Cited by 112Cellular transport and secretionLysosomal Storage Disorders ResearchAutophagy in Disease and Therapy

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Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders

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Feng, Tuancheng, Lacrampe, Alexander, Hu, Fenghua·2021·Acta Neuropathologica

DOI 10.1007/s00401-020-02246-3PMC PMC8049516

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Abstract

TMEM106B, encoding a lysosome membrane protein, has been recently associated with brain aging, hypomyelinating leukodystrophy and multiple neurodegenerative diseases, such as frontotemporal lobar degeneration (FTLD) and limbic-predominant age-related TDP-43 encephalopathy (LATE). During the past decade, considerable progress has been made towards our understanding of the cellular and physiological functions of TMEM106B. TMEM106B regulates many aspects of lysosomal function, including lysosomal pH, lysosome movement, and lysosome exocytosis. Both an increase and decrease in TMEM106B levels result in lysosomal abnormalities. In mouse models, TMEM106B deficiency leads to lysosome trafficking and myelination defects and FTLD related pathology. In humans, alterations in TMEM106B levels or function are intimately linked to neuronal proportions, brain aging, and brain disorders. Further elucidation of the physiological function of TMEM106B and changes in TMEM106B under pathological conditions will facilitate therapeutic development to treat brain disorders associated with TMEM106B.

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See all 112

Authors: Feng, T., Lacrampe, A., & Hu, F.
Affiliations: Cornell University (US)
Corresponding author: Hu, Fenghua
ORCID: Feng, Tuancheng
Lacrampe, Alexander
Hu, Fenghua
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 2021-01-01
Volume: 141
Issue: 3
Pages: 327-339
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s00401-020-02246-3
PMC: PMC8049516
OpenAlex: W3114567345
Cited by: 110
References: 94
Citations by year: 2026: 13 · 2025: 27 · 2024: 25 · 2023: 25 · 2022: 13 · 2021: 6
FWCI: 2.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Acta Neuropathologica (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS088448 & R01NS095954)
the Bluefield project to cure frontotemporal dementia
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: TMEM106B, lysosomal function, lysosomal pH, lysosomal trafficking, lysosome exocytosis, hypomyelinating leukodystrophy, frontotemporal lobar degeneration, limbic-predominant age-related TDP-43 encephalopathy, brain aging, myelination defects, neurodegenerative diseases
MeSH terms: Aging, Animals, Brain, Brain Diseases, Humans, Membrane Proteins, Nerve Tissue Proteins

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Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders

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