Cited by 85Fatty Acid Research and HealthAdipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men

Paschos, George K., Zampelas, Antonis, Panagiotakos, Demosthenes B., Katsiougiannis, Stergios, Griffin, Bruce A., Votteas, Vasilios, Skopouli, Fotini N.·2007·European Journal of Nutrition

Abstract

Background Dietary alpha-linolenic acid (ALA) has been associated with reduced risk of development of atherosclerosis. Adiponectin is a hormone specifically secreted by adipocytes and considered to have anti-atherogenic properties.Aim of the study We examined the effect of increased dietary intake of ALA on plasma concentration of adiponectin.Methods Thirty-five non-diabetic, dyslipidemic men, 38-71 years old, were randomly allocated to take either 15 ml of flaxseed oil rich in ALA (8.1 g/day; n = 18), or 15 ml of safflower oil per day, containing the equivalent n-6 fatty acid (11.2 g/day linoleic acid, LA; n = 17) (control group). The intervention period lasted for 12 weeks.Results Plasma levels of adiponectin did not change after the increase in dietary intake of ALA in the flaxseed oil supplementation group, compared to the control group. No changes in body mass index, serum lipid concentrations, LDL density, or plasma TNF-alpha were found in the flaxseed oil versus the control group.Conclusions Dietary ALA has no effect on plasma adiponectin concentration in dyslipidemic men.

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Crossref · 10.1007/s00394-007-0668-5

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  • Cross-sectional studies of healthy subjects and haemodialysis patients showed a positive relationship between dietary advanced glycation end product intake and plasma inflammatory markers.

    “Finally, cross-sectional studies of healthy subjects and of patients undergoing haemodialysis showed a positive relationship between dietary AGE intake and plasma inflammatory markers (515,520) .”

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Authors
Paschos, G. K., Zampelas, A., Panagiotakos, D. B., Katsiougiannis, S., Griffin, B. A., Votteas, V., & Skopouli, F. N.
Affiliations
  • Harokopio University of Athens (GR)
  • Agricultural University of Athens (GR)
  • National and Kapodistrian University of Athens (GR)
  • University of Surrey (GB)
  • Laiko General Hospital of Athens (GR)
Corresponding author
Zampelas, Antonis
Venue
European Journal of Nutrition
Published
2007-07-11
Volume
46
Issue
6
Pages
315-320
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
OpenAlex
W2034137313
Cited by
85
References
28
Citations by year
2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 15 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 2 · 2013: 6 · 2012: 4
FWCI
3.41
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
linseed oil, alpha-linolenic acid, adiponectin, dyslipidemia, safflower oil, omega-6 fatty acids, linoleic acid, plasma adiponectin, dietary supplementation, atherosclerosis, TNF-α, LDL cholesterol, serum lipids
MeSH terms
Adult, Aged, Humans, Hyperlipidemias, Linseed Oil, Lipids, Male, Middle Aged, Safflower Oil, Treatment Outcome, alpha-Linolenic Acid, Dietary Supplements, Adiponectin

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