Cited by 216Mindfulness and Compassion InterventionsOpioid Use Disorder TreatmentSubstance Abuse Treatment and Outcomes

Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity

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Garland, Eric L., Froeliger, Brett, Howard, Matthew O.·2014·Psychopharmacology

Abstract

Rationale Dysregulated reward processing is a hallmark feature of drug addiction; however, scant research has evaluated restructuring reward processing in the context of addiction treatment.Objectives We examined effects of Mindfulness-Oriented Recovery Enhancement (MORE) on reward responsiveness (RR) and opioid cue-reactivity in a sample of chronic pain patients with opioid use problems. We previously reported that MORE decreased pain, opioid misuse, and craving relative to a social support control group (SG). Here, we examined whether these outcomes were linked to changes in RR in a subset of participants.Methods Participants were chronic pain patients (71 % women, age 46.6 ± 13.9) who received MORE (n = 20) or SG (n = 29). RR was measured before and after 8 weeks of treatment via heart rate (HR) and heart rate variability (HRV) responses during a dot probe task that included opioid-related, pain-related, and natural reward stimuli, as well as craving ratings.Results The MORE group, who reported decreased opioid misuse and opioid craving during treatment, evidenced less subjective opioid cue-reactivity, greater HR decelerations, and greater increases in HRV to all cues after treatment compared to the SG; HR and HRV effects were most pronounced for natural reward cues. Within the MORE group, HR deceleration to natural reward cues was correlated with increased subjective arousal to the cues, whereas HR deceleration to opioid cues was correlated with decreased subjective arousal. Effects of MORE on craving were mediated by enhanced RR.Conclusions Results suggest that during treatment with MORE, cardiac-autonomic responsiveness to non-drug reward increases, while reactivity to opioid reward decreases. Studies are needed to discern whether changes in RR were a result or a determinant of reductions in opioid misuse and craving. RR may play a role in addiction treatment.

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  1. Garland EL 2013 Mindfulness-Oriented Recovery Enhancement for Addiction, Stress, and Pain NASW Press Washington, D.C

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Authors
Garland, E. L., Froeliger, B., & Howard, M. O.
Affiliations
  • University of Utah (US)
  • Medical University of South Carolina (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Garland, Eric L.
Venue
Psychopharmacology
Published
2014-03-05
Volume
231
Issue
16
Pages
3229-3238
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2064924323
Cited by
216
References
72
Citations by year
2026: 4 · 2025: 12 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 19 · 2020: 54 · 2019: 23 · 2018: 14 · 2017: 15 · 2016: 8 · 2015: 15 · 2014: 6
FWCI
17.36
Type
journal article
Language
en
Open access
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Fahs-Beck Fund for Research and Experimentation
  • National Institutes of Health
  • National Institute on Drug Abuse (DA 032517, R03DA032517, R34DA037005, DA037005)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
Mindfulness-Oriented Recovery Enhancement, reward responsiveness, opioid use disorder, chronic pain, opioid misuse, opioid craving, heart rate variability, natural reward, addiction treatment, mindfulness-based interventions
MeSH terms
Adult, Affect, Arousal, Attention, Cues, Female, Heart Rate, Humans, Male, Middle Aged, Opioid-Related Disorders, Reward, Self Report, Chronic Pain, Prescription Drug Misuse, Mindfulness

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