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Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment
Open accessAbstract
Rationale Identification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services. Objectives Given that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency heart rate variability (HFHRV) and alcohol attentional bias (AB) as potential relapse risk indices. Method Alcohol-dependent patients in long-term residential treatment who had participated in mindfulness-oriented therapy or an addiction support group completed a spatial cueing task as a measure of alcohol AB and an affect-modulated alcohol cue-reactivity protocol while HFHRV was assessed. Results Post-treatment HFHRV cue-reactivity and alcohol AB significantly predicted the occurrence and timing of relapse by 6-month follow-up, independent of treatment condition and after controlling for alcohol dependence severity. Alcohol-dependent patients who relapsed exhibited a significantly greater HFHRV reactivity to stress-primed alcohol cues than patients who did not relapse. Conclusions Cue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings.
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“Contrary to their hypotheses, MORE did not significantly increase self-reported mindfulness, nor did it result in significant decrements in craving, but significantly reduced symptoms associated with chronic pain and prescription opioid misuse.”
From Mindfulness-Based Interventions for the Treatment of Substance and Behavioral Addictions: A Systematic Review (2018) · cites this paper as [30]
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Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Hosmer, D. W., & Lemeshow, S. (2000) · doi:10.1002/0471722146 · Cited by 20,302
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
(1998) · PubMed · Cited by 10,216
Heart rate variability: origins, methods, and interpretive caveats
BERNTSON, G. G., THOMAS BIGGER, J., ECKBERG, D. L., GROSSMAN, P., KAUFMANN, P. G., MALIK, M., NAGARAJA, H. N., PORGES, S. W., SAUL, J. P., STONE, P. H., et al. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02140.x · Cited by 3,962
Survival analysis using sas®: a practical guide
Allison, P. D. (1995) · International Linear Collider · Cited by 3,570
A model of neurovisceral integration in emotion regulation and dysregulation
Thayer, J. F., & Lane, R. D. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00338-4 · Cited by 3,092
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · cited 4×
“Two important candidate variables are alcohol cue-reactivity and alcohol attentional bias (Carter and Tiffany 1999; Fadardi and Cox 2006; Field and Cox 2008; Glautier and Drummond 1994; Stritzke et al. 2004; Townshend and Duka 2007).”
InfluentialA cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554
Incentive-sensitization and addiction
Robinson, T. E., & Berridge, K. C. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.9611038.x · Cited by 1,435
Attentional bias in addictive behaviors: A review of its development, causes, and consequences
FIELD, M., & COX, W. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.03.030 · Cited by 1,376
A review of research on the Alcohol Use Disorders Identification Test (AUDIT).
Allen, J., Litten, R., Fertig, J., & Babor, T. (1997) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03811.x · Cited by 1,016
Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches
Franken, I. H. A. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00081-2 · Cited by 805
Self-citationNeural correlates of heart rate variability during emotion
Lane, R. D., Kateri Mcrae, A., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.056 · Cited by 687
Central and autonomic nervous system interaction is altered by short-term meditation
Tang, Y.-Y., Ma, Y., Fan, Y., Feng, H., Wang, J., Feng, S., Lu, Q., Hu, B., Lin, Y., Li, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904031106 · Cited by 680
Heart rate variability reflects self-regulatory strength, effort, and fatigue
Segerstrom, S. C., & Nes, L. S. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.01888.x · Cited by 606
Field, M., Munafò, M. R., & Franken, I. H. A. (2009) · Psychological Bulletin · doi:10.1037/a0015843 · Cited by 602
Self-citationGr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598
Beat to beat variability in cardiovascular variables: Noise or music?
Appel, M. L., Berger, R. D., Saul, J. P., Smith, J. M., & Cohen, R. J. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90408-7 · Cited by 557
The Addiction-Stroop test: Theoretical considerations and procedural recommendations.
Cox, W. M., Fadardi, J. S., & Pothos, E. M. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.443 · Cited by 541
Respiratory sinus arrhythmia, emotion, and emotion regulation during social interaction
Butler, E. A., Wilhelm, F. H., & Gross, J. J. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00467.x · Cited by 520
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466
Llabre, M. M., Spitzer, S. B., Saab, P. G., Ironson, G. H., & Schneiderman, N. (1991) · Psychophysiology · doi:10.1111/j.1469-8986.1991.tb01017.x · Cited by 459
A cognitive processing model of alcohol craving and compulsive alcohol use
Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.3.x · Cited by 445
The role of stress in addiction relapse
Sinha, R. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0050-6 · Cited by 423
Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients
Schoenmakers, T. M., de Bruin, M., Lux, I. F. M., Goertz, A. G., Van Kerkhof, D. H. A. T., & Wiers, R. W. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.11.022 · Cited by 373
Experimental manipulation of attentional bias increases the motivation to drink alcohol
Field, M., & Eastwood, B. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0202-5 · Cited by 347
Alcohol attentional bias as a predictor of alcohol abusers’ treatment outcome
Cox, W. M., Hogan, L. M., Kristian, M. R., & Race, J. H. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00219-3 · Cited by 340
Identifying the neural circuitry of alcohol craving and relapse vulnerability
Heinz, A., Beck, A., Grüsser, S. M., Grace, A. A., & Wrase, J. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00136.x · Cited by 326
George, O., & Koob, G. F. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.05.002 · Cited by 322
Garland, E. L., Gaylord, S. A., Boettiger, C. A., & Howard, M. O. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400690 · Cited by 319
Self-citationCarney, R. M., Freedland, K. E., Stein, P. K., Skala, J. A., Hoffman, P., & Jaffe, A. S. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00007 · Cited by 319
Reversing the sequence: Reducing alcohol consumption by overcoming alcohol attentional bias
Fadardi, J. S., & Cox, W. M. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.11.015 · Cited by 300
Field, M., Mogg, K., Zetteler, J., & Bradley, B. P. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1855-1 · Cited by 287
Ingjaldsson, J. T., Laberg, J. C., & Thayer, J. F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01926-1 · Cited by 275
Cephalic phase responses, craving and food intake in normal subjects
Nederkoorn, C., Smulders, F. T. Y., & Jansen, A. (2000) · Appetite · doi:10.1006/appe.2000.0328 · Cited by 273
Stress Enhancement of Craving During Sobriety: A Risk for Relapse
Breese, G. R., Chu, K., Dayas, C. V., Funk, D. R., Knapp, D. J., Koob, G. F., Lê, A. D., Dell, L. E. O., Overstreet, D. H., Roberts, A. J., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153544.83656.3c · Cited by 251
Cue reactivity as a predictor of drinking among male alcoholics.
Rohsenow, D. J., Monti, P. M., Rubonis, A. V., Sirota, A. D., NIAURA, R. S., Colby, S. M., Wunschel, S. M., & Abrams, D. B. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.3.620 · Cited by 241
A controlled trial of cue exposure treatment in alcohol dependence.
Drummond, C., & Glautier, S. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.62.4.809 · Cited by 218
Attentional re‐training decreases attentional bias in heavy drinkers without generalization
Schoenmakers, T. M., Wiers, R. W. H. J., Jones, B. T., Bruce, G., & Jansen, A. T. M. (2007) · Addiction · doi:10.1111/j.1360-0443.2006.01718.x · Cited by 206
Experimental manipulation of attentional biases in heavy drinkers: do the effects generalise?
Field, M., Duka, T., Eastwood, B., Child, R. B., Santarcangelo, M., & Gayton, M. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0760-9 · Cited by 193
Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics
Braus, D. F., Wrase, J., Grüsser, S. M., Hermann, D., Ruf, M., Flor, H., Mann, K. F., & Heinz, A. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170038 · Cited by 192
Carrasco, M. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)54003-8 · Cited by 181
Relapse to smoking during unaided cessation: clinical, cognitive and motivational predictors
Powell, J. E., Dawkins, L., West, R., Powell, J. F., & Pickering, A. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1975-8 · Cited by 181
Wu, S.-D., & Lo, P.-C. (2008) · Biomedical Research · doi:10.2220/biomedres.29.245 · Cited by 153
Does smoking cue‐induced craving tell us anything important about nicotine dependence?
Perkins, K. A. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02550.x · Cited by 146
Avoidance of alcohol-related stimuli in alcohol-dependent inpatients.
Townshend, J. M., & Duka, T. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00429.x · Cited by 140
Methamphetamine craving induced in an online virtual reality environment
Culbertson, C. S., Nicolas, S., Zaharovits, I., London, E. D., Garza, R. D. L., Brody, A. L., & Newton, T. F. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.07.005 · Cited by 136
Assessment of Substance Cue Reactivity: Advances in Reliability, Specificity, and Validity.
Stritzke, W. G. K., Breiner, M. J., Curtin, J. J., & Lang, A. R. (2004) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.18.2.148 · Cited by 124
Stress increases attentional bias for alcohol cues in social drinkers who drink to cope
Field, M., & Powell, H. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm064 · Cited by 120
Garland, E. L., Boettiger, C. A., Gaylord, S., Chanon, V. W., & Howard, M. O. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-011-9378-7 · Cited by 106
Self-citationPu, J., Schmeichel, B. J., & Demaree, H. A. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.07.006 · Cited by 98
Effect of medication and psychotherapy on heart rate variability in panic disorder
Garakani, A., Martinez, J. M., Aaronson, C. J., Voustianiouk, A., Kaufmann, H., & Gorman, J. M. (2008) · Depression and Anxiety · doi:10.1002/da.20533 · Cited by 97
Garland, E. L., Boettiger, C. A., & Howard, M. O. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.014 · Cited by 89
Self-citationGarland, E. L., Franken, I. H. A., Sheetz, J. J., & Howard, M. O. (2012) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0027199 · Cited by 84
Self-citationAlcohol dependence and cue reactivity.
Glautier, S., & Drummond, C. (1994) · Journal of Studies on Alcohol · doi:10.15288/jsa.1994.55.224 · Cited by 81
Trait mindfulness predicts attentional and autonomic regulation of alcohol cue-reactivity
Garland, E. L. (2011) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000060 · Cited by 78
Self-citationAlcohol attentional bias: drinking salience or cognitive impairment?
Fadardi, J. S., & Cox, W. M. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0268-0 · Cited by 73
Lo, S. K., Li, I. T., Tsou, T., & See, L. (1995) · PubMed · Cited by 73
Field, M., & Quigley, M. (2009) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0017090 · Cited by 69
Blunted vagal reactivity predicts stress-precipitated tobacco smoking
Ashare, R. L., Sinha, R., Lampert, R. J., Weinberger, A. H., Anderson, G. M., Lavery, M. E., Yanagisawa, K., & McKee, S. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2473-3 · Cited by 57
Heart rate variability as an index of cue reactivity in alcoholics
Rajan, I., Murthy, P., Ramakrishnan, A. G., Gangadhar, B. N., & Janakiramaiah, N. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00399-5 · Cited by 49
Exposure to smoking cues: Cardiovascular and autonomic effects
Erblich, J., Bovbjerg, D. H., & Sloan, R. P. (2011) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.02.011 · Cited by 47
Chang, R.-Y., Koo, M., Yu, Z., Kan, C., Chu, I., Hsu, C.-T., & Chen, C. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0166 · Cited by 42
No effect of negative mood on the alcohol cue reactivity of in-patient alcoholics
Jansma, A., BRETELER, M. H. M., Schippers, G. M., de Jong, C. A. J., & van der Staak, C. P. F. (2000) · Addictive Behaviors · doi:10.1016/s0306-4603(99)00037-4 · Cited by 33
Stockhorst, U., Huenig, A., Ziegler, D., & Scherbaum, W. A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.014 · Cited by 27
Changes in Autonomic Control of Heart Associated with Classical Appetitive Conditioning in Rats
Inagaki, H., Kuwahara, M., & Tsubone, H. (2005) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.54.61 · Cited by 16
Research works printed but not linked: 1
- Rawson R, McCann MJ (2006) Counselor’s treatment manual: matrix intensive outpatient treatment for people with stimulant use disorders. DHHS Publication, Washington, DC
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Garland, E. L., Froeliger, B., Zeidan, F., Partin, K., & Howard, M. O. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.006 · Cited by 277
Self-citationSancho, M., De Gracia, M., Rodríguez, R. C., Mallorquí-Bagué, N., Sánchez-González, J., Trujols, J., Sánchez, I., Jiménez-Murcia, S., & Menchón, J. M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00095 · Cited by 224
“However, several trials showed other or different inclusion criteria: (1) residency at the treatment center or therapeutic community (20, 30, 37); (2) to be able to speak and read Persian (53); (3) to be 18–29 (40, 50), 18–20 (42), 14 or older (48), 18–40”
BackgroundMethodInfluentialWeiss, N. H., Sullivan, T. P., & Tull, M. T. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.01.013 · Cited by 239
Garland, E. L., Froeliger, B., & Howard, M. O. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3504-7 · Cited by 216
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Metadata
- Authors
- Garland, E. L., Franken, I. H. A., & Howard, M. O.
- Affiliations
- Florida State University (US)
- Erasmus University Rotterdam (NL)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Garland, Eric L.
- Venue
- Psychopharmacology
- Published
- 2011-12-28
- Volume
- 222
- Issue
- 1
- Pages
- 17-26
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3346884
- OpenAlex
- W2107603646
- Cited by
- 170
- References
- 70
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 18 · 2019: 20 · 2018: 19 · 2017: 10 · 2016: 12 · 2015: 16 · 2014: 9 · 2013: 13 · 2012: 6
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R03DA032517)
- National Center for Complementary and Integrative Health (T32AT003378)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- alcohol relapse, alcoholism, heart rate variability, attentional bias, alcohol cue reactivity, relapse risk prediction, addiction support groups, residential treatment, prognostic factors
- MeSH terms
- Adult, Alcoholism, Attention, Cues, Female, Follow-Up Studies, Heart Rate, Humans, Male, Recurrence, Self-Help Groups, Severity of Illness Index, Cognitive Behavioral Therapy, Treatment Outcome
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