Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity
Open accessAbstract
Rationale Dysregulated reward processing is a hallmark feature of drug addiction; however, scant research has evaluated restructuring reward processing in the context of addiction treatment.Objectives We examined effects of Mindfulness-Oriented Recovery Enhancement (MORE) on reward responsiveness (RR) and opioid cue-reactivity in a sample of chronic pain patients with opioid use problems. We previously reported that MORE decreased pain, opioid misuse, and craving relative to a social support control group (SG). Here, we examined whether these outcomes were linked to changes in RR in a subset of participants.Methods Participants were chronic pain patients (71 % women, age 46.6 ± 13.9) who received MORE (n = 20) or SG (n = 29). RR was measured before and after 8 weeks of treatment via heart rate (HR) and heart rate variability (HRV) responses during a dot probe task that included opioid-related, pain-related, and natural reward stimuli, as well as craving ratings.Results The MORE group, who reported decreased opioid misuse and opioid craving during treatment, evidenced less subjective opioid cue-reactivity, greater HR decelerations, and greater increases in HRV to all cues after treatment compared to the SG; HR and HRV effects were most pronounced for natural reward cues. Within the MORE group, HR deceleration to natural reward cues was correlated with increased subjective arousal to the cues, whereas HR deceleration to opioid cues was correlated with decreased subjective arousal. Effects of MORE on craving were mediated by enhanced RR.Conclusions Results suggest that during treatment with MORE, cardiac-autonomic responsiveness to non-drug reward increases, while reactivity to opioid reward decreases. Studies are needed to discern whether changes in RR were a result or a determinant of reductions in opioid misuse and craving. RR may play a role in addiction treatment.
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In mechanistic analyses from a RCT of MORE as a treatment for prescription opioid misuse among chronic pain patients, MORE produced significant increases in cardiac-autonomic and electrocortical responses to natural reward stimuli that were, in turn, associated with decreases in opioid craving.
“In mechanistic analyses from a RCT of MORE as a treatment for prescription opioid misuse among chronic pain patients, MORE produced significant increases in cardiac-autonomic and electrocortical responses to natural reward stimuli that were, in turn, associated with decreases in opioid craving [30, 31]”
From Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research (2018) · cites this paper as [30]
In an RCT, MORE significantly reduced attentional bias toward opioid cues and decreased subjective craving responses during an opioid cue-reactivity protocol.
“decreased cue-reactivity was observed in an RCT in which MORE was shown to significantly reduce attentional bias toward opioid cues [52] and decrease subjective craving responses during an opioid cue-reactivity protocol [30].”
From Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research (2018) · cites this paper as [30]
Increasing physiological responsiveness to natural rewards via mindful savoring predicts decreased prescription opioid misuse and craving.
“Similarly, evidence that increasing physiological responsiveness to natural rewards via mindful savoring predicts decreased prescription opioid misuse [75] and craving [30] has led to an enriched emphasis on mindful savoring practice in the MORE intervention.”
From Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research (2018) · cites this paper as [30]
Taking part in MORE was linked to stronger cardiac markers of natural reward processing.
“enhanced cardiac46 and electrocortical indices of natural reward processing”
MORE's effects of raising autonomic and electroencephalographic responses to natural reward stimuli were linked to lower drug craving.
“MORE’s effects on increasing autonomic and electroencephalographic responses to natural reward stimuli were associated with reductions in drug craving,46,47”
Taking part in MORE was linked to better parasympathetically mediated heart rate variability while attending to emotional information.
“improved parasympathetically mediated HRV during attention to emotional information,46”
MORE seemed to lower reactivity to drug cues.
“reducing drug cue reactivity,46”
Study heterogeneity was investigated using Baujat plots together with Q and I2 statistics.
“Study heterogeneity was investigated using Baujat plots in conjunction with the Q and I 2 statistics.52,53”
From Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis (2020) · cites this paper as [53]
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Self-citationFroeliger, B., Mathew, A. R., McConnell, P. A., Eichberg, C., Saladin, M. E., Carpenter, M. J., & Garland, E. L. (2017) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2017/7018014 · Cited by 83 · see citing works
Self-citationLi, M. J., Black, D. S., & Garland, E. L. (2016) · Personality and Individual Differences · doi:10.1016/j.paid.2015.10.027 · Cited by 83 · see citing works
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Self-citationGarland, E. L., Bryan, C. J., Nakamura, Y., Froeliger, B., & Howard, M. O. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4494-4 · Cited by 82 · see citing works
Self-citationGarland, E. L. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.03.019 · Cited by 78 · see citing works
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Garland, E. L., Trøstheim, M., Eikemo, M., Ernst, G., & Leknes, S. (2019) · Psychological Medicine · doi:10.1017/s0033291719002010 · Cited by 72 · see citing works
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Witkiewitz, K. A., Stein, E., Votaw, V. R., Wilson, A. D., Roos, C. R., Gallegos, S. J., Clark, V. P., & Claus, E. D. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14053 · Cited by 66 · see citing works
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Parisi, A. B., Roberts, R. L., Hanley, A. W., & Garland, E. L. (2022) · Mindfulness · doi:10.1007/s12671-022-01964-x · Cited by 62 · see citing works
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Self-citationGarland, E. L., & Howard, M. O. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.09.014 · Cited by 55 · see citing works
Hanley, A. W., de Vibe, M., Solhaug, I., Farb, N., Goldin, P. R., Gross, J. J., & Garland, E. L. (2021) · Stress and Health · doi:10.1002/smi.3035 · Cited by 56 · see citing works
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Self-citationGarland, E. L., Baker, A. K., & Howard, M. O. (2017) · Journal of the Society for Social Work and Research · doi:10.1086/694324 · Cited by 47 · see citing works
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Self-citationZamboni, L., Centoni, F., Fusina, F., Mantovani, E., Rubino, F., Lugoboni, F., & Federico, A. (2021) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001381 · Cited by 54 · see citing works
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Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48 · see citing works
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Warth, M., Keßler, J., Hillecke, T. K., & Bardenheuer, H. J. (2016) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2016.01.008 · Cited by 48 · see citing works
Garland, E. L., Reese, S. E., Bedford, C. E., & Baker, A. K. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000622 · Cited by 49 · see citing works
Self-citationGarland, E. L., Hudak, J., Hanley, A. W., & Nakamura, Y. (2020) · American Psychologist · doi:10.1037/amp0000638 · Cited by 50 · see citing works
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Garland, E. L. (2020) · Pain · doi:10.1097/j.pain.0000000000001988 · Cited by 36 · see citing works
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Garland, E. L. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.928587 · Cited by 30 · see citing works
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Self-citationHoward, M. O., & Garland, E. L. (2015) · Journal of the Society for Social Work and Research · doi:10.1086/681099 · Cited by 29 · see citing works
Self-citationPain Management in the Era of the Opioid Crisis
Bruera, E. D., & Fabbro, E. D. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_208563 · Cited by 29 · see citing works
Riquino, M. R., Priddy, S. E., Howard, M. O., & Garland, E. L. (2018) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-018-0088-6 · Cited by 28 · see citing works
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Russell, K. C., Gillis, H. L. “., & Heppner, W. L. (2015) · Mindfulness · doi:10.1007/s12671-015-0441-4 · Cited by 25 · see citing works
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Garland, E. L., & Howard, M. O. (2018) · Journal of the Society for Social Work and Research · doi:10.1086/697685 · Cited by 22 · see citing works
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Self-citationHeart Rate Variability in Adults With Substance Use Disorder: A Comprehensive Narrative Review
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Smoking cue reactivity in current smokers, former smokers and never smokers
Balter, L. J. T., Good, K. P., & Barrett, S. P. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2015.01.010 · Cited by 21 · see citing works
Priddy, S. E., Hanley, A. W., Riquino, M. R., Platt, K. A., Baker, A. K., & Garland, E. L. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.03.040 · Cited by 19 · see citing works
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Self-citationMindfulness-based interventions for substance use disorders
Rösner, S., Willutzki, R., & Zgierska, A. E. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011723 · Cited by 18 · see citing works
- Authors
- Garland, E. L., Froeliger, B., & Howard, M. O.
- Affiliations
- University of Utah (US)
- Medical University of South Carolina (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Garland, Eric L.
- Venue
- Psychopharmacology
- Published
- 2014-03-05
- Volume
- 231
- Issue
- 16
- Pages
- 3229-3238
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC4111972
- OpenAlex
- W2064924323
- Cited by
- 216
- References
- 72
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 19 · 2020: 54 · 2019: 23 · 2018: 14 · 2017: 15 · 2016: 8 · 2015: 15 · 2014: 6
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Fahs-Beck Fund for Research and Experimentation
- National Institutes of Health
- National Institute on Drug Abuse (DA 032517, R03DA032517, R34DA037005, DA037005)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- Mindfulness-Oriented Recovery Enhancement, reward responsiveness, opioid use disorder, chronic pain, opioid misuse, opioid craving, heart rate variability, natural reward, addiction treatment, mindfulness-based interventions
- MeSH terms
- Adult, Affect, Arousal, Attention, Cues, Female, Heart Rate, Humans, Male, Middle Aged, Opioid-Related Disorders, Reward, Self Report, Chronic Pain, Prescription Drug Misuse, Mindfulness
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