Osteocyte-Driven Bone Remodeling

Bellido, Teresita

doi:10.1007/s00223-013-9774-y

Cited by 384Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

Osteocyte-Driven Bone Remodeling

Open access

Bellido, Teresita·2014·Calcified Tissue International

DOI 10.1007/s00223-013-9774-yPMC PMC3947228

Open this paper in CoChat — free account

Abstract

Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts. The discovery that the inhibitor of bone formation sclerostin is primarily expressed in osteocytes in bone and downregulated by anabolic stimuli provided a mechanism by which osteocytes influence the activity of osteoblasts. Advances of the last few years provided experimental evidence demonstrating that osteocytes also participate in the recruitment of osteoclasts and the initiation of bone remodeling. Apoptotic osteocytes trigger yet-to-be-identified signals that attract osteoclast precursors to specific areas of bone, which in turn differentiate to mature, bone-resorbing osteoclasts. Osteocytes are also the source of molecules that regulate the generation and activity of osteoclasts, such as OPG and RANKL; and genetic manipulations of the mouse genome leading to loss or gain of function or to altered expression of either molecule in osteocytes markedly affect bone resorption. This review highlights these investigations and discusses how the novel concept of osteocyte-driven bone resorption and formation impacts our understanding of the mechanisms by which current therapies control bone remodeling.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00223-013-9774-y

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Osteocyte apoptosis has been recognized as a chemotactic signal to osteoclastic bone resorption.
“Moreover, osteocyte apoptosis has been recognized as a chemotactic signal to osteoclastic bone resorption [70–73].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [73]
HMGB1 and M-CSF have been suggested to be produced by osteocytes that stimulate osteoclast recruitment during bone remodeling.
“High mobility group box protein 1 (HMGB1) [198–200] and M-CSF [201] have also been suggested to be produced by osteocytes that stimulate osteoclast recruitment during bone remodeling [72, 73].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [73]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The amazing osteocyte
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778 · see citing works
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · cited 1× · see citing works
“It is now recognized that decreased osteocyte viability accompanies not only the bone fragility syndrome that characterizes estrogen withdrawal but also glucocorticoid excess, mechanical disuse, and aging [34, 50, 51].”
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350 · see citing works
Self-citation
Matrix-embedded cells control osteoclast formation
Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304 · see citing works
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298 · see citing works
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis
Manolagas, S. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0024 · Cited by 1,210 · see citing works
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163 · see citing works
Self-citation
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · see citing works
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling‐Hampton, K., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg599 · Cited by 1,114 · see citing works
Osteocytes, mechanosensing and Wnt signaling
Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076 · see citing works
Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone
Jilka, R. L., Weinstein, R. S., Bellido, T., Roberson, P. K., PARFITT, A. M., & Manolagas, S. C. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6610 · Cited by 1,042 · see citing works
Self-citation
Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein
Brunkow, M. E., Gardner, J. C., Van Ness, J., Paeper, B. W., Kovacevich, B. R., Proll, S., Skonier, J. E., Zhao, L., Sabo, P. J., Fu, Y.-H., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/318811 · Cited by 1,011 · see citing works
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Poole, K. E. S., Van Bezooijen, R. L., Loveridge, N., Hamersma, H., Papapoulos, S. E., Löwik, C. W., & Reeve, J. (2005) · The FASEB Journal · doi:10.1096/fj.05-4221fje · Cited by 965 · see citing works
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
Li, X., Ominsky, M. S., Niu, Q., Sun, N., Daugherty, B., D’Agostin, D. M., Kurahara, C., Gao, Y., Cao, J., Gong, J., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080216 · Cited by 938 · see citing works
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893 · see citing works
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
Plotkin, L. I., Weinstein, R. S., Parfitt, A. M., Roberson, P. K., Manolagas, S. C., & Bellido, T. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6800 · Cited by 890 · see citing works
Self-citation
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.001 · Cited by 848 · see citing works
Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo
Verborgt, O., Gibson, G. J., & Schaffler, M. B. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.1.60 · Cited by 731 · see citing works
Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids
Almeida, M., Li, H., Martín-Millán, M., Plotkin, L. I., Stewart, S. A., Roberson, P. K., Kousteni, S., O’Brien, C. A., Bellido, T., PARFITT, A. M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702810200 · Cited by 707 · see citing works
Self-citation
Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis
Bellido, T., Ali, A., Gubrij, I. B., Plotkin, L. I., Fu, Q., O’Brien, C. A., Manolagas, S. C., & Jilka, R. L. (2005) · Endocrinology · doi:10.1210/en.2005-0239 · Cited by 640 · see citing works
Self-citation
Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
Lin, C., Jiang, X., Dai, Z., Guo, X., Weng, T., Wang, J., Li, Y., Feng, G., Gao, X., & He, L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090411 · Cited by 631 · see citing works
SOST is a target gene for PTH in bone
Keller, H., & Kneissel, M. (2005) · Bone · doi:10.1016/j.bone.2005.03.018 · Cited by 618 · see citing works
Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis
Krämer, I., Halleux, C. M., Keller, H., Pegurri, M., Gooi, J. H., Weber, P. B., Feng, J. Q., Bonewald, L. F., & Kneissel, M. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01428-09 · Cited by 562 · see citing works
Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone
Robinson, J. A., Chatterjee‐Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y. P., Sauter, L., Babij, P., Brown, E. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602308200 · Cited by 522 · see citing works
Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.
Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060107 · Cited by 494 · see citing works
Self-citation
Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation
Qing, H., Ardeshirpour, L., Divieti Pajevic, P., Dusevich, V., Jähn, K., Kato, S., Wysolmerski, J., & Bonewald, L. F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1567 · Cited by 489 · see citing works
Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression.
Parfitt, A. M. (2002) · Bone · doi:10.1016/s8756-3282(01)00642-1 · Cited by 462 · see citing works
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Tu, X., Rhee, Y., Condon, K. W., Bivi, N., Allen, M. R., Dwyer, D., Stolina, M., Turner, C. H., Robling, A. G., Plotkin, L. I., et al. (2011) · Bone · doi:10.1016/j.bone.2011.10.025 · Cited by 458 · see citing works
Self-citation
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
Loots, G. G., Kneissel, M., Keller, H., Baptist, M., Chang, J., Collette, N. M., Ovcharenko, D., Plajzer-Frick, I., & Rubin, E. M. (2005) · Genome Research · doi:10.1101/gr.3437105 · Cited by 442 · see citing works
Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids
Kousteni, S., Chen, J.-R., Bellido, T., Han, L., Ali, A. A., O'Brien, C. A., Plotkin, L., Fu, Q., Mancino, A. T., Wen, Y., et al. (2002) · Science · doi:10.1126/science.1074935 · Cited by 420 · see citing works
Self-citation
The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone
Tomkinson, A., REEVE, J., Shaw, R. W., & Noble, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4200 · Cited by 417 · see citing works
What old means to bone
Manolagas, S. C., & Parfitt, A. M. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.010 · Cited by 404 · cited 1× · see citing works
“During aging, there is accumulation of microdamage and a decline in osteocyte density accompanied by decreased prevalence of osteocyte-occupied lacunae, an index of premature osteocyte death [76].”
Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
Almeida, M., Li, H., Bellido, T., Manolagas, S. C., & Kousteni, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502168200 · Cited by 394 · see citing works
Self-citation
Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
O’Brien, C. A., Plotkin, L. I., Galli, C., Goellner, J. J., Gortázar, A. R., Allen, M. R., Robling, A. G., Bouxsein, M., Schipani, E., Turner, C. H., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002942 · Cited by 389 · see citing works
Self-citation
Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone
Noble, B., Peet, N. M., Stevens, H. Y., Brabbs, A. C., Mosley, J. R., Reilly, G. C., REEVE, J., Skerry, T. M., & Lanyon, L. E. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00234.2002 · Cited by 381 · see citing works
Transduction of Cell Survival Signals by Connexin-43 Hemichannels
Plotkin, L. I., Manolagas, S. C., & Bellido, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108625200 · Cited by 334 · see citing works
Self-citation
Serum Sclerostin Levels Negatively Correlate with Parathyroid Hormone Levels and Free Estrogen Index in Postmenopausal Women
Mirza, F., Padhi, I. D., Raisz, L. G., & Lorenzo, J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2283 · Cited by 312 · see citing works
The Role of Estrogen in the Control of Rat Osteocyte Apoptosis
Tomkinson, A., Gevers, E. F., Wit, J. M., REEVE, J., & Noble, B. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.8.1243 · Cited by 302 · see citing works
E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation
Zhang, K., Barragan‐Adjemian, C., Ye, L., Kotha, S. P., Dallas, M., Lu, Y., Zhao, S., Harris, M. A., Harris, S. E., Feng, J. Q., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02120-05 · Cited by 299 · see citing works
Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
Weinstein, R. S., Wan, C., Liu, Q., Wang, Y., Almeida, M., O’Brien, C. A., Thostenson, J., Roberson, P. K., Boskey, A. L., Clemens, T. L., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00545.x · Cited by 276 · see citing works
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
Kennedy, O. D., Herman, B. C., Laudier, D. M., Majeska, R. J., Sun, H. B., & Schaffler, M. B. (2012) · Bone · doi:10.1016/j.bone.2012.01.025 · Cited by 275 · cited 1× · see citing works
“expression of VEGF and RANKL is elevated [68], suggesting that signals emanating from apoptotic cells alter the expression of molecules that influence angiogenesis and potentially osteoclast precursor recruitment, as well as osteoclast differentiation.”
Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
Plotkin, L. I., Mathov, I., Aguirre, J. I., PARFITT, A. M., Manolagas, S. C., & Bellido, T. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00278.2004 · Cited by 273 · see citing works
Self-citation
Wnt/β-Catenin Signaling Is a Component of Osteoblastic Bone Cell Early Responses to Load-bearing and Requires Estrogen Receptor α
Armstrong, V. J., Muzylak, M., Sunters, A., Zaman, G., Saxon, L., Price, J. S., & Lanyon, L. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703224200 · Cited by 273 · see citing works
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
Kousteni, S., Li, H., Chen, J., Almeida, M., Plotkin, L. I., Bellido, T., & Manolagas, S. C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17261 · Cited by 272 · see citing works
Self-citation
Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability
Bellido, T., & Plotkin, L. I. (2010) · Bone · doi:10.1016/j.bone.2010.08.008 · Cited by 265 · see citing works
Self-citation
Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261 · see citing works
Self-citation
Identification of differentially expressed genes between osteoblasts and osteocytes
Paić, F., Igwe, J. C., Nori, R., Kronenberg, M. S., Franceschetti, T., Harrington, P., Kuo, L., Shin, D., Rowe, D. W., Harris, S. E., et al. (2009) · Bone · doi:10.1016/j.bone.2009.06.010 · Cited by 261 · see citing works
Effects of Parathyroid Hormone Treatment on Circulating Sclerostin Levels in Postmenopausal Women
Drake, M. T., Srinivasan, B., Mödder, U. I., Peterson, J. M., McCready, L. K., Riggs, B. L., Dwyer, D., Stolina, M., Kostenuik, P. J., & Khosla, S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0720 · Cited by 251 · see citing works
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
Kousteni, S., Li, H., Chen, J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317261 · Cited by 237 · see citing works
The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone
Holmbeck, K., Bianco, P., Pidoux, I., Inoué, S., Billinghurst, R. C., Wu, W. K. K., Chrysovergis, K., Yamada, S. S., Birkedal‐Hansen, H., & Poole, A. R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01581 · Cited by 231 · see citing works
Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction
Kogianni, G., Mann, V., & Noble, B. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080207 · Cited by 221 · see citing works
PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
Rhee, Y., Allen, M. R., Condon, K., Lezcano, V., Ronda, A. C., Galli, C., Olivos, N., Passeri, G., O'Brien, C. A., Bivi, N., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.304 · Cited by 208 · see citing works
Self-citation
Osteocyte apoptosis
Jilka, R. L., Noble, B., & Weinstein, R. S. (2012) · Bone · doi:10.1016/j.bone.2012.11.038 · Cited by 202 · see citing works
Effects of PTH on osteocyte function
Bellido, T., Saini, V., & Pajevic, P. D. (2013) · Bone · doi:10.1016/j.bone.2012.09.016 · Cited by 196 · see citing works
Self-citation
Spatial Distribution of Bax and Bcl-2 in Osteocytes After Bone Fatigue: Complementary Roles in Bone Remodeling Regulation?
Verborgt, O., Tatton, N. A., Majeska, R. J., & Schaffler, M. B. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.5.907 · Cited by 192 · see citing works
Shear stress inhibits while disuse promotes osteocyte apoptosis
Bakker, A. D., Klein‐Nulend, J., & Burger, E. H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.056 · Cited by 185 · see citing works
Beyond gap junctions: Connexin43 and bone cell signaling
Plotkin, L. I., & Bellido, T. (2012) · Bone · doi:10.1016/j.bone.2012.09.030 · Cited by 153 · see citing works
Self-citation
Enhanced Osteoclastic Resorption and Responsiveness to Mechanical Load in Gap Junction Deficient Bone
Zhang, Y., Paul, E. M., Sathyendra, V., Davison, A., Sharkey, N., Bronson, S., Srinivasan, S., Gross, T. S., & Donahue, H. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023516 · Cited by 148 · see citing works
Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone
Qiu, S., Rao, D. S., Palnitkar, S., & PARFITT, A. M. (2002) · Bone · doi:10.1016/s8756-3282(02)00819-0 · Cited by 138 · see citing works
Delineating bone's interstitial fluid pathway in vivo
Wang, L., Ciani, C., Doty, S. B., & Fritton, S. P. (2003) · Bone · doi:10.1016/j.bone.2003.11.022 · Cited by 133 · see citing works
Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling
Sunters, A., Armstrong, V. J., Zaman, G., Kypta, R. M., Kawano, Y., Lanyon, L. E., & Price, J. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027086 · Cited by 122 · see citing works
The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitro
Mann, V., Huber, C., Kogianni, G., Collins, F., & Noble, B. (2006) · Bone · doi:10.1016/j.bone.2006.10.014 · Cited by 119 · see citing works
Sclerostin: A gem from the genome leads to bone-building antibodies
Pászty, C., Turner, C. H., & Robinson, M. K. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.161 · Cited by 118 · see citing works
Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects
Harris, S. E., MacDougall, M., Horn, D., Woodruff, K., Zimmer, S. N., Rebel, V. I., Fajardo, R., Feng, J. Q., Gluhak-Heinrich, J., Harris, M. A., et al. (2012) · Bone · doi:10.1016/j.bone.2011.09.038 · Cited by 116 · see citing works
Attenuated Response to In Vivo Mechanical Loading in Mice With Conditional Osteoblast Ablation of the Connexin43 Gene (Gja1)
Grimston, S. K., Brodt, M. D., Silva, M. J., & Civitelli, R. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080222 · Cited by 114 · see citing works
Patients with primary hyperparathyroidism have lower circulating sclerostin levels than euparathyroid controls
van Lierop, A. H., Witteveen, J. E., Hamdy, N. A. T., & Papapoulos, S. E. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0699 · Cited by 101 · see citing works
RANKL subcellular trafficking and regulatory mechanisms in osteocytes
Honma, M., Ikebuchi, Y., Kariya, Y., Hayashi, M., Hayashi, N., Aoki, S., & Suzuki, H. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1941 · Cited by 98 · see citing works
HMGB1 is a bone‐active cytokine
Yang, J., Shah, R., Robling, A. G., Templeton, E., Yang, H., Tracey, K. J., & Bidwell, J. P. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21268 · Cited by 97 · see citing works
Umbilical Venous IGF-1 Concentration, Neonatal Bone Mass, and Body Composition
Javaid, M. K., Godfrey, K. M., Taylor, P., Shore, S., Breier, B. H., Arden, N. K., & Cooper, C. C. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301211 · Cited by 92 · see citing works
Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43
Plotkin, L. I., & Bellido, T. (2001) · Cell Communication & Adhesion · doi:10.3109/15419060109080757 · Cited by 90 · see citing works
Self-citation
Cloning of a 2.5 kb Murine Bone Sialoprotein Promoter Fragment and Functional Analysis of Putative Osf2 Binding Sites
McKee, M. D., Aubin, J. E., Xiao, G., Thomas, P. E., & Franceschi, R. T. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.3.396 · Cited by 82 · see citing works
Crosstalk between Caveolin-1/Extracellular Signal-regulated Kinase (ERK) and β-Catenin Survival Pathways in Osteocyte Mechanotransduction
Gortázar, A. R., Martín-Millán, M., Bravo, B., Plotkin, L. I., & Bellido, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.437921 · Cited by 74 · see citing works
Self-citation
Inhibition of Lamin A/C Attenuates Osteoblast Differentiation and Enhances RANKL-Dependent Osteoclastogenesis
Rauner, M., Sipos, W., Goettsch, C., Wutzl, A., Foisner, R., Pietschmann, P., & Hofbauer, L. C. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080902 · Cited by 70 · see citing works
Mechanisms of Exercise Effects on Bone
Marcus, R. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50188-8 · Cited by 47 · see citing works
Keratocan is Expressed by Osteoblasts and Can Modulate Osteogenic Differentiation
Igwe, J. C., Gao, Q., Kizivat, T., Kao, W. W. ‐., & Kalajzić, I. (2011) · Connective Tissue Research · doi:10.3109/03008207.2010.546536 · Cited by 40 · see citing works
Selective Estrogen Receptor Modulator Inhibits Osteocyte Apoptosis during Abrupt Estrogen Withdrawal: Implications for Bone Quality Maintenance
Huber, C., Collishaw, S., Mosley, J. R., REEVE, J., & Noble, B. (2007) · Calcified Tissue International · doi:10.1007/s00223-007-9049-6 · Cited by 39 · see citing works
Apoptosis in Bone Cells
Boyce, B. F., Hughes, D. E., Wright, K. R., Xing, L., & Dai, A. (1998) · Springer eBooks · doi:10.1007/978-3-662-09007-7_3 · Cited by 37 · see citing works
Life history of osteocytes: relationship to bone age, bone remodeling, and bone fragility.
PARFITT, A. M. (2002) · PubMed · Cited by 32 · see citing works
Antagonistic interplay between mechanical forces and glucocorticoids in bone: A tale of kinases
Bellido, T. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22660 · Cited by 31 · see citing works
Self-citation
Apoptosis of Bone Cells
Jilka, R. L., Bellido, T., Almeida, M., Plotkin, L. I., O’Brien, C. A., Weinstein, R. S., & Manolagas, S. C. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00032-x · Cited by 29 · see citing works
Self-citation
Spaceflight and the skeleton: lessons for the earthbound.
Bikle, D. D., Halloran, B. P., & Morey-Holton, E. R. (1997) · PubMed · Cited by 22 · see citing works
Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness
Bellido, T. (2007) · BoneKEy-Osteovision · doi:10.1138/20070272 · Cited by 16 · see citing works
Self-citation
Inhibiting the Inhibitor: A New Route to Bone Anabolism
Jilka, R. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090228 · Cited by 12 · see citing works
Mechanisms of Exercise Effects on Bone
Marcus, R. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1/50188-8 · Cited by 12 · see citing works
Apoptosis in Bone Cells
Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., PARFITT, A. M., & Manolagas, S. C. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50112-8 · Cited by 11 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

[37]Rhee Y Allen MR Condon K Plotkin LI Lezcano V Vyas K O'Brien CA 2009 PTH receptor signaling in osteocytes governs periosteal bone formation and intra-cortical remodeling: divergent role of Sost and the Wnt pathway J Bone Min Res 24 S78 PMC3179307 21140374

Sorted by citations

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00762-6 · Cited by 2,519 · see citing works
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
Inflammation, fracture and bone repair
Loi, F., Córdova, L. A., Pajarinen, J., Lin, T., Yao, Z., & Goodman, S. B. (2016) · Bone · doi:10.1016/j.bone.2016.02.020 · Cited by 1,306 · see citing works
Oxidative stress in bone remodeling: role of antioxidants
Domazetovic, V (2017) · Clinical Cases in Mineral and Bone Metabolism · doi:10.11138/ccmbm/2017.14.1.209 · Cited by 758 · see citing works
Role of Thyroid Hormones in Skeletal Development and Bone Maintenance
Bassett, J. H. D., & Williams, G. R. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1106 · Cited by 540 · see citing works
Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases
Agidigbi, T. S., & Kim, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143576 · Cited by 518 · see citing works
Osseointegration and current interpretations of the bone-implant interface
Shah, F. A., Thomsen, P., & Palmquist, A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.018 · Cited by 385 · see citing works
Silk scaffolds in bone tissue engineering: An overview
Bhattacharjee, P., Kundu, B., Naskar, D., Kim, H.-W., Maiti, T. K., Bhattacharya, D., & Kundu, S. C. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.09.027 · Cited by 318 · see citing works
Oxidative Stress and Osteoporosis
Kimball, J. S., Johnson, J. P., & Carlson, D. A. (2021) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.00989 · Cited by 315 · see citing works
A network of trans-cortical capillaries as mainstay for blood circulation in long bones
Grüneboom, A., Hawwari, I., Weidner, D., Culemann, S., Müller, S., Henneberg, S., Brenzel, A., Merz, S. F., Bornemann, L., Zec, K., et al. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0016-5 · Cited by 301 · see citing works
Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
Colaianni, G., Mongelli, T., Cuscito, C., Pignataro, P., Lippo, L., Spiro, G., Notarnicola, A., Severi, I., Passeri, G., Mori, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02557-8 · Cited by 305 · see citing works
Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone
Tu, X., Delgado‐Calle, J., Condon, K. W., Maycas, M., Zhang, H., Carlesso, N., Taketo, M. M., Burr, D. B., Plotkin, L. I., & Bellido, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409857112 · Cited by 278 · see citing works
Self-citation
The osteocyte as a signaling cell
Delgado‐Calle, J., & Bellido, T. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2020 · Cited by 269 · see citing works
Self-citation
Impact of the Autonomic Nervous System on the Skeleton
Elefteriou, F. (2018) · Physiological Reviews · doi:10.1152/physrev.00014.2017 · Cited by 244 · see citing works
Endometriosis-Associated Macrophages: Origin, Phenotype, and Function
Hogg, C., Horne, A. W., & Greaves, E. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00007 · Cited by 241 · see citing works
Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair
Paiva, K. B. S., & Granjeiro, J. M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.05.001 · Cited by 237 · see citing works
The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved
Xiao, D., Zhang, J., Zhang, C., Barbieri, D., Yuan, H., Moroni, L., & Feng, G. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.12.034 · Cited by 220 · see citing works
Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma
Delgado‐Calle, J., Anderson, J. L., Cregor, M. D., Hiasa, M., Chirgwin, J. M., Carlesso, N., Yoneda, T., Mohammad, K. S., Plotkin, L. I., Roodman, G. D., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1703 · Cited by 214 · see citing works
Self-citation
Osteocytic signalling pathways as therapeutic targets for bone fragility
Plotkin, L. I., & Bellido, T. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.71 · Cited by 206 · see citing works
Self-citation
Role of phosphate sensing in bone and mineral metabolism
Chande, S., & Bergwitz, C. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0076-3 · Cited by 189 · see citing works
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
Saul, D., & Khosla, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac008 · Cited by 185 · see citing works
The osteocyte: A multifunctional cell within the bone
Tresguerres, F. G. F., Torres, J., López-Quiles, J., Hernández, G., Vega, J. A., & Tresguerres, I. F. (2019) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2019.151422 · Cited by 184 · see citing works
Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches
Marcucci, G., Domazetovic, V., Nediani, C., Ruzzolini, J., Favre, C., & Brandi, M. L. (2023) · Antioxidants · doi:10.3390/antiox12020373 · Cited by 191 · see citing works
Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?
Sapir‐Koren, R., & Livshits, G. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2808-0 · Cited by 176 · see citing works
Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Serna, J., & Bergwitz, C. (2020) · Nutrients · doi:10.3390/nu12103001 · Cited by 190 · see citing works
Bone Loss Triggered by the Cytokine Network in Inflammatory Autoimmune Diseases
Amarasekara, D. S., Yu, J., & Rho, J. (2015) · Journal of Immunological Research · doi:10.1155/2015/832127 · Cited by 175 · see citing works
Maintaining homeostatic control of periodontal bone tissue
Hathaway‐Schrader, J. D., & Novince, C. M. (2021) · Periodontology 2000 · doi:10.1111/prd.12368 · Cited by 171 · see citing works
Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives
Terkawi, M. A., Matsumae, G., Shimizu, T., Takahashi, D., Kadoya, K., & Iwasaki, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031786 · Cited by 167 · see citing works
Bio-piezoelectricity: fundamentals and applications in tissue engineering and regenerative medicine
Kamel, N. A. (2022) · Biophysical Reviews · doi:10.1007/s12551-022-00969-z · Cited by 142 · see citing works
Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype
Samsa, W. E., Vasanji, A., Midura, R. J., & Kondratov, R. V. (2016) · Bone · doi:10.1016/j.bone.2016.01.006 · Cited by 133 · see citing works
Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth
Delgado‐Calle, J., Anderson, J. L., Cregor, M. D., Condon, K. W., Kuhstoss, S., Plotkin, L. I., Bellido, T., & Roodman, G. D. (2017) · Leukemia · doi:10.1038/leu.2017.152 · Cited by 129 · see citing works
Self-citation
Insights into Oxidative Stress in Bone Tissue and Novel Challenges for Biomaterials
Cerqueni, G., Scalzone, A., Licini, C., Gentile, P., & Mattioli‐Belmonte, M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112433 · Cited by 128 · see citing works
The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States
Choi, J. U. A., Kijas, A. W., Lauko, J., & Rowan, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770143 · Cited by 127 · see citing works
The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens
Mills, E., Yang, L. Y., Nielsen, M. F., Kassem, M. S., Dhillo, W. S., & Comninos, A. N. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab015 · Cited by 131 · see citing works
Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy
Luo, D., Ren, H. J., Li, T., Lian, K., & Lin, D. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3325-5 · Cited by 114 · see citing works
The roles of osteocytes in alveolar bone destruction in periodontitis
Huang, X., Xie, M.-R., Xie, Y.-L., Mei, F., Lu, X., Li, X.-S., & Chen, L.-L. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02664-7 · Cited by 110 · see citing works
Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis
Appelman‐Dijkstra, N. M., & Papapoulos, S. E. (2015) · Drugs · doi:10.1007/s40265-015-0417-7 · Cited by 116 · see citing works
Osteon: Structure, Turnover, and Regeneration
Chang, B., & Liu, X. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2020.0322 · Cited by 114 · see citing works
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats
Taylor, S., Ominsky, M. S., Hu, R., Pacheco, E., He, Y. D., Brown, D. L., Aguirre, J. I., Wronski, T. J., Buntich, S., Afshari, C. A., et al. (2016) · Bone · doi:10.1016/j.bone.2015.12.013 · Cited by 106 · see citing works
Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone
Xu, X., Liu, S., Liu, H., Ru, K., Jia, Y., Wu, Z., Liang, S., Khan, Z., Chen, Z., Qian, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126429 · Cited by 111 · see citing works
Regulation of bone homeostasis: signaling pathways and therapeutic targets
Wu, Z., Li, W., Jiang, K., Lin, Z., Qian, C., Wu, M., Xia, Y., Li, N., Zhang, H., Xiao, H.-X., et al. (2024) · MedComm · doi:10.1002/mco2.657 · Cited by 115 · see citing works
HIF‐1α facilitates osteocyte‐mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro
Zhu, J., Tang, Y., Wu, Q., Ji, Y., Feng, Z., & Kang, F. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28721 · Cited by 108 · see citing works
The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts
Donaubauer, A.-J., Deloch, L., Becker, I., Fietkau, R., Frey, B., & Gaipl, U. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176377 · Cited by 132 · see citing works
YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling
Kegelman, C. D., Coulombe, J. C., Jordan, K. M., Horan, D. J., Qin, L., Robling, A. G., Ferguson, V. L., Bellido, T., & Boerckel, J. D. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3876 · Cited by 95 · see citing works
Self-citation
Apoptotic Osteocytes and the Control of Targeted Bone Resorption
Plotkin, L. I. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0194-3 · Cited by 93 · see citing works
Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading
Plotkin, L. I., Gortázar, A. R., Davis, H. M., Condon, K. W., Gabilondo, H., Maycas, M., Allen, M. R., & Bellido, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.642090 · Cited by 92 · see citing works
Self-citation
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
Fowler, T. W., Acevedo, C., Mazur, C. M., Hall‐Glenn, F., Fields, A. J., Bale, H., Ritchie, R. O., Lotz, J. C., Vail, T. P., & Alliston, T. N. (2017) · Scientific Reports · doi:10.1038/srep44618 · Cited by 90 · see citing works
Glutathione, N-acetylcysteine and Lipoic Acid Down-Regulate Starvation-Induced Apoptosis, RANKL/OPG Ratio and Sclerostin in Osteocytes: Involvement of JNK and ERK1/2 Signalling
Fontani, F., Marcucci, G., Iantomasi, T., Brandi, M. L., & VINCENZINI, M. T. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-9961-0 · Cited by 89 · see citing works
Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B
Pacios, S., Xiao, W., Mattos, M., Lim, J. C.-S., Tarapore, R. S., Alsadun, S., Yu, B., Wang, C., & Graves, D. T. (2015) · Scientific Reports · doi:10.1038/srep16694 · Cited by 89 · see citing works
Destroy to Rebuild: The Connection Between Bone Tissue Remodeling and Matrix Metalloproteinases
Hardy, E., & Fernández-Patrón, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00047 · Cited by 85 · see citing works
ENDOCRINOLOGY AND ADOLESCENCE: Osteoporosis in children: diagnosis and management
Saraff, V., & Högler, W. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-0865 · Cited by 84 · see citing works
Notch signaling: Its essential roles in bone and craniofacial development
Pakvasa, M., Haravu, P., Boachie-Mensah, M., Jones, A., Coalson, E., Liao, J., Zeng, Z., Wu, D., Qin, K., Wu, X., et al. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2020.04.006 · Cited by 79 · see citing works
Treatment needs and current options for postmenopausal osteoporosis
Gennari, L., Rotatori, S., Bianciardi, S., Nuti, R., & Merlotti, D. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1176147 · Cited by 78 · see citing works
Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
Cao, H., Yan, Q., Wang, D., Lai, Y., Zhou, B., Zhang, Q., Jin, W., Lin, S., Lei, Y., Ma, L., et al. (2020) · Bone Research · doi:10.1038/s41413-019-0073-8 · Cited by 76 · see citing works
Inflammation and gut dysbiosis as drivers of CKD–MBD
Evenepoel, P., Stenvinkel, P., Shanahan, C. M., & Pacifici, R. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00736-7 · Cited by 78 · see citing works
Cellular Mechanisms Responsible for Success and Failure of Bone Substitute Materials
Rolvien, T., Barbeck, M., Wenisch, S., Amling, M., & Krause, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102893 · Cited by 75 · see citing works
Silk Fibroin-Alginate-Hydroxyapatite Composite Particles in Bone Tissue Engineering Applications In Vivo
Jo, Y., Kim, S., Kwon, K.-J., Kweon, H., Chae, W., Yang, W., Lee, E.-Y., & Seok, H. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040858 · Cited by 73 · see citing works
MicroRNAs in the control of metastatic bone disease
Browne, G., Taipaleenmäki, H., Stein, G. S., Stein, J. L., & Lian, J. B. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.014 · Cited by 65 · see citing works
Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
Mabilleau, G., Pereira, M., & Chenu, C. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0278 · Cited by 66 · see citing works
Relationship Between Metabolic Syndrome and Bone Health – An Evaluation of Epidemiological Studies and Mechanisms Involved
Chin, K., Wong, S. K., Ekeuku, S. O., & Pang, K.-L. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s275560 · Cited by 64 · see citing works
Role of nutritional vitamin D in osteoporosis treatment
Hou, Y., Wu, C., Liao, M.-T., Shyu, J., Hung, C., Yen, T., Lu, C., & Lu, K. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.05.035 · Cited by 63 · see citing works
Bone metabolism – an underappreciated player
Choi, I. A., Umemoto, A., Mizuno, M., & Park‐Min, K. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00010-9 · Cited by 63 · see citing works
Role of osteocytes in multiple myeloma bone disease
Delgado‐Calle, J., Bellido, T., & Roodman, G. D. (2014) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000090 · Cited by 63 · see citing works
Self-citation
Isolation and Functional Analysis of an Immortalized Murine Cementocyte Cell Line, IDG-CM6
Zhao, N., Nociti, F. H., Duan, P., Prideaux, M., Zhao, H. L., Foster, B. L., Somerman, M. J., & Bonewald, L. F. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2690 · Cited by 62 · see citing works
Mechanisms of bone destruction in multiple myeloma
Terpos, E., Christoulas, D., Gavriatopoulou, M., & Dimopoulos, M. A. (2017) · European Journal of Cancer Care · doi:10.1111/ecc.12761 · Cited by 62 · see citing works
Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis
Rolvien, T., Schmidt, F. N., Milovanovic, P. D., Jähn, K., Riedel, C., Butscheidt, S., Püschel, K., Jeschke, A., Amling, M., & Busse, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-19803-2 · Cited by 61 · see citing works
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00328-y · Cited by 60 · see citing works
Optimized Bioactive Glass: the Quest for the Bony Graft
Granel, H., Bossard, C., Nucke, L., Wauquier, F., Rochefort, G. Y., Guicheux, J., Jallot, É., Lao, J., & Wittrant, Y. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801542 · Cited by 60 · see citing works
Molecular Basis beyond Interrelated Bone Resorption/Regeneration in Periodontal Diseases: A Concise Review
Sadek, K. M., Moshy, S. E., Radwan, I. A., Rady, D., Abbass, M. M. S., El‐Rashidy, A. A., Dörfer, C. E., & El‐Sayed, K. M. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054599 · Cited by 62 · see citing works
Role of Wnt/β-catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients
Folestad, A., Ålund, M., Asteberg, S., Fowelin, J., Aurell, Y., Göthlin, J., & Cassuto, J. (2015) · Acta Orthopaedica · doi:10.3109/17453674.2015.1033606 · Cited by 59 · see citing works
Histone deacetylases (HDAC) in physiological and pathological bone remodelling
Cantley, M. D., Zannettino, A. C. W., Bartold, P. M., Fairlie, D. P., & Haynes, D. R. (2016) · Bone · doi:10.1016/j.bone.2016.11.028 · Cited by 60 · see citing works
The Emerging Role of Osteocytes in Cancer in Bone
Atkinson, E. G., & Delgado‐Calle, J. (2019) · JBMR Plus · doi:10.1002/jbm4.10186 · Cited by 56 · see citing works
Similarities Between Disuse and Age-Induced Bone Loss
Buettmann, E. G., Goldscheitter, G., Hoppock, G. A., Friedman, M. A., Suva, L. J., & Donahue, H. J. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4643 · Cited by 59 · see citing works
Osteocytes and Skeletal Pathophysiology
Delgado‐Calle, J., & Bellido, T. (2015) · Current Molecular Biology Reports · doi:10.1007/s40610-015-0026-y · Cited by 60 · see citing works
Self-citation
Bone adaptation in response to treadmill exercise in young and adult mice
Gardinier, J. D., Rostami, N., Juliano, L., & Zhang, C. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.01.003 · Cited by 58 · see citing works
IL‐17 alters the mesenchymal stem cell niche towards osteogenesis in cooperation with osteocytes
Liao, C., Zhang, C., Jin, L., & Yang, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29323 · Cited by 58 · see citing works
Interoceptive regulation of skeletal tissue homeostasis and repair
Xiao, Y., Han, C., Wang, Y., Zhang, X., Bao, R., Li, Y., Chen, H., Hu, B., & Liu, S. (2023) · Bone Research · doi:10.1038/s41413-023-00285-6 · Cited by 57 · see citing works
Ex Vivo Organ Cultures as Models to Study Bone Biology
Bellido, T., & Delgado‐Calle, J. (2020) · JBMR Plus · doi:10.1002/jbm4.10345 · Cited by 57 · see citing works
Self-citation
High serum levels of sclerostin and Dickkopf-1 are associated with acute ischaemic stroke
He, X., Wang, E., Bao, Y., Wang, F., Zhu, M., Hu, X., & Jin, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.003 · Cited by 56 · see citing works
Osteoimmunology in Periodontitis: Local Proteins and Compounds to Alleviate Periodontitis
Sirisereephap, K., Maekawa, T., Tamura, H., Hiyoshi, T., Domon, H., Isono, T., Terao, Y., Maeda, T., & Tabeta, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105540 · Cited by 56 · see citing works
PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading
Maycas, M., McAndrews, K., Sato, A. Y., Pellegrini, G., Brown, D. M., Allen, M. R., Plotkin, L. I., Gortázar, A. R., Esbrit, P., & Bellido, T. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3007 · Cited by 54 · see citing works
Self-citation
Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin, and Receptor Activator of Nuclear Factor‐κB Ligand in Periodontitis
Ballı, U., Aydoğdu, A., Dede, F. Ö., Türer, Ç. C., & Güven, B. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.150270 · Cited by 54 · see citing works
Iron overload induced osteocytes apoptosis and led to bone loss in Hepcidin−/− mice through increasing sclerostin and RANKL/OPG
Ma, J., Wang, A., Zhang, H., Liu, B., Geng, Y., Xu, Y., Zuo, G., & Peng, J. (2022) · Bone · doi:10.1016/j.bone.2022.116511 · Cited by 52 · see citing works
Insight into the effect of biomaterials on osteogenic differentiation of mesenchymal stem cells: A review from a mitochondrial perspective
Feng, Z., Jin, M., Liang, J., Kang, J., Yang, H., Guo, S., & Sun, X. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.03.032 · Cited by 52 · see citing works
Biomaterials for diabetic bone repair: Influencing mechanisms, multi-aspect progress and future prospects
Wang, B., Huang, Y., Cai, Q., Du, Z., & Li, X. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111282 · Cited by 52 · see citing works
Commercially available bone graft substitutes: the impact of origin and processing on graft functionality
Bow, A. J., Anderson, D. E., & Dhar, M. S. (2019) · Drug Metabolism Reviews · doi:10.1080/03602532.2019.1671860 · Cited by 51 · see citing works
Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathways
Liao, C., Cheng, T., Wang, S., Zhang, C., Jin, L., & Yang, Y. (2017) · Bone · doi:10.1016/j.bone.2017.04.003 · Cited by 49 · see citing works
Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials.
Mou, K., Chan, S. M. H., & Vlahos, R. (2024) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2024.108635 · Cited by 51 · see citing works
Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis
Wu, Y. X., Gan, D., Liu, Z., Qiu, D., Tan, G., Xu, Z., & Xue, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1670716 · Cited by 53 · see citing works
Bone loss in chronic kidney disease: Quantity or quality?
Zheng, C., Zheng, J.-Q., Wu, C., Lu, C., Shyu, J., Yung-Ho, H., Wu, M., Chiu, I., Wang, Y., Lin, Y., et al. (2016) · Bone · doi:10.1016/j.bone.2016.03.017 · Cited by 48 · see citing works
Bone mineralization is regulated by signaling cross talk between molecular factors of local and systemic origin: The role of fibroblast growth factor 23
Sapir-Koren, R., & Livshits, G. (2014) · Biofactors · doi:10.1002/biof.1186 · Cited by 36 · see citing works
Regulatory mechanisms of sclerostin expression during bone remodeling
Koide, M., & Kobayashi, Y. (2018) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-018-0971-7 · Cited by 46 · see citing works
Pulsed electromagnetic fields regulate osteocyte apoptosis, RANKL/OPG expression, and its control of osteoclastogenesis depending on the presence of primary cilia
Wang, P., Tang, C., Wu, J., Yang, Y., Yan, Z., Liu, X., Shao, X., Zhai, M., Gao, J., Liang, S., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27734 · Cited by 46 · see citing works
The Osteoclast Traces the Route to Bone Tumors and Metastases
Russo, S., di Carlo, F. S., & Gianfrancesco, F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886305 · Cited by 48 · see citing works
Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis
Kim, H. J., Kim, H. J., Choi, Y.-J., Bae, M., Hwang, D. S., Shin, S., & Lee, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061467 · Cited by 45 · see citing works
Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment
Bock, N., Shokoohmand, A., Kryza, T., Röhl, J., Meijer, J., Tran, P. A., Nelson, C. C., Clements, J. A., & Hutmacher, D. W. (2019) · Bone Research · doi:10.1038/s41413-019-0049-8 · Cited by 45 · see citing works
Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice
Wang, Y., Yan, Q., Zhao, Y., Liu, X. Z., Lin, S., Zhang, P., Ma, L., Lai, Y., Bai, X., Liu, C.-J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131692 · Cited by 44 · see citing works
Connexin Gap Junctions and Hemichannels Link Oxidative Stress to Skeletal Physiology and Pathology
Hua, R., Zhang, J., Riquelme, M. A., & Jiang, J. X. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00645-9 · Cited by 43 · see citing works
Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expressions of NADPH oxidase 1 (Nox1) and Nox2
Takeno, A., Kanazawa, I., Tanaka, K., Notsu, M., Yokomoto, M., Yamaguchi, T., & Sugimoto, T. (2015) · Bone · doi:10.1016/j.bone.2015.04.025 · Cited by 42 · see citing works
Osteocyte death during orthodontic tooth movement in mice
Moin, S., Kalajzić, Ž., Utreja, A., Nihara, J., Wadhwa, S., Uribe, F. A., & Nanda, R. (2014) · The Angle Orthodontist · doi:10.2319/110713-813.1 · Cited by 42 · see citing works

Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?
Sapir‐Koren, R., & Livshits, G. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2808-0 · Cited by 176 · see citing works
Osteocyte control of osteoclastogenesis
O’Brien, C. A., Nakashima, T., & Takayanagi, H. (2012) · Bone · doi:10.1016/j.bone.2012.08.121 · Cited by 237 · see citing works
The osteocyte plays multiple roles in bone remodeling and mineral homeostasis
Chen, H., Senda, T., & Kubo, K. (2015) · Medical Molecular Morphology · doi:10.1007/s00795-015-0099-y · Cited by 131 · see citing works
Osteocytes and Skeletal Pathophysiology
Delgado‐Calle, J., & Bellido, T. (2015) · Current Molecular Biology Reports · doi:10.1007/s40610-015-0026-y · Cited by 60 · see citing works
Self-citation
The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model
Graham, J. M., Ayati, B. P., Holstein, S. A., & Martin, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063884 · Cited by 70 · see citing works

Authors: Bellido, T.
Affiliations: Richard L. Roudebush VA Medical Center (US)
Corresponding author: Bellido, Teresita
ORCID: Bellido, Teresita
Venue: Calcified Tissue International
Publisher: Springer Science and Business Media LLC
Published: 2013-09-04
Volume: 94
Issue: 1
Pages: 25-34
ISSN: 0171-967X (ISSN-L)
1432-0827
DOI: 10.1007/s00223-013-9774-y
PMC: PMC3947228
OpenAlex: W2016390309
Cited by: 384
References: 84
Citations by year: 2026: 17 · 2025: 20 · 2024: 28 · 2023: 27 · 2022: 38 · 2021: 36 · 2020: 43 · 2019: 43 · 2018: 36 · 2017: 29 · 2016: 23 · 2015: 28 · 2014: 14 · 2013: 1 · 2012: 1
FWCI: 2.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Calcified Tissue International (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (IK6 BX004596, I01 BX002104)
National Institute on Aging (P01 AG-13918, P01AG013918)
Fogarty International Center (R03TW006919)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076007)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059357, KO2-AR-02127, K02AR002127, R01AR053643)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords: osteocytes, bone remodeling, sclerostin, osteoblasts, osteoclasts, bone resorption, osteocyte apoptosis, RANKL, OPG, mechanical stimulation, bone formation
MeSH terms: Animals, Bone and Bones, Cell Differentiation, Humans, Osteoclasts, Osteocytes, Osteogenesis, Bone Remodeling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Osteocyte-Driven Bone Remodeling

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks