Cited by 226Orthopaedic implants and arthroplastyBone Tissue Engineering MaterialsDental Implant Techniques and Outcomes

Biocompatibility of implants: lymphocyte/macrophage interactions

Anderson, James M., McNally, Amy K.·2011·Seminars in Immunopathology

Abstract

The monocyte-derived macrophage is recognized as a critical determinant in biocompatibility, but its appearance in the chronic inflammatory phase is accompanied by the presence of lymphocytes, which have been much less studied in this regard. Here, we first present an overview of the physiologic continuum comprising host reactions to the surgical implantation of biomaterial. Secondly, we describe our collective research efforts, which indicate that lymphocytes are additional and key cellular determinants of biocompatible outcome. Thus, bioengineering advances will require that lymphocyte responses be regarded as integral components of innate inflammatory and immune/immunotoxic cell interactions at sites of biomaterial implantation.

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Crossref · 10.1007/s00281-011-0244-1

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109 of 109 references verified0 citation errors · 0 not checkable

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  • Th2 lymphocyte derived signals such as IL-4 and IL-13 direct M2 polarization of macrophages that in turn produce chemokines such as CCL17, CCL22 and CCL24, which enhance recruitment of Th2 lymphocytes.

    “Likewise, Th2 lymphocyte derived signals such as IL-4 and IL-13 direct M2 polarization of macrophages that in turn produce chemokines such as CCL17, CCL22 and CCL24, which enhance the recruitment of Th2 lymphocytes [68].”
  • Lymphocytes are key cellular determinants of biomaterial outcomes.

    “In addition to the well-established role of macrophages in response to implanted biomaterials, emerging research suggests that lymphocytes are key cellular determinants of biomaterial outcomes [68].”
  • TH1 lymphocytes release IFN-g which polarizes cells toward an M1 phenotype, secreting pro-inflammatory cytokines and chemokines, some of which (IL-12, CXCL-10) escalate the inflammatory response by recruiting more Th1 lymphocytes.

    “TH1 lymphocytes release IFN-g which polarizes cells toward an M1 phenotype, secreting several pro-inflammatory cytokines and chemokines, some of which (IL-12, CXCL-10) escalate the inflammatory response by recruiting more Th1 lymphocytes [68,69].”

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Authors
Anderson, J. M., & McNally, A. K.
Affiliations
Case Western Reserve University (US)
Corresponding author
Anderson, James M.
Venue
Seminars in Immunopathology
Published
2011-01-27
Volume
33
Issue
3
Pages
221-233
ISSN
  • 1863-2297 (ISSN-L)
  • 1863-2300
OpenAlex
W2036077057
Cited by
226
References
109
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 17 · 2022: 16 · 2021: 19 · 2020: 34 · 2019: 18 · 2018: 14 · 2017: 13 · 2016: 18 · 2015: 22 · 2014: 13 · 2013: 10 · 2012: 14
FWCI
2.37
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Immunopathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Biomedical Imaging and Bioengineering (EB 00282)
Topics
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
Keywords
implant biocompatibility, lymphocytes, macrophages, monocyte-derived macrophages, biomaterial implantation, host immune response, chronic inflammation, immunotoxicity, innate immunity, macrophage-lymphocyte interaction
MeSH terms
Animals, Biocompatible Materials, Cell Communication, Humans, Inflammation, Lymphocytes, Macrophages, Wound Healing, Prostheses and Implants

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