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Cited by 511Intracerebral and Subarachnoid Hemorrhage ResearchAlzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., Jucker, M.·2002·Science
DOI 10.1126/science.1078259
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Abstract

Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice,

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Crossref · 10.1126/science.1078259

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1 of 1 references verified0 citation errors · 0 not checkable

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  • In previous studies of active and passive immunization involving generation of certain anti-Aβ antibodies, an increase of CAA and CAA-associated microhemorrhage has been observed.

    “In previous studies of active and passive immunization involving the generation of certain anti-A␤ antibodies, an increase of CAA and CAA-associated microhemorrhage has been observed (Pfeifer et al., 2002).”

    From Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis (2014) · cites this paper as Pfeifer et al., 2002

  • Increased CAA and CAA-associated microhemorrhage are side effects associated with previous passive Aβ immunotherapy, especially with those Aβ antibodies that target aggregated forms of Aβ if the effector function of the antibody is intact.

    “Increased CAA and CAA-associated microhemorrhage (Pfeifer et al., 2002;Wilcock et al., 2004a) are side effects associated with previous passive A␤ immunotherapy, especially with those A␤ antibodies that target aggregated forms of A␤ if the effector function of the antibody is intact (Pfeifer et al., 2002;Wilcock et al., 2004a;Racke et al., 2005).”

    From Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis (2014) · cites this paper as Pfeifer et al., 2002

  • VAβ is detrimental to the function of cerebrovascular circulation through compromising blood-brain-barrier integrity, effecting hemodynamic dysfunction, and facilitating occurrence of spontaneous hemorrhages.

    “VAβ is detrimental to the function of cerebrovascular circulation through compromising blood–brain-barrier integrity [49], effecting hemodynamic dysfunction [29, 50], and facilitating occurrence of spontaneous hemorrhages [25, 26, 36].”

    From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [26]

  • Aβ immunotherapy is well known to escalate incidence of brain microhemorrhages.

    “Aβ immunotherapy can ameliorate VAβ burden and improve compromised vascular reactivity [12, 21, 63], but it is well known to escalate incidence of brain microhemorrhages [21, 26].”

    From APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice (2017) · cites this paper as [26]

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Authors
Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M.
Affiliations
  • University of Basel (CH)
  • Goethe University Frankfurt (DE)
  • Novartis (Switzerland) (CH)
  • Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Jucker, M.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2002-11-15
Volume
298
Issue
5597
Pages
1379-1379
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1078259
OpenAlex
W2002520289
Cited by
511
References
1
Citations by year
2026: 7 · 2025: 15 · 2024: 22 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 11 · 2016: 17 · 2015: 10 · 2014: 22 · 2013: 21 · 2012: 31
FWCI
23.45
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
cerebral hemorrhage, passive immunotherapy, amyloid-beta, amyloid precursor protein, cerebral amyloid angiopathy, knock-in mice
MeSH terms
Alzheimer Disease, Animals, Antibodies, Monoclonal, Capillary Permeability, Cerebral Hemorrhage, Humans, Immunoglobulin G, Immunization, Passive, Male, Mice, Transgenic, Peptide Fragments, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Neocortex, Mice

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