The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats
Abstract
Rationale A growing literature indicates that increased dopamine transmission in the nucleus accumbens contributes to priming-induced reinstatement of cocaine-seeking behavior.Objectives The present experiments were designed to assess the role of D(1)-like dopamine receptors in the nucleus accumbens core and shell subregions in cocaine priming-induced reinstatement of drug seeking.Methods Rats were trained to lever press for cocaine using a fixed ratio (FR) 5 schedule of reinforcement. Drug-seeking was measured by active lever presses during daily 2-h sessions. After approximately 30 days of cocaine self-administration, the animals underwent an extinction phase during which cocaine was replaced with saline. Daily extinction sessions were conducted until responding was consistently less than 10% of the response rate maintained by cocaine self-administration. After the extinction phase, priming-induced reinstatement of cocaine-seeking behavior was assessed.Results Cocaine dose-dependently reinstated cocaine seeking, with robust drug seeking at 10 mg/kg cocaine. Administration of the D(1)-like dopamine receptor antagonist, SCH-23390 (0.1-1.0 micro g), directly into the medial nucleus accumbens shell dose-dependently attenuated drug seeking induced by 10 mg/kg cocaine. Microinjection of 1.0 micro g SCH-23390 into either the nucleus accumbens core or lateral septum had no influence on cocaine-seeking behavior.Conclusions These results indicate that stimulation of D(1)-like dopamine receptors in the medial nucleus accumbens shell contributes to drug-induced reinstatement of cocaine-seeking behavior.
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“For instance, in animals that have extinguished conditioned responding (lever-pressing), systemic administration of cocaine reinstates the conditioned responding, and this cocaine-induced reinstatement is blocked by the administration of dopamine receptor antagonists into the medial shell, but not the core (McFarland and Kalivas, 2001; Anderson et al., 2003; Bachtell et al., 2005; Anderson et al.,”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Anderson et al., 2003
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Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior
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Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598
Brain circuitry and the reinstatement of cocaine-seeking behavior
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Metadata
- Authors
- Anderson, S. M., Bari, A. A., & Pierce, R. C.
- Affiliations
- Boston University (US)
- Corresponding author
- Pierce, R. Christopher
- Venue
- Psychopharmacology
- Published
- 2002-12-19
- Volume
- 168
- Issue
- 1-2
- Pages
- 132-138
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1995006074
- Cited by
- 178
- References
- 33
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 11 · 2015: 6 · 2014: 4 · 2013: 15 · 2012: 13
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (1r01da012171-01a1, 5f31da015263-03)
- National Institute on Drug Abuse (DA 15263, F30DA014205, F30 DA14205, R01 DA12171)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine priming, reinstatement of drug seeking, D1-like receptors, SCH 23390, nucleus accumbens core, lateral septum, cocaine self-administration, extinction, dopamine signaling, cocaine dependence
- MeSH terms
- Animals, Benzazepines, Cocaine, Dose-Response Relationship, Drug, Male, Nucleus Accumbens, Behavior, Addictive, Rats, Sprague-Dawley, Receptors, Dopamine D1, Dopamine Antagonists, Rats
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