Dopamine transporter binding in Gilles de la Tourette syndrome
Abstract
Preliminary studies in patients with Gilles de la Tourette syndrome (TS) provided evidence of presynaptic dopaminergic dysfunction, demonstrating increased reuptake sites. Therefore we investigated striatal dopamine transporter binding in 12 TS patients and 9 control subjects using single photon emission computed tomography and 123I-labeled 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane. In TS patients we found significantly higher relative striatal activity ratios (mean +/- SD 12.33 +/- 3.58) than in controls (9.36 +/- 1.35, P< 0.05). Only five patients, however, showed striatum/occipital cortex ratios more than 2 SD above the normal means. Seven patients had activity ratios within the average ratio of the control group plus 2 SD. Regarding the relationship between clinical parameters and striatum/occipital cortex ratios, we found an association between binding ratios and "self-injurious behavior" and "lack of impulse control." This study corroborates previous data suggesting an involvement of the dopaminergic system in TS pathology. Our results demonstrate that an increase in dopamine transporter capacity is a possible but not a necessary alteration, and which appears more likely when self-injurious behavior and lack of impulse control are associated.
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SPECT investigations in TS have found higher DAT binding in the right caudate, the striatum, the putamen after amphetamine challenge, and the basal ganglia.
“Single-photon emission computed tomography investigations in TS have found higher DAT binding in the right caudate [635], the striatum [636-639], the putamen after amphetamine challenge [640], and the basal ganglia [641].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [638]
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Neurobiological Issues in Tourette’s Syndrome
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PET and SPECT Imaging in Hyperkinetic Movement Disorders
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- Authors
- Müller-Vahl, K. R., Berding, G., Brücke, T., Kolbe, H., Meyer, G. J., Hundeshagen, H., Dengler, R., Knapp, W. H., & Emrich, H. M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- University of Vienna (AT)
- ORCID
- Berding, Georg
- Venue
- Journal of Neurology
- Published
- 2000-07-26
- Volume
- 247
- Issue
- 7
- Pages
- 514-520
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- OpenAlex
- W2004574418
- Cited by
- 95
- References
- 24
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Tourette syndrome, dopamine transporter, striatum, dopaminergic dysfunction, self-harm, impulse control
- MeSH terms
- Adult, Carrier Proteins, Tourette Syndrome, Humans, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Occipital Lobe, Visual Cortex, Tomography, Emission-Computed, Single-Photon, Self-Injurious Behavior, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
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