Bone density and depressive disorder: a meta‐analysis
Open accessAbstract
Background: The aim of this study was to evaluate the evidence of low bone mineral density (BMD) in depression. Low BMD is a major risk factor for osteoporotic fractures and frailty. Methods: The searched database was Pubmed, Meta‐analysis included human studies in men and women fulfilling the following criteria: (1) assessment of BMD in the lumbar spine, the femur or the total hip; (2) comparison of BMD between depressed individuals and the healthy control group; (3) measurement of BMD using dual‐energy X‐ray absorptiometry (DEXA); and (4) data on the mean, standard deviation, or standard error of BMD. Results: Twenty‐one studies were identified, encompassing 1842 depressed and 17,401 nondepressed individuals. Significant negative composite weighted mean effect sizes were identified for the lumbar spine (d = −0.15, 95%CL −0.22 to −0.08), femur (d = −0.34, 95%CL −0.64 to −0.05), and total hip (d = −0.14, 95%CL −0.23 to −0.05) indicating low BMD in depression. Examining men and women shows low bone density in the lumbar spine and femur in women and low bone density in the hip in men. The differences between men and women with MDD and the comparison group tended to be higher when examined by expert interviewers. Low bone density was found in all age groups. Conclusions: Bone mineral density is reduced in patients with depressive disorders. The studies provide little evidence for potential relevant mediating factors.
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MDD is associated with lower bone mineral density at the lumbar spine, femur and total hip, with small to medium effect sizes.
“A meta-analysis pooling the results of 21 cross-sectional studies involving 1,842 participants with MDD and 17,401 controls found that MDD was associated with lower bone mineral density at the lumbar spine, femur and total hip, with small to medium effect sizes110.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [110]
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- Authors
- Schweiger, J. U., Schweiger, U., Hüppe, M., Kahl, K. G., Greggersen, W., & Fassbinder, E.
- Affiliations
- University of Lübeck (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Schweiger, Ulrich
- Venue
- Brain and Behavior
- Publisher
- Wiley
- Published
- 2016-05-18
- Volume
- 6
- Issue
- 8
- Pages
- e00489-e00489
- ISSN
- 2157-9032 (ISSN-L)
- 2162-3279
- PMC
- PMC4980464
- OpenAlex
- W2396108650
- Cited by
- 60
- References
- 57
- Citations by year
- 2026: 7 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 2 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 4
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain and Behavior (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bone mineral density, depressive disorders, major depressive disorder, osteoporosis, bone loss, lumbar spine, femur, total hip, sex differences, osteoporotic fractures, frailty
- MeSH terms
- Depressive Disorder, Humans, Absorptiometry, Photon, Bone Density
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