Cited by 125Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

Impact of stressor exposure on the interplay between commensal microbiota and host inflammation

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Galley, Jeffrey D, Bailey, Michael T·2014·Gut Microbes

Abstract

Exposure to stressful stimuli results in the activation of multiple physiological processes aimed at maintaining homeostasis within the body. These physiological processes also have the capacity to influence the composition of microbial communities, and research now indicates that exposure to stressful stimuli leads to gut microbiota dysbiosis. While the relative abundance of many different bacterial types can be altered during stressor exposure, findings in nonhuman primates and laboratory rodents, as well as humans, indicate that bacteria in the genus Lactobacillus are consistently reduced in the gut during stress. The gut microbiota, including the lactobacilli, have many functions that enhance the health of the host. This review presents studies involving germfree and antibiotic treated mice, as well as mice given Lactobacillus spp. to prevent stressor-induced reductions in lactobacilli, to provide evidence that the microbiota contribute to stressor-induced immunomodulation, both in gut mucosa as well as in systemic compartments. This review will also discuss the evidence that commensal gut microbes have bidirectional effects on gastrointestinal physiology during stressor exposure.

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  • Stress-induced flora disturbance has a vital impact on IBD by influencing host-microbiota crosstalk and regulating the neuro-immune-endocrine system.

    “It has been shown that stress-induced flora disturbance has a vital impact on IBD by influencing host-microbiota crosstalk and regulating the neuro-immune-endocrine system (49–51).”

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Authors
Galley, J. D., & Bailey, M. T.
Affiliations
  • The Ohio State University (US)
  • The Ohio State University Wexner Medical Center (US)
Corresponding author
Bailey, Michael T
Venue
Gut Microbes
Published
2014-04
Volume
5
Issue
3
Pages
390-396
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
OpenAlex
W1974950448
Cited by
125
References
66
Citations by year
2026: 4 · 2025: 13 · 2024: 6 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 14 · 2019: 17 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 4 · 2014: 3
FWCI
0.91
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Complementary and Integrative Health (R01AT006552)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
stress, gut microbiota, Lactobacillus, dysbiosis, host inflammatory response, immunomodulation, commensal bacteria, germ-free mice, antibiotic-treated mice, digestive physiology
MeSH terms
Animals, Bacteria, Humans, Inflammation, Primates, Rodentia, Stress, Physiological, Symbiosis, Gastrointestinal Tract, Host-Pathogen Interactions

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