Cited by 31Attention Deficit Hyperactivity DisorderNeuroethics, Human Enhancement, Biomedical InnovationsNeural and Behavioral Psychology Studies

Methylphenidate alters selective attention by amplifying salience

Open access
ter Huurne, Niels, Fallon, Sean James, van Schouwenburg, Martine, van der Schaaf, Marieke, Buitelaar, Jan, Jensen, Ole, Cools, Roshan·2015·Psychopharmacology

Abstract

Rationale Methylphenidate, the most common treatment of attention deficit hyperactivity disorder (ADHD), is increasingly used by healthy individuals as a "smart drug" to enhance cognitive abilities like attention. A key feature of (selective) attention is the ability to ignore irrelevant but salient information in the environment (distractors). Although crucial for cognitive performance, until now, it is not known how the use of methylphenidate affects resistance to attentional capture by distractors.Objectives The present study aims to clarify how methylphenidate affects distractor suppression in healthy individuals.Methods The effect of methylphenidate (20 mg) on distractor suppression was assessed in healthy subjects (N = 20), in a within-subject double-blind placebo-controlled crossover design. We used a visuospatial attention task with target faces flanked by strong (faces) or weak distractors (scrambled faces).Results Methylphenidate increased accuracy on trials that required gender identification of target face stimuli (methylphenidate 88.9 ± 1.4 [mean ± SEM], placebo 86.0 ± 1.2 %; p = .003), suggesting increased processing of the faces. At the same time, however, methylphenidate increased reaction time when the target face was flanked by a face distractor relative to a scrambled face distractor (methylphenidate 34.9 ± 3.73, placebo 26.7 ± 2.84 ms; p = .027), suggesting enhanced attentional capture by distractors with task-relevant features.Conclusions We conclude that methylphenidate amplifies salience of task-relevant information at the level of the stimulus category. This leads to enhanced processing of the target (faces) but also increased attentional capture by distractors drawn from the same category as the target.

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  • Methylphenidate and amphetamine have been demonstrated to improve selective attention.

    “Similarly, methylphenidate111,112 and amphetamine113 have been demonstrated to improve selective attention”

    From Paying attention to attention in depression (2019) · cites this paper as [112]

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Authors
ter Huurne, N., Fallon, S. J., van Schouwenburg, M., van der Schaaf, M., Buitelaar, J., Jensen, O., & Cools, R.
Affiliations
Radboud University Nijmegen (NL)
Venue
Psychopharmacology
Published
2015-09-09
Volume
232
Issue
23
Pages
4317-4323
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W1615346783
Cited by
31
References
51
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 1 · 2016: 3
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (453-09-002)
  • Cilag
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
methylphenidate, selective attention, distractor suppression, attentional capture, salience, attention deficit hyperactivity disorder, cognitive enhancement, face processing, visuospatial attention, healthy individuals
MeSH terms
Adult, Central Nervous System Stimulants, Attention, Double-Blind Method, Female, Humans, Male, Methylphenidate, Photic Stimulation, Psychomotor Performance, Reaction Time, Cross-Over Studies, Young Adult

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