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Microdosing psychedelics: personality, mental health, and creativity differences in microdosers
Open accessAbstract
Rationale Microdosing psychedelics-the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin-is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-distorting properties, microdosing mayprovide complementary clinical benefits using lower-risk, non-hallucinogenic doses.Objectives This pre-registered study aimed to investigate whether microdosing psychedelics is related to differences in personality, mental health, and creativity.Methods In this observational study, respondents recruited from online forums self-reported their microdosing behaviors and completed questionnaires concerning dysfunctional attitudes, wisdom, negative emotionality, open-mindedness, and mood. Respondents also performed the Unusual Uses Task to assess their creativity.Results Current and former microdosers scored lower on measures of dysfunctional attitudes (p < 0.001, r = - 0.92) and negative emotionality (p = 0.009, r = - 0.85) and higher on wisdom (p < 0.001, r = 0.88), openmindedness(p = 0.027, r = 0.67), and creativity (p < 0.001, r = 0.15) when compared to non-microdosing controls.Conclusions These findings provide promising initial evidence that warrants controlled experimental research to directly test safety and clinical efficacy. As microdoses are easier to administer than full-doses, this new paradigm has the exciting potential to shape future psychedelic research.
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“the data on human psychedelic microdosing are equivocal”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [245]
In the citing paper
“therapeutic benefit of low doses of psychedelics remains to be demonstrated in a well-controlled clinical study”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [245]
In the citing paper
“Interestingly, openmindesness (i.e., openness) was higher and negative emotionality (i.e., neuroticism) was lower in current and former microdosers compared to MD-naïve controls (27).”
From Trait mindfulness and personality characteristics in a microdosing ADHD sample: a naturalistic prospective survey study (2023) · cites this paper as [27]
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Ayahuasca for the treatment of alcohol use disorder
Marinho, E. A. V., Serra, Y. A., Oliveira-Lima, A. J., Marcourakis, T., & Berro, L. F. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.07.007 · Cited by 10
Costa, M. Â. (2022) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2022.2106805 · Cited by 7
A perspective on psychedelic teratogenicity: the utility of zebrafish models
Syed, O. A., Tsang, B., Petranker, R., & Gerlai, R. T. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.08.001 · Cited by 7
Self-citationThe zebrafish for preclinical psilocybin research
Syed, O. A., Tsang, B., & Gerlai, R. T. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105381 · Cited by 7
Cavanna, F., Muller, S. L., de la Fuente, L. A., Zamberlán, F., Palmucci, M., Janeckova, L., Kuchař, M., Pallavicini, C., & Tagliazucchi, E. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.30.470657 · Cited by 7
Haijen, E. C. H. M., Hurks, P. P. M., & Kuypers, K. P. C. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1233585 · Cited by 7
“Interestingly, openmindesness (i.e., openness) was higher and negative emotionality (i.e., neuroticism) was lower in current and former microdosers compared to MD-naïve controls (27).”
ResultPendse, S. R., Kumar, N., & Choudhury, M. D. (2024) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3613904.3642477 · Cited by 8
Between enhancement and risk: A critical review of psychedelic microdosing
Totomanova, I., Haijen, E. C. H. M., Hurks, P. P. M., Ramaekers, J. G., & Kuypers, K. P. C. (2025) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2025.102129 · Cited by 6
Colognesi, M., Gabbia, D., Signor, A., Sarill, M., Centofanti, L., Rinaldi, A., Cascione, L., Nunziata, S., Banzato, M., Mattarei, A., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108080 · Cited by 8
Syed, O. A., Petranker, R., & Tsang, B. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106204 · Cited by 6
Self-citationGray, C. (2020) · Somatechnics · doi:10.3366/soma.2020.0303 · Cited by 6
Imagining a Role for Psychedelics in Dementia Care
George, D. R., & Hanson, R. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.03.008 · Cited by 6
Asking questions of psychedelic microdosing
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Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress?
Kit, A., Conway, K., Makarowski, S., O'Regan, G., Allen, J., Shultz, S. R., Bodnar, T. S., & Christie, B. R. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100732 · Cited by 5
Psychedelic Drug Microdosing Practices: A Qualitative Online Exploration
Miller, E., Bojovic, V., Maddren, O., Rao, P., Adesina, D., Petrenko, A., & Ponton, R. (2024) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2024.2304554 · Cited by 5
Metadata
- Authors
- Anderson, T., Petranker, R., Rosenbaum, D., Weissman, C. R., Dinh-Williams, L.-A., Hui, K., Hapke, E., & Farb, N. A. S.
- Affiliations
- University of Toronto (CA)
- York University (CA)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Anderson, Thomas
- Petranker, Rotem
- ORCID
- Venue
- Psychopharmacology
- Published
- 2019-01-02
- Volume
- 236
- Issue
- 2
- Pages
- 731-740
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2907379922
- Cited by
- 174
- References
- 39
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 26 · 2023: 22 · 2022: 28 · 2021: 24 · 2020: 22 · 2019: 18
- FWCI
- 26.86
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PsyArXiv (OSF Preprints) (submittedVersion)
- PsyArXiv (OSF Preprints) (submittedVersion, cc-by)
- OSF Preprints (OSF Preprints) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Social Psychology › Paranormal Experiences and Beliefs
- Social Sciences › Psychology › Social Psychology › Psychological Well-being and Life Satisfaction
- Keywords
- microdosing, psychedelics, LSD, psilocybin, personality, mental health, creativity, dysfunctional attitudes, negative affectivity, wisdom, open-mindedness, mood
- MeSH terms
- Adult, Anxiety, Creativity, Depression, Dose-Response Relationship, Drug, Emotions, Female, Hallucinogens, Humans, Lysergic Acid Diethylamide, Male, Mental Health, Perception, Personality, Psilocybin, Surveys and Questionnaires
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