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Cited by 34Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

Evaluation of Tourette’s syndrome by 99mTc-TRODAT-1 SPECT/CT imaging

Liu, Hong, Dong, Feng, Meng, Zhaowei, Zhang, Benshu, Tan, Jian, Wang, Yu·2010·Annals of Nuclear Medicine
DOI 10.1007/s12149-010-0389-3
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Abstract

Objective Clinical evidence indicates that the Tourette's syndrome (TS) is associated with hyperactivity of the dopaminergic system; however, imaging studies of dopamine transporter (DAT) in TS patients remain controversial. In this study, we aimed to study DAT binding capacities in a relatively larger sample of drug-naive patients with TS in comparison with controlled subjects by (99m)Tc-TRODAT-1 SPECT/CT imaging. We also aimed to look for any possible correlations between DAT and age, disease duration or tic severity of TS, which have not been thoroughly investigated in previous studies. We tried to provide more evidence for the understanding of the physiopathological mechanism of TS from the molecular imaging perspective.Methods Eighteen drug-naive patients with TS and 8 age- and gender-matched healthy subjects were recruited. Severity of TS was measured with Yale Global Tic Severity Scale. Brain SPECT/CT was performed 2.5 h after injection of (99m)Tc-TRODAT-1. Regions of interest were drawn on the striatum including its sub-regions of caudate and putamen. The cerebellum was used as the reference region. DAT uptake ratio was calculated by subtracting the mean counts per pixel in the cerebellum from the mean counts per pixel in the striatum, caudate or putamen and by dividing the result by the mean counts per pixel in the cerebellum. Comparisons of DAT uptake ratios between TS patients and controls, and comparisons in bilateral striatum and sub-regions in TS patients were carried out. Correlation analysis between DAT uptake ratios and clinical data were also conducted.Results TS patients showed significantly higher uptake of (99m)Tc-TRODAT-1 in bilateral striatum in comparison with the controls. There was no group-specific preferential lateralization in striatal uptake. DAT uptake ratios were not correlated with age and tic severity scores, but significant negative correlation with disease duration was found.Conclusions High level of DAT was demonstrated in drug-naive TS patients compared with normal controls, and it was negatively correlated with TS duration. Therefore, with the extension of the disease duration, certain degree of adaptation might occur in TS patients to compensate for the DAT increase, which suggested that hyper-functional DAT might be involved in the early pathophysiological changes of TS.

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Authors
Liu, H., Dong, F., Meng, Z., Zhang, B., Tan, J., & Wang, Y.
Affiliations
Tianjin Medical University General Hospital (CN)
Corresponding author
Meng, Zhaowei
ORCID
Venue
Annals of Nuclear Medicine
Publisher
Springer Science and Business Media LLC
Published
2010-06-11
Volume
24
Issue
7
Pages
515-521
ISSN
  • 0914-7187 (ISSN-L)
  • 1864-6433
DOI
10.1007/s12149-010-0389-3
OpenAlex
W2044760985
Cited by
34
References
37
Citations by year
2025: 2 · 2024: 2 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
3.15
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Annals of Nuclear Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Yale University
  • Tianjin University
  • Institute of Nuclear Energy Research
  • Tianjin Medical University
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Tourette syndrome, dopamine transporter, 99mTc-TRODAT-1, striatum, caudate nucleus, putamen, disease duration, tic severity, drug-naive patients
MeSH terms
Adolescent, Adult, Age Factors, Female, Tourette Syndrome, Humans, Middle Aged, Time Factors, Tomography, X-Ray Computed, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Case-Control Studies, Tics, Protein Transport, Dopamine Plasma Membrane Transport Proteins, Young Adult

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