Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP‐CIT/SPECT study
Abstract
Objective: To investigate dopamine transporter binding in Gilles de la Tourette syndrome (GTS) with SPECT and [123 I]FP‐CIT. Method: Ten neuroleptic naïve/free patients with GTS, and 10 age‐ and gender‐matched normal volunteers were studied. Subjects were clinically evaluated. GTS severity and affective symptoms were measured and the presence of GTS‐related behaviours were recorded. Results: The GTS group showed significantly higher binding in both caudate and putamen nuclei than the controls. No associations were found between striatal binding ratios and measures of affect or GTS‐related behaviours. Conclusion: Patients with GTS show higher striatal binding of FP‐CIT to the striatum in comparison with age‐ and gender‐matched control subjects, indicating that dopamine transporter abnormalities are involved in the pathophysiology of GTS. These abnormalities appear to be distributed across both caudate and putamen.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SPECT investigations in TS have found higher DAT binding in the right caudate, the striatum, the putamen after amphetamine challenge, and the basal ganglia.
“Single-photon emission computed tomography investigations in TS have found higher DAT binding in the right caudate [635], the striatum [636-639], the putamen after amphetamine challenge [640], and the basal ganglia [641].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [639]
A handful of studies have found no differences in striatal DAT binding in TS.
“However, a handful of studies have found no differences in striatal DAT binding in TS [639,642-644].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [639]
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
The yale global tic severity scale: initial testing of a clinician-rated scale of tic severity
LECKMAN, J. F., RIDDLE, M. A., HARDIN, M. T., ORT, S. I., SWARTZ, K. L., STEVENSON, J., & COHEN, D. J. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198907000-00015 · Cited by 2,146 · see citing works
Course of Tic Severity in Tourette Syndrome: The First Two Decades
Leckman, J. F., Zhang, H., Vitale, A., Lahnin, F., Lynch, K., Bondi, C., Kim, Y.-S., & Peterson, B. S. (1998) · Pediatrics · doi:10.1542/peds.102.1.14 · Cited by 685 · see citing works
The Leyton Obsessional Inventory
Cooper, J. E. (1970) · Psychological Medicine · doi:10.1017/s0033291700040010 · Cited by 461 · see citing works
Peterson, B. S., Riddle, M. A., Cohen, D. J., Katz, L. D., Smith, J. C., Hardin, M. T., & Leckman, J. F. (1993) · Neurology · doi:10.1212/wnl.43.5.941 · Cited by 394 · see citing works
Volumetric MRI changes in basal ganglia of children with Tourette's syndrome
Singer, H. S., Reiss, A. L., Brown, J. E., Aylward, E., Shih, B., Chee, E., Harris, E. L., Reader, M. J., Chase, G. A., Bryan, R. N., et al. (1993) · Neurology · doi:10.1212/wnl.43.5.950 · Cited by 370 · see citing works
Shapiro, E. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810080052006 · Cited by 355 · see citing works
The Gilles de la Tourette Syndrome: the Current Status
Robertson, M. M. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.2.147 · Cited by 294 · see citing works
Self-citationAbnormal dopamine uptake sites in postmortem striatum from patients with tourette's syndrome
Singer, H. S., Hahn, I., & Moran, T. H. (1991) · Annals of Neurology · doi:10.1002/ana.410300408 · Cited by 273 · see citing works
Wolf, S. S., Jones, D. W., Knable, M. B., Gorey, J. G., Lee, K. S., Hyde, T. M., Coppola, R., & Weinberger, D. R. (1996) · Science · doi:10.1126/science.273.5279.1225 · Cited by 252 · see citing works
van Dyck, C. H., Seibyl, J. P., Malison, R. T., Laruelle, M. A., Zoghbi, S. S., Baldwin, R. M., & Innis, R. B. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200201000-00005 · Cited by 251 · see citing works
The Psychopathology of the Gilles de la Tourette Syndrome
Robertson, M. M., Trimble, M., & Lees, A. J. (1988) · The British Journal of Psychiatry · doi:10.1192/bjp.152.3.383 · Cited by 250 · see citing works
Self-citationAge-related decline in striatal dopamine transporter binding with iodine-123-beta-CITSPECT.
van Dyck, C. H., Seibyl, J. P., Malison, R. T., Laruelle, M. A., Wallace, E. A., Zoghbi, S. S., Zea‐Ponce, Y., Baldwin, R. M., Charney, D. S., & Hoffer, P. B. (1995) · PubMed · Cited by 226 · see citing works
[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
Malison, R. T., McDougle, C. J., van Dyck, C. H., Scahill, L. D., Baldwin, R. M., Seibyl, J. P., Price, L. H., Leckman, J. F., & Innis, R. B. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1359 · Cited by 223 · see citing works
Cerebral morphometric abnormalities in Tourette's syndrome
Hyde, T. M., Stacey, M. E., Coppola, R., Handel, S. F., Rickler, K. C., & Weinberger, D. R. (1995) · Neurology · doi:10.1212/wnl.45.6.1176 · Cited by 190 · see citing works
The metabolic anatomy of Tourette's syndrome
Eidelberg, D., Moeller, J. R., Antonini, A., Kazumata, K., DHAWAN, V. M., Budman, C. L., & Feigin, A. (1997) · Neurology · doi:10.1212/wnl.48.4.927 · Cited by 167 · see citing works
Braun, A. R., Stoetter, B., RANDOLPH, C. C., Hsiao, J., Vladar, K., Gernert, J., Carson, R. E., Herscovitch, P., & Chase, T. N. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.64 · Cited by 167 · see citing works
Neumeyer, J. L., Campbell, A., Wang, S., et al. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00037a004 · Cited by 164 · see citing works
Unaltered Dopamine Transporter Availability in Adult Attention Deficit Hyperactivity Disorder
van Dyck, C. H., Quinlan, D. M., Cretella, L. M., Staley, J. K., Malison, R. T., Baldwin, R. M., Seibyl, J. P., & Innis, R. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.2.309 · Cited by 139 · see citing works
High Presynaptic Dopaminergic Activity in Children With Tourette's Disorder
Monique Ernst, D., Zametkin, A. J., Jons, P. H., Matochik, J. A., Pascualvaca, D. M., & Cohen, R. M. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199901000-00024 · Cited by 125 · see citing works
D2-like dopamine receptor density in Tourette syndrome measured by PET.
Wong, D., Singer, H. S., Brandt, J., Shaya, E. K., Chen, C. A., Brown, J. E., Kimball, A. W., GJEDDE, A. H., Dannals, R. F., Ravert, H. T., et al. (1997) · PubMed · Cited by 120 · see citing works
Annotation: Gilles de la Tourette Syndrome—An Update
Robertson, M. M. (1994) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1994.tb01209.x · Cited by 113 · see citing works
Self-citationPET studies of the presynaptic and postsynaptic dopaminergic system in Tourette's syndrome.
Turjanski, N., Sawle, G. V., Playford, E. D., Weeks, R., Lammertsma, A. A., Lees, A. J., & Brooks, D. J. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.6.688 · Cited by 106 · see citing works
Self-citationCocaine‐related movement disorders
Cardoso, F., & Jankovic, J. J. (1993) · Movement Disorders · doi:10.1002/mds.870080210 · Cited by 101 · see citing works
Brain Perfusion Abnormalities in Gilles de la Tourette's Syndrome
Moriarty, J., Costa, D. C., Schmitz, B., Trimble, M., Ell, P. J., & Robertson, M. M. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.167.2.249 · Cited by 99 · see citing works
Self-citationDopamine transporter binding in Gilles de la Tourette syndrome
Müller-Vahl, K. R., Berding, G., Brücke, T., Kolbe, H., Meyer, G. J., Hundeshagen, H., Dengler, R., Knapp, W. H., & Emrich, H. M. (2000) · Journal of Neurology · doi:10.1007/pl00007806 · Cited by 95 · see citing works
Heinz, A., Knable, M. B., Wolf, S. S., Jones, D. W., Gorey, J. G., Hyde, T. M., & Weinberger, D. R. (1998) · Neurology · doi:10.1212/wnl.51.4.1069 · Cited by 95 · see citing works
SPECT imaging of cerebral blood flow in Tourette syndrome.
Ma, R., Rasmusson, A. M., Sw, W., & Hoffer, P. B. (1992) · PubMed · Cited by 84 · see citing works
Dopamine Uptake Sites and Dopamine Receptors in Parkinson’s Disease and Schizophrenia
Pearce, R. K. B., Seeman, P. M., Jellinger, K., et al. (2008) · European Neurology · doi:10.1159/000117168 · Cited by 71 · see citing works
Elevated frontal cerebral blood flow in Gilles de la Tourette syndrome: A 99Tcm-HMPAO SPECT study
George, M. S., Trimble, M., Costa, D. C., Robertson, M. M., RING, H. A., & Ell, P. J. (1992) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(92)90022-v · Cited by 70 · see citing works
Self-citationStriatal presynaptic monoaminergic vesicles are not increased in Tourette’s syndrome
Meyer, P., Bohnen, N. I., Minoshima, S., Koeppe, R. A., Wernette, K., Kilbourn, M. R., Kuhl, D. E., Frey, K. A., & Albin, R. L. (1999) · Neurology · doi:10.1212/wnl.53.2.371 · Cited by 69 · see citing works
Dopamine receptor availability in Tourette's Syndrome
George, M. S., Robertson, M. M., Costa, D. C., Ell, P. J., Trimble, M., Pilowsky, L. S., & Verhoeff, N. P. L. G. (1994) · Psychiatry Research · doi:10.1016/0925-4927(94)90014-0 · Cited by 66 · see citing works
Self-citationDopamine D2 receptor imaging inGilles de la Tourette syndrome
Müller‐Vahl, K., Berding, G., KOLBE, H., Meyer, G.-J., Hundeshagen, H., Dengler, R., Knapp, W. H., & Emrich, H. M. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.101003165.x · Cited by 55 · see citing works
Kuikka, J. T., Bergstr�m, K. A., Ahonen, A. K., et al. (1995) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00941854 · Cited by 53 · see citing works
van Dyck, C. H. (2002) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.10.1.36 · Cited by 53 · see citing works
Stamenkovic, M., Schindler, S. D., Asenbaum, S., Neumeister, A., Willeit, M., Willinger, U., de Zwaan, M., Riederer, F., Aschauer, H. N., & Kasper, S. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)00134-6 · Cited by 52 · see citing works
Ase, A. R., Amdiss, F., Hébert, C., Huang, N., van Gelder, N. M., & Reader, T. A. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050142 · Cited by 51 · see citing works
PET studies on the integrity of the pre and postsynaptic dopaminergic system in Tourette syndrome
Brooks, D. J., Turjanski, N., Sawle, G. V., Playford, E. D., & Lees, A. J. (1992) · PubMed · doi:10.82444/warw.33722950 · Cited by 39 · see citing works
Self-citationNeuroleptics and Dopamine Transporters
Reader, T. A., Ase, A. R., Huang, N., et al. (1998) · Neurochemical Research · doi:10.1023/a:1022405621365 · Cited by 27 · see citing works
Gilles de la Tourette Syndrome
Tanguay, P. E. (1981) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60730-5 · Cited by 23 · see citing works
SPET Instrumentation: Characteristics and New Developments
George, M. S., RING, H. A., Costa, D. C., et al. (1991) · Springer eBooks · doi:10.1007/978-1-4471-1901-2_3 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Recent advances in Tourette syndrome research
Albin, R. L., & Mink, J. W. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.001 · Cited by 478 · see citing works
the ESSTS Guidelines Group, Roessner, V., Plessen, K. J., Rothenberger, A., Ludolph, A. G., Rizzo, R., Skov, L., Strand, G., Stern, J. S., Termine, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0163-7 · Cited by 461 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Neurobiology of Tourette Syndrome: Current Status and Need for Further Investigation: Table 1.
Felling, R. J., & Singer, H. S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0150-11.2011 · Cited by 227 · see citing works
Neuromodulation in Tourette syndrome: dopamine and beyond
Buse, J., Schoenefeld, K., Münchau, A., & Roessner, V. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.004 · Cited by 185 · see citing works
Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders
van Velzen, L. S., Vriend, C., de Wit, S. J., & van den Heuvel, O. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00419 · Cited by 159 · see citing works
Yeh, C.-B., Lee, C.-S., Ma, K.-H., Lee, M.-S., Chang, C.-J., & Huang, W.-S. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.01.003 · Cited by 41 · see citing works
Evaluation of Tourette’s syndrome by 99mTc-TRODAT-1 SPECT/CT imaging
Liu, H., Dong, F., Meng, Z., Zhang, B., Tan, J., & Wang, Y. (2010) · Annals of Nuclear Medicine · doi:10.1007/s12149-010-0389-3 · Cited by 34 · see citing works
[99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome
Hwang, W.-J., Yao, W.-J., Fu, Y.-K., & Yang, A.-S. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.04.006 · Cited by 29 · see citing works
Evaluating dopamine transporter activity with 99mTc-TRODAT-1 SPECT in drug-naive Tourette's adults
Yeh, C.-B., Lee, C.-H., Chou, Y.-H., Chang, C.-J., Ma, K.-H., & Huang, W.-S. (2006) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000239485.53780.16 · Cited by 29 · see citing works
- Authors
- Serra‐Mestres, J., Ring, H. A., Costa, D. C., Gacinovic, S., Walker, Z., Lees, A. J., Robertson, M. M., & Trimble, M. R.
- Affiliations
- University of London (GB)
- University College London (GB)
- UCL Queen Square Institute of Neurology (GB)
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2004-01-16
- Volume
- 109
- Issue
- 2
- Pages
- 140-146
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2053187997
- Cited by
- 76
- References
- 41
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 7
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University College London
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Tourette syndrome, dopamine transporter, 123I-FP-CIT, caudate nucleus, putamen, neuroleptic-naive patients, affective symptoms, pathophysiology
- MeSH terms
- Adolescent, Adult, Corpus Striatum, Dopamine, Female, Tourette Syndrome, Humans, Iodine Radioisotopes, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Putamen, Tropanes, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
