Beta cell mass in diabetes: a realistic therapeutic target?

Meier, J. J.

doi:10.1007/s00125-008-0936-9

Cited by 155Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

Beta cell mass in diabetes: a realistic therapeutic target?

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Meier, J. J.·2008·Diabetologia

DOI 10.1007/s00125-008-0936-9

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Abstract

Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.

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Expansion of bona fide human β-cells has not been convincingly demonstrated.
“Sadly, expansion of bona fide human β-cells has not been convincingly demonstrated (13–15).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [14]
Regeneration of β-cell function in experimental animal models has been widely observed in rodents but remains elusive and controversial in humans.
“Regeneration of β-cell function in experimental animal models has been widely observed in rodents but remains elusive and controversial in humans (13,14).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [14]

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Meier JJ, Butler PC (2005) Insulin secretion. In: DeGroot LJ, Jameson JL (eds) Endocrinology, 5th edn. Elsevier Saunders, Philadelphia, pp 961-973

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Authors: Meier, J. J.
Affiliations: St. Josef-Hospital (DE)
Corresponding author: Meier, J. J.
ORCID: Meier, J. J.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2008-03-04
Volume: 51
Issue: 5
Pages: 703-713
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-008-0936-9
OpenAlex: W2166312550
Cited by: 155
References: 104
Citations by year: 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 13
FWCI: 3.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: beta-cell mass, type 1 diabetes, type 2 diabetes, beta-cell death, diabetes treatment
MeSH terms: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Insulin Resistance, Regeneration, Apoptosis, Insulin-Secreting Cells

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Beta cell mass in diabetes: a realistic therapeutic target?

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