Cited by 407Sesquiterpenes and Asteraceae StudiesNatural Compounds in Disease TreatmentNatural product bioactivities and synthesis

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Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

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Salminen, A., Lehtonen, M., Suuronen, T., Kaarniranta, K., Huuskonen, J.·2008·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-008-8103-5PMC PMC11131807

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Abstract

Traditional medicine has been a fertile source for revealing novel lead molecules for modern drug discovery. In plants, terpenoids represent a chemical defense against environmental stress and provide a repair mechanism for wounds and injuries. Interestingly, effective ingredients in several plant-derived medicinal extracts are also terpenoid compounds of monoterpenoid, sesquiterpenoid, diterpenoid, triterpenoid and carotenoid groups. Inflammatory diseases and cancer are typical therapeutic indications of traditional medicines. Thus folk medicine supports the studies which have demonstrated that plant-derived terpenoid ingredients can suppress nuclear factor-kappaB (NF-kappaB) signaling, the major regulator in the pathogenesis of inflammatory diseases and cancer.We review the extensive literature on the different types of terpenoid molecules, totalling 43, which have been verified both inhibiting the NF-kappaB signaling and suppressing the process of inflammation and cancer. It seems that during evolution, plants have established a terpene-based host defense which also represents a cornucopia of effective therapeutic compounds for common human diseases.

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Authors: Salminen, A., Lehtonen, M., Suuronen, T., Kaarniranta, K., & Huuskonen, J.
Affiliations: University of Eastern Finland (FI)
Corresponding author: Salminen, A.
ORCID: Salminen, A.
Lehtonen, M.
Kaarniranta, K.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2008-05-31
Volume: 65
Issue: 19
Pages: 2979-2999
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-008-8103-5
PMC: PMC11131807
OpenAlex: W2064721285
Cited by: 406
References: 122
Citations by year: 2026: 14 · 2025: 27 · 2024: 22 · 2023: 26 · 2022: 20 · 2021: 26 · 2020: 24 · 2019: 26 · 2018: 26 · 2017: 26 · 2016: 28 · 2015: 19 · 2014: 28 · 2013: 25 · 2012: 19
FWCI: 5.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Keywords: terpenoids, NF-κB signaling, anti-inflammatory agents, anticancer agents, monoterpenoids, sesquiterpenes, diterpenoids, triterpenoids, carotenoids, traditional medicine, plant defense, inflammatory diseases
MeSH terms: Anti-Inflammatory Agents, Antineoplastic Agents, Humans, Medicine, Traditional, Neoplasms, Plants, Terpenes, Molecular Structure, NF-kappa B

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Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

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