Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works

Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · cited 1× · see citing works

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L. C., Jouanny, P., Dubois, B., Eisner, L., Flitman, S., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000073623.84147.a8 · Cited by 1,356 · see citing works

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup

Sperling, R. A., Jack, C. R., Black, S. E., Frosch, M. P., Greenberg, S. M., Hyman, B. T., Scheltens, P., Carrillo, M. C., Thies, W., Bednar, M. M., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2351 · Cited by 857 · see citing works

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

Holtzman, D. M., Herz, J., & Bu, G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006312 · Cited by 782 · see citing works

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

Salloway, S., Sperling, R., Gilman, S., Fox, N. C., Blennow, K., Raskind, M., Sabbagh, M., Honig, L. S., Doody, R., van Dyck, C. H., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c67808 · Cited by 753 · see citing works

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

Rinne, J. O., Brooks, D. J., Rossor, M. N., Fox, N. C., Bullock, R., Klunk, W. E., Mathis, C. A., Blennow, K., Barakos, J., Okello, A. A., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70043-0 · Cited by 701 · see citing works

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

Sperling, R., Salloway, S., Brooks, D. J., Tampieri, D., Barakos, J., Fox, N. C., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70015-7 · Cited by 512 · see citing works

Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M. (2002) · Science · doi:10.1126/science.1078259 · Cited by 511 · see citing works

Lymphatic drainage of the brain and the pathophysiology of neurological disease

Weller, R. O., Djuanda, E., Yow, H.-Y., & Carare, R. O. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0457-0 · Cited by 488 · see citing works

Clinical manifestations of cerebral amyloid angiopathy–related inflammation

Eng, J. A., Frosch, M. P., Choi, K., Rebeck, G. W., & Greenberg, S. M. (2004) · Annals of Neurology · doi:10.1002/ana.10810 · Cited by 417 · see citing works

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

Calhoun, M. E., Burgermeister, P., Phinney, A. L., Stalder, M., Tolnay, M., Wiederhold, K.-H., Abramowski, D., Sturchler-Pierrat, C., Sommer, B., Staufenbiel, M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14088 · Cited by 410 · see citing works

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage.

Wilcock, D. M., Rojiani, A. M., Rosenthal, A., Subbarao, S., Freeman, M. J., Gordon, M. N., & Morgan, D. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-24 · Cited by 388 · see citing works

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ‐Degrading Enzymes in Alzheimer's Disease

Miners, J. S., Baig, S., Palmer, J. C., Palmer, L. E., Kehoe, P. G., & Love, S. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00132.x · Cited by 380 · see citing works

A -related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy

Scolding, N. J. (2005) · Brain · doi:10.1093/brain/awh379 · Cited by 372 · see citing works

Review: sporadic cerebral amyloid angiopathy

Attems, J., Jellinger, K., Thal, D. R., & Van Nostrand, W. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01137.x · Cited by 371 · see citing works

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

Hawkes, C. A., Härtig, W., Kacza, J., Schliebs, R., Weller, R. O., Nicoll, J. A. R., & Carare, R. O. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0801-7 · Cited by 359 · see citing works

Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD

Bayer, A. J., Bullock, R., Jones, R. W., Wilkinson, D., Paterson, K. R., Jenkins, L., Millais, S. B., & Donoghue, S. (2005) · Neurology · doi:10.1212/01.wnl.0000148604.77591.67 · Cited by 356 · see citing works

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

Boche, D., Zotova, E., Weller, R. O., Love, S., Neal, J. W., Pickering, R. M., Wilkinson, D., Holmes, C., & Nicoll, J. A. R. (2008) · Brain · doi:10.1093/brain/awn261 · Cited by 316 · see citing works

Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization

Zotova, E., Bharambe, V., Cheaveau, M., Morgan, W., Holmes, C., Harris, S., Neal, J. W., Love, S., Nicoll, J. A. R., & Boche, D. (2013) · Brain · doi:10.1093/brain/awt210 · Cited by 272 · see citing works

Aβ Species Removal After Aβ ₄₂ Immunization

Nicoll, J. A. R., Barton, E., Boche, D., Neal, J. W., Ferrer, I., Thompson, P., Vlachouli, C., Wilkinson, D., Bayer, A., Games, D., et al. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240466.10758.ce · Cited by 265 · see citing works

Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease

Zlokovic, B. V. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2152 · Cited by 263 · see citing works

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

Vellas, B. J., Black, R. S., Thal, L. J., Fox, N. C., Daniels, M., McLennan, G., Tompkins, C., Leibman, C. W., Pomfret, M., & Grundman, M. (2009) · Current Alzheimer Research · doi:10.2174/156720509787602852 · Cited by 256 · see citing works

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

Arbel‐Ornath, M., Hudry, E., Eikermann‐Haerter, K., Hou, S. S., Gregory, J. L., Zhao, L., Betensky, R. A., Frosch, M. P., Greenberg, S. M., & Bacskai, B. J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1145-2 · Cited by 256 · see citing works

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

Hawkes, C. A., Sullivan, P. M., Hands, S. L., Weller, R. O., Nicoll, J. A. R., & Carare, R. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041636 · Cited by 177 · see citing works

?-Amyloid formation by myocytes of leptomeningeal vessels

Wisniewski, H. M., & Węgiel, J. (1994) · Acta Neuropathologica · doi:10.1007/bf00296738 · Cited by 162 · see citing works

The Apolipoprotein E ε2 Allele and the Pathological Features in Cerebral Amyloid Angiopathy-related Hemorrhage

McCarron, M. O., Nicoll, J. A. R., Stewart, J., Ironside, J. W., Mann, D. M. A., Love, S., Graham, D. I., & Dewar, D. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199907000-00005 · Cited by 160 · see citing works

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

Serrano-Pozo, A., William, C. M., Ferrer, I., Uro-Coste, E., Delisle, M.-B., Maurage, C.-A., Hock, C., Nitsch, R. M., Masliah, E., Growdon, J. H., et al. (2010) · Brain · doi:10.1093/brain/awq056 · Cited by 159 · see citing works

<i>APOE</i>ɛ4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein

Chalmers, K., Wilcock, G. K., & Love, S. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.00457.x · Cited by 156 · see citing works

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid‐β from the mouse brain

Hawkes, C. A., Gatherer, M., Sharp, M. M., Dorr, A. E., Yuen, H. M., Kalaria, R. N., Weller, R. O., & Carare, R. O. (2013) · Aging Cell · doi:10.1111/acel.12045 · Cited by 153 · see citing works

Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer’s disease pathogenesis

Boche, D., Denham, N., Holmes, C., & Nicoll, J. A. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0719-5 · Cited by 135 · see citing works

Immune Reactions Associated With Cerebral Amyloid Angiopathy

Yamada, M., Itoh, Y., Shintaku, M., Kawamura, J., Jensson, Ó., Thorsteinsson, L., Suematsu, N., Matsushita, M., & Otomo, E. (1996) · Stroke · doi:10.1161/01.str.27.7.1155 · Cited by 125 · see citing works

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis

Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works

Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Aβ42 immunisation in Alzheimer’s disease

Boche, D., Donald, J., Love, S., Harris, S., Neal, J. W., Holmes, C., & Nicoll, J. A. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0705-y · Cited by 85 · see citing works

Cerebral Amyloid Angiopathy

(2012) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-385883-2.00006-0 · Cited by 84 · see citing works

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes

Utter, S., Tamboli, I. Y., Walter, J., Upadhaya, A. R., Birkenmeier, G., Pietrzik, C. U., Ghebremedhin, E., & Thal, D. R. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181836a71 · Cited by 79 · see citing works

Vascular alterations in PDAPP mice after anti‐Aβ immunotherapy: Implications for amyloid‐related imaging abnormalities

Zago, W., Schroeter, S., Guido, T., Khan, K., Seubert, P., Yednock, T., Schenk, D., Gregg, K. M., Games, D., Bard, F., et al. (2013) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2012.11.010 · Cited by 75 · see citing works

Occurrence and co-localization of amyloid β-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

Thal, D. R., Larionov, S., Abramowski, D., Wiederhold, K., Dooren, T. V., Yamaguchi, H., Haass, C., LEUVEN, F. V., Staufenbiel, M., & Capetillo‐Zarate, E. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.029 · Cited by 58 · see citing works

Antibody-Mediated Clearance of Amyloid-β Peptide from Cerebral Amyloid Angiopathy Revealed by QuantitativeIn VivoImaging

Prada, C. M., Garcı́a-Alloza, M., Betensky, R. A., Zhang-Nunes, S., Greenberg, S. M., Bacskai, B. J., & Frosch, M. P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5426-06.2007 · Cited by 56 · see citing works

Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease

Carare, R. O., Teeling, J. L., Hawkes, C. A., Püntener, U., Weller, R. O., Nicoll, J. A. R., & Perry, V. H. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-48 · Cited by 50 · see citing works

Solanezumab for Alzheimer's disease

Samadi, H., & Sultzer, D. L. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.578573 · Cited by 48 · see citing works

The biochemical aftermath of anti-amyloid immunotherapy

Maarouf, C. L., Daugs, I. D., Kokjohn, T. A., Kalback, W. M., Patton, R., Luehrs, D. C., Masliah, E., Nicoll, J. A. R., Sabbagh, M. N., Beach, T. G., et al. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-39 · Cited by 43 · see citing works

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

Rolyan, H., Feike, A. C., Upadhaya, A. R., Waha, A., Dooren, T. V., Haass, C., Birkenmeier, G., Pietrzik, C. U., LEUVEN, F. V., & Thal, D. R. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-010-0572-7 · Cited by 36 · see citing works

Clearance systems in the brain—implications for Alzheimer disease

Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678 · see citing works

APOE and Alzheimer’s disease: Advances in genetics, pathophysiology, and therapeutic approaches

Serrano-Pozo, A., Das, S., & Hyman, B. T. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30412-9 · Cited by 1,037 · see citing works

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0281-2 · Cited by 947 · see citing works

Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics

Hampel, H., Elhage, A., Cho, M., Apostolova, L. G., Nicoll, J. A. R., & Atri, A. (2023) · Brain · doi:10.1093/brain/awad188 · Cited by 412 · see citing works

Alzheimer's disease: From immunotherapy to immunoprevention

Jucker, M., & Walker, L. C. (2023) · Cell · doi:10.1016/j.cell.2023.08.021 · Cited by 353 · see citing works

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

Banerjee, G., Carare, R. O., Cordonnier, C., Greenberg, S. M., Schneider, J. A., Smith, E. E., van Buchem, M. A., van der Grond, J., Verbeek, M. M., & Werring, D. J. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314697 · Cited by 242 · see citing works

The role of APOE in cerebrovascular dysfunction

Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W. J., & Bu, G. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1547-z · Cited by 231 · see citing works

Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease

Nicoll, J. A. R., Buckland, G. R., Harrison, C. H., Page, A. M., Harris, S., Love, S., Neal, J., Holmes, C., & Boche, D. (2019) · Brain · doi:10.1093/brain/awz142 · Cited by 205 · see citing works

Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease

Liao, F., Yoon, H., & Kim, J. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000383 · Cited by 191 · see citing works

Alzheimer disease

Calderón‐Garcidueñas, A. L., & Duyckaerts, C. J. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00023-7 · Cited by 120 · see citing works

Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK

Ritchie, D. L., Adlard, P., Peden, A., Lowrie, S., Grice, M. L., Burns, K., Jackson, R. J., Yull, H. M., Keogh, M. J., Wei, W., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1703-0 · Cited by 114 · see citing works

Immunotherapies for Neurodegenerative Diseases

Mortada, I., Farah, R., Nabha, S. M., Ojcius, D. M., Fares, Y., Almawi, W. Y., & Sadier, N. S. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.654739 · Cited by 112 · see citing works

Amyloid-related imaging abnormalities: manifestations, metrics and mechanisms

Greenberg, S. M., Bax, F., & van Veluw, S. J. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-024-01053-8 · Cited by 103 · see citing works

Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits

Scholtzova, H., Do, E., Dhakal, S., Sun, Y., Liu, S., Mehta, P. D., & Wisniewski, T. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1967-16.2016 · Cited by 82 · see citing works

The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets

Qi, X.-M., & Ma, J. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0091-7 · Cited by 81 · see citing works

Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Kim, S. H., Ahn, J. H., Yang, H. J., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01042-0 · Cited by 76 · see citing works

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

Liao, F., Zhang, T. J., Jiang, H., Lefton, K. B., Robinson, G. O., Vassar, R., Sullivan, P. M., & Holtzman, D. M. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0250-y · Cited by 77 · see citing works

Three major effects of APOEε4 on Aβ immunotherapy induced ARIA

Foley, K. E., & Wilcock, D. M. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1412006 · Cited by 72 · see citing works

Brain volume change following anti-amyloid β immunotherapy for Alzheimer's disease: amyloid-removal-related pseudo-atrophy

Belder, C. R. S., Boche, D., Nicoll, J. A. R., Jaunmuktane, Z., Zetterberg, H., Schott, J. M., Barkhof, F., & Fox, N. C. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00335-1 · Cited by 77 · see citing works

Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease

Ryan, N. S., Biessels, G. J., Kim, L. G., Nicholas, J. M., Barber, P. A., Walsh, P., Gami‐Patel, P., Morris, H. R., de Bastos-Leite, A. J., Schott, J. M., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.026 · Cited by 71 · see citing works

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

Franco-Bocanegra, D. K., George, B., Lau, L. C., Holmes, C., Nicoll, J. A. R., & Boche, D. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0828-x · Cited by 64 · see citing works

Glymphatic system dysfunction in neurodegenerative diseases

Beschörner, N., & Nedergaard, M. (2024) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001252 · Cited by 60 · see citing works

tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β

Park, L., Zhou, J., Koizumi, K., Wang, G., Anfray, A., Ahn, S. J., Seo, J., Zhou, P., Zhao, L., Paul, S. M., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1140-20.2020 · Cited by 54 · see citing works

Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies

van Veluw, S. J., Benveniste, H., Bakker, E. N. T. P., Carare, R. O., Greenberg, S. M., Iliff, J. J., Lorthois, S., Nostrand, W. E. V., Petzold, G. C., Shih, A. Y., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05277-1 · Cited by 50 · see citing works

Alzheimer’s Disease: Drug Discovery

Huang, X. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020 · Cited by 45 · see citing works

Quantification of molecular interactions between ApoE, amyloid-beta (Aβ) and laminin: Relevance to accumulation of Aβ in Alzheimer's disease

Zekonyte, J., Sakai, K., Nicoll, J. A. R., Weller, R. O., & Carare, R. O. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.025 · Cited by 40 · see citing works

Invited Review – Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials

Boche, D., & Nicoll, J. A. R. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12642 · Cited by 40 · see citing works

A Simulation Model of Periarterial Clearance of Amyloid-β from the Brain

Diem, A. K., Tan, M., Bressloff, N. W., Hawkes, C. A., Morris, A. W. J., Weller, R. O., & Carare, R. O. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00018 · Cited by 35 · see citing works

Cerebral Superficial Siderosis

Weidauer, S., Neuhaus, E., & Hattingen, E. (2022) · Clinical Neuroradiology · doi:10.1007/s00062-022-01231-5 · Cited by 34 · see citing works

Dementia and Cognitive Impairment Reduction after Laser Transcatheter Treatment of Alzheimer’s Disease

Maksimovich, I. V. (2015) · World Journal of Neuroscience · doi:10.4236/wjns.2015.53021 · Cited by 32 · see citing works

Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization

Jäkel, L., Boche, D., Nicoll, J. A. R., & Verbeek, M. M. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0791-6 · Cited by 29 · see citing works

Beyond the amyloid cascade: An update of Alzheimer's disease pathophysiology

Gouilly, D., Rafiq, M., Nogueira, L., Salabert, A., Payoux, P., Péran, P., & Pariente, J. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2022.12.006 · Cited by 27 · see citing works

Evaluating clinical meaningfulness of anti-β-amyloid therapies amidst amyloid-related imaging abnormalities concern in Alzheimer’s disease

Aljuhani, M., Ashraf, A., & Edison, P. (2024) · Brain Communications · doi:10.1093/braincomms/fcae435 · Cited by 22 · see citing works

Differential effects of apoE and apoJ mimetic peptides on the action of an anti-Aβ scFv in 3xTg-AD mice

Montoliu‐Gaya, L., Güell‐Bosch, J., Esquerda-Canals, G., Roda, A. R., Serra-Mir, G., Lope‐Piedrafita, S., Sánchez‐Quesada, J. L., & Villegas, S. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.012 · Cited by 21 · see citing works

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor–treated APP transgenic mice

Beckmann, N., Doelemeyer, A., Zurbruegg, S., Bigot, K., Theil, D. J., Frieauff, W., Kolly, C., Moulin, P., Neddermann, D., Kreutzer, R., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.05.009 · Cited by 22 · see citing works

Acquired cerebral amyloid angiopathy: An emerging concept

Yamada, M., Hamaguchi, T., & Sakai, K. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.05.012 · Cited by 21 · see citing works

Histopathological correlates of haemorrhagic lesions on ex vivo magnetic resonance imaging in immunized Alzheimer’s disease cases

Scherlek, A. A., Kozberg, M. G., Nicoll, J. A. R., Perosa, V., Freeze, W. M., van der Weerd, L., Bacskai, B. J., Greenberg, S. M., Frosch, M. P., Boche, D., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac021 · Cited by 20 · see citing works

Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons

Hu, H., Wan, S., Hu, Y., Wang, Q., Li, H., & Zhang, N. (2025) · Annals of Medicine · doi:10.1080/07853890.2024.2445194 · Cited by 19 · see citing works

Targeting lysyl-oxidase (LOX) may facilitate intramural periarterial drainage for the treatment of Alzheimer's disease

Kelly, L., Sharp, M. M., Thomas, I., Brown, C., Schrag, M., Antunes, L. V., Solopova, E., Martínez‐González, J., Rodrı́guez, C., & Carare, R. O. (2023) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2023.100171 · Cited by 16 · see citing works

Immunotherapy Targeting Amyloid-ß Peptides in Alzheimer’s Disease

Zampar, S., & Wirths, O. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch2 · Cited by 17 · see citing works

Age dependence of retinal vascular plexus attenuation in the triple transgenic mouse model of Alzheimer's disease

Nazari, H. K., Karimaghaei, C., van der Merwe, R. K., Montalbano, M., Taglialatela, G., Vargas, G., Zhang, W., & Motamedi, M. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108879 · Cited by 15 · see citing works

Recent Trends in Active and Passive Immunotherapies of Alzheimer’s Disease

Alshamrani, M. (2023) · Antibodies · doi:10.3390/antib12020041 · Cited by 16 · see citing works

APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice

Zhou, Y., Zhao, W., Al‐Muhtasib, N., & Rebeck, G. W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142184 · Cited by 9 · see citing works

Cerebral Amyloid Angiopathy: Clinical Presentation, Sequelae and Neuroimaging Features—An Update

Weidauer, S., & Hattingen, E. (2025) · Biomedicines · doi:10.3390/biomedicines13030603 · Cited by 10 · see citing works

Safety, tolerability, immunogenicity, and efficacy of ABvac40 active immunotherapy against Aβ40 in patients with mild cognitive impairment or very mild Alzheimer's disease: A randomized, double‐blind, placebo‐controlled phase 2 study

Pascual‐Lucas, M., Lacosta, A. M., Montañés, M., Canudas, J., Loscos, J., Monleón, I., Allué, J. A., Sarasa, L., Fandos, N., Romero, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70776 · Cited by 9 · see citing works

The underlying role of pericyte-related cerebral lymphatic microcirculation dysfunction in cerebral small vessel disease

Cao, T., Yang, C., Zhang, J., Yan, Y., Chen, Z., Peng, X., Xia, C., Pan, M., Zou, C., & Lü, T. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107101 · Cited by 8 · see citing works

Proportions of Basement Membrane Proteins in Cerebrovascular Smooth Muscle Cells After Exposure to Hypercapnia and Amyloid Beta

Dewing, J. M., Keable, A., Laslo, A., Chinezu, L., Ivănescu, A. D., Ratnayaka, J. A., Kalaria, R. N., SLEVIN, M. A., Verma, A. K., & Carare, R. O. (2025) · Cells · doi:10.3390/cells14080614 · Cited by 6 · see citing works

Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits

Scholtzova, H., Do, E., Dhakal, S., Sun, Y., Liu, S., Mehta, P. D., & Wısnıewskı, T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1967-16.2017 · Cited by 6 · see citing works

Clinical and neuroimaging precursors in cerebral amyloid angiopathy: impact of the Boston criteria version 2.0

Weidauer, S., Tafreshi, M., Förch, C., Hattingen, E., Arendt, C. T., & Friedauer, L. (2024) · European Journal of Neurology · doi:10.1111/ene.16425 · Cited by 4 · see citing works

Impacto terapêutico da fotobiomodulação no tratamento da doença de Alzheimer: Uma revisão integrativa

Carvalho, J. M. S., dos Santos, L., & Navarro, R. S. (2021) · Research Society and Development · doi:10.33448/rsd-v10i8.17046 · Cited by 4 · see citing works

Amyloid‐β plaques may be reduced in advanced stages of cerebral amyloid angiopathy in the elderly

Okamoto, K., Amari, M., Fukuda, T., Suzuki, K., & Takatama, M. (2020) · Neuropathology · doi:10.1111/neup.12662 · Cited by 4 · see citing works

Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer’s disease

Welikovitch, L. A., Oakley, D. H., Bennett, R. E., Serrano‐Pozo, A., Zhu, H., Ruiz‐Uribe, N. E., Zwang, T. J., Chibnik, L. B., Gómez‐Isla, T., Frosch, M. P., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03037-y · Cited by 4 · see citing works

Cerebral Amyloid Angiopathy in Patients with Cognitive Impairment: Cerebrospinal Fluid Biomarkers

Rothenberg, K. G., Bekris, L. M., Leverenz, J. B., Wu, J. C. N., Lee, J., Statsevych, V., Ruggieri, P. M., & Jones, S. E. (2024) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000539884 · Cited by 3 · see citing works

Electrochemical Detection of Isoform‐Specific Interaction between Apolipoprotein E and Amyloid‐β

Su, H., Jin, Y., Noroozifar, M., & Kerman, K. (2018) · ChemElectroChem · doi:10.1002/celc.201800985 · Cited by 3 · see citing works

Cerebral amyloid angiopathy‐related inflammation and dementia

Sakai, K., & Yamada, M. (2021) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12634 · Cited by 3 · see citing works

Update on Alzheimer’s Disease

Jellinger, K. A. (2015) · EMJ Neurology · doi:10.33590/emjneurol/10311025 · Cited by 1 · see citing works

Development of magnetic resonance imaging techniques for mouse models of Alzheimer's Disease

O’Callaghan, J. M. (2015) · UCL Discovery (University College London)

Neuropathology and molecular biology of iatrogenic Creutzfeldt-Jakob disease in UK human growth hormone recipients

Ironside, J. W. (2017) · ERA

Cerebral Amyloid Angiopathy: Emerging Evidence for Novel Pathophysiology and Pathogenesis

Yamada, M., Sakai, K., Hamaguchi, T., & Noguchi‐Shinohara, M. (2020) · Stroke revisited · doi:10.1007/978-981-10-1430-7_7

自己組織化単分子膜を用いた有機不揮発性メモリの作製と閾値制御(センサ,デバイス,一般)

中川, 隆., 横田, 知., 関谷, 毅., 竹内, 健., 染谷, 隆., & Klauk, H. (2010) · 電子情報通信学会技術研究報告. OME, 有機エレクトロニクス

Capillary angiopathy and aquaporin-4 after Aβ immunisation in Alzheimer’s disease – potential relevance to Amyloid-Related Imaging AbnormalitiesPreprint

Harrison, C. H., Sakai, K., Johnston, D. A., Holmes, C., Boche, D., & Nicoll, J. A. R. (2022) · medRxiv · doi:10.1101/2022.12.08.22283144

Zerebrale Amyloidangiopathie und ihre Folgen

Weidauer, S. (2024) · Radiologie up2date · doi:10.1055/a-2339-8420

Additional file 4 of Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Kim, S. H., Ahn, J. H., Yang, H., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13199131

Additional file 3 of Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Kim, S. H., Ahn, J. H., Yang, H., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13199128

Additional file 2 of Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Kim, S. H., Ahn, J. H., Yang, H., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13199125

Additional file 1 of Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Kim, S. H., Ahn, J. H., Yang, H., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13199122

Additional file 5 of Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

Kim, S. H., Ahn, J. H., Yang, H., Lee, P., Koh, G. Y., & Jeong, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13199134

Intravenous anti-Aβ immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 micePreprint

Pikus, P., Healey, G. S., Xia, E., Shautidze, G., Siddapureddy, N., Lee, Y., Albanese, C., Rodriguez, O. C., Turner, R. S., & Rebeck, G. W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704876

Contribution à l’étude des anticorps dirigés contre le peptide Aβ et de leur implication dans l’angiopathie amyloïde cérébrale

Chantran, Y. (2020) · theses.fr (ABES) · doi:10.70675/85da59a6z44afz49ecz8d9bz231a28465826

Spontaneous and Iatrogenic Amyloid-Related Imaging Abnormalities (ARIA): Clues for Immunotherapy in Alzheimer’s Disease

Zedde, M., Basso, G., Piazza, F., & Pascarella, R. (2026) · Springer eBooks · doi:10.1007/978-3-032-23618-0_7

Beyond Amyloid: Systemic and Brain Frailty as Determinants of Response to Anti-Amyloid Therapy in Alzheimer’s Disease—A Conceptual Review

Prelog, P. R., Zupan, M., Šabović, M., Frol, S., & Kramberger, M. G. (2026) · Medicina · doi:10.3390/medicina62081489

Investigating oral blarcamesine for treatment of early Alzheimer’s disease

Chandrasekaran, A., Paget‐Blanc, A., Decourt, B., & Sabbagh, M. N. (2026) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2026.2732056

O3–06–02: Cerebral amyloid angiopathy‐associated vasculopathy and apolipoprotein E accumulation after beta‐amyloid immunotherapy for Alzheimer's disease

Nicoll, J. A. R., Sakai, K., Love, S., & Boche, D. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.04.268 · Cited by 1 · see citing works

Effects of Abeta immunotherapy on cerebral amyloidangiopathy in Alzheimer’s disease

Boche, D., Barton, E., Neal, J., Ferrer, I., Wilkinson, D. G., Bayer, A. L., Holmes, C., Weller, R. O., & Nicoll, J. A. R. (2006) · Neuropathology and Applied Neurobiology

O3‐07‐06: Processes underlying the vascular pathophysiology associated with Aβ immunization in Alzheimer's disease

Nicoll, J. A. R., Hawkes, C. A., Holmes, C., Weller, R. O., Perry, V. H., Boche, D., Teeling, J. L., & Carare, R. O. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.05.440

Intravenous anti-Aβ immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 micePreprint

Pikus, P., Healey, G. S., Xia, E., Shautidze, G., Siddapureddy, N., Lee, Y., Albanese, C., Rodriguez, O. C., Turner, R. S., & Rebeck, G. W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704876

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

Boche, D., Zotova, E., Weller, R. O., Love, S., Neal, J. W., Pickering, R. M., Wilkinson, D., Holmes, C., & Nicoll, J. A. R. (2008) · Brain · doi:10.1093/brain/awn261 · Cited by 316 · see citing works