Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,397 · see citing works

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works

Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes

Cannon, C. P., Braunwald, E., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040583 · Cited by 4,938 · see citing works

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,355 · see citing works

Statin-associated myopathy

Thompson, P. D., Clarkson, P., & Karas, R. H. (2003) · JAMA · doi:10.1001/jama.289.13.1681 · Cited by 1,463 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Safety of Statins: Focus on Clinical Pharmacokinetics and Drug Interactions

Bellosta, S., Paoletti, R., & Corsini, A. (2004) · Circulation · doi:10.1161/01.cir.0000131519.15067.1f · Cited by 578 · see citing works

Statin-associated myopathy with normal creatine kinase levels

Phillips, P. S., Haas, R. H., Bannykh, S., Hathaway, S., Gray, N. L., Kimura, B. J., Vladutiu, G. D., England, J. D. F., & and the Scripps Mercy Clinical Research Center* (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-7-200210010-00009 · Cited by 565 · see citing works

The Role of Coenzyme Q10 in Statin-Associated Myopathy

Marcoff, L., & Thompson, P. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.049 · Cited by 537 · see citing works

Suction applied to a muscle biopsy maximizes sample size

Evans, W. J., Phinney, S. D., & Young, V. R. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198201000-00018 · Cited by 520 · see citing works

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

Guijarro, C., Blanco‐Colio, L. M., Ortego, M., Alonso, C., Ortíz, A., Plaza, J. J. G., Dı́az-Jullien, C., Hernández, G., & Egido, J. (1998) · Circulation Research · doi:10.1161/01.res.83.5.490 · Cited by 390 · see citing works

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

WANAGAT, J., CAO, Z., PATHARE, P., & AIKEN, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0320com · Cited by 378 · see citing works

Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle

Lawler, J. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00186-2 · Cited by 370 · see citing works

Mechanisms of disuse muscle atrophy: role of oxidative stress

Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00469.2004 · Cited by 368 · see citing works

Regulation of the Permeability Transition Pore in Skeletal Muscle Mitochondria

Fontaine, E. M., Eriksson, O., Ichas, F., & Bernardi, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12662 · Cited by 347 · see citing works

Simple quantitative detection of mitochondrial superoxide production in live cells

Mukhopadhyay, P., Rajesh, M., Kashiwaya, Y., Haskó, G., & Pacher, P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.106 · Cited by 328 · see citing works

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

PAIVA, H., THELEN, K., COSTER, R., SMET, J., PAEPE, B., MATTILA, K., LAAKSO, J., LEHTIMAKI, T., VONBERGMANN, K., & LUTJOHANN, D. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.03.006 · Cited by 308 · see citing works

Toxicity of statins on rat skeletal muscle mitochondria

Kaufmann, P., Török, M., Zahno, A., Waldhauser, K. M., Brecht, K., & Krähenbühl, S. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6235-z · Cited by 263 · see citing works

Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process

Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N., & Leverve, X. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2179 · Cited by 263 · cited 1× · see citing works

Lipid‐lowering drugs and mitochondrial function: effects of HMG‐CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio

DE PINIEUX, G., CHARIOT, P., AMMI‐SAÏD, M., LOUARN, F., LEJONC, J. L., ASTIER, A., JACOTOT, B., & GHERARDI, R. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.04178.x · Cited by 262 · see citing works

Statin-induced apoptosis and skeletal myopathy

Dirks, A. J., & Jones, K. M. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00226.2006 · Cited by 240 · see citing works

Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways

Antonsson, B. E. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009865.70898.36 · Cited by 232 · see citing works

Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems

Sinzinger, H. F., & O’Grady, J. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2003.02044.x · Cited by 223 · see citing works

Oxidative stress and the mitochondrial theory of aging in human skeletal muscle

Parise, G., Jan, K. J., Douglas, M. J., Phillips, S. M., & Tarnopolsky, M. A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.002 · Cited by 223 · see citing works

Statin-Induced Muscle Necrosis in the Rat: Distribution, Development, and Fibre Selectivity

Westwood, F. R., Bigley, A. L., Randall, K., Marsden, A. M., & Scott, R. C. (2005) · Toxicologic Pathology · doi:10.1080/01926230590908213 · Cited by 212 · see citing works

Lipid-Lowering Drugs and Risk of Myopathy: A Population-Based Follow-Up Study

Gaist, D., Rodríguez, L. A. G., Huerta, C., Hallas, J., & Sindrup, S. H. (2001) · Epidemiology · doi:10.1097/00001648-200109000-00017 · Cited by 210 · see citing works

Meta-analysis of drug-induced adverse events associated with intensive-dose statin therapy

Silva, M. J., Matthews, M. L., Jarvis, C. I., Nolan, N. M., Belliveau, P., Malloy, M., & Gandhi, P. J. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.02.008 · Cited by 207 · see citing works

Statins: a new insight into their mechanisms of action and consequent pleiotropic effects.

Jasińska-Stroschein, M., Owczarek, J., & Orszulak–Michalak, D. (2007) · PubMed · Cited by 192 · see citing works

New insights into mechanisms of statin-associated myotoxicity

Sirvent, P., Mercier, J. G., & Lacampagne, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.010 · Cited by 190 · see citing works

Lovastatin increases exercise-induced skeletal muscle injury

Thompson, P. D., Zmuda, J. M., Domalik, L. J., Zimet, R., Staggers, J. E., & Guyton, J. R. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90218-3 · Cited by 177 · see citing works

Simvastatin triggers mitochondria-induced Ca2+ signaling alteration in skeletal muscle

Sirvent, P., Mercier, J., Vassort, G., & Lacampagne, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.070 · Cited by 154 · see citing works

Response of the ubiquitin-proteasome pathway to changes in muscle activity

Reid, M. B. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00545.2004 · Cited by 154 · see citing works

Rhabdomyolysis with HMG‐CoA reductase inhibitors and gemfibrozil combination therapy

Chang, J. T., Staffa, J. A., Parks, M. A., & Green, L. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.977 · Cited by 152 · see citing works

Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinone

Johnson, T. E. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.04.010 · Cited by 146 · see citing works

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice

Yokota, T., Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobirin, M. A., Ono, T., Suga, T., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00267.2009 · Cited by 139 · see citing works

Apoptotic signaling induced by H2O2-mediated oxidative stress in differentiated C2C12 myotubes

Siu, P. M., Wang, Y., & Alway, S. E. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.01.014 · Cited by 131 · see citing works

Differential metabolic effects of distinct statins

Koh, K. K., Sakuma, I., & Quon, M. J. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.10.036 · Cited by 130 · see citing works

Simvastatin induces impairment in skeletal muscle while heart is protected

Sirvent, P., Bordenave, S., Vermaelen, M., Roels, B., Vassort, G., Mercier, J., Raynaud, E., & Lacampagne, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.108 · Cited by 116 · see citing works

Molecular basis of statin-associated myopathy

Vaklavas, C., Chatzizisis, Y. S., Ziakas, A., Zamboulis, C., & Giannoglou, G. D. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.021 · Cited by 114 · see citing works

Delineation of Myotoxicity Induced by 3-Hydroxy-3-methylglutaryl CoA Reductase Inhibitors in Human Skeletal Muscle Cells

Sacher, J., Weigl, L. G., Werner, M., Szegedi, C., & HOHENEGGER, M. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.086462 · Cited by 103 · see citing works

Myotoxicity associated with lipid-lowering drugs

Baer, A. N., & Wortmann, R. L. (2006) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328010c559 · Cited by 93 · see citing works

Statin myopathy: Incidence, risk factors, and pathophysiology

Sewright, K. A., Clarkson, P. M., & Thompson, P. D. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0050-3 · Cited by 90 · see citing works

Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes

Odagiri, K., Katoh, H., Kawashima, H., Tanaka, T. L., Ohtani, H., Saotome, M., Urushida, T., Satoh, H., & Hayashi, H. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.12.022 · Cited by 83 · see citing works

Statins induce calcium-dependent mitochondrial permeability transition

Velho, J. A., Okanobo, H., Degasperi, G. R., Matsumoto, M. Y., Alberici, L. C., Cosso, R. G., Oliveira, H. C. F., & Vercesi, A. E. (2005) · Toxicology · doi:10.1016/j.tox.2005.11.007 · Cited by 77 · see citing works

Effects of ubiquinone (coenzyme Q10) on myopathy in statin users

Schaars, C. F., & Stalenhoef, A. F. H. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283168ecd · Cited by 74 · see citing works

Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study

Pierno, S., Didonna, M. P., Cippone, V., Luca, A. D., Pisoni, M., Frigeri, A., Nicchia, G. P., Svelto, M., Chiesa, G., Sirtori, C. R., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706917 · Cited by 65 · see citing works

Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro

Demyanets, S., Kaun, C., Pfaffenberger, S., Hohensinner, P. J., Rega‐Kaun, G., Pammer, J., Maurer, G., Huber, K., & Wojta, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.01.016 · Cited by 57 · see citing works

Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle

van Vliet, A. K., Nègre‐Aminou, P., van Thiel, G. C. F., Bolhuis, P. A., & Cohen, L. (1996) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00467-4 · Cited by 38 · see citing works

Preventive effects of bicarbonate on cerivastatin-induced apoptosis

Kobayashi, M., Kaido, F., Kagawa, T., Itagaki, S., Hirano, T., & Iseki, K. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.04.010 · Cited by 26 · see citing works

Statins Effect on Smooth Muscle Cell Proliferation

Bellosta, S., Arnaboldi, L., Gerosa, L., Canavesi, M., Parente, R., Baetta, R., Paoletti, R., & Corsini, A. (2004) · Seminars in Vascular Medicine · doi:10.1055/s-2004-869591 · Cited by 25 · see citing works

Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells

Veerkamp, J. H., Smit, J. W. A., Benders, A. A. G. M., & Oosterhof, A. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00122-0 · Cited by 19 · see citing works

Serum from hypercholesterolemic patients treated with atorvastatin or simvastatin inhibits cultured human smooth muscle cell proliferation

Arnaboldi, L., Guzzetta, M., Pazzucconi, F., Radaelli, G., Paoletti, R., Sirtori, C. R., & Corsini, A. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.012 · Cited by 7 · see citing works

Position paper Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach, M., Rizzo, M., Toth, P. P., Farnier, M., Davidson, M. H., Al‐Rasadi, K., Aronow, W. S., Athyros, V. G., Djuric, D. M., Владиславович, Е. М., et al. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.49807 · Cited by 381 · see citing works

Effects of statins on mitochondrial pathways

Mollazadeh, H., Tavana, E., Fanni, G., Bo, S., Banach, M., Pirro, M., von Haehling, S., Jamialahmadi, T., & Sahebkar, A. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12654 · Cited by 259 · see citing works

Simvastatin Impairs Exercise Training Adaptations

Mikus, C. R., Boyle, L. J., Borengasser, S. J., Oberlin, D. J., Naples, S. P., Fletcher, J. A., Meers, G. M.-E., Ruebel, M. L., Laughlin, M. H., Dellsperger, K. C., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.074 · Cited by 244 · see citing works

High-Resolution Respirometry for Simultaneous Measurement of Oxygen and Hydrogen Peroxide Fluxes in Permeabilized Cells, Tissue Homogenate and Isolated Mitochondria

Makrecka‐Kuka, M., Krumschnabel, G., & Gnaiger, E. (2015) · Biomolecules · doi:10.3390/biom5031319 · Cited by 237 · see citing works

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components

Turner, R. M., & Pirmohamed, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010022 · Cited by 201 · see citing works

Mitophagy Is Required for Acute Cardioprotection by Simvastatin

Andres, A. M., Hernandez, G., Lee, P., Huang, C., Ratliff, E. P., Sin, J., Thornton, C. A., Damasco, M. V., & Gottlieb, R. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5416 · Cited by 189 · see citing works

Statins: Adverse reactions, oxidative stress and metabolic interactions

Liu, A., Wu, Q., Guo, J., Arés, I., Rodríguez, J.-L., Martínez‐Larrañaga, M., Yuan, Z., Anadón, A., Wang, X., & Martínez, M. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.10.004 · Cited by 168 · see citing works

Simvastatin Effects on Skeletal Muscle

Larsen, S., Stride, N., Hey-Mogensen, M., Hansen, C. N., Bang, L. E., Bundgaard, H., Nielsen, L. B., Helge, J. W., & Dela, F. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.036 · Cited by 165 · see citing works

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel: This paper is also published in parallel in Archives of Medical Science [Banach M, Rizzo M, Toth PP, et al. Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Arch Med Sci 2015; 11(1): 1–23]

Banach, M., Rizzo, M., Toth, P. P., Farnier, M., Davidson, M. H., Al-Rasadi, K., Aronow, W. S., Athyros, V., Djuric, D. M., Ezhov, M. V., et al. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1039980 · Cited by 162 · see citing works

Myotoxicity of statins: Mechanism of action

du Souich, P., Roederer, G. O., & Dufour, R. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.029 · Cited by 162 · see citing works

Mechanisms of statin-associated skeletal muscle-associated symptoms

Bouitbir, J., Sanvee, G. M., Panajatovic, M. V., Singh, F., & Krähenbühl, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.010 · Cited by 146 · see citing works

The role of mitochondria in statin‐induced myopathy

Apostolopoulou, M., Corsini, A., & Roden, M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12461 · Cited by 142 · see citing works

Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo

Gouni‐Berthold, I., Berthold, H. K., Huh, J. Y., Berman, R., Spenrath, N., Krone, W., & Mantzoros, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072858 · Cited by 133 · see citing works

Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans

Merritt, E. K., Stec, M. J., Thalacker-Mercer, A., Windham, S. T., Cross, J. M., Shelley, D. P., Craig Tuggle, S., Kosek, D. J., Kim, J.-S., & Bamman, M. M. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00019.2013 · Cited by 127 · see citing works

Microchannel Acoustophoresis does not Impact Survival or Function of Microglia, Leukocytes or Tumor Cells

Burguillos, M. Á., Magnusson, C., Antfolk, M., Lenshof, A., Augustsson, P., Hansson, M. J., Elmér, E., Lilja, H. G., Brundin, P., Laurell, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064233 · Cited by 122 · see citing works

Mechanisms and assessment of statin‐related muscular adverse effects

Moßhammer, D., Schaeffeler, E., Schwab, M. G., & Mörike, K. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12360 · Cited by 110 · see citing works

The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity

Bonifacio, A., Sanvee, G. M., Bouitbir, J., & Krähenbühl, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.04.010 · Cited by 93 · see citing works

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

Bouitbir, J., Singh, F., Charles, A., Schlagowski, A.-I., Bonifacio, A., Echaniz‐Laguna, A., Gény, B., Krähenbühl, S., & Zoll, J. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6190 · Cited by 95 · see citing works

Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins

Sirvent, P., Fabre, O., Bordenave, S., Hillaire-Buys, D., Raynaud De Mauverger, E., Lacampagne, A., & Mercier, J. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.008 · Cited by 90 · see citing works

Statins, Bcl-2, and Apoptosis: Cell Death or Cell Protection?

Wood, W. G., Igbavboa, U., Muller, W. E., & Eckert, G. P. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8496-5 · Cited by 89 · see citing works

Statin-associated myopathy and the quest for biomarkers: can we effectively predict statin-associated muscle symptoms?

Muntean, D. M., Thompson, P. D., Catapano, A. L., Stasiolek, M., Fabis, J., Muntner, P., Serban, M.-C., & Banach, M. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.001 · Cited by 82 · see citing works

Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans

Fisher-Wellman, K. H., Weber, T. M., Cathey, B. L., Brophy, P. M., Gilliam, L. A. A., Kane, C. L., Maples, J. M., Gavin, T. P., Houmard, J. A., & Neufer, P. D. (2014) · Diabetes · doi:10.2337/db13-0940 · Cited by 82 · see citing works

Cu@SnS/SnO2 nanoparticles as novel sorbent for dispersive micro solid phase extraction of atorvastatin in human plasma and urine samples by high-performance liquid chromatography with UV detection: Application of central composite design (CCD)

Dastkhoon, M., Ghaedi, M., Asfaram, A., Arabi, M., Ostovan, A., & Goudarzi, A. (2016) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2016.10.030 · Cited by 79 · see citing works

Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress

Urbano, F., Bugliani, M., Filippello, A., Scamporrino, A., Mauro, S. D., Pino, A. D., Scicali, R., Noto, D., Rabuazzo, A. M., Averna, M. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11070-x · Cited by 78 · see citing works

Risk of diabetes in patients treated with HMG-CoA reductase inhibitors

Cho, Y., Choe, E.-Y., Lee, Y., Seo, J. W., Choi, Y., Yun, Y., Wang, H. J., Ahn, C. W., Soo, B., Lee, H. C., et al. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.008 · Cited by 73 · see citing works

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Bonifacio, A., Mullen, P. J., Mityko, I. S., Navegantes, L. C. C., Bouitbir, J., & Krähenbühl, S. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1378-4 · Cited by 61 · see citing works

Modulation of Coenzyme Q10 Content and Oxidative Status in Human Dermal Fibroblasts Using HMG-CoA Reductase Inhibitor over a Broad Range of Concentrations. From Mitohormesis to Mitochondrial Dysfunction and Accelerated Aging

Marcheggiani, F., Cirilli, I., Orlando, P., Silvestri, S., Vogelsang, A., Knott, A., Blatt, T., Weise, J. M., & Tiano, L. (2019) · Aging · doi:10.18632/aging.101926 · Cited by 53 · see citing works

Biochemistry of Statins

Egom, E. E. A., & Hafeez, H. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.10.005 · Cited by 54 · see citing works

Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes

Li, W., Liang, X., Zeng, Z., Yu, K., Zhan, S., Su, Q., Yan, Y., Mansai, H., Qiao, W., Yang, Q., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.029 · Cited by 50 · see citing works

Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation

Guardia, P. G. L., Alberici, L. C., Ravagnani, F. G., Catharino, R. R., & Vercesi, A. E. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00103 · Cited by 46 · see citing works

Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition

Emami, A., Shojaei, S., Rosa, S. C. D. S., Aghaei, M., Samiei, E., Vosoughi, A. R., Kalantari, F., Kawalec, P., Thliveris, J. A., Sharma, P. K., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172616 · Cited by 42 · see citing works

Do Statins Cause Diabetes?

Goldstein, M. R., & Mascitelli, L. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0368-x · Cited by 41 · see citing works

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin‐mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

Mallinson, J. E., Constantin‐Teodosiu, D., Glaves, P. D., Martin, E. A., Davies, W. J., Westwood, F. R., Sidaway, J. E., & Greenhaff, P. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238022 · Cited by 40 · see citing works

Skeletal muscle metabolic adaptations to endurance exercise training are attainable in mice with simvastatin treatment

Southern, W. M., Nichenko, A. S., Shill, D. D., Spencer, C. C., Jenkins, N. T., McCully, K. K., & Call, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172551 · Cited by 39 · see citing works

Neuropsychological and physiological correlates of fatigue following traumatic brain injury

Zgaljardic, D. J., Durham, W. J., Mossberg, K. A., Foreman, J., Joshipura, K. D., Masel, B. E., Urban, R. J., & Sheffield‐Moore, M. (2014) · Brain Injury · doi:10.3109/02699052.2014.884242 · Cited by 38 · see citing works

Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet

Jiménez-Santos, M. A., Juárez‐Rojop, I. E., Tovilla‐Zárate, C. A., Espinosa-García, M. T., Juárez-Oropeza, M. A., Ramón-Frías, T., Bermudez‐Ocaña, D. Y., & Díaz-Zagoya, J. C. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-22 · Cited by 37 · see citing works

Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin

Costa, R. A. P. E., Fernandes, M. P., de Souza-Pinto, N. C., & Vercesi, A. E. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.001 · Cited by 35 · see citing works

Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q10

Busanello, E. N. B., Marques, A. C. S., Lander, N. M., de Oliveira, D. N., Catharino, R. R., Oliveira, H. C. F., & Vercesi, A. E. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00185 · Cited by 34 · see citing works

The Impact of Exercise on Statin-Associated Skeletal Muscle Myopathy

Chung, H. R., Vakil, M., Munroe, M., Parikh, A., Meador, B. M., Wu, P. T., Jeong, J., Woods, J. A., Wilund, K. R., & Boppart, M. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168065 · Cited by 33 · see citing works

Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study

Barrat, E., Zaïr, Y., Sirvent, P., Chauveau, P., Maudet, C., Housez, B., Derbord, E., Lescuyer, J.-F., Bard, J.-M., Cazaubiel, M., et al. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0486-2 · Cited by 31 · see citing works

The Influence of Statins on the Aerobic Metabolism of Endothelial Cells

Broniarek, I., Dominiak, K., Gałgański, Ł., & Jarmuszkiewicz, W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041485 · Cited by 29 · see citing works

Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells

Huang, X., Liang, N. N., Fuming, Z., Lin, W., & Ma, W. (2024) · Antioxidants · doi:10.3390/antiox13060679 · Cited by 31 · see citing works

Simvastatin Inhibits Glucose Metabolism and Legumain Activity in Human Myotubes

Smith, R. L., Solberg, R., Jacobsen, L. L., Voreland, A. L., Rustan, A. C., Thoresen, G. H., & Johansen, H. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085721 · Cited by 29 · see citing works

Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan

Miller, B. F., & Thyfault, J. P. (2020) · Physiology · doi:10.1152/physiol.00013.2020 · Cited by 29 · see citing works

Geranylgeraniol Prevents Statin‐Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy

Jaśkiewicz, A., Pająk, B., Litwiniuk, A., Urbańska, K., & Orzechowski, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6463807 · Cited by 28 · see citing works

Use of antidepressants and statins and short-term risk of new-onset diabetes among high risk adults

Bhattacharya, R., Ajmera, M., Bhattacharjee, S., & Sambamoorthi, U. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.016 · Cited by 27 · see citing works

High-dose atorvastatin therapy progressively decreases skeletal muscle mitochondrial respiratory capacity in humans

RYAN, T. E., Torres, M. J., Lin, C., Clark, A. H., Brophy, P. M., Smith, C. A. S., Smith, C. D., Morris, E. M., Thyfault, J. P., & Neufer, P. D. (2024) · JCI Insight · doi:10.1172/jci.insight.174125 · Cited by 26 · see citing works

Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape

Ren, L., Xuan, L., Han, F., Zhang, J., Gong, L., Lv, Y., Zhang, W., Yang, S. T., Xu, B., Yan, Y., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115076 · Cited by 25 · see citing works

PGC-1β modulates statin-associated myotoxicity in mice

Singh, F., Zoll, J., Duthaler, U., Charles, A., Panajatovic, M. V., LAVERNY, G., McWilliams, T. G., METZGER, D., Gény, B., Krähenbühl, S., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2369-7 · Cited by 23 · see citing works

Statin therapy, myopathy and exercise--a case report

Semple, S. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-40 · Cited by 22 · see citing works

The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study

Asping, M., Stride, N. O., Søgaard, D., Dohlmann, T. L., Helge, J. W., Dela, F., & Larsen, S. (2017) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-017-2224-4 · Cited by 22 · see citing works

Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes

Kwak, H., Woodlief, T., Green, T. D., Cox, J. H., Hickner, R. C., Neufer, P. D., & Cortright, R. N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071157 · Cited by 22 · see citing works

Skeletal muscle ultrastructure and function in statin-tolerant individuals

Rengo, J. L., Callahan, D. M., Savage, P. D., Ades, P. A., & Toth, M. J. (2015) · Muscle & Nerve · doi:10.1002/mus.24722 · Cited by 21 · see citing works

Statin therapy is associated with the development of new-onset diabetes after transplantation in liver recipients with high fasting plasma glucose levels

Cho, Y., Lee, M. J., Choe, E. Y., Jung, C. H., Joo, D. J., Kim, M. S., Soo, B., Park, J., & Kang, E. S. (2014) · Liver Transplantation · doi:10.1002/lt.23831 · Cited by 20 · see citing works

The Role of Mitochondria in Statin-Induced Myopathy

Bell, G. M., Thoma, A., Hargreaves, I. P., & Lightfoot, A. P. (2024) · Drug Safety · doi:10.1007/s40264-024-01413-9 · Cited by 21 · see citing works

Involvement of Monocarboxylate Transporter 4 Expression in Statin-Induced Cytotoxicity

Kikutani, Y., Kobayashi, M., Konishi, T., Sasaki, S., Narumi, K., Furugen, A., Takahashi, N., & Iseki, K. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.01.014 · Cited by 19 · see citing works

Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement

Zheng, P., Zhang, Q., Ma, W., Hu, R., Gu, Y., Bian, Z., Yang, D., Chen, X., & Wu, H. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176085 · Cited by 18 · see citing works

Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice

Marques, A. C. S., Busanello, E. N. B., de Oliveira, D. N., Catharino, R. R., Oliveira, H. C. F., & Vercesi, A. E. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00685 · Cited by 18 · see citing works

PGC‐1α plays a pivotal role in simvastatin‐induced exercise impairment in mice

Panajatovic, M. V., Singh, F., Roos, N. J., Duthaler, U., Handschin, C., Krähenbühl, S., & Bouitbir, J. (2019) · Acta Physiologica · doi:10.1111/apha.13402 · Cited by 17 · see citing works

Statin-induced Myopathy in Skeletal Muscle: the Role of Exercise

Kwak, H. (2014) · Journal of Lifestyle Medicine · doi:10.15280/jlm.2014.4.2.71 · Cited by 16 · see citing works

In Vivo Pravastatin Treatment Reverses Hypercholesterolemia Induced Mitochondria-Associated Membranes Contact Sites, Foam Cell Formation, and Phagocytosis in Macrophages

Assis, L. H. D. P., Dorighello, G. G., Rentz, T., de Souza, J. C., Vercesi, A. E., & Oliveira, H. C. F. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.839428 · Cited by 15 · see citing works

A short-term statin treatment changes the contractile properties of fast-twitch skeletal muscles

Boulanger‐Piette, A., Dufresne, S. S., & Frenette, J. (2016) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-016-1306-2 · Cited by 15 · see citing works

Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells

Sanvee, G. M., Bouitbir, J., & Krähenbühl, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-43938-5 · Cited by 15 · see citing works

Cytostatic Effect of Repeated Exposure to Simvastatin: A Mechanism for Chronic Myotoxicity Revealed by the Use of Mesodermal Progenitors Derived from Human Pluripotent Stem Cells

Peric, D., Barragán, I., Giraud-Triboult, K., Egesipe, A.-L., Meyniel‐Schicklin, L., Cousin, C., Lotteau, V., Petit, V., Touhami, J., Battini, J., et al. (2015) · Stem Cells · doi:10.1002/stem.2107 · Cited by 14 · see citing works

Diverse Action of Selected Statins on Skeletal Muscle Cells—An Attempt to Explain the Protective Effect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM)

Jaśkiewicz, A., Pająk, B., Łabieniec-Watała, M., Palma, C. D., & Orzechowski, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050694 · Cited by 13 · see citing works

Red yeast rice induces less muscle fatigue symptom than simvastatin in dyslipidemic patients: a single center randomized pilot trial

Xue, Y., Tao, L., Wu, S., Wang, G., Lu, Q., Li, J., Liao, L., Tang, J.-F., & Ji, K. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0560-z · Cited by 12 · see citing works

Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studies

Irwin, J. C., Fenning, A. S., Ryan, K., & Vella, R. K. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.040 · Cited by 12 · see citing works

Simvastatin profoundly impairs energy metabolism in primary human muscle cells

Mäkinen, S., Datta, N., Nguyen, Y. H., Kyrylenko, P., Laakso, M., & Koistinen, H. A. (2020) · Endocrine Connections · doi:10.1530/ec-20-0444 · Cited by 12 · see citing works

Modulation of Phospholipid Bilayer Properties by Simvastatin

Teo, R. D., & Tieleman, D. P. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c03359 · Cited by 12 · see citing works

Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis

Dayel, F. F. B., Alfirevic, A., & Chadwick, A. E. (2023) · Biomedicines · doi:10.3390/biomedicines11051485 · Cited by 11 · see citing works

Alleviation of Simvastatin-Induced Myopathy in Rats by the Standardized Extract of Ginkgo Biloba (EGb761): Insights into the Mechanisms of Action

Mahmoud, A. R., Kamel, E. O., Ahmed, M. A., Ahmed, E. A., & Abd‐Elhamid, T. H. (2019) · Cells Tissues Organs · doi:10.1159/000507048 · Cited by 11 · see citing works

Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats

Ghalwash, M., Elmasry, A., & El-Adeeb, N. (2018) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2017-0156 · Cited by 10 · see citing works

Diabetogenic effect of pravastatin is associated with insulin resistance and myotoxicity in hypercholesterolemic mice

Lorza‐Gil, E., García‐Arévalo, M., Favero‐Santos, B. C., Gomes‐Marcondes, M. C. C., & Oliveira, H. C. F. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2045-6 · Cited by 9 · see citing works

Cholesterol Management in Neurology: Time for Revised Strategies?

Andronie-Cioară, F. L., Jurcău, A., Jurcău, M. C., Nistor-Cseppento, C. D., & Simion, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12121981 · Cited by 9 · see citing works

Oxidative Stress-Induced Adverse Effects of Three Statins Following Single or Repetitive Treatments in Mice

Al-Shalchi, R. F., & MOHAMMAD, F. K. (2024) · Cureus · doi:10.7759/cureus.51433 · Cited by 7 · see citing works

Simvastatin Impairs the Inflammatory and Repair Phases of the Postinjury Skeletal Muscle Regeneration

Otrocka‐Domagała, I., Paździor‐Czapula, K., & Maślanka, T. (2018) · BioMed Research International · doi:10.1155/2018/7617312 · Cited by 7 · see citing works

Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury

Wei, J., Huan, Y., Heng, Z., Zhao, C., Jia, L., Yu, Y., & Gao, Y. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2021.104477 · Cited by 7 · see citing works

l-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats

Murad, H. A. S. (2016) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1500065 · Cited by 6 · see citing works

Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization?

d’Hose, D., Mignion, L., Hamelin, L., Sonveaux, P., Jordan, B. F., & Gallez, B. (2022) · Biomolecules · doi:10.3390/biom12101418 · Cited by 6 · see citing works

Effect of Statins on Superoxide Dismutase Level: A Systematic Review

Daliri, M., Simental‐Mendía, L. E., Jamialahmadi, T., Kesharwani, P., Reiner, Ž., & Sahebkar, A. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230831145809 · Cited by 6 · see citing works

Metabolic Syndrome and Chronic Simvastatin Therapy Enhanced Human Cardiomyocyte Stress before and after Ischemia- Reperfusion in Cardio-Pulmonary Bypass Patients

Corsetti, G., Pasini, E., Ferrari-Vivaldi, M., Romano, C., Bonomini, F., Tasca, G., Dioguardi, F. S., Rezzani, R., & Assanelli, D. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500423 · Cited by 6 · see citing works

Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of Rats

Seo, D. Y., Heo, J., No, M., Yoo, S.-Z., Ko, J. R., Park, D., Kang, J., Kim, C., Jung, S., Han, J., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072292 · Cited by 6 · see citing works

Statins, toxicity, and their adverse effects via oxidative imbalance

Anadón, A., Arés, I., Martínez-Larrañaga, M. R., & Martínez, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819092-0.00026-1 · Cited by 5 · see citing works

Effect of statins on mitochondrial function and contractile force in human skeletal and cardiac muscle

Somers, T., Siddiqi, S., Janssen, M. C. M., Morshuis, W. J., Maas, R. G. C., Buikema, J. W., van den Broek, P. H. H., Schirris, T. J. J., & Rüssel, F. G. M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117492 · Cited by 5 · see citing works

The Ca 2+ /CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs’ side effect

Jianfei, L., Wang, M., Ma, C.-L., Chen, B., Zhang, J., & Wang, B. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.10.005 · Cited by 5 · see citing works

Is sarcopenia an associated factor of increased administration of specific medications in patients with heart failure? A systematic review and meta-analysis

Saied, S., Prokopidis, K., Adenaya, A., Isanejad, M., & Sankaranarayanan, R. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1293537 · Cited by 4 · see citing works

Interaction of atorvastatin with the human glial transporter SLC16A1.

Sasaki, S., Futagi, Y., Ideno, M., Kobayashi, M., Narumi, K., Furugen, A., & Iseki, K. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.06.033 · Cited by 6 · see citing works

Assessment of bee venom therapy in animal model of statin-induced myopathy

Kader, A. A., Azmy, R. M., Maher, E. A., Sayed, B. B. E., Khalil, A. S., Ghalwash, M., & Mahmoud, M. M. (2019) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-019-0120-9 · Cited by 4 · see citing works

Mitochondrial Oxidative Stress and Calcium-Dependent Permeability Transition are Key Players in the Mechanisms of Statins-Associated Side Effects

Busanello, E. N. B., Marques, A. C. S., Lorza‐Gil, E., Oliveira, H. C. F., & Vercesi, A. E. (2018) · InTech eBooks · doi:10.5772/intechopen.71610 · Cited by 3 · see citing works

Statins Stimulate Hepatic Glucose Production via the miR-183/96/182 ClusterPreprint

Marquart, T. J., Allen, R. M., Chen, M. R., Dorn, G. W., Matkovich, S. J., & Baldán, Á. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/726695 · Cited by 3 · see citing works

In Vitro Oxidative Stress And Anticholinesterase Effects of Atorvastatin, Simvastatin, And Rosuvastatin in the Mouse Brain

Al-Shalchi, R. F., & MOHAMMAD, F. K. (2024) · Applied In Vitro Toxicology · doi:10.1089/aivt.2024.0032 · Cited by 2 · see citing works

Chronic Hepatitis B: A Critical Discussion

Long, J., Wang, M., Chen, B., Zhang, J., & Wang, B. (2017) · Future Virology · doi:10.2217/fvl-2016-0094 · Cited by 2 · see citing works

Erkek Rat Testislerinde Busulfan Kaynaklı Hasara Karşı Vitamin E, Melatonin, L-karnitin ve Atorvastatin’in Koruyucu Etkisi: Gen Ekspresyonunun Değerlendirilmesi

Salehinezhad, F., Eshraghi, H., Kadivar, A., Shirian, S., Asghari, A., Aali, E., & Davoodian, N. (2019) · Kafkas Universitesi Veteriner Fakultesi Dergisi · doi:10.9775/kvfd.2019.21726 · Cited by 1 · see citing works

The effect of simvastatin induced neurotoxicity on mitochondrial function in human neuronal cells

Millichap, L. E., Turton, N., Alomosh, R., Heaton, R. A., Bateman, A., Al‐Shanti, N., Lightfoot, A. P., Damiani, E., Marcheggiani, F., Orlando, P., et al. (2025) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2025.2471807 · Cited by 1 · see citing works

Investigating the combined effects of statins and exercise on skeletal muscle mitochondrial content and function, cardiorespiratory fitness and quality of life in individuals with dyslipidaemia: protocol for a randomised placebo-controlled trial

Sjúrðarson, T., Larsen, S., Jensen, S. B. K., Bejder, J., Rasmussen, J., Borg, S. Á., Kristiansen, J., Meinhardsson, J. M., Olsen, H. W., Ellingsgaard, H., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-101425 · Cited by 1 · see citing works

Importance of Plasma Membrane Nanodomains in Skeletal Muscle Regeneration

Pająk, B., & Orzechowski, A. (2015) · InTech eBooks · doi:10.5772/60615

The Impact of Physical Activity on Statin-Associated Skeletal Muscle Myopathy

Chung, H. R., Wu, P.-T., Fitschen, P. J., Kistler, B. M., Park, H. W., Jeong, J. H., Wilund, K. R., Woods, J., & Boppart, M. D. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000477291.98365.c0

impair regenerative capacity in aging humans Heightened muscle inflammation susceptibility may

Kim, J., Bamman, M. M., Cross, J. M., Shelley, D., Tuggle, S. C., Kosek, D. J., Merritt, E. K., Stec, M. J., Thalacker‐Mercer, A. E., Williams, J. Y., et al. (2015)

Regulation of legumain in human cells

Smith, R. L. (2014) · NORA - Norwegian Open Research Archives

Er cysteinproteaser involvert i statinindusert myotoksisitet

Voreland, A. L. (2013) · NORA - Norwegian Open Research Archives

Simvastatin Increases Mitochondrial Oxidative Stress and Reduces Mitochondrial Ca2+ Retention Capacity in Human Skeletal Myotubes

Kwak, H., Lin, C., Kane, D. A., Lee, N.-S., Boyle, K. E., Houmard, J. A., Cortright, R. N., & Neufer, P. D. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389360.98999.bc

Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation

Guardia, P. G. L., Alberici, L. C., Ravagnani, F. G., Catharino, R. R., & Vercesi, A. E. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00103 · Cited by 46 · see citing works

Myotoxic effects of statins in primary human muscle cells (P2.011)

Grunwald, S. A., Popp, O., Jedraszczak, N., Patone, G., Dittmar, G. A. G., & Spuler, S. (2015) · Neurology · doi:10.1212/wnl.84.14_supplement.p2.011

Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy

Mikashinovich, Z. I., Belousova, E. S., & Sarkisyan, O. G. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3633-1 · Cited by 16 · see citing works

Skeletal muscle toxicity and statins : role of mitochondrial adaptations

Singh, F. (2016) · theses.fr (ABES) · doi:10.70675/362675f3z0a19z46f5z977az009dcec8ed40