Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement
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α6* nicotinic acetylcholine receptors (nAChRs) are highly and selectively expressed by mesostriatal dopamine (DA) neurons. These neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. Yet the functional role of α6* nAChRs in midbrain DA neurons is mostly unknown. The aim of this study was to determine the composition and in vivo functional role of α6* nAChR in mesolimbic DA neurons of male rats. Immunoprecipitation and immunopurification techniques coupled with cell-specific lesions showed that the composition of α6* nAChR in the mesostriatal system is heterogeneous, with (non-α4)α6β2* being predominant in the mesolimbic pathway and α4α6β2* in the nigrostriatal pathway. We verified whether α6* receptors mediate the systemic effects of nicotine on the mesolimbic DA pathway by perfusing the selective antagonists α-conotoxin MII (CntxMII) (α3/α6β2* selective) or α-conotoxin PIA (CntxPIA) (α6β2* selective) into ventral tegmental area (VTA). The intra-VTA perfusion of CntxMII or CntxPIA markedly decreased systemic nicotine-elicited DA release in the nucleus accumbens and habituated locomotion; the intra-VTA perfusion of CntxMII also decreased the rate of nicotine infusion in the maintenance phase of nicotine, but not of food, self-administration. Overall, the results of these experiments show that the α6β2* nAChRs expressed in the VTA are necessary for the effects of systemic nicotine on DA neuron activity and DA-dependent behaviors such as locomotion and reinforcement, and suggest that α6β2*-selective compounds capable of crossing the blood–brain barrier may affect the addictive properties of nicotine and therefore be useful in the treatment of tobacco dependence.
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Conotoxins selective for α6/β2* nAChRs disrupt nicotine self-administration in rats when infused into the VTA and decrease motivation to lever press for nicotine on a progressive ratio schedule after training.
“Similarly, conotoxins selective for α6/β2 Ã nAChRs disrupt nicotine self-administration in the rat when infused into the VTA (Gotti et al. 2010) and following selfadministration training, these conotoxins decrease the motivation to lever press for nicotine on a progressive ratio schedule (Brunzell et al. 2010).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Gotti et al. 2010
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Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
LIGAND: A versatile computerized approach for characterization of ligand-binding systems
Munson, P. J., & Rodbard, D. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90515-1 · Cited by 8,494 · see citing works
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320 · see citing works
Self-citationBrain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
Self-citationWise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881 · see citing works
Nicotinic Receptors at the Amino Acid Level
Corringer, P., Novère, N. G. L., & Changeux, J. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.431 · Cited by 823 · see citing works
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works
Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization
Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science · doi:10.1126/science.1099420 · Cited by 686 · see citing works
Role of dopamine in the behavioural actions of nicotine related to addiction
Chiara, G. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00122-9 · Cited by 680 · see citing works
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674 · see citing works
Self-citationNicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J.-P., Evrard, A., Cazala, P., Cormier, A., Mameli-Engvall, M., et al. (2005) · Nature · doi:10.1038/nature03694 · Cited by 566 · cited 1× · see citing works
“As regards 2* nAChRs, whose fundamental role in mediating nicotine effects on DA neurons and nicotine reinforcement has been clearly established (Picciotto et al., 1998; Maskos et al., 2005; Walters et al., 2006), a strong case has been made for 4 2* nAChRs.”
BackgroundRollema, H., Chambers, L. K., Coe, J. W., Glowa, J., Hurst, R. S., Lebel, L. A., Lu, Y., Mansbach, R. S., Mather, R. J., Rovetti, C. C., et al. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.10.016 · Cited by 533 · see citing works
Nisell, M., Nomikos, G. G., & Svensson, T. H. (1994) · Synapse · doi:10.1002/syn.890160105 · Cited by 510 · see citing works
Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 505 · see citing works
Self-citationStructural and functional diversity of native brain neuronal nicotinic receptors
Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., & Zoli, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.05.024 · Cited by 469 · see citing works
Self-citationNovère, N. L., & Changeux, J. (1995) · Journal of Molecular Evolution · doi:10.1007/bf00167110 · Cited by 429 · see citing works
Kalvass, J. C., & Maurer, T. S. (2002) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.325 · Cited by 422 · see citing works
Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08785.2002 · Cited by 407 · see citing works
Self-citationSalminen, O., Murphy, K. L., McIntosh, J. M., Drago, J., Marks, M. J., Collins, A. C., & Grady, S. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1526 · Cited by 401 · see citing works
Le Novere, N., Zoli, M., & Changeux, J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01206.x · Cited by 385 · see citing works
Self-citationPons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., & Fratta, W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-08.2008 · Cited by 312 · see citing works
Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors
Mameli-Engvall, M., Evrard, A., Pons, S., Maskos, U., Svensson, T. H., Changeux, J.-P., & Faure, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.007 · Cited by 296 · see citing works
Azam, L., Winzer‐Serhan, U. H., Chen, Y.-L., & Leslie, F. M. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10138 · Cited by 258 · see citing works
The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum
Grady, S. R., Salminen, O., Laverty, D. C., Whiteaker, P., McIntosh, J. M., Collins, A. C., & Marks, M. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.032 · Cited by 252 · see citing works
Marubio, L. M., Gardier, A. M., Durier, S., David, D., Klink, R., Arroyo‐Jimenez, M. M., McIntosh, J. M., Rossi, F., Champtiaux, N., Zoli, M., et al. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02564.x · Cited by 242 · see citing works
Self-citationExley, R., Clements, M. A., Hartung, H., McIntosh, J. M., & Cragg, S. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301617 · Cited by 242 · see citing works
Grady, S. R., Moretti, M., Zoli, M., Marks, M. J., Zanardi, A., Pucci, L., Clementi, F., & Gotti, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5121-08.2009 · Cited by 222 · see citing works
Self-citationWalters, C. L., Brown, S., Changeux, J.-P., Martin, B., & Damaj, M. I. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0295-x · Cited by 206 · see citing works
Drenan, R. M., Grady, S. R., Whiteaker, P., McClure-Begley, T., McKinney, S., Miwa, J. M., Bupp, S., Heintz, N., McIntosh, J. M., Bencherif, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.009 · Cited by 197 · see citing works
Analogs of α-Conotoxin MII Are Selective for α6-Containing Nicotinic Acetylcholine Receptors
McIntosh, J. M., Azam, L., Staheli, S. T., Dowell, C. D., Lindstrom, J. M., Kuryatov, A., Garrett, J. E., Marks, M. J., & Whiteaker, P. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.944 · Cited by 194 · see citing works
Charpantier, E., Barnéoud, P., Moser, P. C., Besnard, F., & Sgard, F. (1998) · Neuroreport · doi:10.1097/00001756-199809140-00033 · Cited by 166 · see citing works
Exposure to nicotine and sensitization of nicotine-induced behaviors
Vezina, P., McGehee, D. S., & Green, W. N. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.038 · Cited by 151 · see citing works
Translational research in medication development for nicotine dependence
Lerman, C. E., LeSage, M. G., Perkins, K. A., O’Malley, S. S., Siegel, S. J., Benowitz, N. L., & Corrigall, W. A. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2361 · Cited by 149 · see citing works
Salminen, O., Drapeau, J. A., McIntosh, J. M., Collins, A. C., Marks, M. J., & Grady, S. R. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.031492 · Cited by 149 · see citing works
α-Conotoxin PIA Is Selective for α6 Subunit-Containing Nicotinic Acetylcholine Receptors
Dowell, C. D., Olivera, B. M., Garrett, J. E., Staheli, S. T., Watkins, M., Kuryatov, A., Yoshikami, D., Lindstrom, J. M., & McIntosh, J. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08445.2003 · Cited by 145 · see citing works
Involvement of the α3 Subunit in Central Nicotinic Binding Populations
Whiteaker, P., Peterson, C. G., Xu, W., McIntosh, J. M., Paylor, R. E., Beaudet, A. L., Collins, A. C., & Marks, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02522.2002 · Cited by 145 · see citing works
Gotti, C., Moretti, M., Clementi, F., Riganti, L., McIntosh, J. M., Collins, A. C., Marks, M. J., & Whiteaker, P. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.011940 · Cited by 133 · see citing works
Self-citationFerrari, R., Le Novère, N., Picciotto, M. R., Changeux, J. P., & Zoli, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.02009.x · Cited by 132 · see citing works
Self-citationCheetham, S. C., Viggers, J., Butler, S., Prow, M. R., & Heal, D. J. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00134-4 · Cited by 121 · see citing works
Cohen, C., Bergis, O. E., Galli, F., Lochead, A. W., Jegham, S., Biton, B., Léonardon, J., Avenet, P., Sgard, F., Besnard, F., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049262 · Cited by 114 · see citing works
Laviolette, S. R., & van der Kooy, D. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1317-6 · Cited by 113 · see citing works
Brunzell, D. H., Boschen, K. E., Hendrick, E. S., Beardsley, P. M., & McIntosh, J. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.171 · Cited by 95 · see citing works
Moretti, M., Vailati, S., Zoli, M., Lippi, G., Riganti, L., Longhi, R., Viegi, A., Clementi, F., & Gotti, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.1.85 · Cited by 89 · see citing works
Self-citationNovère, N. G. L., Zoli, M., Léna, C., Ferrari, R., Picciotto, M. R., Merlo‐Pich, E., & Changeux, J. (1999) · Neuroreport · doi:10.1097/00001756-199908200-00012 · Cited by 86 · see citing works
Self-citationJanhunen, S. K., & Ahtee, L. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.09.008 · Cited by 81 · see citing works
Perez, X. A., Bordia, T., McIntosh, J. M., Grady, S. R., & Quik, M. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048843 · Cited by 77 · see citing works
Glick, S. D., Ramirez, R. L., Livi, J. M., & Maisonneuve, I. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.045 · Cited by 76 · see citing works
Gotti, C., Moretti, M., Zanardi, A., Gaimarri, A., Champtiaux, N., Changeux, J., Whiteaker, P., Marks, M. J., Clementi, F., & Zoli, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.015925 · Cited by 71 · see citing works
Self-citationDifferential central distribution of optic nerve components in the rat
Lund, J. S., Remington, F. L., & Lund, R. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)90250-x · Cited by 69 · see citing works
Mugnaini, M., Garzotti, M., Sartori, I., Pilla, M. A., Repeto, P., Heidbreder, C. A., & Tessari, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.008 · Cited by 64 · see citing works
Self-citationMeyer, E. L., Yoshikami, D., & McIntosh, J. M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05266.x · Cited by 58 · see citing works
Taraschenko, O. D., Shulan, J. M., Maisonneuve, I. M., & Glick, S. D. (2007) · Synapse · doi:10.1002/syn.20396 · Cited by 53 · see citing works
Tang, A., Bungay, P. M., & Gonzales, R. A. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00003-7 · Cited by 50 · see citing works
Electrolytic lesions of the habenula attenuate brain stimulation reward
Morissette, M.-C., & Boye, S. M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.08.021 · Cited by 43 · see citing works
Yoshimura, R. F., Hogenkamp, D. J., Li, W. Y., Tran, M. B., Belluzzi, J. D., Whittemore, E. R., Leslie, F. M., & Gee, K. W. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.128751 · Cited by 42 · see citing works
Zanetti, L., Picciotto, M. R., & Zoli, M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0598-6 · Cited by 38 · see citing works
Self-citationCox, B. C., Marritt, A. M., Perry, D. C., & Kellar, K. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05282.x · Cited by 35 · see citing works
Oral absorption and in vivo biodistribution of α-conotoxin MII and a lipidic analogue
Blanchfield, J. T., Gallagher, O. P., Cros, C. D., Lewis, R. J., Alewood, P. F., & Tóth, I. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.138 · Cited by 26 · see citing works
Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats
Chiamulera, C., Tedesco, V., Zangrandi, L., Giuliano, C., & Fumagalli, G. F. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108097718 · Cited by 25 · see citing works
Self-citationMarkou, A., Chiamulera, C., & West, R. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00026-6 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
1 of the 64 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dopamine release in the basal ganglia
Rice, M. E., Patel, J. C., & Cragg, S. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.066 · Cited by 281 · see citing works
Diversity of native nicotinic receptor subtypes in mammalian brain
Zoli, M., Pistillo, F., & Gotti, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.003 · Cited by 277 · see citing works
Self-citationNicotine as a potential neuroprotective agent for Parkinson's disease
Quik, M., Perez, X. A., & Bordia, T. (2012) · Movement Disorders · doi:10.1002/mds.25028 · Cited by 242 · see citing works
Placebo-controlled trial of cytisine for smoking cessation
West, R., Zatonski, W., Cedzynska, M., Lewandowska, D., Pazik, J., Aveyard, P., & Stapleton, J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102035 · Cited by 234 · see citing works
Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction
Wittenberg, R. E., Wolfman, S. L., Biasi, M. D., & Dani, J. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108256 · Cited by 200 · see citing works
α6β2* and α4β2* Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson’s Disease
Quik, M., & Wonnacott, S. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003269 · Cited by 194 · see citing works
Molecular Mechanisms Underlying Behaviors Related to Nicotine AddictionPreprint
Picciotto, M. R., & Kenny, P. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012112 · Cited by 178 · see citing works
Exley, R., Maubourguet, N., David, V., Eddine, R., Evrard, A., Pons, S., Marti, F., Threlfell, S., Cazala, P., McIntosh, J. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103000108 · Cited by 159 · see citing works
Mechanisms of Nicotine Addiction
Picciotto, M. R., & Kenny, P. J. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039610 · Cited by 157 · see citing works
Hendrickson, L. M., Guildford, M. J., & Tapper, A. R. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00029 · Cited by 132 · see citing works
Tuesta, L. M., Fowler, C. D., & Kenny, P. J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.026 · Cited by 129 · see citing works
Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity
Faure, P., Tolu, S., Valverde, S., & Naudé, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.040 · Cited by 125 · see citing works
Wu, C., Lee, C., & Ho, Y. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2434 · Cited by 123 · see citing works
Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling
Papke, R. L., & Lindstrom, J. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108021 · Cited by 123 · see citing works
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 126 · see citing works
Liu, L., Zhao-Shea, R., McIntosh, J. M., Gardner, P. D., & Tapper, A. R. (2012) · Molecular Pharmacology · doi:10.1124/mol.111.076661 · Cited by 121 · see citing works
Molecules and circuits involved in nicotine addiction: The many faces of smoking
Picciotto, M. R., & Mineur, Y. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.028 · Cited by 117 · see citing works
Biogenesis, trafficking and up-regulation of nicotinic ACh receptors
Colombo, S. F., Mazzo, F., Pistillo, F., & Gotti, C. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.06.023 · Cited by 118 · see citing works
Self-citationPistillo, F., Clementi, F., Zoli, M., & Gotti, C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.002 · Cited by 113 · see citing works
Self-citationNicotinic Receptors in Neurodegeneration
Posadas, I., López‐Hernández, B., & Ceña, V. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030005 · Cited by 113 · see citing works
Zhao-Shea, R., Liu, L., Soll, L. G., Improgo, M. R., Meyers, E. E., McIntosh, J. M., Grady, S. R., Marks, M. J., Gardner, P. D., & Tapper, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.240 · Cited by 113 · see citing works
Brunzell, D. H., & McIntosh, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.299 · Cited by 114 · see citing works
Kramer, P. F., Brill-Weil, S. G., Cummins, A. C., Zhang, R., Camacho-Hernandez, G. A., Newman, A. H., Eldridge, M. A. G., Averbeck, B. B., & Khaliq, Z. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.011 · Cited by 104 · see citing works
Striatal α5 Nicotinic Receptor Subunit Regulates Dopamine Transmission in Dorsal Striatum
Exley, R. A., McIntosh, J. M., Marks, M. J., Maskos, U., & Cragg, S. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4985-11.2012 · Cited by 104 · see citing works
Psychopharmacology of Tobacco and Alcohol Comorbidity: a Review of Current Evidence
Adams, S. H. (2017) · Current Addiction Reports · doi:10.1007/s40429-017-0129-z · Cited by 101 · see citing works
Kuryatov, A., & Lindstrom, J. M. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.066159 · Cited by 97 · see citing works
Quik, M., Perez, X. A., & Grady, S. R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.001 · Cited by 94 · see citing works
Nicotine Potentiation of Excitatory Inputs to Ventral Tegmental Area Dopamine Neurons
Mao, D., Gallagher, K., & McGehee, D. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5671-10.2011 · Cited by 90 · see citing works
Nicotinic Receptors in Addiction Pathways
Leslie, F. M., Mojica, C., & Reynaga, D. D. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083659 · Cited by 87 · see citing works
Nicotine and endogenous opioids: neurochemical and pharmacological evidence
Hadjiconstantinou, M., & Neff, N. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.010 · Cited by 81 · see citing works
Doyon, W. M., Thomas, A. M., Ostroumov, A., Dong, Y., & Dani, J. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.007 · Cited by 77 · see citing works
Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms
Dutertre, S., Nicke, A., & Tsetlin, V. I. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.011 · Cited by 77 · see citing works
Azam, L., Maskos, U., Changeux, J., Dowell, C. D., Christensen, S. B., Biasi, M. D., & McIntosh, J. M. (2010) · The FASEB Journal · doi:10.1096/fj.10-166272 · Cited by 77 · see citing works
Toll, L., Zaveri, N. T., Polgar, W. E., Jiang, F., Khroyan, T. V., Zhou, W., Xie, X., Stauber, G. B., Costello, M. R., & Leslie, F. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.322 · Cited by 78 · see citing works
Positive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review
Hurley, L. L., Taylor, R. E., & Tizabi, Y. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9275-6 · Cited by 79 · see citing works
Nicotinic Regulation of Energy Homeostasis
Zoli, M., & Picciotto, M. R. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts159 · Cited by 77 · see citing works
Self-citationNicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4 subtype
Hone, A. J., Meyer, E. L., McIntyre, M., & McIntosh, J. M. (2011) · The FASEB Journal · doi:10.1096/fj.11-195883 · Cited by 76 · see citing works
An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants
Baddick, C. G., & Marks, M. J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.04.019 · Cited by 75 · see citing works
McCallum, S. E., Cowe, M. A., Lewis, S. W., & Glick, S. D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.015 · Cited by 73 · see citing works
Cholinergic modulation of food and drug satiety and withdrawal
Avena, N. M., & Rada, P. V. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.020 · Cited by 72 · see citing works
Sanjakdar, S. S., Maldoon, P. P., Marks, M. J., Brunzell, D. H., Maskos, U., McIntosh, J. M., Bowers, M. S., & Damaj, M. I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.177 · Cited by 71 · see citing works
Bordia, T., Hrachova, M., Chin, M., McIntosh, J. M., & Quik, M. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.194852 · Cited by 70 · see citing works
Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors
de Kloet, S. F., Mansvelder, H. D., & De Vries, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.014 · Cited by 69 · see citing works
Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine
Wang, L., Shang, S., Kang, X., Teng, S., Zhu, F., Liu, B., Wu, Q., Li, M., Liu, W. Y., Xu, H., et al. (2014) · Nature Communications · doi:10.1038/ncomms4925 · Cited by 68 · see citing works
Panlilio, L. V., Justinová, Z., Mascia, P., Pistis, M., Luchicchi, A., Lecca, S., Barnes, C., Redhi, G. H., Adair, J. E., Heishman, S. J., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.31 · Cited by 67 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Rose, E. J., Ross, T. J., Salmeron, B. J., Lee, M., Shakleya, D. M., Huestis, M. A., & Stein, E. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.013 · Cited by 65 · see citing works
Nicotinic receptors regulate the dynamic range of dopamine release in vivo
Koranda, J. L., Cone, J. J., McGehee, D. S., Roitman, M. F., Beeler, J. A., & Zhuang, X. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00269.2013 · Cited by 62 · see citing works
α6* Nicotinic Acetylcholine Receptor Expression and Function in a Visual Salience Circuit
Mackey, E. D. W., Engle, S. E., Kim, M. R., O’Neill, H. C., Wageman, C. R., Patzlaff, N. E., Wang, Y., Grady, S. R., McIntosh, J. M., Marks, M. J., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0007-12.2012 · Cited by 63 · see citing works
Addiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works
Moretti, M., Mugnaini, M., Tessari, M., Zoli, M., Gaimarri, A., Manfredi, I., Pistillo, F., Clementi, F., & Gotti, C. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064071 · Cited by 58 · see citing works
Self-citationNicotinic Receptor Contributions to Smoking: Insights from Human Studies and Animal Models
Brunzell, D. H., Stafford, A. M., & Dixon, C. I. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0042-2 · Cited by 58 · see citing works
Scherma, M., Muntoni, A. L., Melis, M., Fattore, L., Fadda, P., Fratta, W., & Pistis, M. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4196-3 · Cited by 57 · see citing works
Acute Nicotine Differentially Impacts Anticipatory Valence- and Magnitude-Related Striatal Activity
Rose, E. J., Ross, T. J., Salmeron, B. J., Lee, M., Shakleya, D. M., Huestis, M. A., & Stein, E. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.034 · Cited by 56 · see citing works
Nicotinic Receptor Antagonists as Treatments for Nicotine Abuse
Crooks, P. A., Bardo, M. T., & Dwoskin, L. P. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00013-5 · Cited by 54 · see citing works
Hone, A. J., Ruiz, M., Scadden, M., Christensen, S. B., Gajewiak, J., Azam, L., & McIntosh, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482059 · Cited by 53 · see citing works
Drenan, R. M., & Lester, H. A. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004671 · Cited by 51 · see citing works
Engle, S. E., Shih, P.-Y., McIntosh, J. M., & Drenan, R. M. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087346 · Cited by 51 · see citing works
Zhang, D., Mallela, A., Sohn, D., Carroll, F. I., Bencherif, M., Letchworth, S. R., & Quik, M. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.207639 · Cited by 49 · see citing works
Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior
Cohen, B. N., Mackey, E. D. W., Grady, S. R., McKinney, S. L., Patzlaff, N. E., Wageman, C. R., McIntosh, J. M., Marks, M. J., Lester, H. A., & Drenan, R. M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.047 · Cited by 48 · see citing works
Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement
Morel, C., Montgomery, S. E., & Han, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14160 · Cited by 45 · see citing works
Hone, A. J., Scadden, M., Gajewiak, J., Christensen, S. B., Lindstrom, J. M., & McIntosh, J. M. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080853 · Cited by 46 · see citing works
Structure of Neuronal Nicotinic Receptors
Fasoli, F., & Gotti, C. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13665-3_1 · Cited by 45 · see citing works
Self-citationLong-Term Nicotine Exposure Depresses Dopamine Release in Nonhuman Primate Nucleus Accumbens
Perez, X. A., Ly, J., McIntosh, J. M., & Quik, M. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.194084 · Cited by 43 · see citing works
Schilaty, N. D., Hedges, D. M., Jang, E. Y., Folsom, R. J., Yorgason, J. T., McIntosh, J. M., & Steffensen, S. C. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.211490 · Cited by 42 · see citing works
Brunzell, D. H., McIntosh, J. M., & Papke, R. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12421 · Cited by 40 · see citing works
Wang, S., van der Vaart, A. D., Xu, Q., Seneviratne, C., Pomerleau, O. F., Pomerleau, C. S., Payne, T. J., Ma, J. Z., & Li, M. D. (2013) · Human Genetics · doi:10.1007/s00439-013-1398-9 · Cited by 40 · see citing works
Anderson, S. M., & Brunzell, D. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048665 · Cited by 40 · see citing works
Liu, L., Zhao-Shea, R., McIntosh, J. M., & Tapper, A. R. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.06.015 · Cited by 40 · see citing works
Johnston, T. H., Huot, P., Fox, S. H., Koprich, J. B., Szeliga, K. T., James, J. W., Graef, J. D., Letchworth, S. R., Green-Jordan, K., Hill, M. P., et al. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.005 · Cited by 40 · see citing works
Pucci, L., Grazioso, G., Dallanoce, C., Rizzi, L., Micheli, C. D., Clementi, F., Bertrand, S., Bertrand, D., Longhi, R., Amici, M. D., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-179853 · Cited by 40 · see citing works
Self-citationExley, R. A., Clements, M. A., Hartung, H., McIntosh, J. M., Franklin, M., Bermúdez, I., & Cragg, S. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12298 · Cited by 40 · see citing works
Baker, L. K., Mao, D., Chi, H., Govind, A. P., Vallejo, Y. F., Iacoviello, M., Herrera, S., Cortright, J. J., Green, W. N., McGehee, D. S., et al. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12114 · Cited by 39 · see citing works
Basolateral amygdala CB1 cannabinoid receptors mediate nicotine-induced place preference
Hashemizadeh, S., Sardari, M., & Rezayof, A. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.010 · Cited by 39 · see citing works
Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors
Letchworth, S. R., & Whiteaker, P. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.022 · Cited by 39 · see citing works
Garção, P., Szabó, E. C., Wopereis, S., de Castro, A. A., Tomé, Â. R., Prediger, R. D., Cunha, R. A., Agostinho, P. M., & Köfalvi, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12234 · Cited by 39 · see citing works
Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse
Skike, C. E. V., Maggio, S. E., Reynolds, A. R., Casey, E. M., Bardo, M. T., Dwoskin, L. P., Prendergast, M., & Nixon, K. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.004 · Cited by 39 · see citing works
Nirogi, R. V. S., Goura, V., Abraham, R., & Jayarajan, P. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.021 · Cited by 39 · see citing works
Potential Therapeutic Application for Nicotinic Receptor Drugs in Movement Disorders
Quik, M., Boyd, J. T., Bordia, T., & Perez, X. A. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty063 · Cited by 38 · see citing works
Role for α6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice
Quik, M., Park, K. M., Hrachova, M., Mallela, A., Huang, L. Z., McIntosh, J. M., & Grady, S. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.029 · Cited by 37 · see citing works
Tvete, I. F., Bjørner, T., & Skomedal, T. (2015) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2015.1117282 · Cited by 37 · see citing works
Development of Novel Pharmacotherapeutics for Tobacco Dependence: Progress and Future Directions
Harmey, D., Griffin, P. R., & Kenny, P. J. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts201 · Cited by 37 · see citing works
Roche, D. J. O., Ray, L. A., Yardley, M. M., & King, A. C. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0081-3 · Cited by 37 · see citing works
Marks, M. J., Grady, S. R., Salminen, O., Paley, M. A., Wageman, C. R., McIntosh, J. M., & Whiteaker, P. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12721 · Cited by 37 · see citing works
Rollema, H., & Hurst, R. S. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4921-9 · Cited by 38 · see citing works
Pistillo, F., Fasoli, F., Moretti, M., McClure‐Begley, T. D., Zoli, M., Marks, M. J., & Gotti, C. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.016 · Cited by 35 · see citing works
Self-citationUslaner, J. M., Winrow, C. J., Gotter, A. L., Roecker, A. J., Coleman, P. J., Hutson, P. H., Lê, A. D., & Renger, J. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.012 · Cited by 35 · see citing works
AT ‐1001: a high‐affinity α3β4 nAChR ligand with novel nicotine‐suppressive pharmacology
Cippitelli, A., Wu, J., Gaiolini, K. A., Mercatelli, D., Schoch, J., Gorman, M., Muñoz, A. R., Ciccocioppo, R., Khroyan, T. V., Yasuda, D. M., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13034 · Cited by 36 · see citing works
Capelli, A. M., Castelletti, L., Chen, Y. H., Keyl, H. V. D., Pucci, L., Oliosi, B., Salvagno, C., Bertani, B., Gotti, C., Powell, A., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01213.x · Cited by 34 · see citing works
Self-citationBashiri, H., Rezayof, A., Sahebgharani, M., Tavangar, S. M., & Zarrindast, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.010 · Cited by 33 · see citing works
Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms
Zuo, W., Xiao, C., Gao, M., Hopf, F. W., Krnjević, K., McIntosh, J. M., Fu, R., Wu, J., Bekker, A., & Ye, J.-H. (2016) · Scientific Reports · doi:10.1038/srep32937 · Cited by 32 · see citing works
Ngolab, J., Liu, L., Zhao-Shea, R., Gao, G., Gardner, P. D., & Tapper, A. R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4453-14.2015 · Cited by 32 · see citing works
Brunzell, D. H. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts089 · Cited by 32 · see citing works
Paterson, N. E., Min, W., Hackett, A., Lowe, D., Hanania, T., Caldarone, B. J., & Ghavami, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.037 · Cited by 30 · see citing works
Berry, J. N., Engle, S. E., McIntosh, J. M., & Drenan, R. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.052 · Cited by 30 · see citing works
Jain, A., Kuryatov, A., Wang, J., Kamenecka, T. M., & Lindstrom, J. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.749150 · Cited by 31 · see citing works
Cholinergic Receptors and Addiction
Papke, R. L., Brunzell, D. H., & Biasi, M. D. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_139 · Cited by 30 · see citing works
Lee, A. M., & Messing, R. O. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106277108 · Cited by 30 · see citing works
Hone, A. J., Talley, T. T., Bobango, J., Melo, C. H., Hararah, F., Gajewiak, J., Christensen, S. B., Harvey, P. J., Craik, D. J., & McIntosh, J. M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005649 · Cited by 29 · see citing works
Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol
Gao, F., Chen, D., Ma, X., Sudweeks, S. N., Yorgason, J. T., Gao, M., Turner, D., Eaton, J. B., McIntosh, J. M., Lukas, R. J., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.021 · Cited by 29 · see citing works
- Authors
- Gotti, C., Guiducci, S., Tedesco, V., Corbioli, S., Zanetti, L., Moretti, M., Zanardi, A., Rimondini, R., Mugnaini, M., Clementi, F., Chiamulera, C., & Zoli, M.
- Affiliations
- University of Milan (IT)
- University of Modena and Reggio Emilia (IT)
- University of Verona (IT)
- GlaxoSmithKline (Italy) (IT)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-04-14
- Volume
- 30
- Issue
- 15
- Pages
- 5311-5325
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632743
- OpenAlex
- W2051648601
- Cited by
- 226
- References
- 64
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 15 · 2015: 21 · 2014: 26 · 2013: 30 · 2012: 29
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by-nc-sa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- GlaxoSmithKline
- Compagnia di San Paolo
- Fondazione Cariplo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotinic acetylcholine receptors, ventral tegmental area, mesolimbic dopamine system, nicotine, dopamine release, nucleus accumbens, locomotion, nicotine self-administration, nicotine reinforcement, alpha-conotoxin MII, receptor heterogeneity, nicotine dependence, tobacco dependence
- MeSH terms
- Animals, Corpus Striatum, Dopamine, Feeding Behavior, Male, Mesencephalon, Motor Activity, Neural Pathways, Neurons, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Reinforcement, Psychology, Self Administration, Rats, Sprague-Dawley, Ventral Tegmental Area, Nicotinic Agonists, Nicotinic Antagonists, Conotoxins, Rats
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