Cited by 111Adipokines, Inflammation, and Metabolic DiseasesFibroblast Growth Factor ResearchLiver Disease Diagnosis and Treatment

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Hepatokines: unlocking the multi-organ network in metabolic diseases

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Iroz, Alison, Couty, Jean-Pierre, Postic, Catherine·2015·Diabetologia

DOI 10.1007/s00125-015-3634-4

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Abstract

In the face of urbanisation, surplus energy intake, sedentary habits and obesity, type 2 diabetes has developed into a major health concern worldwide. Commonly overlooked in contemporary obesity research, the liver is emerging as a central regulator of whole body energy homeostasis. Liver-derived proteins known as hepatokines are now considered attractive targets for the development of novel type 2 diabetes treatments. This commentary presents examples of three leading hepatokines: fetuin-A, the first to be described and correlated with increased inflammation and insulin resistance; angiopoietin-like protein (ANGPTL)8/betatrophin, initially proposed for its action on beta cell proliferation, although this effect has recently been brought into question; and fibroblast growth factor 21 (FGF21), an insulin-sensitising hormone that is an appealing drug target because of its beneficial metabolic actions. Novel discoveries in hepatokine research may lead to promising biomarkers and treatments for metabolic disorders and type 2 diabetes. This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015).

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Retracted
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“Identified as an adaptor protein for saturated fatty acidmediated activation of Toll-like receptor 4, this fetuin-A–fatty acid synergy may induce inflammatory signalling and insulin resistance—two important driving forces behind type 2 diabetes [6].”
Background
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Retracted
Adipose Tissue-Liver Axis: a key Link in Adiposity
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Increased Circulating Levels of EDA in Newly Diagnosed Type 2 Diabetic PatientsPreprint
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An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes
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Authors: Iroz, A., Couty, J.-P., & Postic, C.
Affiliations: Inserm (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Postic, Catherine
ORCID: Couty, Jean-Pierre
Postic, Catherine
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2015-06-02
Volume: 58
Issue: 8
Pages: 1699-1703
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-015-3634-4
OpenAlex: W593049947
Cited by: 111
References: 23
Citations by year: 2026: 3 · 2025: 10 · 2024: 6 · 2023: 12 · 2022: 9 · 2021: 6 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 15 · 2016: 13 · 2015: 3
FWCI: 10.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale (U1016)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: hepatokines, fetuin-A, FGF21, type 2 diabetes, obesity, insulin resistance, energy homeostasis, liver, therapeutic target, biomarkers
MeSH terms: Angiopoietin-like Proteins, Angiopoietin-Like Protein 8, Animals, Diabetes Mellitus, Type 2, Fibroblast Growth Factors, Humans, Insulin Resistance, Liver, Metabolic Diseases, Obesity, Peptide Hormones, alpha-2-HS-Glycoprotein

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Hepatokines: unlocking the multi-organ network in metabolic diseases

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