β2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
Open accessAbstract
Rationale Previous research indicates that acute nicotine administration enhances the acquisition of contextual fear conditioning and trace cued fear conditioning. Pharmacological inhibition of alpha4beta2 nicotinic acetylcholine receptors (nAChRs), but not alpha7 nAChRs, blocked the enhancing effect of nicotine on contextual fear conditioning. Similarly, genetic deletion of the beta2 nAChR subunit but not the alpha7 nAChR subunit blocked the enhancing effect of nicotine on contextual fear conditioning.Objectives In the present study, nAChR subunit knockout mice were used to compare the involvement of beta2 subunit-containing nAChRs and alpha7 subunit-containing nAChRs in the effects of nicotine on hippocampus-dependent trace cued fear conditioning and contextual fear conditioning.Methods beta2 nAChR subunit knockout mice, alpha7 nAChR subunit knockout mice, and their wild-type littermates received either nicotine or saline 5 minutes before training and testing. Mice were trained using five conditioned stimulus (CS; 30 s, 85 dB white noise)--trace (30 s)--unconditioned stimulus (US; 2 s footshock) pairings. Freezing to the context and freezing to the CS were assessed 24 h later.Results Both contextual and trace cued fear conditioning were enhanced by nicotine administration in wild-type littermates and in alpha7 nAChR subunit knockout mice. In contrast, neither contextual fear conditioning nor trace cued fear conditioning was enhanced by nicotine administration in beta2 nAChR subunit knockout mice.Conclusions These results suggest that beta2 subunit-containing nAChRs but not alpha7 nAChR subunit-containing nAChRs are critically involved in the enhancing effect of nicotine on contextual and trace cued fear conditioning.
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The enhancement of fear conditioning by nicotine requires β2-containing but not α7-containing nAChRs.
“This enhancement by nicotine requires β2-containing but not α7-containing nAChRs [199].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [199]
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Self-citationParameshwaran, K., Buabeid, M. A., Bhattacharya, S., Uthayathas, S., Kariharan, T., Dhanasekaran, M., & Suppiramaniam, V. D. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.007 · Cited by 26 · see citing works
Staib, J. M., Valle, R. R. D., & Knox, D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.05.009 · Cited by 26 · see citing works
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Lotfipour, S., Mojica, C., Nakauchi, S., Lipovsek, M., Silverstein, S., Cushman, J. D., Tirtorahardjo, J. A., Poulos, A., Elgoyhen, A. B., Sumikawa, K., et al. (2017) · Learning & Memory · doi:10.1101/lm.045369.117 · Cited by 24 · see citing works
Sensorimotor gating and spatial learning in α7‐nicotinic receptor knockout mice
Azzopardi, E., Typlt, M., Jenkins, B. W., & Schmid, S. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12038 · Cited by 23 · see citing works
Molecular Mechanisms Underlying the Motivational Effects of Nicotine
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Role of β2-containing nicotinic acetylcholine receptors in auditory event-related potentials
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Michalak, A., & Biała, G. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.023 · Cited by 22 · see citing works
Kutlu, M. G., Holliday, E. D., & Gould, T. J. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.021 · Cited by 18 · see citing works
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Connor, D. A., & Gould, T. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.033 · Cited by 15 · see citing works
Self-citationYildirim, E., Connor, D. A., & Gould, T. J. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000111 · Cited by 13 · see citing works
Self-citationThe enhancement of contextual fear conditioning by ABT-418
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Connor, D. A., Kutlu, M. G., & Gould, T. J. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117695861 · Cited by 8 · see citing works
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The Effects of Nicotine on Learning and Memory
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AKT2 Modulates Astrocytic Nicotine Responses In Vivo
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Alcohol and nicotinic acetylcholine receptors
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Genes candidatos para la comorbilidad entre trastornos de ansiedad y trastornos adictivos.
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Contribution of Translational Genetic Research to Our Understanding of Nicotine Dependence
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- Authors
- Davis, J. A., & Gould, T. J.
- Affiliations
- Temple University (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Psychopharmacology
- Published
- 2006-11-30
- Volume
- 190
- Issue
- 3
- Pages
- 343-352
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2722435
- OpenAlex
- W2072227438
- Semantic Scholar
- 504fc6cb7dedba8685745d0706d55810faa6cc69
- Cited by
- 72
- References
- 69
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 2 · 2013: 9 · 2012: 9
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA017949, R01DA017949, T32DA007237)
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, nicotinic acetylcholine receptors, beta2 subunit, alpha7 subunit, contextual fear conditioning, hippocampal-dependent memory
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Conditioning, Classical, Conditioning, Operant, Cues, Dose-Response Relationship, Drug, Fear, Female, Genotype, Heterozygote, Hippocampus, Male, Mice, Inbred C57BL, Nicotine, Receptors, Nicotinic, Time Factors, Mice, Knockout, Mice, alpha7 Nicotinic Acetylcholine Receptor
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