Depression and osteoporosis: epidemiology and potential mediating pathways

Mezuk, B.; Eaton, W. W.; Golden, S. H.

doi:10.1007/s00198-007-0449-2

Cited by 134Bone health and osteoporosis researchBone Metabolism and DiseasesMenopause: Health Impacts and Treatments

Depression and osteoporosis: epidemiology and potential mediating pathways

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Mezuk, B., Eaton, W. W., Golden, S. H.·2008·Osteoporosis International

DOI 10.1007/s00198-007-0449-2PMC PMC2776700

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Abstract

Introduction There have been numerous studies examining the association between depression and bone mineral density (BMD), but the underlying nature of this relationship remains unclear. Independent of this association, there is a growing body of evidence that depression impacts the risk for fracture in older adults. This article reviews the current epidemiological evidence regarding comorbidity of depression, low bone mineral density, and fracture.Methods A review of the literature on depression, depressive symptoms, low BMD, osteoporosis, and fracture using electronic databases.Results We reviewed 20 studies of the association between depression and BMD and five reports of the relationship between depression and fractures. Potential mediating mechanisms (both physiological and behavioral) are discussed, as well as potential confounding influences (e.g., medication use).Conclusions Most studies support the finding that depression is associated with increased risk for both low BMD and fractures, but variation in study design, sample composition, and exposure measurement make comparisons across studies difficult. Researchers should be aware of potential confounders, such as medication use, that may influence results. Future research should focus on identifying mediating pathways and targets for intervention in the relationships between depression, low BMD, and fracture.

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Two recent meta-analyses confirmed that depression is associated with low bone mineral density and should be considered as an important risk factor for osteoporosis, although this increased risk may be mediated by antidepressants.
“Two recent meta-analyses confirmed that depression is associated with low BMD and should be considered as an important risk factor for osteoporosis, although this increased risk may be mediated by AD (484,485).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [484]

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Authors: Mezuk, B., Eaton, W. W., & Golden, S. H.
Affiliations: Johns Hopkins University (US)
Corresponding author: Mezuk, B.
ORCID: Mezuk, B.
Eaton, W. W.
Golden, S. H.
Venue: Osteoporosis International
Publisher: Springer Science and Business Media LLC
Published: 2007-09-01
Volume: 19
Issue: 1
Pages: 1-12
ISSN: 0937-941X (ISSN-L)
1433-2965
DOI: 10.1007/s00198-007-0449-2
PMC: PMC2776700
OpenAlex: W2024321527
Cited by: 134
References: 98
Citations by year: 2026: 7 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 11 · 2016: 5 · 2015: 4 · 2014: 13 · 2013: 5 · 2012: 10
FWCI: 1.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Osteoporosis International (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (F31-MH78443, R01 MH47447, R01MH047447, T32MH-14592, F31MH078443, T32MH014592)
National Institute on Drug Abuse (R01DA026652)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: depression, osteoporosis, bone mineral density, fracture risk, older adults, depressive symptoms, comorbidities, mediation pathways
MeSH terms: Adult, Aged, Aged, 80 and over, Asia, Australia, Depressive Disorder, Europe, Female, Humans, Male, Middle Aged, Osteoporosis, Risk Factors, United States, Bone Density, Fractures, Bone

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Depression and osteoporosis: epidemiology and potential mediating pathways

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