Methylphenidate Effects on Prefrontal Functioning During Attentional-Capture and Response Inhibition
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Background Methylphenidate improves motor response inhibition, typically assessed with the stop-signal task. The exact underlying mechanism for this, however, remains unknown. In addition, recent studies highlight that stop signals can have a confounding attentional-capture effect because of their low frequency in the task. In the current study, we assessed the effects of methylphenidate on neural networks of inhibitory control and attentional-capture within the context of two inhibitory control tasks.Methods The effects of methylphenidate (40 mg) were assessed using functional magnetic resonance imaging in 16 healthy volunteers in a within-subject, double-blind, placebo-controlled design.Results Methylphenidate significantly reduced activation of different regions within the right inferior frontal gyrus/insula to infrequent stimuli associated with successful inhibition, failed inhibition, and attentional capture. These inferior frontal gyrus regions showed different interregional connections with inhibitory and attention networks. For failed inhibitions, methylphenidate increased activation within performance-monitoring regions, including the superior frontal, anterior cingulate, and parietal-occipital cortices, but only after controlling for attentional capture.Conclusions Our findings suggest that the improvement of response inhibition seen following methylphenidate administration is due to its influence on underlying attentional mechanisms linked to response control requirements.
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Dopamine-dependent activation in the anterior cingulate has been associated with increased error awareness and performance monitoring.
“Furthermore, dopamine-dependent activation in the anterior cingulate has also been associated with increased error awareness and performance monitoring (Hester et al. 2012; Pauls et al. 2012).”
From Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder (2019) · cites this paper as Pauls et al. 2012
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- Authors
- Pauls, A. M., O'Daly, O. G., Rubia, K., Riedel, W. J., Williams, S. C. R., & Mehta, M. A.
- Affiliations
- King's College London (GB)
- Maastricht University (NL)
- Corresponding author
- Pauls, Astrid M.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 72
- Issue
- 2
- Pages
- 142-149
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2012989506
- Cited by
- 57
- References
- 61
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 2 · 2012: 3
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Eli Lilly and Company
- Pfizer
- British Association for Psychopharmacology
- Universiteit Maastricht
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- methylphenidate, response inhibition, attentional capture, stop-signal task, prefrontal cortex, inferior frontal gyrus, insula, performance monitoring, anterior cingulate cortex
- MeSH terms
- Adult, Attention, Brain Mapping, Double-Blind Method, Frontal Lobe, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Methylphenidate, Neural Pathways, Occipital Lobe, Parietal Lobe, Placebos, Psychomotor Performance, Prefrontal Cortex, Cross-Over Studies
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