Cited by 242Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine

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Kenney, Justin W., Gould, Thomas J.·2008·Molecular Neurobiology

Abstract

A long-standing relationship between nicotinic acetylcholine receptors (nAChRs) and cognition exists. Drugs that act at nAChRs can have cognitive-enhancing effects and diseases that disrupt cognition such as Alzheimer's disease and schizophrenia are associated with altered nAChR function. Specifically, hippocampus-dependent learning is particularly sensitive to the effects of nicotine. However, the effects of nicotine on hippocampus-dependent learning vary not only with the doses of nicotine used and whether nicotine is administered acutely, chronically, or withdrawn after chronic nicotine treatment but also vary across different hippocampus-dependent tasks such as the Morris water maze, the radial arm maze, and contextual fear conditioning. In addition, nicotine has variable effects across different types of hippocampal long-term potentiation (LTP). Because different types of hippocampus-dependent learning and LTP involve different neural and molecular substrates, comparing the effects of nicotine across these paradigms can yield insights into the mechanisms that may underlie the effects of nicotine on learning and memory and aid in understanding the variable effects of nicotine on cognitive processes. This review compares and contrasts the effects of nicotine on hippocampus-dependent learning and LTP and briefly discusses how the effects of nicotine on learning could contribute to nicotine addiction.

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Authors
Kenney, J. W., & Gould, T. J.
Affiliations
Temple University (US)
Corresponding author
Gould, Thomas J.
Venue
Molecular Neurobiology
Published
2008-08
Volume
38
Issue
1
Pages
101-121
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
OpenAlex
W2130009335
Cited by
242
References
230
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 24 · 2015: 15 · 2014: 34 · 2013: 21 · 2012: 23
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA015515, R03AA015515)
  • National Institute on Drug Abuse (DA017949, R01DA017949, DA 07237, T32DA007237)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
nicotine, nicotinic acetylcholine receptors, hippocampus-dependent learning, synaptic plasticity, long-term potentiation, learning and memory, nicotine withdrawal, cognitive enhancement, nicotine dependence, Alzheimer's disease, schizophrenia, contextual fear conditioning, Morris water maze, radial maze
MeSH terms
Animals, Hippocampus, Humans, Learning, Memory, Neuronal Plasticity, Nicotine, Receptors, Nicotinic, Long-Term Potentiation, Substance-Related Disorders

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