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Cited by 162Algal biology and biofuel productionDiatoms and Algae ResearchMicrobial Metabolic Engineering and Bioproduction

Diatom cultivation and biotechnologically relevant products. Part I: Cultivation at various scales

Lebeau, Thierry, Robert, Jean-Michel·2003·Applied Microbiology and Biotechnology
DOI 10.1007/s00253-002-1176-4
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Abstract

Biotechnological applications of diatoms are still in development. Further development at the industrial scale will depend on optimisation of the culture process with the aim of reducing costs. Because of the photoautotrophic status of the majority of diatoms, microalgal cultures suffer from the limitation of light diffusion, which requires the development of suitable photobioreactors. Thus, genetically engineered microalgae that may be cultivated in heterotrophic conditions present a new opportunity. Other limiting factors, such as nutrients (phosphate, nitrogen, silicon), pH, temperature, bioturbation and many more must be taken into account. Most of the time, metabolic stress conditions lead to an overproduction of the products of interest, with a decrease in biomass production as a consequence. Outdoor cultures in open ponds are usually devoted to aquaculture for the feeding of shrimps and bivalve molluscs (commercial production), while closed axenic indoor/outdoor photobioreactors are used for biotechnological compounds of homogeneous composition (still at the laboratory scale). In addition to the optimum culture conditions that have to be taken into account for photobioreactor design, the localisation of produced metabolites (intra- or extracellular) may also be taken into account when choosing the design. Microalgal cell immobilisation may be a suitable technique for application to benthic diatoms, which are usually sensitive to bioturbation and/or metabolites which may be overexpressed.

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  • Outdoor pond systems have lower initial capital costs, but historically these open pond systems have relied mainly on outcompeting contaminating organisms by using densely grown axenic or nearly axenic starter cultures.

    “Outdoor pond systems have lower initial capital costs, but historically these open pond systems have relied mainly on outcompeting contaminating organisms by using densely grown axenic (or nearly axenic) starter cultures [58,59].”

    From Biofuels from algae: Challenges and potential (2010) · cites this paper as [58]

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Authors
Lebeau, T., & Robert, J.-M.
Affiliations
Institut Des Substances et Organismes de la Mer (FR)
Corresponding author
Lebeau, Thierry
ORCID
Lebeau, Thierry
Venue
Applied Microbiology and Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2003-02
Volume
60
Issue
6
Pages
612-623
ISSN
  • 0175-7598 (ISSN-L)
  • 1432-0614
DOI
10.1007/s00253-002-1176-4
OpenAlex
W2022478052
Cited by
162
References
78
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 8
FWCI
5.70
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Applied Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Physical Sciences › Materials Science › Biomaterials › Diatoms and Algae Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords
diatom cultivation, microalgae, photobioreactors, heterotrophic cultivation, bioturbation, nutrient limitation, metabolic stress, cell immobilization, benthic diatoms, biotechnology products
MeSH terms
Animals, Animal Feed, Biological Products, Biotechnology, Botany, Genetic Engineering, Hydrogen-Ion Concentration, Light, Mollusca, Nitrogen, Phosphates, Photosynthesis, Seawater, Stress, Mechanical, Temperature, Diatoms, Silicates, Aquaculture, Biomass, Cells, Immobilized, Bioreactors, Penaeidae

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