citing works
Maguey-González, J. A., Michel, M. A., Baxter, M. F. A., Tellez, G., Moore, P. A., Jr., Solís-Cruz, B., Hernández‐Patlan, D., Merino-Guzmán, R., Hernández-Velasco, X., Latorre, J. D., et al. (2018) · Animal Science Journal · doi:10.1111/asj.13011 · Cited by 36 · see citing works
Chang, Y.-T., Ko, H.-T., Wu, P.-L., Kumar, R., Wang, H., & Lu, H. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01180-23 · Cited by 35 · see citing works
Arteaga-Henríquez, G., Rosales-Ortiz, S. K., Vásquez, A. A., Bitter, I., Ginsberg, Y., Ibañez-Jiménez, P., Kilencz, T., Lavebratt, C., Matura, S., Reif, A., et al. (2020) · Trials · doi:10.1186/s13063-019-4040-x · Cited by 34 · see citing works
Hernández‐Gómez, O., Wuerthner, V. P., & Hua, J. (2019) · Microbial Ecology · doi:10.1007/s00248-019-01351-5 · Cited by 33 · see citing works
The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders
Queiroz, S. A. L., Ton, A. M. M., Pereira, T. D. M. C., Campagnaro, B. P., Martinelli, L., Picos, A., Campos‐Toimil, M., & Vasquez, E. C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.872594 · Cited by 32 · see citing works
From “Leaky Gut” to Impaired Glia-Neuron Communication in Depression
Rudzki, L., & Maes, M. H. J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_9 · Cited by 30 · see citing works
Liang, Y., Du, M., Li, X., Gao, J., Li, Q., Li, H., Li, J., Gao, X., Cong, H., Huang, Y., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2470372 · Cited by 29 · see citing works
The Microbiome in Early Life: Self‐Completion and Microbiota Protection as Health Priorities
Dietert, R. R. (2014) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.21116 · Cited by 26 · see citing works
Dynamics of Gut Microbiota Recovery after Antibiotic Exposure in Young and Old Mice (A Pilot Study)
Laubitz, D., Typpo, K., Midura‐Kiela, M. T., Brown, C. M., Barberán, A., Ghishan, F. K., & Kiela, P. R. (2021) · Microorganisms · doi:10.3390/microorganisms9030647 · Cited by 26 · see citing works
Sgro, M., Kodila, Z. N., Brady, R. D., Reichelt, A. C., Mychasiuk, R., & Yamakawa, G. R. (2021) · SLEEP · doi:10.1093/sleep/zsab268 · Cited by 25 · see citing works
The menstrual cycle may not be limited to the endometrium but also may impact gut permeability
Roomruangwong, C., Carvalho, A. F., Geffard, M., & Maes, M. H. J. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2019.30 · Cited by 27 · see citing works
Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel
van Thiel, I. A. M., de Jonge, W. J., Chiu, I. M., & van den Wijngaard, R. M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00196.2019 · Cited by 26 · see citing works
Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions
Proshkina, E., Solovev, I. A., Shaposhnikov, M. V., & Moskalev, A. (2020) · Molecular Biology · doi:10.1134/s0026893320060096 · Cited by 21 · see citing works
Rosell‐Cardona, C., Leigh, S., Knox, E. G., Tirelli, E., Lyte, J. M., Goodson, M. S., Kelley‐Loughnane, N., Aburto, M. R., Cryan, J. F., & Clarke, G. A. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100992 · Cited by 18 · see citing works
Untreated Early Childhood Caries and Possible Links with Brain Development
Foláyan, M. O., Femi-Akinlosotu, O. M., Adeoti, B., & Olorunmoteni, O. E. (2023) · BioMed · doi:10.3390/biomed3040035 · Cited by 21 · see citing works
Adrenal cortex–medulla interactions in adaptation to stress and disease
Bornstein, S. R., Berger, I., Scriba, L. D., Santambrogio, A., & Steenblock, C. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.06.005 · Cited by 18 · see citing works
Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенции
Proshkina, E., Соловьёв, И. А., Shaposhnikov, M. V., & Moskalev, A. A. (2020) · Molecular Biology · doi:10.31857/s0026898420060099 · Cited by 18 · see citing works
Unraveling the Gut‐Brain‐Immune Interplay in Herpes Simplex Virus‐Associated Neurodegeneration
Bautista, J., Ávila‐Coello, D., Hidalgo‐Tinoco, C., Bueno‐Miño, J., & López‐Cortés, A. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70504 · Cited by 16 · see citing works
Discrete role for maternal stress and gut microbes in shaping maternal and offspring immunity
Chen, H. J., Bischoff, A., Galley, J. D., Peck, L., Bailey, M. T., & Gur, T. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100480 · Cited by 16 · see citing works
Kłak, K., Maciuszek, M., Michalik, A., Mazur, M., Zawisza, M., Pecio, A., Nowak, B. F., & Chadzińska, M. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110301 · Cited by 17 · see citing works
Sun, Y., Deng, G., Fan, J., Feng, F., Ge, Q., Song, Y., & Kang, X. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114123 · Cited by 15 · see citing works
Recent Anti-Microbial Exposure Is Associated with More Complications after Elective Surgery
Guidry, C. A., Shah, P. M., Dietch, Z. C., Elwood, N. R., Krebs, E. D., Mehaffey, J. H., & Sawyer, R. G. (2018) · Surgical Infections · doi:10.1089/sur.2018.031 · Cited by 15 · see citing works
Richards, P., Wigley, P., López, J., Wormell, D., & Barbón, A. R. (2021) · Animal Microbiome · doi:10.1186/s42523-020-00062-4 · Cited by 14 · see citing works
Li, H., Liu, P., Sun, T., Li, Y., Wu, J., Huang, Y., Yang, J., Yuan, M., Zhang, J., Yang, J., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03326-2 · Cited by 12 · see citing works
Bikov, A., Dragonieri, S., Csoma, B., Mazzuca, C., Finamore, P., Rocchi, G., Putignani, L., Guarino, M. P. L., & Scarlata, S. (2022) · Microorganisms · doi:10.3390/microorganisms10122457 · Cited by 11 · see citing works
Social isolation induces intestinal barrier disorder and imbalances gut microbiota in mice
Wang, Y., Ullah, H., Deng, T., Ren, X., Zhao, Z., Xin, Y., & Qiu, J. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137714 · Cited by 11 · see citing works
Jaggers, R. M., DiSabato, D. J., Loman, B. R., Kontic, D., Spencer, K. D., Allen, J. M., Godbout, J. P., Quan, N., Gur, T. L., & Bailey, M. T. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s332793 · Cited by 10 · see citing works
Heat Stress and Gut Microbiota: Effects on Poultry Productivity
Akinyem, F. T., Bello, S. F., Uyanga, V. A., Oretomiloy, C., & Meng, H. (2020) · International Journal of Poultry Science · doi:10.3923/ijps.2020.294.302 · Cited by 10 · see citing works
Huang, Z., Huang, J., Leung, C., Zhang, C. J. P., Akinwunmi, B., & Ming, W. (2024) · Human Genomics · doi:10.1186/s40246-024-00588-7 · Cited by 9 · see citing works
Fecal identification markers impact the feline fecal microbiota
Nealon, N. J., Wood, A., Rudinsky, A. J., Klein, H., Salerno, M., Parker, V. J., Quimby, J. M., Howard, J., & Winston, J. A. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1039931 · Cited by 9 · see citing works
Andrews, K., & González, A. (2019) · Developmental Psychobiology · doi:10.1002/dev.21823 · Cited by 10 · see citing works
Stoyanova, M., Gledacheva, V., & Nikolova, S. (2025) · Applied Sciences · doi:10.3390/app15126441 · Cited by 9 · see citing works
Rodriguez‐Palacios, A., Staempfli, H. R., & Weese, J. S. (2017) · International Journal of Microbiology · doi:10.1155/2017/2439025 · Cited by 7 · see citing works
Gubert, C., Kong, G., Shadani, S., Connell, S., Masson, B. A., van de Garde, N., Narayana, V. K., Renoir, T., & Hannan, A. J. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf056 · Cited by 7 · see citing works
Chen, Q., Wang, Z., Shao, D., & Shi, S. (2022) · World s Poultry Science Journal · doi:10.1080/00439339.2022.2106344 · Cited by 6 · see citing works
Influence of Chronic Social Defeat Stress on Digestive System Functioning in Rats
Toyoda, A., Iio, W., Matsukawa, N., & Tsukahara, T. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.280 · Cited by 5 · see citing works
Linhares, I. M., Minis, E. E., Robial, R., & Witkin, S. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815249-2.00011-7 · Cited by 5 · see citing works
From "Leaky Gut" to Impaired Glia-neuron Communication in DepressionPreprint
Rudzki, L., & Maes, M. H. J. (2020) · Preprints.org · doi:10.20944/preprints202006.0058.v1 · Cited by 4 · see citing works
Migration-driven microbial adaptation and ecological spillover in birds
Tufail, A., Bo, T., Zhao, N., Duan, J., Jin, J., Khan, B. N., Qu, Y., Song, G., & Fumin, L. (2026) · ISME Communications · doi:10.1093/ismeco/ycag042 · Cited by 3 · see citing works
Holdsworth, E. A., Williams, J. E., Pace, R. M., Caffé, B., Gartstein, M. A., McGuire, M. A., McGuire, S., & Meehan, C. L. (2025) · American Journal of Human Biology · doi:10.1002/ajhb.70061 · Cited by 3 · see citing works
Anisman, H., & Kusnecov, A. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91904-3.00017-3 · Cited by 3 · see citing works
Samami, E., Starkweather, A. R., Kelly, D. L., & Lyon, D. (2025) · Cancer Reports · doi:10.1002/cnr2.70224 · Cited by 2 · see citing works
Acute Reactivity of Individuals With High and Low Levels of Ongoing Stress
Naliboff, B. D., Ravichandran, S., Labus, J. S., Hassouna, R., Nevé, B. L., Lourenço, J., Maillard, A., Vaughan, A., Liu, X. C., Mayer, E. A., et al. (2025) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001441 · Cited by 2 · see citing works
- Authors
- Galley, J. D., & Bailey, M. T.
- Affiliations
- The Ohio State University (US)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Bailey, Michael T
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2014-04
- Volume
- 5
- Issue
- 3
- Pages
- 390-396
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4153778
- OpenAlex
- W1974950448
- Cited by
- 125
- References
- 66
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 6 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 14 · 2019: 17 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 4 · 2014: 3
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gut Microbes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Complementary and Integrative Health (R01AT006552)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- stress, gut microbiota, Lactobacillus, dysbiosis, host inflammatory response, immunomodulation, commensal bacteria, germ-free mice, antibiotic-treated mice, digestive physiology
- MeSH terms
- Animals, Bacteria, Humans, Inflammation, Primates, Rodentia, Stress, Physiological, Symbiosis, Gastrointestinal Tract, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review