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Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study
Open accessAbstract
AIMS/HYPOTHESIS: The study investigated cross-sectional associations of total amount and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome. METHODS: We included 2,497 participants (mean age 60.0 ± 8.1 years, 52% men) from The Maastricht Study who were asked to wear an activPAL accelerometer 24 h/day for 8 consecutive days. We calculated the daily amount of sedentary time, daily number of sedentary breaks and prolonged sedentary bouts (≥30 min), and the average duration of the sedentary bouts. To determine glucose metabolism status, participants underwent an oral glucose tolerance test. Associations of sedentary behaviour variables with glucose metabolism status and the metabolic syndrome were examined using multinomial logistic regression analyses. RESULTS: Overall, 1,395 (55.9%) participants had normal glucose metabolism, 388 (15.5%) had impaired glucose metabolism and 714 (28.6%) had type 2 diabetes. The odds ratio per additional hour of sedentary time was 1.22 (95% CI 1.13, 1.32) for type 2 diabetes and 1.39 (1.27, 1.53) for the metabolic syndrome. No significant or only weak associations were seen for the number of sedentary breaks, number of prolonged sedentary bouts or average bout duration with either glucose metabolism status or the metabolic syndrome. CONCLUSIONS/INTERPRETATION: An extra hour of sedentary time was associated with a 22% increased odds for type 2 diabetes and a 39% increased odds for the metabolic syndrome. The pattern in which sedentary time was accumulated was weakly associated with the presence of the metabolic syndrome. These results suggest that sedentary behaviour may play a significant role in the development and prevention of type 2 diabetes, although longitudinal studies are needed to confirm our findings.
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“It has been shown that sedentary behaviour is a risk factor for cardiometabilic health and all-cause mortality, indepently of the amount of physical activity [86, 87].”
From Can consumer wearable activity tracker-based interventions improve physical activity and cardiometabolic health in patients with chronic diseases? A systematic review and meta-analysis of randomised controlled trials (2020) · cites this paper as [87]
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Metadata
- Authors
- van der Berg, J. D., Stehouwer, C. D. A., Bosma, H., van der Velde, J. H. P. M., Willems, P. J. B., Savelberg, H. H. C. M., Schram, M. T., Sep, S. J. S., van der Kallen, C. J. H., Henry, R. M. A., Dagnelie, P. C., Schaper, N. C., & Koster, A.
- Affiliations
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- ORCID
- Venue
- Diabetologia
- Published
- 2016-02-02
- Volume
- 59
- Issue
- 4
- Pages
- 709-718
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC4779127
- OpenAlex
- W2259694028
- Cited by
- 299
- References
- 31
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 23 · 2023: 24 · 2022: 42 · 2021: 36 · 2020: 39 · 2019: 24 · 2018: 31 · 2017: 23 · 2016: 17
- FWCI
- 25.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Diabetologia (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- the Province of Limburg
- European Regional Development Fund via OP-Zuid
- the Pearl String Initiative Diabetes (Amsterdam, the Netherlands)
- Stichting De Weijerhorst (Maastricht, the Netherlands)
- the Dutch Ministry of Economic Affairs (31O.041)
- European Union Seventh Framework Programme (PCIG09-GA-2011-293621)
- Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands)
- Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)
- Cardiovascular Research Institute Maastricht (CARIM, Maastricht, the Netherlands)
- School for Public Health and Primary Care (CAPHRI, Maastricht, the Netherlands)
- the Cardiovascular Center (CVC, Maastricht, the Netherlands)
- Health Foundation Limburg (Maastricht, the Netherlands)
- Janssen-Cilag B.V. (Tilburg, the Netherlands)
- School for Nutrition and Translational Research in Metabolism (NUTRIM, Maastricht, the Netherlands)
- Stichting Annadal (Maastricht, the Netherlands)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- sedentary behavior, type 2 diabetes, metabolic syndrome, glucose metabolism, sedentary breaks, prolonged sedentary bouts, accelerometer-measured sedentary time, Maastricht Study
- MeSH terms
- Aged, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Factors, Metabolic Syndrome, Sedentary Behavior
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