The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The role of physical activity in the management of impaired glucose tolerance: a systematic review
Open accessAbstract
Although physical activity is widely reported to reduce the risk of type 2 diabetes in individuals with prediabetes, few studies have examined this issue independently of other lifestyle modifications. The aim of this review is to conduct a systematic review of controlled trials to determine the independent effect of exercise on glucose levels and risk of type 2 diabetes in people with prediabetes (IGT and/or IFG). A detailed search of MEDLINE (1966-2006) and EMBASE (1980-2006) found 279 potentially relevant studies, eight of which met the inclusion criteria for this review. All eight studies were controlled trials in individuals with impaired glucose tolerance. Seven studies used a multi-component lifestyle intervention that included exercise, diet and weight loss goals and one used a structured exercise training intervention. Four studies used the incidence of diabetes over the course of the study as an outcome variable and four relied on 2-h plasma glucose as an outcome measure. In the four studies that measured the incidence of diabetes as an outcome, the risk of diabetes was reduced by approximately 50% (range 42-63%); as these studies reported only small changes in physical activity levels, the reduced risk of diabetes is likely to be attributable to factors other than physical activity. In the remaining four studies, only one reported significant improvements in 2-h plasma glucose even though all but one reported small to moderate increases in maximal oxygen uptake. These results indicate that the contribution of physical activity independent of dietary or weight loss changes to the prevention of type 2 diabetes in people with prediabetes is equivocal.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Fewer RCTs solely targeted PA behavior in individuals with or at risk of developing type 2 diabetes ( 279 , 284 , 285 ).”
From Exercise and Type 2 Diabetes (2010) · cites this paper as [285]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 2×
“individuals with IGT on incidence of type 2 diabetes [ 10-12 ] relied on self-reported”
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
Compendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1183 · Cited by 6,220
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320
Follow-up report on the diagnosis of diabetes mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3160 · Cited by 3,784
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women.
Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G., & Willett, W. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010492 · Cited by 2,901
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s5 · Cited by 2,689
Amos, A., Mccarty, D. J., & Zimmet, P. (1997) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199712)14:5+ · Cited by 2,247
Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A., & Sigal, R. J. (2001) · JAMA · doi:10.1001/jama.286.10.1218 · Cited by 1,889
Ramachandran, A., Snehalatha, C., Mary, S., Mukesh, B., Bhaskar, A. D., Vijay, V., & Indian Diabetes Prevention Programme (IDPP) (2006) · Diabetologia · doi:10.1007/s00125-005-0097-z · Cited by 1,881
The Finnish Diabetes Prevention Study (DPS)
Lindström, J., Louheranta, A., Mannelin, M., Rastas, M., Salminen, V., Eriksson, J., Uusitupa, M., Tuomilehto, J., & for the Finnish Diabetes Prevention Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3230 · Cited by 1,848
Development of a shuttle walking test of disability in patients with chronic airways obstruction.
Singh, S., Morgan, M. D., Scott, S., Walters, D., & Hardman, A. E. (1992) · Thorax · doi:10.1136/thx.47.12.1019 · Cited by 1,435
Franz, M. J., Bantle, J. P., Beebe, C. A., Brunzell, J. D., Chiasson, J.-L., Garg, A., Holzmeister, L. A., Hoogwerf, B., Mayer-Davis, E., Mooradian, A. D., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.148 · Cited by 1,165
Unwin, N. C., Shaw, J. E., Zimmet, P., & Alberti, K. G. M. M. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00835.x · Cited by 1,112
Eriksson, K. F., & Lindg�rde, F. (1991) · Diabetologia · doi:10.1007/bf00400196 · Cited by 1,092
Physical Activity/Exercise and Type 2 Diabetes
Sigal, R. J., Kenny, G. P., Wasserman, D. H., Castaneda-Sceppa, C., & White, R. D. (2006) · Diabetes Care · doi:10.2337/dc06-9910 · Cited by 949
A Prospective Study of Exercise and Incidence of Diabetes Among US Male Physicians
Manson, J. E. (1992) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1992.03490010065031 · Cited by 778
Exercise for type 2 diabetes mellitus
Thomas, D., Elliott, E. J., & Naughton, G. A. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002968.pub2 · Cited by 728
[The Da Qing IGT and Diabetes study].
Ayame, H. (2005) · PubMed · Cited by 658
Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males
Kosaka, K., Noda, M., & Kuzuya, T. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.06.010 · Cited by 656
Edelstein, S. L., Knowler, W. C., Bain, R. P., Andres, R., Barrett-Connor, E. L., Dowse, G. K., Haffher, S. M., Pettitt, D. J., Sorkin, J. D., Muller, D. C., et al. (1997) · Diabetes · doi:10.2337/diab.46.4.701 · Cited by 641
Edelstein, S. L., Knowler, W. C., Bain, R. P., Andres, R., Barrett-Connor, E. L., Dowse, G. K., Haffner, S. M., Pettitt, D. J., Sorkin, J. D., Muller, D. C., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.4.701 · Cited by 641
Physical Activity in the Prevention of Type 2 Diabetes
Laaksonen, D. E., Lindström, J., Lakka, T. A., Eriksson, J. G., Niskanen, L., Wikström, K., Aunola, S., Keinänen-Kiukaanniemi, S., Laakso, M., Valle, T. T., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.158 · Cited by 614
Lowering the Criterion for Impaired Fasting Glucose Is in Order
GENUTH, S. M. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3331 · Cited by 559
The Prevention or Delay of Type 2 Diabetes
American Diabetes Association, & National Institute of Diabetes, D. A. K. D. (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s62 · Cited by 520
The Prevention or Delay of Type 2 Diabetes
American Diabetes Association (2002) · Diabetes Care · doi:10.2337/diacare.25.4.742 · Cited by 493
Eschwège, É., Richard, J. L., Thibult, N., Ducimetière, P., Warnet, J., Claude, J., & Rosselin, G. (1985) · PubMed · Cited by 311
Brooks, G. A., Butte, N. F., Rand, W. M., Flatt, J. P., & Caballero, B. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.921s · Cited by 252
Ko, G. T. C., Chan, J. C. N., Woo, J., Lau, E. M. C., Yeung, M. W., Chow, C., & Cockram, C. S. (1998) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329803500107 · Cited by 207
Estimated Number of Adults With Prediabetes in the U.S. in 2000
Benjamin, S. M., Valdez, R. A., Geiss, L. S., Rolka, D. B., & Narayan, K. M. V. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.645 · Cited by 191
Kuller, L. H., Velentgas, P., Barzilay, J. I., Beauchamp, N. J., O’Leary, D. H., & Savage, P. J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.823 · Cited by 181
American Diabetes Association (2002) · Diabetes Care · doi:10.2337/diacare.25.1.202 · Cited by 169
Lifestyle Intervention According to General Recommendations Improves Glucose Tolerance
Mensink, M., Blaak, E. E., Corpeleijn, E., Saris, W. H. M., de Bruin, T. W. A., & Feskens, E. J. M. (2003) · Obesity Research · doi:10.1038/oby.2003.211 · Cited by 122
Oldroyd, J. C., Unwin, N. C., White, M. J., Mathers, J. C., & Alberti, K. G. M. M. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.09.018 · Cited by 115
Mensink, M., Feskens, E. J. M., Saris, W. H. M., de Bruin, T. W., & Blaak, E. E. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802249 · Cited by 111
Perspectives on Health and Exercise
McKenna, J., & Riddoch, C. (2002) · Cited by 94
Lindahl, B., Nilsson, T., Jansson, J., Asplund, K., & Hallmans, G. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00537.x · Cited by 88
Carr, D. B., Utzschneider, K. M., Boyko, E. J., Asberry, P. J., Hull, R. L., Kodama, K., Callahan, H. S., Matthys, C. C., Leonetti, D. L., Schwartz, R. S., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.340 · Cited by 69
Intra- and interindividual variability of glucose tolerance in an elderly population
Feskens, E. J. M. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90058-h · Cited by 65
Kriska, A. M., Blair, S. N., & Pereira, M. A. (1994) · PubMed · Cited by 64
The Potential Role of Physical Activity in the Prevention of Non-Insulin-Dependent Diabetes Mellitus
Kriska, A. M., Blair, S. N., & Pereira, M. A. (1994) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199401000-00007 · Cited by 26
Keith, R. C. M. (1965) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1965.tb08223.x · Cited by 14
Objective measurement of physical activity
Cooper, A. R. (2003) · Bristol Research (University of Bristol) · Cited by 12
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7
Cited by
Sorted by citations
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan-Taber, L., Albright, A. L., & Braun, B. (2010) · Diabetes Care · doi:10.2337/dc10-9990 · Cited by 1,955
“Fewer RCTs solely targeted PA behavior in individuals with or at risk of developing type 2 diabetes (279,284,285).”
the Tehran Lipid and Glucose Study Group, Azizi, F., Ghanbarian, A., Momenan, A. A., Hadaegh, F., Mirmiran, P., Hedayati, M., Mehrabi, Y., & Zahediasl, S. (2009) · Trials · doi:10.1186/1745-6215-10-5 · Cited by 931
(2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181eeb61c · Cited by 567
Dunkley, A. J., Bodicoat, D. H., Greaves, C. J., Russell, C., Yates, T., Davies, M. J., & Khunti, K. (2014) · Diabetes Care · doi:10.2337/dc13-2195 · Cited by 542
Self-citation
Metadata
- Authors
- Yates, T., Khunti, K., Bull, F., Gorely, T., & Davies, M. J.
- Affiliations
- Loughborough University (GB)
- University of Leicester (GB)
- Corresponding author
- Yates, T.
- Venue
- Diabetologia
- Published
- 2007-04-06
- Volume
- 50
- Issue
- 6
- Pages
- 1116-1126
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC1871609
- OpenAlex
- W2021955902
- Cited by
- 161
- References
- 45
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 7 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetologia (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- physical activity, exercise training, impaired glucose tolerance, prediabetes, type 2 diabetes prevention, 2-hour plasma glucose, VO2max, lifestyle intervention
- MeSH terms
- Blood Glucose, Humans, Exercise, Randomized Controlled Trials as Topic, Treatment Outcome, Glucose Intolerance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
