Lumbar Bone Mineral Density in Patients With Major Depression: Evidence of Increased Bone Loss at Follow-Up
Abstract
OBJECTIVE: This study investigated whether an increase in the loss of bone mineral density occurs with major depression. METHOD: The authors measured lumbar bone density with the use of quantitative computerized tomography in a longitudinal assessment of 18 depressed patients older than 40 years on hospital admission and 21 healthy women and men. The follow-up period lasted at least 24 months. RESULTS: A repeated measures analysis of variance model with depression and gender as factors showed that bone loss was greater for the depressed patients than for the comparison subjects and greater for men than for women. CONCLUSIONS: Major depression may be associated with increased bone loss, especially for men.
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Although the association between depression and loss of bone mineral density has been reported inconsistently, most studies have found low bone mineral density in patients with depressive symptoms or major depressive disorder.
“Although the association between depression and loss of BMD has been reported inconsistently, most studies have found low BMD in patients with depressive symptoms or major depressive disorder (477-483).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [481]
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Self-citation
- Authors
- Schweiger, U., Weber, B., Deuschle, M., & Heuser, I.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- American Journal of Psychiatry
- Published
- 2000-01-01
- Volume
- 157
- Issue
- 1
- Pages
- 118-120
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2120342720
- Cited by
- 101
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 3
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, bone mineral density, bone loss, lumbar spine, osteoporosis, sex differences, older adults, longitudinal follow-up
- MeSH terms
- Adult, Depressive Disorder, Female, Follow-Up Studies, Hospitalization, Humans, Lumbar Vertebrae, Male, Sex Factors, Tomography, X-Ray Computed, Absorptiometry, Photon, Bone Density, Bone Demineralization, Pathologic
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