Beta‐amyloid deposition and the aging brain

Rodrigue, Karen M.; Kennedy, Kristen M.; Park, Denise C.

doi:10.1007/s11065-009-9118-x

Cited by 230Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAging and Gerontology Research

Beta‐amyloid deposition and the aging brain

Open access

Rodrigue, Karen M., Kennedy, Kristen M., Park, Denise C.·2009·Neuropsychology Review

DOI 10.1007/s11065-009-9118-xPMC PMC2844114

Open this paper in CoChat — free account

Abstract

A central issue in cognitive neuroscience of aging research is pinpointing precise neural mechanisms that determine cognitive outcome in late adulthood as well as identifying early markers of less successful cognitive aging. One promising biomarker is beta amyloid (Abeta) deposition. Several new radiotracers have been developed that bind to fibrillar Abeta providing sensitive estimates of amyloid deposition in various brain regions. Abeta imaging has been primarily used to study patients with Alzheimer's Disease (AD) and individuals with Mild Cognitive Impairment (MCI); however, there is now building data on Abeta deposition in healthy controls that suggest at least 20% and perhaps as much as a third of healthy older adults show significant deposition. Considerable evidence suggests amyloid deposition precedes declines in cognition and may be the initiator in a cascade of events that indirectly leads to age-related cognitive decline. We review studies of Abeta deposition imaging in AD, MCI, and normal adults, its cognitive consequences, and the role of genetic risk and cognitive reserve.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s11065-009-9118-x

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

AD is not driven by a single pathological process but by complex interactions among neurons and glial cells-including astrocytes, microglia, and oligodendrocytes-that contribute to synaptic dysfunction, neuroinflammation, white matter injury, and neuronal loss.
“AD is not driven by a single pathological process but rather by complex interactions among neurons and glial cells—including astrocytes, microglia, and oligodendrocytes—that contribute to synaptic dysfunction, neuroinflammation, white matter injury, and neuronal loss.”
From Diffusion MRI reveals amyloid plaque–associated cellular signatures through spatial transcriptomic integration (2026) · cites this paper as [3]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951 · see citing works
Cognitive reserve
Stern, Y. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.03.004 · Cited by 2,943 · see citing works
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862 · see citing works
The adaptive brain: aging and neurocognitive scaffolding
Park, D. C., & Reuter-Lorenz, P. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093656 · Cited by 2,790 · see citing works
Self-citation
Insights into the ageing mind: a view from cognitive neuroscience
Hedden, T., & Gabrieli, J. D. E. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1323 · Cited by 2,223 · see citing works
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Models of visuospatial and verbal memory across the adult life span.
Park, D. C., Lautenschlager, G. J., Hedden, T., Davidson, N. S., Smith, A. D., & Smith, P. K. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.2.299 · Cited by 1,792 · see citing works
Self-citation
APP Processing and Synaptic Function
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works
Disruption of Large-Scale Brain Systems in Advanced Aging
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., & Buckner, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.038 · Cited by 1,592 · see citing works
Neuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works
Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Differential aging of the brain: Patterns, cognitive correlates and modifiers
Raz, N., & Rodrigue, K. M. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.001 · Cited by 1,195 · see citing works
Self-citation
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
Dickerson, B. C., Bakkour, A., Salat, D. H., Feczko, E., Pacheco, J., Greve, D. N., Grodstein, F., Wright, C. I., Blacker, D., Rosas, H. D., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn113 · Cited by 1,153 · see citing works
Imaging β-amyloid burden in aging and dementia
Rowe, C. C., Ng, S., Ackermann, U., Gong, S. J., Pike, K., Savage, G., Cowie, T. F., Dickinson, K. L., Maruff, P., Darby, D., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000261919.22630.ea · Cited by 1,104 · see citing works
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
Jack, C. R., Lowe, V. J., Weigand, S. D., Wiste, H. J., Senjem, M. L., Knopman, D. S., Shiung, M. M., Gunter, J. L., Boeve, B. F., Kemp, B. J., et al. (2009) · Brain · doi:10.1093/brain/awp062 · Cited by 1,099 · see citing works
Frequent amyloid deposition without significant cognitive impairment among the elderly
Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., Ziolko, S. K., James, J. A., Snitz, B. E., Houck, P. R., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1509 · Cited by 1,059 · see citing works
[ 11 C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
Mintun, M. A., LaRossa, G. N., Sheline, Y. I., Dence, C. S., Lee, S. Y., Mach, R. H., Klunk, W. E., Mathis, C. A., DeKosky, S. T., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228230.26044.a4 · Cited by 1,036 · see citing works
Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027 · see citing works
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
Jack, C. R., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., Knopman, D. S., Boeve, B. F., Klunk, W. E., Mathis, C. A., et al. (2008) · Brain · doi:10.1093/brain/awm336 · Cited by 958 · see citing works
ApoE Promotes the Proteolytic Degradation of Aβ
Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876 · see citing works
-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
Pike, K. E., Savage, G., Villemagne, V. L., Ng, S., Moss, S. A., Maruff, P., Mathis, C. A., Klunk, W. E., Masters, C. L., & Rowe, C. C. (2007) · Brain · doi:10.1093/brain/awm238 · Cited by 789 · see citing works
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785 · see citing works
Localization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Brains of Living Patients With Alzheimer Disease
Shoghi, K. I., Small, G. W., Agdeppa, E. D., Kepe, V., Ercoli, L. M., Siddarth, P., Read, S., Satyamurthy, N., Petrič, A., Huang, S., et al. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200201000-00004 · Cited by 774 · see citing works
PET of Brain Amyloid and Tau in Mild Cognitive Impairment
Small, G. W., Kepe, V., Ercoli, L. M., Siddarth, P., Bookheimer, S. Y., Miller, K. J., Lavretsky, H., Burggren, A. C., Cole, G. M., Vinters, H. V., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054625 · Cited by 731 · see citing works
PET imaging of amyloid deposition in patients with mild cognitive impairment
Forsberg, A., Engler, H., Almkvist, O., Blomquist, G., Hagman, G., Wall, A. E., Ringheim, A., Långström, B., & Nordberg, A. K. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.029 · Cited by 725 · see citing works
Evolution of the neuropathology of Alzheimer's disease
Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710 · see citing works
Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects
Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., Koeppe, R. A., Mathis, C. A., Weiner, M. W., Jagust, W. J., et al. (2009) · Brain · doi:10.1093/brain/awn320 · Cited by 684 · see citing works
In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18 F-AV-45 (Flobetapir F 18)
Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., Dannals, R. F., Nandi, A., Brašić, J. R., Ye, W., et al. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.069088 · Cited by 684 · see citing works
Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
Rowe, C. C., Ackerman, U., Browne, W. F., Mulligan, R. S., Pike, K. E., O'Keefe, G. J., Tochon‐Danguy, H., Chan, G., Berlangieri, S. U., Jones, G. R., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70001-2 · Cited by 671 · see citing works
Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
Ingelsson, M., Fukumoto, H., Newell, K. L., Growdon, J. H., Hedley–Whyte, E. T., Frosch, M. P., Albert, M. S., Hyman, B. T., & Irizarry, M. C. (2004) · Neurology · doi:10.1212/01.wnl.0000115115.98960.37 · Cited by 666 · see citing works
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works
CSF Aβ 42 levels correlate with amyloid-neuropathology in a population-based autopsy study
Strozyk, D., Blennow, K., White, L. R., & Launer, L. J. (2003) · Neurology · doi:10.1212/01.wnl.0000046581.81650.d0 · Cited by 604 · see citing works
Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
Lopresti, B. J., Klunk, W. E., Mathis, C. A., Hoge, J. A., Ziolko, S. K., Lu, X., MELTZER, C. C., Schimmel, K., Tsopelas, N. D., DeKosky, S. T., et al. (2005) · PubMed · Cited by 536 · see citing works
Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study
Edison, P., Archer, H. A., Hinz, R., Hammers, A., Pavese, N., Tai, Y. F., Hotton, G., Cutler, D., Fox, N., Kennedy, A., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000244749.20056.d4 · Cited by 518 · see citing works
Aging and the Neural Correlates of Successful Picture Encoding: Frontal Activations Compensate for Decreased Medial-Temporal Activity
Gutchess, A. H., Welsh, R. C., Hedden, T., Bangert, A. S., Minear, M. E., Liu, L. L., & Park, D. C. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929052880048 · Cited by 461 · see citing works
Self-citation
PET amyloid ligand [ 11 C]PIB uptake is increased in mild cognitive impairment
Kemppainen, N. M., Aalto, S., Wilson, I. A., Någren, K., Helin, S., Brück, A., Oikonen, V., Kailajärvi, M., Scheinin, M., Viitanen, M. H., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000260969.94695.56 · Cited by 306 · see citing works
Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease
Villemagne, V. L., Pike, K. E., Darby, D., Maruff, P. T., Savage, G. R., Ng, S., Ackermann, U., Cowie, T., Currie, J. N., Chan, S. G., et al. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.02.008 · Cited by 291 · see citing works
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
Li, Y., Rinne, J. O., Mosconi, L., Pirraglia, E., Rusinek, H., DeSanti, S., Kemppainen, N., Någren, K., Kim, B.-C., Tsui, W., et al. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0833-y · Cited by 278 · see citing works
Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid
Grimmer, T., Riemenschneider, M., Förstl, H., Henriksen, G., Klunk, W. E., Mathis, C. A., Shiga, T., Wester, H.-J., Kurz, A., & Drzezga, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.027 · Cited by 278 · see citing works
Shrinkage of the Entorhinal Cortex over Five Years Predicts Memory Performance in Healthy Adults
Rodrigue, K. M., & Raz, N. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4166-03.2004 · Cited by 278 · see citing works
Self-citation
Effect ofAPOEgenotype on amyloid plaque load and gray matter volume in Alzheimer disease
Drzezga, A., Grimmer, T., Henriksen, G., Mühlau, M., Perneczky, R., Miederer, I., Praus, C., Sorg, C., Wohlschläger, A., Riemenschneider, M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a2e8d0 · Cited by 248 · see citing works
Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices
Nitsch, R. M., Farber, S. A., Growdon, J. H., & Wurtman, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5191 · Cited by 244 · see citing works
Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease
Kemppainen, N. M., Aalto, S., Karrasch, M., Någren, K., Savisto, N., Oikonen, V., Viitanen, M., Parkkola, R., & Rinne, J. O. (2008) · Annals of Neurology · doi:10.1002/ana.21212 · Cited by 239 · see citing works
Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment
Andreasen, N. C., Minthon, L., Vanmechelen, E., Vanderstichele, H., Davidsson, P., Winblad, B. G., & Blennow, K. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00617-5 · Cited by 236 · see citing works
The Development of Amyloid β Protein Deposits in the Aged Brain
Thal, D. R., Capetillo-Zarate, E., Del Tredici, K., & Braak, H. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.6.re1 · Cited by 234 · see citing works
Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve.
Fotenos, A. F., Mintun, M., Snyder, A., Morris, J., & Buckner, R. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.27 · Cited by 228 · see citing works
Voxel-based analysis of PET amyloid ligand [ 11 C]PIB uptake in Alzheimer disease
Kemppainen, N. M., Aalto, S., Wilson, I. A., Någren, K., Helin, S., Brück, A., Oikonen, V., Kailajärvi, M., Scheinin, M., Viitanen, M. H., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000240117.55680.0a · Cited by 227 · see citing works
β‐amyloid burden is not associated with rates of brain atrophy
Josephs, K. A., Whitwell, J. L., Ahmed, Z., Shiung, M. M., Weigand, S. D., Knopman, D. S., Boeve, B. F., Parisi, J. E., Petersen, R. C., Dickson, D. W., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21223 · Cited by 224 · see citing works
Impact of APOE in mild cognitive impairment
Farlow, M. R., He, Y., Tekin, S., Xu, J., Lane, R. M., & Charles, H. C. (2004) · Neurology · doi:10.1212/01.wnl.0000144279.21502.b7 · Cited by 199 · see citing works
Do CSF total tau, phosphorylated tau, and β-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature
Diniz, B. S., Pinto, J. A., & Forlenza, O. V. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701535502 · Cited by 168 · see citing works
Age-Based Structural Dynamics Between Perceptual Speed and Knowledge in the Berlin Aging Study: Direct Evidence for Ability Dedifferentiation in Old Age.
Ghisletta, P., & Lindenberger, U. (2003) · Psychology and Aging · doi:10.1037/0882-7974.18.4.696 · Cited by 158 · see citing works
Regional brain atrophy in cognitively intact adults with a single APOE ε4 allele
Wishart, H. A., Saykin, A. J., McAllister, T. W., Rabin, L. A., McDonald, B. C., Flashman, L. A., Roth, R. M., Mamourian, A. C., Tsongalis, G. J., & Rhodes, C. H. (2006) · Neurology · doi:10.1212/01.wnl.0000238079.00472.3a · Cited by 157 · see citing works
Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial
Study, T. A. D. C., Grundman, M., Sencakova, D., Jack, C. R., Petersen, R. C., Kim, H. T., Schultz, A. N., Weiner, M., DeCarli, C. S., DeKosky, S. T., et al. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0006-6 · Cited by 150 · see citing works
Current and future uses of neuroimaging for cognitively impaired patients
Small, G. W., Bookheimer, S. Y., Thompson, P. M., Cole, G. M., Huang, S.-C., Kepe, V., & Barrio, J. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70019-x · Cited by 142 · see citing works
Follow-up of [ 11 C]PIB uptake and brain volume in patients with Alzheimer disease and controls
Scheinin, N. M., Aalto, S., Koikkalainen, J. R., Lötjönen, J. M. P., Karrasch, M., Kemppainen, N. M., Viitanen, M. H., Någren, K., Helin, S., Scheinin, M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bacf1b · Cited by 128 · see citing works
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · cited 2× · see citing works
“…Deposition Risk There is a large literature on the risk conveyed by carrying the APOE-ε4 allele for age-related decline in cognitive function in both normal adults and AD patients and this is the best characterized genetic polymorphism associated with AD (Corder et al. 1993; Farrer et al. 1997).”
Background
Three-year follow-up of cerebrospinal fluid tau, β-amyloid 42 and 40 concentrations in Alzheimer's disease
Tapiola, T., Pirttilä, T., Mikkonen, M., Mehta, P. D., Alafuzoff, I. I., Koivisto, K. J., & Soininen, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00767-9 · Cited by 122 · see citing works
Detection of Alzheimer Pathology In Vivo Using Both 11C-PIB and 18F-FDDNP PET
Tolboom, N., Yaqub, M. M., van der Flier, W. M., Boellaard, R., Luurtsema, G., Windhorst, A. D., Barkhof, F., Scheltens, P., Lammertsma, A. A., & van Berckel, B. N. M. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.056499 · Cited by 119 · see citing works
Cerebrospinal fluid biomarkers for disease stage and intensity in cognitively impaired patients
Wahlund, L.-O., & Blennow, K. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01483-0 · Cited by 114 · see citing works
Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease
Braskie, M. N., Klunder, A. D., Hayashi, K. M., Protas, H. D., Kepe, V., Miller, K. J., Huang, S.-C., Barrio, J. R., Ercoli, L. M., Siddarth, P., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.012 · Cited by 114 · see citing works
18F-labeled styrylpyridines as PET agents for amyloid plaque imaging
Zhang, W., Kung, M., Oya, S., Hou, C., & Kung, H. F. (2006) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2006.10.003 · Cited by 111 · see citing works
The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation
Klunk, W. E., & Mathis, C. A. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283168e1a · Cited by 92 · see citing works
Amyloid imaging in Alzheimer's disease
Nordberg, A. K. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.03.020 · Cited by 89 · see citing works
Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
Fripp, J., Bourgeat, P., Acosta, O., Raniga, P., Modat, M., Pike, K. E., Jones, G., O'Keefe, G., Masters, C. L., Ames, D., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.053 · Cited by 80 · see citing works
Test-retest variability of quantitative [11C]PIB studies in Alzheimer’s disease
Tolboom, N., Yaqub, M. M., Boellaard, R., Luurtsema, G., Windhorst, A. D., Scheltens, P., Lammertsma, A. A., & van Berckel, B. N. M. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1129-6 · Cited by 76 · see citing works
CSF beta-amyloid, cognition, and APOE genotype in Alzheimer’s disease
Samuels, S., Silverman, J. M., Marin, D. B., Peskind, E. R., Younki, S. G., Greenberg, D. A., Schnur, E., Santoro, J., & Davis, K. L. (1999) · Neurology · doi:10.1212/wnl.52.3.547 · Cited by 67 · see citing works
A amyloid deposition in the language system and how the brain responds
Nelissen, N., Vandenbulcke, M., Fannes, K., Verbruggen, A., Peeters, R. R., Dupont, P. J., Laere, K. V., Bormans, G. M., & Vandenberghe, R. R. (2007) · Brain · doi:10.1093/brain/awm133 · Cited by 67 · see citing works
Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles.
Schmidt, M. L., Lee, V. M. ‐., & Trojanowski, J. Q. (1990) · PubMed Central · Cited by 63 · see citing works
Successful Aging
Park, D. C., & Goh, J. O. S. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002061 · Cited by 60 · see citing works
Self-citation
Influence of Cognitive Status, Age, and APOE-4 Genetic Risk on Brain FDDNP Positron-Emission Tomography Imaging in Persons Without Dementia
Small, G. W., Siddarth, P., Burggren, A. C., Kepe, V., Ercoli, L. M., Miller, K. J., Lavretsky, H., Thompson, P. M., Cole, G. M., Huang, S. C., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.516 · Cited by 57 · see citing works
Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI
Nordlund, A., Rolstad, S., KLANG, O., LIND, K., PEDERSEN, M., Blennow, K., Edman, Å., Hansen, S., & Wallin, A. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s135561770808079x · Cited by 53 · see citing works
Biomarkers in Relation to Cognitive Reserve in Patients with Mild Cognitive Impairment – Proof of Concept
Rolstad, S., Nordlund, A., Eckerström, C., Gustavsson, M. H., Zetterberg, H., & Wallin, A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000203130 · Cited by 34 · see citing works
Mapping brain β-amyloid
Jagust, W. J. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832d93c7 · Cited by 23 · see citing works
Amyloid + Activation = Alzheimer's?
Jagust, W. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.008 · Cited by 15 · see citing works
POSTPARTUM THROMBOSIS OF A DEVELOPMENTAL VENOUS ANOMALY
Prasad, S., Hurst, R. W., & Kasner, S. E. (2009) · Neurology · doi:10.1212/01.wnl.0000338623.26818.5f · Cited by 9 · see citing works
IMAGING β-AMYLOID BURDEN IN AGING AND DEMENTIA
Linazasoro, G. (2008) · Neurology · doi:10.1212/01.wnl.0000318046.06992.24 · Cited by 7 · see citing works
Use of eINDs for evaluation of multiple related PET amyloid plaque imaging agents.
Skovronsky, D. (2008) · PubMed · Cited by 5 · see citing works
P1‐284: In vivo imaging of amyloid deposition in Alzheimer's disease using the novel radioligand [18F] Av‐45
Rosenberg, P. B., Zhou, Y., Kumar, A., Ravert, H. T., Brašić, J. R., Ye, W., Alexander, M., Dannals, R. F., Galecki, J., Lyketsos, C. G., et al. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.874 · Cited by 2 · see citing works
O1‐01‐01: Relation between amyloid burden, brain atrophy and memory in Alzheimer's disease
Bourgeat, P., Villemagne, V. L., Fripp, J., Pike, K. E., Raniga, P., Acosta, O., Szoeke, C. E. I., Sebastien Ourselin, A., Ames, D. J., Ellis, K. A., et al. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.187 · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

Ichise M Plett S Joshi A Stern Y van Heertum R Lowe V 2008 Quantitative comparison of three novel 18F-labeled ligands for PET imaging of brain amyloid-β plaques in Alzheimer’s disease Journal of Nuclear Medicine 49 214
Raz N Kennedy KM 2009 A systems approach to age-related change: Neuroanatomical changes, their modifiers, and cognitive correlates Jagust W D’Esposito M Imaging the aging brain Ch 4 43 70 Oxford UP NYC
Skovronsky D Coleman RE Frey K Garg P Ichise M Lowe V 2008 Results of multi-center clinical trials comparing four 18F PET amyloid-imaging agents: preclinical to clinical correlations Journal of Nuclear Medicine Meeting Abstracts 49 1 34P

Sorted by citations

Normal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes
Lee, J., & Kim, H.-J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931536 · Cited by 310 · see citing works
Risk Factors for β-Amyloid Deposition in Healthy Aging: Vascular and Genetic Effects
Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., & Park, D. C. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1342 · Cited by 249 · see citing works
Self-citation
Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia
Schilling, T., & Eder, C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22675 · Cited by 117 · see citing works
Vision function abnormalities in Alzheimer disease
Tzekov, R., & Mullan, M. (2014) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2013.10.002 · Cited by 94 · see citing works
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Zhao, P., Xu, Y., Jiang, L.-L., Fan, X., Ku, Z., Li, L., Liu, X., Deng, M., Arase, H., Zhu, J.-J., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00550-y · Cited by 54 · see citing works
Diffusion MRI reveals amyloid plaque–associated cellular signatures through spatial transcriptomic integration
Han, X., Hu, R., Ping, X., Chen, J., Liu, J., Liu, Z., Jin, X., Gao, X., Lin, M., Zhao, Y., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71908
Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes?
Singh-Reilly, N., Sintini, I., Ali, F., Duffy, J. R., Clark, H. M., Utianski, R. L., Meade, G., Machulda, M. M., Satoh, R., Lowe, V. J., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1771092

Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS
Sumowski, J. F., Rocca, M. A., Leavitt, V. M., Dackovic, J. R., Mesaroš, Š., Drulovic, J. S., DeLuca, J., & Filippi, M. (2014) · Neurology · doi:10.1212/wnl.0000000000000433 · Cited by 203 · see citing works
Tau and amyloid biomarkers modify the degree to which cognitive reserve and brain reserve predict cognitive decline
McKenzie, C., Bucks, R. S., Weinborn, M., et al. (2022) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617722000546 · Cited by 9 · see citing works
P3‐139: Crossword puzzles delay onset of accelerated cognitive decline in preclinical dementia, contributing to cognitive reserve
Hall, C. B., Lipton, R. B., & Verghese, J. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.1114
Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis
Bettcher, B. M., Gross, A. L., Gavett, B. E., Widaman, K. F., Fletcher, E., Dowling, N. M., Buckley, R. F., Arenaza‐Urquijo, E. M., Zahodne, L. B., Hohman, T. J., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.016 · Cited by 51 · see citing works
Subjective Cognitive Decline, Cognitive Reserve Indicators, and the Incidence of Dementia
Jia, F., Li, Y., Li, M., & Cao, F. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.08.005 · Cited by 52 · see citing works

Authors: Rodrigue, K. M., Kennedy, K. M., & Park, D. C.
Affiliations: The University of Texas at Dallas (US)
Corresponding author: Park, Denise C.
ORCID: Rodrigue, Karen M.
Kennedy, Kristen M.
Park, Denise C.
Venue: Neuropsychology Review
Publisher: Springer Science and Business Media LLC
Published: 2009-11-12
Volume: 19
Issue: 4
Pages: 436-450
ISSN: 1040-7308 (ISSN-L)
1573-6660
DOI: 10.1007/s11065-009-9118-x
PMC: PMC2844114
OpenAlex: W2065971926
Cited by: 230
References: 86
Citations by year: 2026: 11 · 2025: 19 · 2024: 16 · 2023: 20 · 2022: 31 · 2021: 23 · 2020: 21 · 2019: 15 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 10 · 2013: 10 · 2012: 9
FWCI: 0.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychology Review (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (RF1AG006265, R01AG006265, R37AG006265, AG-006265-23)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords: amyloid-beta deposition, cognitive aging, amyloid imaging, Alzheimer's disease, mild cognitive impairment, healthy older adults, radioactive tracers, genetic risk, cognitive reserve, age-related cognitive decline, biomarkers
MeSH terms: Aging, Brain, Cognition Disorders, Humans, Models, Neurological, Amyloid beta-Peptides, Genetic Predisposition to Disease, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Beta‐amyloid deposition and the aging brain

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks