Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging
Open accessAbstract
OBJECTIVE: Late-life depression (LLD) has a substantial public health impact and is both a risk factor for and a prodrome of dementia. Positron emission tomography (PET) studies of cerebral glucose metabolism have demonstrated sensitivity in evaluating neural circuitry involved in depression, aging, incipient cognitive decline, and dementia. The present study evaluated the long term effects of a course of antidepressant treatment on glucose metabolism in LLD patients. METHODS: Nine LLD patients and seven non-depressed control subjects underwent clinical and cognitive evaluations as well as brain magnetic resonance imaging and PET studies of cerebral glucose metabolism at baseline, after 8 weeks of treatment with citalopram for a major depressive episode (patients only), and at an approximately 2-year follow-up. RESULTS: The majority of LLD patients were remitted at follow-up (7/9). Neither patients nor controls showed significant cognitive decline. The patients showed greater increases in glucose metabolism than the controls in regions associated with mood symptoms (anterior cingulate and insula). Both groups showed decreases in metabolism in posterior association cortices implicated in dementia. CONCLUSIONS: Longitudinal changes in cerebral glucose metabolism are observed in controls and in LLD patients without significant cognitive decline that are more extensive than the decreases in brain volume. Longer duration follow-up studies and the integration of other molecular imaging methods will have implications for understanding the clinical and neurobiological significance of these metabolic changes.
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Regional reductions in brain glucose utilization occur with aging and to a greater extent in MCI and AD.
“Regional reductions in brain glucose utilization occur with aging and to a greater extent in MCI and AD [185-193].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [186]
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- Authors
- Marano, C. M., Workman, C. I., Kramer, E., Hermann, C. R., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D., & Smith, G. S.
- Affiliations
- Johns Hopkins University (US)
- Zucker Hillside Hospital (US)
- Northwell Health (US)
- Corresponding author
- Smith, Gwenn S.
- ORCID
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2012-06-27
- Volume
- 28
- Issue
- 4
- Pages
- 417-423
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- PMC
- PMC3974580
- OpenAlex
- W1522731215
- Cited by
- 24
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 6
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH 86881, MH 01621, MH-49936, MH M01 RR 018535, R01MH064823, MH 57078, R01MH049936, MH 64823, R01MH057078, R01MH086881, K02MH001621)
- National Center for Research Resources (M01RR018535)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- geriatric depression, brain glucose metabolism, citalopram, antidepressant treatment, normal aging, cognitive decline, dementia risk, anterior cingulate cortex, insula, posterior association cortex, brain volume
- MeSH terms
- Aged, Aged, 80 and over, Aging, Cerebellum, Cognition Disorders, Major Depressive Disorder, Depressive Disorder, Major, Female, Glucose, Humans, Longitudinal Studies, Male, Citalopram, Age of Onset, Positron-Emission Tomography
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