Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice
Open accessAbstract
Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally and may underlie the stereotyped progression of neurodegenerative Tauopathies. However, the involvement of templated misfolding of Tau in neuronal network dysfunction and behavioral outcomes remains to be explored in detail. Here we analyzed the repercussions of prion-like spreading of Tau-pathology via neuronal connections on neuronal network function in TauP301S transgenic mice. Spontaneous and GABA(A)R-antagonist-induced neuronal network activity were affected following templated Tau-misfolding using synthetic preformed Tau fibrils in cultured primary neurons. Electrophysiological analysis in organotypic hippocampal slices of Tau transgenic mice demonstrated impaired synaptic transmission and impaired long-term potentiation following Tau-seed induced Tau-aggregation. Intracerebral injection of Tau-seeds in TauP301S mice, caused prion-like spreading of Tau-pathology through functionally connected neuroanatomical pathways. Electrophysiological analysis revealed impaired synaptic plasticity in hippocampal CA1 region 6 months after Tau-seeding in entorhinal cortex (EC). Furthermore, templated Tau aggregation impaired cognitive function, measured in the object recognition test 6 months post-seeding. In contrast, Tau-seeding in basal ganglia and subsequent spreading through functionally connected neuronal networks involved in motor control, resulted in motoric deficits reflected in clasping and impaired inverted grid hanging, not significantly affected following Tau-seeding in EC. Immunostaining, biochemical and electron microscopic analysis in the different models suggested early pathological forms of Tau, including Tau-oligomers, rather than fully mature neurofibrillary tangles (NFTs) as culprits of neuronal dysfunction. We here demonstrate for the first time using in vitro, ex vivo and in vivo models, that prion-like spreading of Tau-misfolding by Tau seeds, along unique neuronal connections, causes neuronal network dysfunction and associated behavioral dysfunction. Our data highlight the potential relevance of this mechanism in the symptomatic progression in Tauopathies. We furthermore demonstrate that the initial site of Tau-seeding thereby determines the behavioral outcome, potentially underlying the observed heterogeneity in (familial) Tauopathies, including in TauP301 mutants.
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Degeneration could be initiated through synaptic or axonal mechanisms, independent of apoptosis.
“These observations raise the prospect that degeneration could be initiated through synaptic or axonal mechanisms, independent of apoptosis, a mechanism which has been widely studied in other model systems, such as spinal cord injury and Multiple Sclerosis 59–61.”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [60]
The Discussion (page unavailable) reports impaired synaptic plasticity and points to a postsynaptic mechanism for tau-seeding-induced neuronal dysfunction. It does not establish that degeneration is initiated through synaptic or axonal mechanisms, or that the process is independent of apoptosis. (LLM, conf=0.83)
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- Authors
- Stancu, I.-C., Vasconcelos, B., Ris, L., Wang, P., Villers, A., Peeraer, E., Buist, A., Terwel, D., Baatsen, P., Oyelami, T., Pierrot, N., Casteels, C., Bormans, G., Kienlen-Campard, P., Octave, J.-N., Moechars, D., & Dewachter, I.
- Affiliations
- UCLouvain (BE)
- University of Mons (BE)
- Janssen (Belgium) (BE)
- KU Leuven (BE)
- Corresponding author
- Dewachter, Ilse
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2015-04-11
- Volume
- 129
- Issue
- 6
- Pages
- 875-894
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4436846
- OpenAlex
- W2109355761
- Cited by
- 143
- References
- 76
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 18 · 2016: 18 · 2015: 3
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion, cc-by)
- ORBi UMONS (submittedVersion)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, prion-like seeding, tauopathy, neuronal network dysfunction, synaptic transmission, long-term potentiation, synaptic plasticity, hippocampus, entorhinal cortex, basal ganglia, motor impairment, cognitive impairment, object recognition, tau oligomers, neurofibrillary tangles, GABA-A receptor antagonists, organotypic hippocampal slices
- MeSH terms
- Animals, Animals, Newborn, Calcium, Cognition Disorders, Disease Models, Animal, Exploratory Behavior, Hippocampus, Membrane Potentials, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Nerve Net, Prions, Fura-2, Neurofibrillary Tangles, tau Proteins, Tauopathies, Mice, Proteostasis Deficiencies, In Vitro Techniques
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