Cited by 421Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

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AMP-activated protein kinase and its downstream transcriptional pathways

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Cantó, Carles, Auwerx, Johan·2010·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-010-0454-zPMC PMC3622821

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Abstract

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place through the acute modulation of key metabolic enzymes via direct phosphorylation, but also through a slower transcriptional adaptative response. The question of how AMPK regulates the expression of a number of gene sets, such as those related to mitochondrial biogenesis, energy production and oxidative protection, is only beginning to be elucidated, and still many questions remain to be answered. In this review we will try to integrate our current knowledge on how AMPK regulates transcription in muscle and liver, which will serve as examples to illustrate the major advances in the field and the key challenges ahead.

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Authors: Cantó, C., & Auwerx, J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Auwerx, Johan
ORCID: Cantó, Carles
Auwerx, Johan
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2010-07-17
Volume: 67
Issue: 20
Pages: 3407-3423
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-010-0454-z
PMC: PMC3622821
OpenAlex: W2067872036
Cited by: 421
References: 183
Citations by year: 2026: 17 · 2025: 28 · 2024: 19 · 2023: 23 · 2022: 20 · 2021: 24 · 2020: 25 · 2019: 23 · 2018: 28 · 2017: 32 · 2016: 20 · 2015: 27 · 2014: 25 · 2013: 30 · 2012: 33
FWCI: 3.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
reroDoc Digital Library (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-59820, P01DK059820)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: AMPK, transcriptional regulation, energy sensing, mitochondrial biogenesis, muscle, liver, metabolic adaptation, gene expression regulation
MeSH terms: Animals, Humans, Models, Biological, Transcription, Genetic, Signal Transduction, AMP-Activated Protein Kinases

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AMP-activated protein kinase and its downstream transcriptional pathways

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