Cited by 206Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

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The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

Walters, Carrie L., Brown, Sharon, Changeux, Jean-Pierre, Martin, Billy, Damaj, M. Imad·2006·Psychopharmacology

DOI 10.1007/s00213-005-0295-x

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Abstract

Rationale Tobacco use is implicated in approximately 440,000 deaths per year, making it the leading cause of preventable death in the United States. Although it is generally recognized that tobacco use is correlated with a variety of health-related complications, many smokers are unsuccessful in their efforts to stop smoking using current cessation therapies. Objectives Given that nicotine is the addictive component of tobacco, successful smoking cessation therapies must address the various processes, including reward, which contribute to nicotine addiction. As such, determining the nicotinic receptor subtypes involved in nicotine reward is of utmost importance to understanding how nicotine addiction progresses. Methods Conditioned place preference (CPP) in three-chamber conditioning boxes was performed. For antagonist studies, drug was given on all conditioning sessions 10 min before nicotine or saline injection and placement in the boxes. Results We have demonstrated that a pretreatment with the alpha4beta2 subunit of the nicotinic acetylcholine receptor (nAChR) antagonist dihydro-beta-erythroidine (2.0 mg/kg, s.c.) blocked nicotine (0.5 mg/kg, s.c.) CPP in wild-type mice (C57BL/6 mice). In contrast, pretreatment with an antagonist of the alpha7 subunit of the nAChR, methyllycaconitine (MLA, 5.0 or 10.0 mg/kg, s.c.), had no effect on this behavior. Finally, we showed that mice lacking the beta2 subunit of the nAChR did not exhibit nicotine CPP while alpha7 knock-out mice di…

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Authors: Walters, C. L., Brown, S., Changeux, J.-P., Martin, B., & Damaj, M. I.
Affiliations: Virginia Commonwealth University (US)
Institut Pasteur (FR)
Corresponding author: Walters, Carrie L.
ORCID: Changeux, Jean-Pierre
Damaj, M. Imad
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-01-14
Volume: 184
Issue: 3-4
Pages: 339-344
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-005-0295-x
OpenAlex: W2142606268
Cited by: 206
References: 30
Citations by year: 2026: 3 · 2025: 8 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 16 · 2013: 22 · 2012: 14
FWCI: 7.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (DA 07027, R01DA012610, DA 05274, DA-12610, T32DA007027)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotinic acetylcholine receptors, beta2 subunit, alpha7 subunit, nicotine reward, nicotine dependence, conditioned place preference, dihydro-beta-erythroidine, methyllycaconitine, tobacco use
MeSH terms: Aconitine, Animals, Choice Behavior, Conditioning, Psychological, Dihydro-beta-Erythroidine, Female, Heterozygote, Male, Mice, Inbred C57BL, Motivation, Premedication, Receptors, Nicotinic, Reinforcement Schedule, Social Environment, Tobacco Use Disorder, Mice, Knockout, Mice, alpha7 Nicotinic Acetylcholine Receptor

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The β2 but not α7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

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