Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
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OBJECTIVE: The objective of the study is to compare the diagnostic value of regional sampling of the cerebral metabolic rate of glucose metabolism (MRglc) using [18F]-fluoro-2-deoxyglucose ([18F]FDG)-positron emission tomography (PET) and amyloid-beta pathology using Pittsburgh Compound-B ([11C]PIB)-PET in the evaluation of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) compared to normal elderly (NL). MATERIALS AND METHODS: AD patients, 7 NL, 13 MCI, and 17, received clinical, neuropsychological, magnetic resonance imaging (MRI), FDG, and PIB-PET exams. Parametric images of PIB uptake and MRglc were sampled using automated regions-of-interest (ROI). RESULTS: AD showed global MRglc reductions, and MCI showed reduced hippocampus (HIP) and inferior parietal lobe (IP) MRglc compared to NL. On PIB, AD patients showed significantly increased uptake in the middle frontal gyrus (MFG), posterior cingulate cortex (PCC), and IP (ps < 0.05). PIB uptake in MCI subjects was either AD or NL-like. HIP MRglc and MFG PIB uptake were the best discriminators of NL from MCI and NL from AD. These two best measures showed high diagnostic agreement for AD (94%) and poor agreement for MCI (54%). For the NL vs. MCI discrimination, combining the two best measures increased the accuracy for PIB (75%) and for FDG (85%) to 90%. CONCLUSION: For AD, the pattern of regional involvement for FDG and PIB differ, but both techniques show high diagnostic accuracy and 94% case by case agreement. In the classification of NL and MCI, FDG is superior to PIB, but there is only 54% agreement at a case level. Combining the two modalities improves the diagnostic accuracy for MCI.
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Regional reductions in brain glucose utilization occur with aging and to a greater extent in MCI and AD.
“Regional reductions in brain glucose utilization occur with aging and to a greater extent in MCI and AD [185-193].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [191]
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- Authors
- Li, Y., Rinne, J. O., Mosconi, L., Pirraglia, E., Rusinek, H., DeSanti, S., Kemppainen, N., Någren, K., Kim, B.-C., Tsui, W., & de Leon, M. J.
- Affiliations
- New York University (US)
- University of Turku (FI)
- Chonnam National University (KR)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Rinne, Juha O.
- ORCID
- Venue
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2008-06-20
- Volume
- 35
- Issue
- 12
- Pages
- 2169-2181
- ISSN
- 1619-7070 (ISSN-L)
- 1619-7089
- PMC
- PMC2693402
- OpenAlex
- W1985945455
- Cited by
- 278
- References
- 44
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 10 · 2019: 17 · 2018: 15 · 2017: 10 · 2016: 19 · 2015: 20 · 2014: 24 · 2013: 13 · 2012: 23
- FWCI
- 18.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- Turun Yliopistollinen Keskussairaala
- National Institutes of Health (AG12101, AG08051)
- National Institute on Aging (R01AG022374, AG 12101, R01AG012101, P30AG008051, AG 08051, R01AG013616, AG 13616)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, mild cognitive impairment, FDG-PET, amyloid PET, Pittsburgh compound B, regional cerebral glucose metabolism, amyloid-beta pathology, hippocampus, inferior parietal lobule, posterior cingulate cortex, middle frontal gyrus, diagnostic accuracy, normal aging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Aniline Compounds, Brain, Cognition Disorders, Female, Humans, Male, Middle Aged, Regression Analysis, Sensitivity and Specificity, Thiazoles, Fluorodeoxyglucose F18, Positron-Emission Tomography, Benzothiazoles
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