Hydrothermal Focusing of Chemical and Chemiosmotic Energy, Supported by Delivery of Catalytic Fe, Ni, Mo/W, Co, S and Se, Forced Life to Emerge
Abstract
Energised by the protonmotive force and with the intervention of inorganic catalysts, at base Life reacts hydrogen from a variety of sources with atmospheric carbon dioxide. It seems inescapable that life emerged to fulfil the same role (i.e., to hydrogenate CO(2)) on the early Earth, thus outcompeting the slow geochemical reduction to methane. Life would have done so where hydrothermal hydrogen interfaced a carbonic ocean through inorganic precipitate membranes. Thus we argue that the first carbon-fixing reaction was the molybdenum-dependent, proton-translocating formate hydrogenlyase system described by Andrews et al. (Microbiology 143:3633-3647, 1997), but driven in reverse. Alkaline on the inside and acidic and carbonic on the outside - a submarine chambered hydrothermal mound built above an alkaline hydrothermal spring of long duration - offered just the conditions for such a reverse reaction imposed by the ambient protonmotive force. Assisted by the same inorganic catalysts and potential energy stores that were to evolve into the active centres of enzymes supplied variously from ocean or hydrothermal system, the formate reaction enabled the rest of the acetyl coenzyme-A pathway to be followed exergonically, first to acetate, then separately to methane. Thus the two prokaryotic domains both emerged within the hydrothermal mound-the acetogens were the forerunners of the Bacteria and the methanogens were the forerunners of the Archaea.
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The complaint that acetate has defied chemical synthesis in aqueous solution directly from CO2 and H2 in the laboratory probably relates to electron bifurcation, whereby aqueous acetate synthesis from CO2 with Fe±0 is facile.
“An additional complaint of Nitschke & Russell [210] that ‘acetate has defied chemical synthesis in aqueous solution directly from CO2 and H2 in the laboratory’ probably relates to electron bifurcation, whereby aqueous acetate synthesis from CO2 with Fe±0 is facile [62].”
From Early bioenergetic evolution (2013) · cites this paper as [210]
It is simplistic to argue that non-protein/inorganic equivalents of these machines with unspecified structures and unknown chemistry could have served as consumers of the first putative natural pH gradients.
“However, it is simplistic to argue that non-protein/inorganic equivalents of these machines with unspecified structures, and utilizing completely unknown chemistry, could have served as consumers of those first putative natural pH gradients (Russell and Hall 2002; Russell 2007; Nitschke and Russell 2009; Russell et al. 2014).”
From Natural pH Gradients in Hydrothermal Alkali Vents Were Unlikely to Have Played a Role in the Origin of Life (2016) · cites this paper as Nitschke and Russell 2009
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Schultz, A., & Baltscheffsky, M. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.09.003 · Cited by 25 · see citing works
From Naphtho- to Benzoquinones - (R)evolutionary Reorganisations of Electron Transfer Chains
Nitschke, W., Kramer, D., Riedel, A., & Liebl, U. (1995) · Springer eBooks · doi:10.1007/978-94-009-0173-5_225 · Cited by 24 · see citing works
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Analysis of ancient sequence motifs in the H+‐PPase family
Hedlund, J., Cantoni, R., Baltscheffsky, M., Baltscheffsky, H., & Persson, B. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05514.x · Cited by 18 · see citing works
The Hydrothermal Source of Energy and Materials at the Origin of Life
Russell, M. J., & Hall, A. J. (2010) · ACS Symposium Series · doi:10.1021/bk-2009-1025.ch003 · Cited by 17 · see citing works
Self-citationYockey, H. (1995) · Journal of Theoretical Biology · doi:10.1006/jtbi.1995.0204 · Cited by 14 · see citing works
Osborn, H. F. (1917) · Charles Scribner's Sons eBooks · doi:10.5962/bhl.title.7397 · Cited by 6 · see citing works
A Helium Series in the Extreme Ultraviolet
Lyman, T. (1919) · Science · doi:10.1126/science.50.1299.481 · Cited by 6 · see citing works
Wong, J. T.-F. (2008) · Cited by 6 · see citing works
Coevolution theory of the genetic code: is the precursor–product hypothesis invalid?
Davis, B. K. (2005) · BioEssays · doi:10.1002/bies.20332 · Cited by 6 · see citing works
Origin and Evolution of Very Early Sequence Motifs in Enzymes
Baltscheffsky, H., Persson, B., Schultz, A., Pérez‐Castiñeira, J. R., & Baltscheffsky, M. (2004) · Cellular origin and life in extreme habitats · doi:10.1007/978-94-007-1003-0_17 · Cited by 4 · see citing works
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Buckel, W., & Thauer, R. K. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.07.002 · Cited by 797 · see citing works
Alternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?
Fuchs, G. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102801 · Cited by 726 · see citing works
Serpentinization as a source of energy at the origin of life
RUSSELL, M. J., HALL, A. J., & MARTIN, W. (2010) · Geobiology · doi:10.1111/j.1472-4669.2010.00249.x · Cited by 527 · see citing works
Self-citationThe origin of membrane bioenergetics
Lane, N., & Martin, W. F. (2012) · Cell · doi:10.1016/j.cell.2012.11.050 · Cited by 452 · see citing works
How did LUCA make a living? Chemiosmosis in the origin of life
Lane, N., Allen, J. F., & Martin, W. (2010) · BioEssays · doi:10.1002/bies.200900131 · Cited by 377 · see citing works
The Origin of Life in Alkaline Hydrothermal Vents
Sojo, V., Herschy, B., Whicher, A., Camprubí, E., & Lane, N. (2016) · Astrobiology · doi:10.1089/ast.2015.1406 · Cited by 341 · see citing works
Insight into the evolution of the iron oxidation pathways
Ilbert, M., & Bonnefoy, V. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.10.001 · Cited by 343 · see citing works
Sousa, F. L., Thiergart, T., Landan, G., Nelson-Sathi, S., Pereira, I. A. C., Allen, J. F., Lane, N., & Martin, W. F. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0088 · Cited by 286 · see citing works
“Recently, Nitschke & Russell [210, p. 482] have argued that the Wood–Ljungdahl pathway ‘appears inadequate to drive reductions, condensations and biosyntheses required of an emergent metabolic cooperative’.”
BackgroundInfluentialThe Drive to Life on Wet and Icy Worlds
Russell, M. J., Barge, L. M., Bhartia, R., Bocanegra, D., Bracher, P. J., Branscomb, E., Kidd, R., McGlynn, S., Meier, D. H., Nitschke, W., et al. (2014) · Astrobiology · doi:10.1089/ast.2013.1110 · Cited by 288 · see citing works
“Indeed, as we have argued here and previously, the main prebiotic molecules were CO2, CH4, H2, HPO4 , P4O10, NH3, NO, FeS, Fe3S4, Ni, Co, Mg, Mo, W, and the like (Nitschke and Russell, 2009).”
InfluentialSelf-citationFrom Chemical Gardens to Chemobrionics
Barge, L. M., Cardoso, S. S. S., Cartwright, J. H. E., Cooper, G. J. T., Cronin, L., Wit, A. D., Doloboff, I. J., Escribano, B., Goldstein, R. E., Haudin, F., et al. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00014 · Cited by 297 · see citing works
Self-citationOlson, K. R., & Straub, K. D. (2015) · Physiology · doi:10.1152/physiol.00024.2015 · Cited by 271 · see citing works
The Origin and Nature of Life on Earth: The Emergence of the Fourth Geosphere
Smith, E., & Morowitz, H. J. (2016) · doi:10.1017/cbo9781316348772 · Cited by 215 · see citing works
Metal availability and the expanding network of microbial metabolisms in the Archaean eon
Moore, E. K., Jelen, B. I., Giovannelli, D., Raanan, H., & Falkowski, P. G. (2017) · Nature Geoscience · doi:10.1038/ngeo3006 · Cited by 197 · see citing works
An origin-of-life reactor to simulate alkaline hydrothermal vents
Herschy, B., Whicher, A., Camprubi, E., Watson, C., Dartnell, L., Ward, J., Evans, J. R. G., & Lane, N. (2014) · Journal of Molecular Evolution · doi:10.1007/s00239-014-9658-4 · Cited by 194 · see citing works
Unifying concepts in anaerobic respiration: Insights from dissimilatory sulfur metabolism
Grein, F., Ramos, A. R., Venceslau, S. S., & Pereira, I. A. C. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.09.001 · Cited by 200 · see citing works
On the universal core of bioenergetics
Schoepp‐Cothenet, B., van Lis, R., Atteia, A., Baymann, F., Capowiez, L., Ducluzeau, A., Duval, S., ten Brink, F., Russell, M. J., & Nitschke, W. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.09.005 · Cited by 184 · see citing works
Self-citationPromotion of protocell self-assembly from mixed amphiphiles at the origin of life
Jordan, S. F., Rammu, H., Zheludev, I. N., Hartley, A. M., Maréchal, A., & Lane, N. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-1015-y · Cited by 178 · see citing works
Huang, H., Wang, S., Moll, J., & Thauer, R. K. (2012) · Journal of Bacteriology · doi:10.1128/jb.00385-12 · Cited by 177 · see citing works
The prokaryotic Mo/W-bisPGD enzymes family: A catalytic workhorse in bioenergetic
Grimaldi, S., Schoepp‐Cothenet, B., Ceccaldi, P., Guigliarelli, B., & Magalon, A. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.01.011 · Cited by 159 · see citing works
On the antiquity of metalloenzymes and their substrates in bioenergetics
Nitschke, W., McGlynn, S. E., Milner-White, E. J., & Russell, M. J. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.02.008 · Cited by 152 · see citing works
Self-citationBeating the acetyl coenzyme A-pathway to the origin of life
Nitschke, W., & Russell, M. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0258 · Cited by 143 · see citing works
Self-citationRedox bifurcations: Mechanisms and importance to life now, and at its origin
Nitschke, W., & Russell, M. J. (2011) · BioEssays · doi:10.1002/bies.201100134 · Cited by 130 · see citing works
Self-citationThe inevitable journey to being
Russell, M. J., Nitschke, W., & Branscomb, E. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0254 · Cited by 174 · see citing works
Self-citationSchoepp‐Cothenet, B., van Lis, R., Philippot, P., Magalon, A., Russell, M. J., & Nitschke, W. (2012) · Scientific Reports · doi:10.1038/srep00263 · Cited by 119 · see citing works
Self-citationYamaguchi, A., Yamamoto, M., Takai, K., Ishii, T., Hashimoto, K., & Nakamura, R. (2014) · Electrochimica Acta · doi:10.1016/j.electacta.2014.07.078 · Cited by 119 · see citing works
Proton gradients at the origin of life
Lane, N. (2017) · BioEssays · doi:10.1002/bies.201600217 · Cited by 115 · see citing works
The Model [NiFe]-Hydrogenases of Escherichia coli
Sargent, F. (2016) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2016.02.008 · Cited by 114 · see citing works
Martin, W. F. (2012) · FEBS Letters · doi:10.1016/j.febslet.2011.09.031 · Cited by 108 · see citing works
Reactive Oxygen Species: Radical Factors in the Evolution of Animal Life
Taverne, Y. J. H. J., Merkus, D., Bogers, A. J. J. C., Halliwell, B. B., Duncker, D. J., & Lyons, T. W. (2018) · BioEssays · doi:10.1002/bies.201700158 · Cited by 110 · see citing works
The Role of Microbial Electron Transfer in the Coevolution of the Biosphere and Geosphere
Jelen, B. I., Giovannelli, D., & Falkowski, P. G. (2016) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095521 · Cited by 101 · see citing works
Turnstiles and bifurcators: The disequilibrium converting engines that put metabolism on the road
Branscomb, E., & Russell, M. J. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.10.003 · Cited by 105 · see citing works
Self-citationMethane on Mars and Habitability: Challenges and Responses
Yung, Y., Chen, P., Nealson, K., Atreya, S., Beckett, P., Blank, J., Ehlmann, B., Eiler, J., Etiope, G., Ferry, J. G., et al. (2018) · Astrobiology · doi:10.1089/ast.2018.1917 · Cited by 85 · see citing works
Self-citationA prebiotic basis for ATP as the universal energy currency
Pinna, S., Kunz, C., Halpern, A., Harrison, S. A., Jordan, S. F., Ward, J., Werner, F., & Lane, N. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001437 · Cited by 103 · see citing works
Green Rust: The Simple Organizing ‘Seed’ of All Life?
Russell, M. J. (2018) · Life · doi:10.3390/life8030035 · Cited by 101 · see citing works
Self-citationHow oxygen reacts with oxygen-tolerant respiratory [NiFe]-hydrogenases
Wulff, P., Day, C., Sargent, F., & Armstrong, F. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322393111 · Cited by 100 · see citing works
Evans, R. M., Parkin, A., Roessler, M. M., Murphy, B. J., Adamson, H., Lukey, M. J., Sargent, F., Volbeda, A., Fontecilla-Camps, J. C., & Armstrong, F. A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja311055d · Cited by 99 · see citing works
Escapement mechanisms and the conversion of disequilibria; the engines of creation
Branscomb, E., Biancalani, T., Goldenfeld, N., & Russell, M. (2017) · Physics Reports · doi:10.1016/j.physrep.2017.02.001 · Cited by 96 · see citing works
Self-citationIron-Sulfide-Bearing Chimneys as Potential Catalytic Energy Traps at Life's Emergence
Mielke, R. E., Robinson, K. J., White, L. M., McGlynn, S. E., McEachern, K., Bhartia, R., Kanik, I., & Russell, M. J. (2011) · Astrobiology · doi:10.1089/ast.2011.0667 · Cited by 95 · see citing works
Self-citationThermodynamic dissipation theory for the origin of life
Michaelian, K. (2011) · Earth System Dynamics · doi:10.5194/esd-2-37-2011 · Cited by 97 · see citing works
Acetyl Phosphate as a Primordial Energy Currency at the Origin of Life
Whicher, A., Camprubi, E., Pinna, S., Herschy, B., & Lane, N. (2018) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-018-9555-8 · Cited by 81 · see citing works
Efficient Hydrogen-Dependent Carbon Dioxide Reduction by Escherichia coli
Roger, M., Brown, F. K., Gabrielli, W., & Sargent, F. (2017) · Current Biology · doi:10.1016/j.cub.2017.11.050 · Cited by 86 · see citing works
Camprubí, E., de Leeuw, J. W., House, C. H., Raulin, F., Russell, M. J., Spang, A., Tirumalai, M. R., & Westall, F. (2019) · Space Science Reviews · doi:10.1007/s11214-019-0624-8 · Cited by 84 · see citing works
Self-citationPandelia, M., Lubitz, W., & Nitschke, W. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.04.012 · Cited by 77 · see citing works
Self-citationTerrestrial aftermath of the Moon-forming impact
Sleep, N. H., Zahnle, K. J., & Lupu, R. (2014) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2013.0172 · Cited by 73 · see citing works
Geological and Geochemical Constraints on the Origin and Evolution of Life
Sleep, N. H. (2018) · Astrobiology · doi:10.1089/ast.2017.1778 · Cited by 71 · see citing works
Van Kranendonk, M. J., Baumgartner, R., Djokic, T., Ota, T., Steller, L., Garbe, U., & Nakamura, E. (2021) · Astrobiology · doi:10.1089/ast.2019.2107 · Cited by 71 · see citing works
Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine
Jordan, S. F., Ioannou, I. A., Rammu, H., Halpern, A., Bogart, L. K., Ahn, M., Vasiliadou, R., Christodoulou, J. C., Maréchal, A., & Lane, N. J. (2021) · Nature Communications · doi:10.1038/s41467-021-26158-2 · Cited by 72 · see citing works
Design, Fabrication, and Test of a Hydrothermal Reactor for Origin-of-Life Experiments
Mielke, R. E., Russell, M. J., Wilson, P. R., McGlynn, S. E., Coleman, M. L., Kidd, R. D., & Kanik, I. (2010) · Astrobiology · doi:10.1089/ast.2009.0456 · Cited by 66 · see citing works
Self-citationGeoelectrochemical CO production: Implications for the autotrophic origin of life
Kitadai, N., Nakamura, R., Yamamoto, M., Takai, K., Li, Y., Yamaguchi, A., Gilbert, A. R., Ueno, Y., Yoshida, N., & Oono, Y. (2018) · Science Advances · doi:10.1126/sciadv.aao7265 · Cited by 63 · see citing works
Pinske, C., & Sargent, F. (2016) · MicrobiologyOpen · doi:10.1002/mbo3.365 · Cited by 64 · see citing works
Life as a guide to prebiotic nucleotide synthesis
Harrison, S. A., & Lane, N. (2018) · Nature Communications · doi:10.1038/s41467-018-07220-y · Cited by 63 · see citing works
Microbial selenium metabolism: a brief history, biogeochemistry and ecophysiology
Wells, M., & Stolz, J. F. (2020) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiaa209 · Cited by 61 · see citing works
Branscomb, E., & Russell, M. J. (2018) · BioEssays · doi:10.1002/bies.201700182 · Cited by 59 · see citing works
Self-citationMethane: Fuel or Exhaust at the Emergence of Life?
Russell, M. J., & Nitschke, W. (2017) · Astrobiology · doi:10.1089/ast.2016.1599 · Cited by 58 · see citing works
Self-citationMcGlynn, S. E., Kanik, I., & Russell, M. J. (2012) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2011.0211 · Cited by 55 · see citing works
Self-citationMarreiros, B. C., Sena, F. V., Sousa, F. M., Batista, A. P., & Pereira, M. M. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13352 · Cited by 56 · see citing works
Marelja, Z., Leimkühler, S., & Missirlis, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00050 · Cited by 57 · see citing works
Jackson, J. B. (2016) · Journal of Molecular Evolution · doi:10.1007/s00239-016-9756-6 · Cited by 52 · see citing works
“An equivalent mechanism in the primitive HCF (Nitschke and Russell 2009) with both the H 2 oxidation and CO 2 reduction sites on the same (vent) side of the membrane (Fig.”
BackgroundInfluentialLi, Y., Yamaguchi, A., Yamamoto, M., Takai, K., & Nakamura, R. (2016) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.6b08343 · Cited by 53 · see citing works
Links Between Hydrothermal Environments, Pyrophosphate, Na+, and Early Evolution
Holm, N. G., & Baltscheffsky, H. (2011) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-011-9235-4 · Cited by 52 · see citing works
Functional Capabilities of the Earliest Peptides and the Emergence of Life
Milner‐White, E. J., & Russell, M. J. (2011) · Genes · doi:10.3390/genes2040671 · Cited by 51 · see citing works
Self-citationHuang, X. (2018) · Astrobiology · doi:10.1089/ast.2016.1628 · Cited by 50 · see citing works
Life as a Guide to Its Own Origins
Harrison, S. A., Rammu, H., Liu, F., Halpern, A., Palmeira, R. N., & Lane, N. J. (2023) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110421-101509 · Cited by 42 · see citing works
Russell, M. J., & Ponce, A. (2020) · Life · doi:10.3390/life10110291 · Cited by 44 · see citing works
Self-citationThe “Water Problem”(sic), the Illusory Pond and Life’s Submarine Emergence—A Review
Russell, M. J. (2021) · Life · doi:10.3390/life11050429 · Cited by 44 · see citing works
Self-citationLigand Field Theory and the Origin of Life as an Emergent Feature of the Periodic Table of Elements
Morowitz, H. J., Srinivasan, V., & Smith, E. (2010) · Biological Bulletin · doi:10.1086/bblv219n1p1 · Cited by 42 · see citing works
The “green” phylogenetic clade of Rieske/cytb complexes
Nitschke, W., van Lis, R., Schoepp‐Cothenet, B., & Baymann, F. (2010) · Photosynthesis Research · doi:10.1007/s11120-010-9532-1 · Cited by 36 · see citing works
Self-citationElectron Transfer between Electrically Conductive Minerals and Quinones
Taran, O. (2017) · Frontiers in Chemistry · doi:10.3389/fchem.2017.00049 · Cited by 36 · see citing works
The Fuel Cell Model of Abiogenesis: A New Approach to Origin-of-Life Simulations
Barge, L. M., Kee, T. P., Doloboff, I. J., Hampton, J. M., Ismail, M. S., Pourkashanian, M. M., Zeytounian, J. L., Baum, M. M., Moss, J. A., Lin, C., et al. (2014) · Astrobiology · doi:10.1089/ast.2014.1140 · Cited by 34 · see citing works
The active site structure and catalytic mechanism of arsenite oxidase
Warelow, T. P., Pushie, M. J., Cotelesage, J. J. H., Santini, J. M., & George, G. N. (2017) · Scientific Reports · doi:10.1038/s41598-017-01840-y · Cited by 32 · see citing works
TCA Cycle Replenishing Pathways in Photosynthetic Purple Non-Sulfur Bacteria Growing with Acetate
Petushkova, E. P., Mayorova, E., & Tsygankov, A. A. (2021) · Life · doi:10.3390/life11070711 · Cited by 32 · see citing works
FeS/S/FeS 2 Redox System and Its Oxidoreductase-like Chemistry in the Iron-Sulfur World
Wang, W., Yang, B., Qu, Y., Liu, X., & Su, W. (2011) · Astrobiology · doi:10.1089/ast.2011.0624 · Cited by 32 · see citing works
Electron transport chains as a window into the earliest stages of evolution
Goldman, A. D., Weber, J. M., LaRowe, D. E., & Barge, L. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210924120 · Cited by 30 · see citing works
Huang, X., & Zhang, J. (2011) · RSC Advances · doi:10.1039/c1ra00353d · Cited by 30 · see citing works
Possible mechanisms of CO 2 reduction by H 2 via prebiotic vectorial electrochemistry
Vasiliadou, R., Dimov, N., Szita, N., Jordan, S. F., & Lane, N. J. (2019) · Interface Focus · doi:10.1098/rsfs.2019.0073 · Cited by 28 · see citing works
Aqueous electrochemistry: The toolbox for life's emergence from redox disequilibria
Nitschke, W., Schoepp‐Cothenet, B., Duval, S., Zuchan, K., Farr, O., Baymann, F., Panico, F., Minguzzi, A., Branscomb, E., & Russell, M. J. (2022) · Electrochemical Science Advances · doi:10.1002/elsa.202100192 · Cited by 25 · see citing works
Self-citationGlasses as sources of condensed phosphates on the early earth
Holm, N. G. (2014) · Geochemical Transactions · doi:10.1186/1467-4866-15-8 · Cited by 24 · see citing works
Duval, S., Santini, J. M., Lemaire, D., Chaspoul, F., Russell, M. J., Grimaldi, S., Nitschke, W., & Schoepp‐Cothenet, B. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.05.003 · Cited by 24 · see citing works
Self-citationWhy Does Life Start, What Does It Do, Where Will It Be, And How Might We Find It?
Russell, M. J., & Kanik, I. (2010) · Journal of Cosmology · Cited by 24 · see citing works
Self-citationPhylogeny of Rieske/cytb Complexes with a Special Focus on the Haloarchaeal Enzymes
Baymann, F., Schoepp‐Cothenet, B., Lebrun, É., van Lis, R., & Nitschke, W. (2012) · Genome Biology and Evolution · doi:10.1093/gbe/evs056 · Cited by 23 · see citing works
Self-citationStochastic Prebiotic Chemistry within Realistic Geological Systems
Dass, A. V., Hickman‐Lewis, K., Brack, A., Kee, T. P., & Westall, F. (2016) · ChemistrySelect · doi:10.1002/slct.201600829 · Cited by 28 · see citing works
Hydrogenation reactions of carbon on Earth: Linking methane, margarine, and life
McGlynn, S. E., Glass, J. B., Johnson-Finn, K. N., Klein, F., Sanden, S., Schrenk, M. O., Ueno, Y., & Brovarone, A. V. (2019) · American Mineralogist · doi:10.2138/am-2020-6928ccbyncnd · Cited by 19 · see citing works
What are inorganic nanozymes? Artificial or inorganic enzymes
Huang, X. (2022) · New Journal of Chemistry · doi:10.1039/d2nj02088b · Cited by 22 · see citing works
Archaea‐First and the Co‐Evolutionary Diversification of Domains of Life
Staley, J. T., & Caetano‐Anollés, G. (2018) · BioEssays · doi:10.1002/bies.201800036 · Cited by 19 · see citing works
Russell, M. J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1145915 · Cited by 20 · see citing works
Self-citationThe Winding Road from Origin to Emergence (of Life)
Nitschke, W., Farr, O., Gaudu, N., Truong, C., Guyot, F., Russell, M. J., & Duval, S. (2024) · Life · doi:10.3390/life14050607 · Cited by 17 · see citing works
Self-citationCharacterizing Bacterial Gene Expression in Nitrogen Cycle Metabolism with RT-qPCR
Graham, J. E., Wantland, N. B., Campbell, M., & Klotz, M. G. (2011) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-386489-5.00014-2 · Cited by 18 · see citing works
Just like the universe the emergence of life had high enthalpy and low entropy beginnings
Nitschke, W., & Russel, M. J. (2010) · HAL · Cited by 18 · see citing works
Self-citationPolyphosphate-Peptide Synergy and the Organic Takeover at the Emergence of Life
Milner‐White, E. J., & Russell, M. J. (2010) · ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) · Cited by 17 · see citing works
Self-citationHuang, X., Harmer, J. R., Schenk, G., & Southam, G. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1349020 · Cited by 18 · see citing works
The intelligence paradox; will ET get the metabolic syndrome? Lessons from and for Earth
Nunn, A. V. W., Guy, G. W., & Bell, J. D. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-34 · Cited by 16 · see citing works
Al-Attar, S., Rendon, J., Sidore, M., Duneau, J., Seduk, F., Biaso, F., Grimaldi, S., Guigliarelli, B., & Magalon, A. (2021) · ACS Catalysis · doi:10.1021/acscatal.1c03988 · Cited by 15 · see citing works
Huang, X. (2024) · iScience · doi:10.1016/j.isci.2024.109555 · Cited by 16 · see citing works
The “Origin-of-Life Reactor” and Reduction of CO2 by H2 in Inorganic Precipitates
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The Divergence and Natural Selection of Autocatalytic Primordial Metabolic Systems
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- Authors
- Nitschke, W., & Russell, M. J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- California Institute of Technology (US)
- Corresponding author
- Russell, Michael J.
- Venue
- Journal of Molecular Evolution
- Published
- 2009-11
- Volume
- 69
- Issue
- 5
- Pages
- 481-496
- ISSN
- 0022-2844 (ISSN-L)
- 1432-1432
- OpenAlex
- W2015506896
- Cited by
- 132
- References
- 120
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 7 · 2018: 16 · 2017: 9 · 2016: 11 · 2015: 4 · 2014: 11 · 2013: 7 · 2012: 16
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-06-BLAN-0384)
- NASA Astrobiology Institute
- Jet Propulsion Laboratory
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Paleontology and Stratigraphy of Fossils
- Physical Sciences › Earth and Planetary Sciences › Atmospheric Science › Earth Systems and Cosmic Evolution
- Keywords
- origin of life, hydrothermal vents, proton motive force, formate hydrogenlyase, CO2 fixation, inorganic catalysts, molybdenum, proton translocation, acetogenic bacteria, methanogenic archaea, early Earth
- MeSH terms
- Origin of Life, Acetates, Archaea, Bacteria, Copper, Energy Metabolism, Hot Temperature, Iron, Methane, Models, Biological, Molybdenum, Nickel, Osmosis, Seawater, Selenium, Sulfur, Trace Elements, Proton-Motive Force, Evolution, Chemical, Chemoautotrophic Growth
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