Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men
Abstract
Background Dietary alpha-linolenic acid (ALA) has been associated with reduced risk of development of atherosclerosis. Adiponectin is a hormone specifically secreted by adipocytes and considered to have anti-atherogenic properties.Aim of the study We examined the effect of increased dietary intake of ALA on plasma concentration of adiponectin.Methods Thirty-five non-diabetic, dyslipidemic men, 38-71 years old, were randomly allocated to take either 15 ml of flaxseed oil rich in ALA (8.1 g/day; n = 18), or 15 ml of safflower oil per day, containing the equivalent n-6 fatty acid (11.2 g/day linoleic acid, LA; n = 17) (control group). The intervention period lasted for 12 weeks.Results Plasma levels of adiponectin did not change after the increase in dietary intake of ALA in the flaxseed oil supplementation group, compared to the control group. No changes in body mass index, serum lipid concentrations, LDL density, or plasma TNF-alpha were found in the flaxseed oil versus the control group.Conclusions Dietary ALA has no effect on plasma adiponectin concentration in dyslipidemic men.
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Cross-sectional studies of healthy subjects and haemodialysis patients showed a positive relationship between dietary advanced glycation end product intake and plasma inflammatory markers.
“Finally, cross-sectional studies of healthy subjects and of patients undergoing haemodialysis showed a positive relationship between dietary AGE intake and plasma inflammatory markers (515,520) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [520]
Cites
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
de Lorgeril, M., Renaud, S., Salen, P., Monjaud, I., Mamelle, N., Martin, J. L., Guidollet, J., Touboul, P., & Delaye, J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92580-1 · Cited by 2,122 · see citing works
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,074 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works
Yokota, T., Oritani, K., Takahashi, I., Ishikawa, J., Matsuyama, A., Ouchi, N., Kihara, S., Funahashi, T., Tenner, A. J., Tomiyama, Y., et al. (2000) · Blood · doi:10.1182/blood.v96.5.1723 · Cited by 1,294 · see citing works
Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,221 · see citing works
Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181 · see citing works
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80467-0 · Cited by 1,169 · see citing works
Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors
Lee, C., Olson, P., & Evans, R. M. (2003) · Endocrinology · doi:10.1210/en.2003-0288 · Cited by 891 · see citing works
Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
Ascherio, A., Rimm, E. B., Giovannucci, E. L., Spiegelman, D. L., Stampfer, M. J., & Willett, W. C. (1996) · BMJ · doi:10.1136/bmj.313.7049.84 · Cited by 732 · see citing works
Arita, Y., Kihara, S., Ouchi, N., Maeda, K., Kuriyama, H., Okamoto, Y., Kumada, M., Hotta, K., Nishida, M., Takahashi, M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000018622.84402.ff · Cited by 694 · see citing works
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., & Paschke, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6307 · Cited by 655 · see citing works
Hara, K., Horikoshi, M., Yamauchi, T., Yago, H., Miyazaki, O., Ebinuma, H., Imai, Y., Nagai, R., & Kadowaki, T. (2006) · Diabetes Care · doi:10.2337/dc05-1801 · Cited by 574 · see citing works
Decreased Plasma Adiponectin Concentrations in Women with Dyslipidemia
Matsubara, M., Maruoka, S., & Katayose, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8550 · Cited by 544 · see citing works
Griffin, B. A., CASLAKE, M. J., Yip, B., Tait, G. W., Packard, C. J., & Shepherd, J. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90131-2 · Cited by 231 · see citing works
Self-citationMantzoros, C. S., Li, T., Manson, J. E., Meigs, J. B., & Hu, F. B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0372 · Cited by 224 · see citing works
Association of Adiponectin with Coronary Heart Disease and Mortality: The Rancho Bernardo Study
Laughlin, G. A., Barrett-Connor, E. L., May, S. J., & Langenberg, C. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk001 · Cited by 222 · see citing works
Hulthe, J., Hultén, L. M., & Fagerberg, B. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00313-5 · Cited by 153 · see citing works
(2005) · PubMed · Cited by 146 · see citing works
Kelley, D. S., Nelson, G. J., Love, J. E., Branch, L. B., Taylor, P. C., Schmidt, P. C., Mackey, B. E., & Iacono, J. M. (1993) · Lipids · doi:10.1007/bf02536085 · Cited by 135 · see citing works
Tsioufis, C. P., Dimitriadis, K. S., Chatzis, D., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.05.052 · Cited by 131 · see citing works
Circulating Adiponectin and Plasma Fatty Acid Profile
Fernández‐Real, J. M., Vendrell, J. J., & Ricart, W. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.041350 · Cited by 98 · see citing works
SINGER, P. A., Berger, I., Wirth, M., Gödicke, W., Jaeger, W., & Voigt, S. (1986) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(86)90125-3 · Cited by 93 · see citing works
Djoussé, L., Hunt, S. C., Arnett, D. K., Province, M. A., Eckfeldt, J. H., & Ellison, R. C. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.6.1098 · Cited by 79 · see citing works
Hashimoto, N., Kanda, J., Nakamura, T., Horie, A., Kurosawa, H., Hashimoto, T., Sato, K., Kushida, S., Suzuki, M., Yano, S., et al. (2006) · Metabolism · doi:10.1016/j.metabol.2006.08.005 · Cited by 65 · see citing works
Naturopathic medicine--a 10-year perspective (from a 35-year view).
Pizzorno, J. E. (2005) · PubMed · Cited by 49 · see citing works
Flagged first, then by citations
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Dietary sources of omega 3 fatty acids: public health risks and benefits
Tur, J. A., Bibiloni, M. M., Sureda, A., & Pons, A. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512001456 · Cited by 283 · see citing works
Meta-analysis of the effects of flaxseed interventions on blood lipids
Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O. H., & Lin, X. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27469 · Cited by 264 · see citing works
Hutchins, A. M., Brown, B. D., Cunnane, S. C., Domitrovich, S. G., Adams, E. R., & Bobowiec, C. E. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.02.012 · Cited by 166 · see citing works
Hadi, A., Askarpour, M., Salamat, S., Ghaedi, E., Symonds, M. E., & Miraghajani, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104622 · Cited by 71 · see citing works
Askarpour, M., Karimi, M., Hadi, A., Ghaedi, E., Symonds, M. E., Miraghajani, M., & Javadian, P. (2020) · Cytokine · doi:10.1016/j.cyto.2019.154922 · Cited by 54 · see citing works
Rahimlou, M., Jahromi, N. B., Hasanyani, N., & Ahmadi, A. R. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz048 · Cited by 52 · see citing works
Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00619-3 · Cited by 40 · see citing works
- Authors
- Paschos, G. K., Zampelas, A., Panagiotakos, D. B., Katsiougiannis, S., Griffin, B. A., Votteas, V., & Skopouli, F. N.
- Affiliations
- Harokopio University of Athens (GR)
- Agricultural University of Athens (GR)
- National and Kapodistrian University of Athens (GR)
- University of Surrey (GB)
- Laiko General Hospital of Athens (GR)
- Corresponding author
- Zampelas, Antonis
- Venue
- European Journal of Nutrition
- Published
- 2007-07-11
- Volume
- 46
- Issue
- 6
- Pages
- 315-320
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- OpenAlex
- W2034137313
- Cited by
- 85
- References
- 28
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 15 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- linseed oil, alpha-linolenic acid, adiponectin, dyslipidemia, safflower oil, omega-6 fatty acids, linoleic acid, plasma adiponectin, dietary supplementation, atherosclerosis, TNF-α, LDL cholesterol, serum lipids
- MeSH terms
- Adult, Aged, Humans, Hyperlipidemias, Linseed Oil, Lipids, Male, Middle Aged, Safflower Oil, Treatment Outcome, alpha-Linolenic Acid, Dietary Supplements, Adiponectin
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