The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice
Abstract
Rationale Tobacco use is implicated in approximately 440,000 deaths per year, making it the leading cause of preventable death in the United States. Although it is generally recognized that tobacco use is correlated with a variety of health-related complications, many smokers are unsuccessful in their efforts to stop smoking using current cessation therapies. Objectives Given that nicotine is the addictive component of tobacco, successful smoking cessation therapies must address the various processes, including reward, which contribute to nicotine addiction. As such, determining the nicotinic receptor subtypes involved in nicotine reward is of utmost importance to understanding how nicotine addiction progresses. Methods Conditioned place preference (CPP) in three-chamber conditioning boxes was performed. For antagonist studies, drug was given on all conditioning sessions 10 min before nicotine or saline injection and placement in the boxes. Results We have demonstrated that a pretreatment with the alpha4beta2 subunit of the nicotinic acetylcholine receptor (nAChR) antagonist dihydro-beta-erythroidine (2.0 mg/kg, s.c.) blocked nicotine (0.5 mg/kg, s.c.) CPP in wild-type mice (C57BL/6 mice). In contrast, pretreatment with an antagonist of the alpha7 subunit of the nAChR, methyllycaconitine (MLA, 5.0 or 10.0 mg/kg, s.c.), had no effect on this behavior. Finally, we showed that mice lacking the beta2 subunit of the nAChR did not exhibit nicotine CPP while alpha7 knock-out mice di…
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In the citing paper
“In recent years evidence has emerged that the β2*-nAChRs are a critical neural substrate mediating the effects of nicotine in brain.”
From β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking (2009) · cites this paper as [23]
In the citing paper
“Notably, the β2-subunit has been linked primarily to the reinforcing effects of nicotine22, 83, 84 and combines with the α3-6 subunits.”
From β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking (2009) · cites this paper as [83]
In the citing paper
“Despite its contribution to nicotine-dependent plasticity in the VTA, knockout of the α7 subunit in mice does not affect nicotine place preference (Walters et al. 2006) or acquisition of nicotine self-administration (Pons et al. 2008).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Walters et al. 2006
Citations
Cites
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Self-citationConditioned place preference: what does it add to our preclinical understanding of drug reward?
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Long-term potentiation of excitatory inputs to brain reward areas by nicotine
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Self-citationAbnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668
Self-citationNicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J.-P., Evrard, A., Cazala, P., Cormier, A., Mameli-Engvall, M., et al. (2005) · Nature · doi:10.1038/nature03694 · Cited by 566 · cited 1×
“However, when the β2 subunit is re-expressed in the VTA only in these mice, the nicotine-induced dopamine release and nicotine selfadministration are both recovered (Maskos et al. 2005).”
BackgroundSelf-citationOrr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494
Research works printed but not linked: 1
- Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. Oxford University Press
Cited by
Sorted by citations
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453
Self-citationReward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366
“…−/− mice (Pons et al. 2008), consistent with the pharmacological evidence indicating that the α7 subunit does not influence chronic nicotine self-administration in trained rats (Grottick & Higgins 2000) nor nicotine-induced conditioned place preference (Stolerman et al. 2004, Walters et al. 2006).”
BackgroundPons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., & Fratta, W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-08.2008 · Cited by 312
Self-citationModulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242
Metadata
- Authors
- Walters, C. L., Brown, S., Changeux, J.-P., Martin, B., & Damaj, M. I.
- Affiliations
- Virginia Commonwealth University (US)
- Institut Pasteur (FR)
- Corresponding author
- Walters, Carrie L.
- Venue
- Psychopharmacology
- Published
- 2006-01-14
- Volume
- 184
- Issue
- 3-4
- Pages
- 339-344
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2142606268
- Cited by
- 206
- References
- 30
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 16 · 2013: 22 · 2012: 14
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA 07027, R01DA012610, DA 05274, DA-12610, T32DA007027)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotinic acetylcholine receptors, beta2 subunit, alpha7 subunit, nicotine reward, nicotine dependence, conditioned place preference, dihydro-beta-erythroidine, methyllycaconitine, tobacco use
- MeSH terms
- Aconitine, Animals, Choice Behavior, Conditioning, Psychological, Dihydro-beta-Erythroidine, Female, Heterozygote, Male, Mice, Inbred C57BL, Motivation, Premedication, Receptors, Nicotinic, Reinforcement Schedule, Social Environment, Tobacco Use Disorder, Mice, Knockout, Mice, alpha7 Nicotinic Acetylcholine Receptor
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