Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism?

Li, Xia; Zhao, Jun; Li, Zhigang; Zhang, Li; Huo, Zejun

doi:10.1155/2020/8850653

Cited by 35Acupuncture Treatment Research StudiesNerve injury and regenerationMicroRNA in disease regulation

Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism?

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Li, Xia, Zhao, Jun, Li, Zhigang, Zhang, Li, Huo, Zejun·2020·Neural Plasticity

DOI 10.1155/2020/8850653PMC PMC7527896

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Abstract

As the global population ages, the incidence of neurodegenerative diseases has risen. Furthermore, it has been suggested that depression, especially in elderly people, may also be an indication of latent neurodegeneration. Stroke, Alzheimer’s disease (AD), and Parkinson’s disease (PD) are usually accompanied by depression. The urgent challenge is further enforced by psychiatric comorbid conditions, particularly the feeling of despair in these patients. Fortunately, as our understanding of the neurobiological substrates of maladies affecting the central nervous system (CNS) has increased, more therapeutic options and novel potential biological mechanisms have been presented: (1) Neurodegenerative diseases share some similarities in their pathological characteristics, including changes in neuron structure or function and neuronal plasticity. (2) MicroRNAs (miRNAs) are small noncoding RNAs that contribute to the pathogenesis of diverse neurological disease. (3) One ubiquitous neurotrophin, brain-derived neurotrophic factor (BDNF), is crucial for the development of the nervous system. Accumulating data have indicated that miRNAs not only are related to BDNF regulation but also can directly bind with the 3′-UTR of BDNF to regulate BDNF and participate in neuroplasticity. In this short review, we present evidence of shared biological substrates among stroke, AD, PD, and depression and summarize the possible influencing mechanisms of acupuncture on the neuroplasticity of these diseases. We discuss neuroplasticity underscored by the roles of miRNAs and BDNF, which might further reveal the potential biological mechanism of neurodegenerative diseases and depression by acupuncture.

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Aberrant miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders.
“aberrant miRNA can contribute to cancers, cardiovascular diseases, metabolic diseases, immune-mediated disorders, and neurological disorders, etc.230,231”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [230]
Section 2.2.2 links miRNA dysregulation to Parkinson’s disease, and section 2.3 links it to Alzheimer’s disease. The cited paper therefore supports the neurological-disorders part of the claim, but the passages do not support the additional claims about cancers, cardiovascular diseases, metabolic diseases, or immune-mediated disorders. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Authors: Li, X., Zhao, J., Li, Z., Zhang, L., & Huo, Z.
Affiliations: School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China
Beijing University of Chinese Medicine (CN)
Peking University (CN)
Corresponding author: Zhang, Li
Huo, Zejun
ORCID: Zhao, Jun
Li, Zhigang
Zhang, Li
Huo, Zejun
Venue: Neural Plasticity
Publisher: Wiley
Published: 2020-09-22
Volume: 2020
Pages: 1-17
ISSN: 1687-5443 (ISSN-L)
2090-5904
DOI: 10.1155/2020/8850653
PMC: PMC7527896
OpenAlex: W3089280195
Cited by: 35
References: 126
Citations by year: 2026: 7 · 2025: 12 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 2
FWCI: 0.67
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Neural Plasticity (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81574052, 81973938)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords: acupuncture, neuroplasticity, neurodegenerative diseases, depression, microRNA, brain-derived neurotrophic factor, Alzheimer's disease, Parkinson's disease, stroke, psychiatric comorbidity, 3' UTR regulation, geriatric depression
MeSH terms: Animals, Brain, Depressive Disorder, Gene Expression Regulation, Humans, Neuronal Plasticity, Neurons, Acupuncture Therapy, Brain-Derived Neurotrophic Factor, Neurodegenerative Diseases, MicroRNAs

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Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism?

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