Cited by 95Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

Dopamine transporter binding in Gilles de la Tourette syndrome

Müller-Vahl, Kirsten R., Berding, Georg, Brücke, Thomas, Kolbe, Hans, Meyer, Geerd J., Hundeshagen, Heinz, Dengler, Reinhard, Knapp, Wolfram H. +1 more·2000·Journal of Neurology

Abstract

Preliminary studies in patients with Gilles de la Tourette syndrome (TS) provided evidence of presynaptic dopaminergic dysfunction, demonstrating increased reuptake sites. Therefore we investigated striatal dopamine transporter binding in 12 TS patients and 9 control subjects using single photon emission computed tomography and 123I-labeled 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane. In TS patients we found significantly higher relative striatal activity ratios (mean +/- SD 12.33 +/- 3.58) than in controls (9.36 +/- 1.35, P< 0.05). Only five patients, however, showed striatum/occipital cortex ratios more than 2 SD above the normal means. Seven patients had activity ratios within the average ratio of the control group plus 2 SD. Regarding the relationship between clinical parameters and striatum/occipital cortex ratios, we found an association between binding ratios and "self-injurious behavior" and "lack of impulse control." This study corroborates previous data suggesting an involvement of the dopaminergic system in TS pathology. Our results demonstrate that an increase in dopamine transporter capacity is a possible but not a necessary alteration, and which appears more likely when self-injurious behavior and lack of impulse control are associated.

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Crossref · 10.1007/pl00007806

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Authors
Müller-Vahl, K. R., Berding, G., Brücke, T., Kolbe, H., Meyer, G. J., Hundeshagen, H., Dengler, R., Knapp, W. H., & Emrich, H. M.
Affiliations
  • Medizinische Hochschule Hannover (DE)
  • University of Vienna (AT)
Venue
Journal of Neurology
Published
2000-07-26
Volume
247
Issue
7
Pages
514-520
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
OpenAlex
W2004574418
Cited by
95
References
24
Citations by year
2025: 1 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
FWCI
6.70
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Tourette syndrome, dopamine transporter, striatum, dopaminergic dysfunction, self-harm, impulse control
MeSH terms
Adult, Carrier Proteins, Tourette Syndrome, Humans, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Occipital Lobe, Visual Cortex, Tomography, Emission-Computed, Single-Photon, Self-Injurious Behavior, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins

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