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Cited by 299

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Frailty and sarcopenia: definitions and outcome parameters

Open access
Cooper, C., Dere, W., Evans, W., Kanis, J. A., Rizzoli, R., Sayer, A. A., Sieber, C. C., Kaufman, J.-M., Abellan van Kan, G., Boonen, S., Adachi, J., Mitlak, B., Tsouderos, Y., Rolland, Y., Reginster, J.-Y. L.·2012·Osteoporosis International

Abstract

An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.

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Registry

Crossref · 10.1007/s00198-012-1913-1

Cites

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Metadata

Authors
Cooper, C., Dere, W., Evans, W., Kanis, J. A., Rizzoli, R., Sayer, A. A., Sieber, C. C., Kaufman, J.-M., Abellan van Kan, G., Boonen, S., Adachi, J., Mitlak, B., Tsouderos, Y., Rolland, Y., & Reginster, J.-Y. L.
Venue
Osteoporosis International
Published
2012-01-31
Volume
23
Issue
7
Pages
1839-1848
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
OpenAlex
W2081427992
Cited by
299
References
24
FWCI
18.49
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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