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Cited by 102Bone health and osteoporosis researchMenopause: Health Impacts and TreatmentsBone Metabolism and Diseases

Depression and low bone mineral density: a meta-analysis of epidemiologic studies

Wu, Q., Magnus, J. H., Liu, J., Bencaz, A. F., Hentz, J. G.·2009·Osteoporosis International
DOI 10.1007/s00198-009-0918-x
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Abstract

Summary The association between depression and loss of bone mineral density (BMD) has been reported inconsistently. This meta-analysis, which pooled results from 14 qualifying individual studies, found that depression was associated with a significantly decreased BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression.Introduction The reported association between depression and loss of BMD has been controversial. This meta-analysis was conducted to determine whether depression and BMD are associated and to identify the variation in some subgroups.Methods English-language articles published before October 2008 were used as the data source. A total of six case-controlled and eight cross-sectional studies met prestated inclusion criteria (N = 10,523). Information on study design, participant characteristics, measurements of BMD and depression, and control for potential confounders was abstracted independently by two investigators using a standardized protocol.Results Overall, depression was associated with a significant decrease in mean BMD of spine (-0.053 g/cm(2) [95% confidence interval {CI} -0.087 to -0.018 g/cm(2)]) and hip (-0.052 g/cm(2) [95% CI -0.083 to -0.022 g/cm(2)]). A substantially greater BMD decrease was observed in depressed women (-0.076 g/cm(2) in spine; -0.059 g/cm(2) in hip) and in cases of clinical depression (-0.074 g/cm(2) in spine; -0.080 g/cm(2) in hip).Conclusion Depression is associated with low BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression. Depression should be considered as an important risk factor for osteoporosis.

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Authors
Wu, Q., Magnus, J. H., Liu, J., Bencaz, A. F., & Hentz, J. G.
Affiliations
  • Mayo Clinic (US)
  • Tulane University (US)
  • Northern Arizona University (US)
Corresponding author
Wu, Q.
ORCID
Venue
Osteoporosis International
Publisher
Springer Science and Business Media LLC
Published
2009-04-03
Volume
20
Issue
8
Pages
1309-1320
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
DOI
10.1007/s00198-009-0918-x
OpenAlex
W2055157541
Cited by
102
References
62
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 6
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Osteoporosis International (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Scholarship - UNLV (University of Nevada Reno) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
depression, bone mineral density, osteoporosis, bone loss, women, major depressive disorder, spine, hip, risk factors
MeSH terms
Adult, Aged, Depressive Disorder, Female, Hip Joint, Humans, Male, Middle Aged, Osteoporosis, Research Design, Sensitivity and Specificity, Spine, Bone Density, Publication Bias

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