Deep eutectic solvent–based headspace single-drop microextraction for the quantification of terpenes in spices
Open accessAbstract
Deep eutectic solvents (DESs) were investigated as extracting solvent for headspace single-drop microextraction (HS-SDME). The extraction efficiency of 10 DESs mainly composed of tetrabutylammonium bromide (N 4444 Br) and long-chain alcohols was evaluated for the extraction of terpenes from six spices (cinnamon, cumin, fennel, clove, thyme, and nutmeg). The DES composed of N 4444 Br and dodecanol at a molar ratio of 1:2 showed the highest extraction efficiency and was selected to conduct the extractions of terpenes in the rest of the study. HS-SDME was optimized by design of experiments. Only two parameters from the four studied showed a significant influence on the efficiency of the method: the extraction time and the extraction temperature. The optimal extraction conditions were determined by response surface methodology. All extracts were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). More than 40 terpenes were extracted and identified in nutmeg, the richest extract in terpenes in this study. Quantitative analysis based on 29 standards was conducted for each extract. Good linearity was obtained for all standards (R 2 > 0.99) in the interval of 1 to 500 μg/g. Limits of quantification ranged from 0.47 μg/g (borneol) to 86.40 μg/g (α-farnesene) with more than half of the values under 2 μg/g. HS-SDME is simple, rapid, and cheap compared with conventional extraction methods. The use of DESs makes this extraction method "greener" and it was shown that DESs can be suitable solvents for the extraction of bioactive compounds from plants.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Triaux et al.'s DES-HS-SDME application to 27 terpenes showed that half of the studied compounds had LOQs lower than 2 μg/g.
“The application to 27 different terpens showed that half of the studied compounds had LOQs lower than 2 μg/g”
From Microextraction Techniques with Deep Eutectic Solvents (2020) · cites this paper as [96]
Section 3.3 (Calibration) reports that more than half of the studied compounds had LOQs below 2 µg/g, but it gives the calibration count as 29 terpenes, not 27. Section 3.1 uses 27 for a separate solvent-screening comparison, not for the LOQ result. (LLM, conf=0.91)
Experimental — accuracy not yet measuredDES-HS-SDME is a simple, cheap, green, and efficient technique for the extraction of terpenes.
“Therefore, DES-HS-SDME is a simple, cheap, green, and efficient technique for the extraction of terpenes [96].”
From Microextraction Techniques with Deep Eutectic Solvents (2020) · cites this paper as [96]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Response surface methodology (RSM) as a tool for optimization in analytical chemistry
Bezerra, M. A., Santelli, R. E., Oliveira, E. P., Villar, L. S., & Escaleira, L. A. (2008) · Talanta · doi:10.1016/j.talanta.2008.05.019 · Cited by 6,075 · see citing works
Abbott, A. P., Capper, G., Davies, D. L., Rasheed, R. K., & Tambyrajah, V. (2003) · Chemical Communications · doi:10.1039/b210714g · Cited by 5,738 · see citing works
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517 · see citing works
Deep eutectic solvents: syntheses, properties and applications
Zhang, Q., De Oliveira Vigier, K., Royer, S., & Jérôme, F. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35178a · Cited by 4,899 · see citing works
Mechanisms of antibacterial action of three monoterpenes
Trombetta, D., Castelli, F., Sarpietro, M. G., Venuti, V., Cristani, M., Daniele, C., Saija, A., Mazzanti, G., & Bisignano, G. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2474-2478.2005 · Cited by 1,359 · see citing works
Experimental design and optimization
Lundstedt, T., Seifert, E., Abramo, L., Thelin, B., Nyström, Å., Pettersen, J., & Bergman, R. (1998) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/s0169-7439(98)00065-3 · Cited by 1,162 · see citing works
Candioti, L. V., Zan, M. M. D., Cámara, M. S., & Goicoechea, H. C. (2014) · Talanta · doi:10.1016/j.talanta.2014.01.034 · Cited by 1,159 · see citing works
Terpene synthases and the regulation, diversity and biological roles of terpene metabolism
Tholl, D. (2006) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2006.03.014 · Cited by 886 · see citing works
Natural products: the secondary metabolites.
Hanson, J. R. (2003) · Cited by 757 · see citing works
Diao, W.-R., Hu, Q. P., Zhang, H., & Xu, J. (2013) · Food Control · doi:10.1016/j.foodcont.2013.06.056 · Cited by 683 · see citing works
New horizons in the extraction of bioactive compounds using deep eutectic solvents: A review
Zainal-Abidin, M. H., Hayyan, M., Hayyan, A., & Jayakumar, N. S. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.05.012 · Cited by 643 · see citing works
Recent developments in deep eutectic solvents in chemical sciences
Tang, B., & Row, K. H. (2013) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-013-1050-3 · Cited by 538 · see citing works
Natural designer solvents for greening analytical chemistry
Espino, M., de los Ángeles Fernández, M., Gomez, F. J. V., & Silva, M. F. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.11.006 · Cited by 418 · see citing works
Headspace Solvent Microextraction
Theis, A. L., Waldack, A. J., Hansen, S. M., & Jeannot, M. A. (2001) · Analytical Chemistry · doi:10.1021/ac015569c · Cited by 316 · see citing works
An Overview of the Pharmacological Properties and Potential Applications of Natural Monoterpenes
Kozioł, A., Stryjewska, A., Librowski, T., Sałat, K., Gaweł, M., Moniczewski, A., & Lochyński, S. (2014) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557514666141127145820 · Cited by 223 · see citing works
Cao, J., Chen, L., Li, M., Cao, F., Zhao, L., & Su, E. (2018) · Green Chemistry · doi:10.1039/c7gc03820h · Cited by 178 · see citing works
Ionic liquids: solvents and sorbents in sample preparation
Clark, K. D., Emaus, M. N., Varona, M., Bowers, A. N., & Anderson, J. L. (2017) · Journal of Separation Science · doi:10.1002/jssc.201700864 · Cited by 157 · see citing works
Tang, W., Dai, Y., & Row, K. H. (2018) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-018-1346-6 · Cited by 148 · see citing works
Trends in solventless sample preparation techniques for environmental analysis
Wardencki, W., Curyło, J., & Namieśnik, J. (2006) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2006.07.004 · Cited by 145 · see citing works
Essential Oils and Their Constituents: Anticonvulsant Activity
de Almeida, R. N., Agra, M. D. F., Maior, F. N. S., & de Sousa, D. P. (2011) · Molecules · doi:10.3390/molecules16032726 · Cited by 142 · see citing works
Monoterpenes as a renewable source of biologically active compounds
Salakhutdinov, N. F., Volcho, K. P., & Yarovaya, О. I. (2017) · Pure and Applied Chemistry · doi:10.1515/pac-2017-0109 · Cited by 139 · see citing works
Marongiu, B., Piras, A., Porcedda, S., Tuveri, E., Sanjust, E., Meli, M., Sollai, F. A., Zucca, P., & Rescigno, A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071938f · Cited by 113 · see citing works
Smyth, D. R., & Berleth, T. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.11.014 · Cited by 113 · see citing works
Tang, B., Bi, W., Zhang, H., & Row, K. H. (2014) · Chromatographia · doi:10.1007/s10337-013-2607-3 · Cited by 105 · see citing works
Application of PLE for the determination of essential oil components from Thymus vulgaris L.
Dawidowicz, A. L., Rado, E., Wianowska, D., Mardarowicz, M., & Gawdzik, J. (2008) · Talanta · doi:10.1016/j.talanta.2008.04.050 · Cited by 103 · see citing works
Terpenoid Metabolic Engineering in Photosynthetic Microorganisms
Vavitsas, K., Fabris, M., & Vickers, C. E. (2018) · Genes · doi:10.3390/genes9110520 · Cited by 92 · see citing works
Yang, C., Wang, J., & Li, D. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.07.069 · Cited by 89 · see citing works
de Oliveira, M. S., da Costa, W. A., PEREIRA, D. S., Botelho, J. R. S., Menezes, T. O. D. A., Andrade, E. H. D. A., da Silva, S. H. M., Filho, A. P. D. S. S., & de Carvalho, R. N. (2016) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2016.08.010 · Cited by 86 · see citing works
Jeong, K. M., Jin, Y., Yoo, D. E., Han, S. Y., Kim, E. M., & Lee, J. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.079 · Cited by 85 · see citing works
Piras, A., Rosa, A., Marongiu, B., Atzeri, A., Dessì, M., Falconieri, D., & Porcedda, S. (2012) · Journal of Food Science · doi:10.1111/j.1750-3841.2012.02618.x · Cited by 80 · see citing works
Yousefi, S. M., Shemirani, F., & Ghorbanian, S. A. (2018) · Journal of Separation Science · doi:10.1002/jssc.201700807 · Cited by 79 · see citing works
Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice
Yano, S., Suzuki, Y., Yuzurihara, M., Kase, Y., Takeda, S., Watanabe, S., Aburada, M., & Miyamoto, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.020 · Cited by 76 · see citing works
Jalali‐Heravi, M., & Sereshti, H. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.05.096 · Cited by 69 · see citing works
Extraction of Natural Products from Plants – An Introduction
Bart, H. (2011) · doi:10.1002/9783527635122.ch1 · Cited by 55 · see citing works
Ortho-eugenol exhibits anti-nociceptive and anti-inflammatory activities
da Fonsêca, D. V., Salgado, P. R. R., Neto, H. D. C. A., Golzio, A. M. F. D. O., Filho, M. R. D. C., de Melo, C. G. F., Leite, F. C., Piuvezam, M. R., Pordeus, L. C. D. M., Barbosa‐Filho, J. M., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.06.005 · Cited by 53 · see citing works
Su, E., Yang, M., Cao, J., Lu, C., Wang, J., & Cao, F. (2017) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2017.1309661 · Cited by 44 · see citing works
Moradi, M., Kaykhaii, M., Ghiasvand, A., Shadabi, S., & Salehinia, A. (2011) · Phytochemical Analysis · doi:10.1002/pca.1368 · Cited by 36 · see citing works
Jiang, C., Wei, S., Li, X., Zhao, Y., Shao, M., Zhang, H., & Yu, A. (2013) · Talanta · doi:10.1016/j.talanta.2013.01.028 · Cited by 29 · see citing works
Vaghar-Lahijani, G., Azar, P. A., Tehrani, M. S., & Soleimani, M. (2017) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2016.1274999 · Cited by 22 · see citing works
Yang, J., Wei, H., Yu, C., Shi, Y., & Zhang, H. (2012) · Chromatographia · doi:10.1007/s10337-012-2335-0 · Cited by 21 · see citing works
Simpson, G. I. C., & Jackson, Y. A. (2002) · Journal of Essential Oil Research · doi:10.1080/10412905.2002.9699743 · Cited by 20 · see citing works
NATURAL PRODUCTS AS PHARMACEUTICALS AND SOURCES FOR LEAD STRUCTURES
Newman, D. J., Cragg, G. M. L., & Kingston, D. G. I. (2003) · Elsevier eBooks · doi:10.1016/b978-012744481-9/50010-6 · Cited by 14 · see citing works
sawaddipanich, V., & Chanthai, S. (2016) · Oriental Journal Of Chemistry · doi:10.13005/ojc/320301 · Cited by 10 · see citing works
Sadeghian, F., Ebrahimi, P., Shakeri, A., & Jamali, M. R. (2016) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmw038 · Cited by 6 · see citing works
Tang, B., Tian, M., & Row, K. H. (2013) · Analytical Letters · doi:10.1080/00032719.2013.832278 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cao, J., & Su, E. (2021) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2021.127965 · Cited by 356 · see citing works
Deep eutectic solvents. The new generation of green solvents in analytical chemistry
Santana‐Mayor, Á., Rodríguez‐Ramos, R., Herrera‐Herrera, A. V., Socas‐Rodríguez, B., & Rodríguez‐Delgado, M. Á. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116108 · Cited by 302 · see citing works
Deep eutectic solvents in liquid-phase microextraction: Contribution to green chemistry
Santos, L. B., de Assis, R. D. S., Barreto, J. A., Bezerra, M. A., Novaes, C. G., & Lemos, V. A. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2021.116478 · Cited by 155 · see citing works
Evaluating the status quo of deep eutectic solvent in food chemistry. Potentials and limitations
Boateng, I. D. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135079 · Cited by 108 · see citing works
Sustainable green solvents for microextraction techniques: Recent developments and applications
Carasek, E., Bernardi, G., Morelli, D., & Merib, J. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.461944 · Cited by 99 · see citing works
Wazeer, I., Hizaddin, H. F., Hashim, M. A., & Hadj-Kali, M. K. (2022) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2022.108574 · Cited by 87 · see citing works
Sportiello, L., Favati, F., Condelli, N., Di Cairano, M., Caruso, M. C., Simonato, B., Tolve, R., & Galgano, F. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2022.134703 · Cited by 87 · see citing works
Boateng, I. D. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c05079 · Cited by 84 · see citing works
Ražić, S., Arsenijević, J., Mračević, S. Đ., Mušović, J., & Trtić‐Petrović, T. M. (2023) · The Analyst · doi:10.1039/d3an00498h · Cited by 84 · see citing works
Microextraction Techniques with Deep Eutectic Solvents
Plastiras, O.-E., Andreasidou, E., & Samanidou, V. (2020) · Molecules · doi:10.3390/molecules25246026 · Cited by 84 · see citing works
“Therefore, DES-HS-SDME is a simple, cheap, green, and efficient technique for the extraction of terpenes [96].”
MethodYıldırım, S., Cocovi-Solberg, D. J., Uslu, B., Solich, P., & Horstkotte, B. (2022) · Talanta · doi:10.1016/j.talanta.2022.123476 · Cited by 81 · see citing works
Calderón‐Oliver, M., & Ponce‐Alquicira, E. (2021) · Molecules · doi:10.3390/molecules26071869 · Cited by 80 · see citing works
Green chemistry methods for food analysis: Overview of sample preparation and determination
Alahmad, W., Kaya, S. I., Çetinkaya, A., Varanusupakul, P., & Özkan, S. A. (2023) · Advances in Sample Preparation · doi:10.1016/j.sampre.2023.100053 · Cited by 72 · see citing works
Chromá, R., Vilková, M., Shepa, I., Makoś‐Chełstowska, P., & Andruch, V. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.115617 · Cited by 69 · see citing works
Hosseininezhad, B., Nemati, M., Farajzadeh, M. A., Khosrowshahi, E. M., & Mogaddam, M. R. A. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117346 · Cited by 59 · see citing works
Deep Eutectic Solvents Application in Food Analysis
Ortega-Zamora, C., González‐Sálamo, J., & Hernández‐Borges, J. (2021) · Molecules · doi:10.3390/molecules26226846 · Cited by 52 · see citing works
Farooq, M. Q., Zeger, V. R., & Anderson, J. L. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.462588 · Cited by 51 · see citing works
Biomass Valorization Using Natural Deep Eutectic Solvents: What’s New in France?
Wils, L., Hilali, S., & Boudesocque‐Delaye, L. (2021) · Molecules · doi:10.3390/molecules26216556 · Cited by 50 · see citing works
Mehravar, A., Feizbakhsh, A., Sarafi, A. H. M., Konoz, E., & Faraji, H. (2020) · Journal of Chromatography A · doi:10.1016/j.chroma.2020.461618 · Cited by 46 · see citing works
Zhang, Y., Chen, M., Li, L., Lv, Y., & Ma, Q. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117412 · Cited by 44 · see citing works
Andruch, V., Kalyniukova, A., Płotka‐Wasylka, J., Jatkowska, N., Snigur, D. V., Zaruba, S., Płatkiewicz, J., Zgoła‐Grześkowiak, A., & Werner, J. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108509 · Cited by 42 · see citing works
The Potential of Microextraction Techniques for the Analysis of Bioactive Compounds in Food
Pereira, J. A. M., Casado, N., Porto-Figueira, P., & Câmara, J. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.825519 · Cited by 41 · see citing works
Metal-containing and magnetic ionic liquids in analytical extractions and gas separations
Varona, M., Eor, P., Neto, L. C. F., Merib, J. D. O., & Anderson, J. L. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2021.116275 · Cited by 38 · see citing works
Green materials for greener food sample preparation: A review
Saura‐Cayuela, M., Lara-Torres, S., Pacheco‐Fernández, I., Trujillo‐Rodríguez, M. J., Ayala, J. H., & Pino, V. (2023) · Green Analytical Chemistry · doi:10.1016/j.greeac.2023.100053 · Cited by 35 · see citing works
El‐Deen, A. K., Abdallah, N. A., Elmansi, H., Belal, F. F., & Magdy, G. (2023) · Talanta · doi:10.1016/j.talanta.2023.124813 · Cited by 34 · see citing works
Overview of Different Modes and Applications of Liquid Phase-Based Microextraction Techniques
Câmara, J. S., Perestrelo, R., Olayanju, B., Berenguer, C. V., Kabir, A., & Pereira, J. A. M. (2022) · Processes · doi:10.3390/pr10071347 · Cited by 28 · see citing works
Single‐drop microextraction technique for the determination of antibiotics in environmental water
Li, G., & Row, K. H. (2021) · Journal of Separation Science · doi:10.1002/jssc.202100682 · Cited by 27 · see citing works
Principles for developing greener liquid-phase microextraction methods
Kokosa, J. M. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117256 · Cited by 26 · see citing works
Microextraction of essential oils: A review
Zhao, J., Quinto, M., Zakia, F., & Li, D. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464357 · Cited by 24 · see citing works
Zhao, L., Zhang, Z., Jiang, H., Guo, Y., Chen, Z., Wang, X., & Jing, X. (2023) · Talanta · doi:10.1016/j.talanta.2023.124831 · Cited by 22 · see citing works
Current trends to green food sample preparation. A review
Cesaris, M. G. D., Antonelli, L., Lucci, E., Felli, N., Bosco, C. D., & Gentili, A. (2024) · Journal of Chromatography Open · doi:10.1016/j.jcoa.2024.100170 · Cited by 21 · see citing works
Phytomass Valorization by Deep Eutectic Solvents—Achievements, Perspectives, and Limitations
Jablonský, M., & Šíma, J. (2020) · Crystals · doi:10.3390/cryst10090800 · Cited by 19 · see citing works
Chen, M., Li, M., Zhang, W., Bai, H., & Ma, Q. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c03561 · Cited by 17 · see citing works
Katrak, V. K., Patel, N. A., & Ijardar, S. P. (2026) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2025.2486209 · Cited by 16 · see citing works
Green active food packaging films based on nanocomposites of PHBV/sepiolite/essential oils
da Costa, R. C., Oliveira, P. R., Nandi, L. G., Bobermin, D. M., Miotto, M., Bellettini, I. C., Crespo, J. D. S., Daitx, T. S., Teixeira, C. D. S., & Carli, L. N. (2025) · Sustainable Food Technology · doi:10.1039/d4fb00232f · Cited by 16 · see citing works
Ghiasvand, M. K. H., Heydarinasab, A., Shahriari, S., & Fouladitajar, A. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127477 · Cited by 16 · see citing works
Długosz, O., Ochnik, M., Sochocka, M., Franz, D., Orzechowska, B., Chmielowiec‐Korzeniowska, A., Drabik, A., & Banach, M. (2022) · Sustainable materials and technologies · doi:10.1016/j.susmat.2022.e00433 · Cited by 16 · see citing works
Karpitskiy, D. A., Бессонова, Е. А., Shishov, A. Y., & Kartsova, L. A. (2023) · Phytochemical Analysis · doi:10.1002/pca.3272 · Cited by 15 · see citing works
Wei, Z., Zhang, W., Du, M., Zhong, H., & Fang, X. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139333 · Cited by 15 · see citing works
Sydow, A., Becker, L., Lombard, É., Ulber, R., Guillouet, S., & Holtmann, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101194 · Cited by 14 · see citing works
Wang, Y., Zhao, S., Yang, L., Liu, C., Wang, H., Li, D., Zhang, W., Li, L., Song, C., & Li, C. (2021) · European Food Research and Technology · doi:10.1007/s00217-021-03878-9 · Cited by 14 · see citing works
The role of liquid phase microextraction in plant and animal food analysis
Kokosa, J. M. (2024) · Exploration of Foods and Foodomics · doi:10.37349/eff.2024.00038 · Cited by 13 · see citing works
Yan, J., Ma, S., Feng, M., Zheng, J., & Guo, M. (2022) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2022.2112764 · Cited by 13 · see citing works
Tymczewska, A., Klebba, J., & Szydłowska‐Czerniak, A. (2023) · Applied Sciences · doi:10.3390/app13126987 · Cited by 14 · see citing works
Deep eutectic solvents in microextraction
Alshana, U., & Soylak, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822139-6.00019-5 · Cited by 12 · see citing works
Strižincová, P., Šurina, I., Jablonský, M., Majová, V., Ház, A., Hroboňová, K., & Špačková, A. (2024) · Processes · doi:10.3390/pr12040653 · Cited by 12 · see citing works
Almeida, J. M. S., Pedro, Z. S. B., Buoro, R. M., & Brett, C. M. A. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202401752 · Cited by 11 · see citing works
Родинков, О. В., Znamenskaya, E., Spivakovskyi, V., Shilov, R. A., & Shishov, A. Y. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.107854 · Cited by 11 · see citing works
Pócsová, T., Okanovič, S., & Hrouzková, S. (2025) · Molecules · doi:10.3390/molecules30091894 · Cited by 10 · see citing works
Wang, Y., Li, N., Jiang, S., & Chen, X. (2021) · Water · doi:10.3390/w14010046 · Cited by 10 · see citing works
Hydrophobic deep eutectic solvents with anti-wear properties for MEMS/NEMS
Donato, M. T., Diogo, H. P., Deuermeier, J., Colaço, R., Branco, L. C., & Saramago, B. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.123643 · Cited by 8 · see citing works
Mehravar, A., Feizbakhsh, A., Sarafi, A. H. M., Konoz, E., & Faraji, H. (2020) · Analytical Methods · doi:10.1039/d0ay01881c · Cited by 7 · see citing works
Retractedde Oliveira, J. B., Menezes, H. C., de Souza, P. P., & Cardeal, Z. D. L. (2026) · npj Science of Food · doi:10.1038/s41538-025-00687-2 · Cited by 6 · see citing works
Fan, B., Wei, J., Yang, J., Liu, Y., & Shuang, S. (2024) · Analytical Methods · doi:10.1039/d4ay01167h · Cited by 6 · see citing works
Jarahi, H., Mohebbi, A., Baghaei, A., Valiyari, S., & Yaripour, S. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.113590 · Cited by 5 · see citing works
Introduction and overview of applications related to green solvents used in sample preparation
Fesliyan, S., Haq, H. U., Altunay, N., Tüzen, M., Azooz, E. A., & Muhamad, Z. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-16122-3.00002-0 · Cited by 4 · see citing works
Modern Green Extraction Techniques
Locatelli, M., Rosato, E., D’Ovidio, C., Bonelli, M., Ulusoy, H. İ., Kabir, A., Ali, I., Savini, F., de Grazia, U., Samanidou, V., et al. (2023) · Wiley eBooks · doi:10.1002/9781119889878.ch3 · Cited by 4 · see citing works
Weyand, F., Bauer, L., Pansare, A. V., Lesch, A. S., & Wang, J. (2025) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2025.119382 · Cited by 2 · see citing works
Pena‐Pereira, F., de la Calle, I., Romero, V., Lavilla, I., & Bendicho, C. (2024) · Integrated analytical systems · doi:10.1007/978-3-031-50527-0_7 · Cited by 2 · see citing works
Wong, X. K., Alasalvar, C., Bo, S., Pan, J., & Chang, S. K. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116798 · Cited by 2 · see citing works
Extraction Techniques in Green Analytical Chemistry
Pighín, A. F., Rigacci, L. N., Camilli, E., Chirillano, A. C., Cufré, J. Á., & Villanueva, M. E. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815049428123010015 · Cited by 1 · see citing works
Terpenes in food and plant samples: Updates on sampling, pretreatment and analysis techniques
Ren, C.-J., Cheng, Z., Zou, Q. S., Feng, X., & Wang, X. (2025) · Arabian Journal of Chemistry · doi:10.25259/ajc_126_2024 · Cited by 1 · see citing works
Advances in sample pretreatment for the analysis of ketamine and its analogs: A review
Qian, M., Liu, J.-X., Zhang, Y., Wang, M.-D., Shao, W. Y., Wang, Y., & Feng, X. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.117012 · Cited by 1 · see citing works
de Souza, A. C. B., Anderson, J. L., & Merib, J. D. O. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.117942 · Cited by 1 · see citing works
Huang, K., Chen, J., Yao, W., & Li, X. (2026) · Analytical Methods · doi:10.1039/d6ay00449k · Cited by 1 · see citing works
Kaur, K., Sharma, P., Kumar, B., Singh, G., Schmitt-Kopplin, P., & Malik, A. K. (2026) · Journal of Food Process Engineering · doi:10.1111/jfpe.70644 · Cited by 1 · see citing works
Recent Applications of Deep Eutectic Solvents
Rodríguez‐Ramos, R., Santana‐Mayor, Á., Socas‐Rodríguez, B., Herrera‐Herrera, A. V., & Rodríguez‐Delgado, M. Á. (2023) · Current and future developments in food science · doi:10.2174/9789815049459123030006 · Cited by 1 · see citing works
Deep Eutectic Solvents (DESs) in Green Sample Preparation
Ortega-Zamora, C., & González‐Sálamo, J. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839166419-00212
Environmentally Friendly Solvents
Montero, L., Rocío‐Bautista, P., & Gilbert‐López, B. (2023) · Current and future developments in food science · doi:10.2174/9789815049459123030005
Trujillo‐Rodríguez, M. J., Saura‐Cayuela, M., Cabrera-González, S. D., Lara-Torres, S., & Pino, V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15978-7.00081-3
Gupta, M., Jain, A., & Verma, K. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13907-9.00012-7
Deep eutectic solvents in forensic drug analysis
Yahaya, N., Zain, N. N. M., Miskam, M., Kamaruzaman, S., & Mohamed, A. H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13907-9.00015-2
Conventional and Miniaturized Sample Preparation Techniques in Food Analysis
Martins, R. O., Borsatto, J. V. B., Will, C., & Lanças, F. M. (2025) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a9840
Mu, K., Liao, R.-Q., Sha, S., Luo, Q.-M., Shao, C.-L., Ju, Z.-G., Zhong, K., Tang, X.-M., Yuan, Y., & Pang, Y.-X. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2026.123569
Galvan, D., Santos, A. V., Turazzi, F. C., Morés, L., Effting, L., da Cunha, N., Bona, E., & Carasek, E. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.119109
Pandit, R., Sahu, R., Soni, P., Pal, R., Khan, A., Dwivedi, A., Patra, A., & Mandal, V. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.106098
- Authors
- Triaux, Z., Petitjean, H., Marchioni, E., Boltoeva, M., & Marcic, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Marcic, Christophe
- Venue
- Analytical and Bioanalytical Chemistry
- Published
- 2020-01-11
- Volume
- 412
- Issue
- 4
- Pages
- 933-948
- ISSN
- 1618-2642 (ISSN-L)
- 1618-2650
- OpenAlex
- W3000579260
- Cited by
- 77
- References
- 45
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 11 · 2023: 19 · 2022: 12 · 2021: 13 · 2020: 5
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Analytical and Bioanalytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Association Nationale de la Recherche et de la Technologie (CIFRE Contract n°2016/0447)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Keywords
- deep eutectic solvents, headspace single-drop microextraction, terpenes, spices, tetrabutylammonium bromide, dodecanol, green extraction, nutmeg, cinnamon, cumin, fennel, Syzygium aromaticum, thyme, borneol, α-farnesene, extraction optimization
- MeSH terms
- Cinnamomum zeylanicum, Gas Chromatography-Mass Spectrometry, Plant Extracts, Solvents, Terpenes, Spices, Myristica, Syzygium, Cuminum, Foeniculum, Thymus Plant, Liquid Phase Microextraction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
