Chronic, Intermittent Microdoses of the Psychedelic N , N -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents
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Drugs capable of ameliorating symptoms of depression and anxiety while also improving cognitive function and sociability are highly desirable. Anecdotal reports have suggested that serotonergic psychedelics administered in low doses on a chronic, intermittent schedule, so-called “microdosing”, might produce beneficial effects on mood, anxiety, cognition, and social interaction. Here, we test this hypothesis by subjecting male and female Sprague Dawley rats to behavioral testing following the chronic, intermittent administration of low doses of the psychedelic N,N-dimethyltryptamine (DMT). The behavioral and cellular effects of this dosing regimen were distinct from those induced following a single high dose of the drug. We found that chronic, intermittent, low doses of DMT produced an antidepressant-like phenotype and enhanced fear extinction learning without impacting working memory or social interaction. Additionally, male rats treated with DMT on this schedule gained a significant amount of body weight during the course of the study. Taken together, our results suggest that psychedelic microdosing may alleviate symptoms of mood and anxiety disorders, though the potential hazards of this practice warrant further investigation.
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The effects of psychoplastogens on structural plasticity in the PFC may explain why they have demonstrated efficacy in many preclinical rodent behavioral tests involving PFC circuitry including the forced swim test and fear extinction learning.
“This may explain why they have demonstrated efficacy in many preclinical rodent behavioral tests involving PFC circuitry including the forced swim test and fear extinction learning (151, 194–197).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [195]
Low doses of DMT produce beneficial effects in rodent behavioral paradigms relevant to treating depression and PTSD comparable to high doses.
“we demonstrated that low doses of DMT produce beneficial effects in rodent behavioral paradigms relevant to treating depression and PTSD comparable to high doses”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [195]
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- Authors
- Cameron, L. P., Benson, C. J., DeFelice, B. C., Fiehn, O., & Olson, D. E.
- Affiliations
- University of California, Davis (US)
- King Abdulaziz University (SA)
- Corresponding author
- Olson, David E.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-04
- Volume
- 10
- Issue
- 7
- Pages
- 3261-3270
- ISSN
- 1948-7193 (ISSN-L)
- PMC
- PMC6639775
- OpenAlex
- W2919894573
- Cited by
- 168
- References
- 72
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 27 · 2023: 23 · 2022: 38 · 2021: 16 · 2020: 15 · 2019: 9 · 2012: 1
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- ACS Chemical Neuroscience (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK104351, U24 DK097154)
- Division of Graduate Education (1650042)
- Department of Biochemistry and Molecular Medicine, University of California, Davis (NA)
- Department of Chemistry, University of California, Davis (NA)
- Genome Center, University of California, Davis (NA)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- N,N-dimethyltryptamine, DMT, psychedelic microdosing, antidepressant-like effects, anxiety, fear extinction learning, working memory, social interaction, weight gain, serotonergic psychedelics, mood disorders
- MeSH terms
- Affect, Animals, Antidepressive Agents, Anxiety, Behavior, Animal, Depression, N,N-Dimethyltryptamine, Extinction, Psychological, Fear, Female, Hallucinogens, Male, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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