Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression
Abstract
Purpose To evaluate the relationship between miR-126 and Crk and discuss the role of miR-126 in the development and progression of endometriosis (EMs).Methods The expression levels of miR-126 and Crk mRNA were quantified using real time fluorescent quantitative polymerase chain reaction (real time PCR) in ectopic endometrium (ECs) and eutopic endometrium (EUs) in patients with EMs and normal endometrium (ENs) in EMs-free subjects. The expression levels of Crk protein in all samples were evaluated by Western blot.Results The expression level of miR-126 was significantly downregulated in ECs versus EUs (p = 5.45E(-5)) in the experimental group and in EUs versus ENs (p = 0.019). The expression level of Crk mRNA did not distinguish ECs from EUs (p = 0.995) but was overexpressed in EUs versus ENs (p = 0.006). Crk protein was overexpressed in ECs versus EUs (p = 0.002) in the experimental group and in EUs versus ENs (p = 1.13E(-6)). The expression level of miR-126 had no correlation with Crk mRNA (p = 0.496) but was negatively correlated with Crk protein (p = 3.134E(-5)). The expression level of miR-126 in EUs and ECs was negatively correlated with American Fertility Society (AFS) stage (p = 0.022, p = 0.025) and AFS score (p = 0.002, p = 0.007). miR-126 expression decreased with the progression of EMs, but the decrease was not significantly different.Conclusions miR-126 may play an initial role in the development and progression of EMs. Crk may be regulated by miR-126, and synergism between abnormal expressions may play an important role in the pathogenesis of EMs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR-542-3p/COX2, miR-126/CRK and miR23a/NR5A1.
“Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR-542-3p/COX2 [128], miR-126/CRK [129] and miR23a/NR5A1 [130].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [129]
Cites
1 retracted
Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam063 · Cited by 261 · see citing works
RetractedIntegrins and Signal Transduction Pathways: the Road Taken
Clark, E. A., & Brugge, J. S. (1995) · Science · doi:10.1126/science.7716514 · Cited by 2,983 · see citing works
Endogenous human microRNAs that suppress breast cancer metastasis
Tavazoie, S. F., Alarcón, C. R., Óskarsson, T., Padua, D. M., Wang, Q., Bos, P. D., Gerald, W. L., & Massagué, J. (2008) · Nature · doi:10.1038/nature06487 · Cited by 1,858 · see citing works
Eskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617 · see citing works
(1927) · PubMed Central · Cited by 1,008 · see citing works
MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
Harris-Tryon, T. A., Yamakuchi, M., Ferlito, M., Mendell, J. T., & Lowenstein, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707493105 · Cited by 1,007 · see citing works
(1984) · PubMed · Cited by 997 · see citing works
Peltier, H. J., & Latham, G. J. (2008) · RNA · doi:10.1261/rna.939908 · Cited by 716 · see citing works
Crk family adaptors–signalling complex formation and biological roles
Feller, S. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204779 · Cited by 465 · see citing works
Guo, C., Sah, J. F., Beard, L., Willson, J. K. V., Markowitz, S. D., & Guda, K. (2008) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20596 · Cited by 393 · see citing works
Endometriosis: The pathophysiology as an estrogen-dependent disease
Kitawaki, J., Kado, N., Ishihara, H., Koshiba, H., Kitaoka, Y., & Honjo, H. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00260-1 · Cited by 370 · see citing works
MicroRNA-regulated pathways associated with endometriosis
Ohlsson Teague, E. M. C., Van der Hoek, K. H., Van der Hoek, M. B., Perry, N., Wagaarachchi, P., Robertson, S. A., Print, C. G., & Hull, L. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0387 · Cited by 357 · see citing works
Gotoh, T., Hattori, S., Nakamura, S., Kitayama, H., Noda, M., Takai, Y., Kaibuchi, K., Matsui, H., Hatase, O., Takahashi, H., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6746 · Cited by 356 · see citing works
The role of microRNAs in endometriosis and associated reproductive conditions
Ohlsson Teague, E. M. C., Print, C. G., & Hull, M. L. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp034 · Cited by 309 · see citing works
miR-126 functions as a tumour suppressor in human gastric cancer
Feng, R., Chen, X., Yu, Y., Su, L., Yu, B., Li, J., Cai, Q., Yan, M., Liu, B., & Zhu, Z. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.06.004 · Cited by 291 · see citing works
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines
Crawford, M., Brawner, E. J., Batte, K., Yu, L., Hunter, M. G., Otterson, G. A., Nuovo, G. J., Marsh, C. B., & Nana-Sinkam, S. P. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.090 · Cited by 256 · see citing works
Burney, R. O., Hamilton, A. E., Aghajanova, L., Vo, K. C., Nezhat, C. N., Lessey, B. A., & Giudice, L. C. (2009) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gap068 · Cited by 254 · see citing works
Zhu, N., Zhang, D., Xie, H., Zhou, Z., Chen, H., Hu, T., Bai, Y., Shen, Y., Yuan, W., Jing, Q., et al. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0723-7 · Cited by 206 · see citing works
Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold
Chodniewicz, D., & Klemke, R. L. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.03.006 · Cited by 190 · see citing works
Schmidt, M., Paes, K., Mazière, A. M. G. L. D., Smyczek, T., Yang, S. C., Gray, A., French, D. M., Kasman, I. M., Klumperman, J., Rice, D. S., et al. (2007) · Development · doi:10.1242/dev.002576 · Cited by 183 · see citing works
Retrograde menstruation in women undergoing chronic peritoneal dialysis.
Blumenkrantz, M. J., Gallagher, N., BASHORE, R. A., & Tenckhoff, H. (1981) · PubMed · Cited by 165 · see citing works
Filigheddu, N., Gregnanin, I., Porporato, P. E., Surico, D., Perego, B., Galli, L., Patrignani, C., Graziani, A., & Surico, N. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/369549 · Cited by 162 · see citing works
Cicinnati, V. R., Shen, Q., Sotiropoulos, G. C., Radtke, A., Gerken, G., & Beckebaum, S. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-350 · Cited by 128 · see citing works
Angiogenesis and antiangiogenic therapy in endometriosis
Becker, C. M., & D’Amato, R. J. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.04.008 · Cited by 122 · see citing works
Birge, R. B., Knudsen, B. S., Besser, D., & Hanafusa, H. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.00258.x · Cited by 121 · see citing works
Rhinn, H., Marchand‐Leroux, C., Croci, N., Plotkine, M., Scherman, D., & Escriou, V. (2008) · BMC Molecular Biology · doi:10.1186/1471-2199-9-62 · Cited by 68 · see citing works
Witz, C. A., Cho, S., Centonze, V. E., Montoya-Rodriguez, I. A., & Schenken, R. S. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04834-3 · Cited by 64 · see citing works
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells
Huang, X., Gschweng, E. H., Handel, B. V., Cheng, D., Mikkola, H. K. A., & Witte, O. N. (2010) · Blood · doi:10.1182/blood-2010-08-302711 · Cited by 64 · see citing works
Endometriosis: harmful survival of an ectopic tissue
Garai, J. (2006) · Frontiers in bioscience · doi:10.2741/1821 · Cited by 61 · see citing works
Mayer, B. J., Hamaguchi, M., & Hanafusa, H. (1988) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1988.053.01.104 · Cited by 57 · see citing works
Watanabe, T., Tsuda, M., Tanaka, S., Ohba, Y., Kawaguchi, H., Majima, T., Sawa, H., & Minami, A. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0064 · Cited by 46 · see citing works
Vestergaard, A. L., Knudsen, U. B., Munk, T., Rosbach, H. K., & Martensen, P. M. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq100 · Cited by 42 · see citing works
Xu, Y., Wang, D. B., Liu, Q., Chen, Y., & Yang, Z. H. (2010) · Human Reproduction · doi:10.1093/humrep/deq197 · Cited by 35 · see citing works
Self-citationGalectin-3 is Overexpressed in Various Forms of Endometriosis
Noël, J., Chapron, C., Borghese, B., Fayt, I., & Anaf, V. (2010) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0b013e3181f5a05e · Cited by 34 · see citing works
The Role of Egfl7 in Vascular Morphogenesis
Schmidt, M., Mazière, A. M. G. L. D., Smyczek, T., Gray, A., Parker, L. H., Filvaroff, E. H., French, D. M., van Dijk, S., Klumperman, J., & Ye, W. (2007) · Novartis Foundation symposium · doi:10.1002/9780470319413.ch3 · Cited by 25 · see citing works
Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran
Aghajanpour, L., Mashayekhi, F., & Rajaei, F. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1479-0 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Update on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195 · see citing works
“Other miRNAs and predicted cognate mRNAs demonstrating differential expression in eutopic endometrium from women with and without endometriosis include miR-23a/CYP19A1 and miR542-3p/COX2 [128], miR-126/CRK [129] andmiR23a/NR5A1 [130].”
Fassbender, A., Vodolazkaia, A., Saunders, P., Lebovic, D., Waelkens, E., De Moor, B., & D'Hooghe, T. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.01.097 · Cited by 150 · see citing works
Wang, Y., Li, Y., Yang, Z., Liu, K., & Wang, D. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000438579 · Cited by 78 · see citing works
Self-citationChallenges in endometriosis miRNA studies — From tissue heterogeneity to disease specific miRNAs
Saare, M., Rekker, K., Laisk, T., Rahmioğlu, N., Zondervan, K. T., Salumets, A., Götte, M., & Peters, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.018 · Cited by 76 · see citing works
Shi, X., Gu, L., Chen, J., Guo, X., & Shi, Y. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1536 · Cited by 77 · see citing works
Li, X., Xiong, W., Long, X., Dai, X., Peng, Y., Xu, Y., Zhang, Z., Zhang, L., & Liu, Y. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab152 · Cited by 70 · see citing works
MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis
Nothnick, W. B. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1599089 · Cited by 69 · see citing works
Plasma miRNAs Display Limited Potential as Diagnostic Tools for Endometriosis
Nisenblat, V., Sharkey, D. J., Wang, Z., Evans, S., Healey, M., Teague, E., Print, C. G., Robertson, S. A., & Hull, M. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01464 · Cited by 63 · see citing works
Forte, A., Cipollaro, M., & Galderisi, U. (2013) · Clinical Science · doi:10.1042/cs20130099 · Cited by 63 · see citing works
Xiong, H., Chen, R., Liu, S., Lin, Q., Chen, H., & Jiang, Q. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26763 · Cited by 53 · see citing works
Self-citationRetractedMeng, X., Liu, J., Wang, H., Peng, C., & Wang, D. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110486 · Cited by 53 · see citing works
Self-citationEndometriosis-associated Ovarian Clear Cell Carcinoma: A Special Entity?
Sun, Y., & Liu, G. (2021) · Journal of Cancer · doi:10.7150/jca.61107 · Cited by 51 · see citing works
The Endometriotic Tumor Microenvironment in Ovarian Cancer
Wendel, J. R. H., Wang, X., & Hawkins, S. M. (2018) · Cancers · doi:10.3390/cancers10080261 · Cited by 51 · see citing works
Self-citationLiu, L. Y., Wang, W., ZHAO, L. Y., Guo, B., Yang, J., ZHAO, X. G., Hou, N., Ni, L., Wang, A. Y., Song, T. S., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2516 · Cited by 49 · see citing works
MicroRNA expression pattern differs depending on endometriosis lesion type†
Haikalis, M. E., Wessels, J. M., Leyland, N. A., Agarwal, S. K., & Foster, W. G. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy019 · Cited by 41 · see citing works
Non-coding RNAs in Uterine Development, Function and Disease
Nothnick, W. B. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7417-8_9 · Cited by 37 · see citing works
Monnaka, V. U., Hernandes, C., Heller, D., & Podgaec, S. (2021) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2021rw5704 · Cited by 33 · see citing works
Identification of MicroRNAs as Potential Biomarkers in Ovarian Endometriosis
Gu, C.-L., Zhang, Z., Fan, W.-S., Li, L.-A., Ye, M.-X., Zhang, Q., Zhang, N.-N., Li, Z., & Meng, Y.-G. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00148-z · Cited by 31 · see citing works
Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise
Nothnick, W. B., Al-Hendy, A. A., & Lue, J. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.02.021 · Cited by 29 · see citing works
Platelet miRNAs and cardiovascular diseases
Eduardo Fuentes, Q., Palomo, I. F., & Alarcón, M. A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.04.016 · Cited by 27 · see citing works
Systematic enrichment analysis of microRNA expression profiling studies in endometriosis.
Wei, S., Xu, H., & Kuang, Y. (2015) · Europe PMC (PubMed Central) · Cited by 26 · see citing works
MiR-126 inhibits the invasion of gastric cancer cell in part by targeting Crk.
Li, X., Wang, F., & Qi, Y. (2014) · PubMed · Cited by 25 · see citing works
Hughes, C. L., Foster, W. G., & Agarwal, S. K. (2015) · BioMed Research International · doi:10.1155/2015/158490 · Cited by 23 · see citing works
Fassbender, A., Dorien, O., Moor, B. D., Waelkens, E., Meuleman, C., Tomassetti, C., Peeraer, K., & D’Hooghe, T. M. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_20 · Cited by 22 · see citing works
Genetic Variants miR-126, miR-146a, miR-196a2, and miR-499 in Polycystic Ovary Syndrome
Li, R., Yu, Y., Jaafar, S. O., Baghchi, B., Farsimadan, M., Arabipour, I., & Vaziri, H. (2022) · British Journal of Biomedical Science · doi:10.3389/bjbs.2021.10209 · Cited by 16 · see citing works
Wilczyński, J. R., Szubert, M., Paradowska, E., & Wilczyński, M. (2022) · Cancers · doi:10.3390/cancers15010111 · Cited by 15 · see citing works
Chandrakanth, A., Firdous, S., Vasantharekha, R., Santosh, W., & Seetharaman, B. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01412-8 · Cited by 14 · see citing works
Sepahi, N., Kohan, L., Jahromi, A. R., Daneshbod, Y., & Hoveidi, E. N. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1290064 · Cited by 14 · see citing works
Wang, W., Wen, J., Liu, X., & Zheng, L. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06412-8 · Cited by 9 · see citing works
Future Directions in Endometriosis Research and Therapeutics
Nothnick, W. B., Marsh, C. A., & Alali, Z. (2018) · Current Women s Health Reviews · doi:10.2174/1573404813666161221164810 · Cited by 9 · see citing works
MiRNAs related in signaling pathways of women’s reproductive diseases: an overview
Bagheri, M., Khansarinejad, B., Mondanizadeh, M., Azimi, M., & Alavi, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09357-0 · Cited by 8 · see citing works
Kiba, A., Banno, K., Yanokura, M., Asada, M., Nakayama, Y., Aoki, D., & Watanabe, T. (2016) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13137 · Cited by 8 · see citing works
How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence
Ghosh, D., Geethadevi, A., Bhat, M. A., Bharti, J. N., Mridha, A., Jb, S., Kk, R., & Sengupta, J. (2019) · Current Opinion in Gynecology and Obstetrics · doi:10.18314/cogo.v2i1.1840 · Cited by 6 · see citing works
Evaluation of the relationship between miR-1271 and GRB2 gene in endometriosis
Yarahmadi, G., Fazeli, J., Dehghanian, M., Mehrjardi, M. Y. V., Javaheri, A., & Kalantar, S. M. (2022) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2022.08.007 · Cited by 5 · see citing works
Sadati, S. A., Chekini, Z., Shekari, F., Hafezi, M., Ghaheri, A., Shahhoseini, M., Moini, A., Aflatonian, R., Totonchi, M., & Afsharian, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-09660-1 · Cited by 5 · see citing works
Vashisht, A., Alali, Z., & Nothnick, W. B. (2020) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-030-51856-1_5 · Cited by 4 · see citing works
Seivani, M. K., Modabber, N., Shadpirouz, M., Amiri, B. S., Bahoorzahi, P., & Bahraminia, S. (2023) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2023.101324 · Cited by 2 · see citing works
Marsh, C. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.87593 · Cited by 1 · see citing works
Endometriosis and susceptibility to COVID-19 infection: a floating river without blanks?
Mormile, R. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07337-6 · Cited by 1 · see citing works
microRNA and Overcoming the Challenges of Their Use in the Diagnosis of Endometriosis
Turpin, V., Leonova, A., Agarwal, S. K., & Foster, W. G. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91324 · Cited by 1 · see citing works
CRK (v-crk sarcoma virus CT10 oncogene homolog (avian))
Tanaka, S. (2012) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/47483
Russu, M. C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84203
Agrawal, S., & Becker, C. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-28584-5_12
Propofol inhibits proliferation and invasion of endometriotic cells by miR-9-5p/TGFBI axis
Li, G., Zhou, Q. Y., Song, J., Xiao, L., Zhu, Y., & Hou, B. (2020) · All Life · doi:10.1080/26895293.2020.1789761
Potential hypothesis for the increased risk of stroke in women with endometriosis
Mormile, R. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.11.036
Non-invasive diagnostics of endometriosis based on plasma miRNA expression
Ordiyants, I. M., Novginov, D. S., Zyukina, Z. V., Khachatryan, A. M., & Titov, S. E. (2024) · Fundamental and Clinical Medicine · doi:10.23946/2500-0764-2023-8-4-24-36
Endometriosis and the risk of ovarian cancer: is miR126 the Achille’s heel?
Mormile, R. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07440-2
The role of p19 C-H-Ras protein in metastasis and proliferative pathways
Cruz, G. D., & Marlen, R. (2013) · TDX (Tesis Doctorals en Xarxa)
MicroRNA Crossroads in PCOS and Endometriosis
Sambath, G., Kalai, J., Usha Rani, G., Osborne, J. W., Sumitha, R., & Parvathi, V. D. (2025) · Reproductive Sciences · doi:10.1007/s43032-025-02037-9
- Authors
- Liu, S., Gao, S., Wang, X. Y., & Wang, D. B.
- Affiliations
- Sheng Jing Hospital (CN)
- Corresponding author
- Wang, Dan Bo
- ORCID
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2011-10-20
- Volume
- 285
- Issue
- 4
- Pages
- 1065-1072
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2075614252
- Cited by
- 49
- References
- 36
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- miR-126, Crk, endometriosis, ectopic endometrium, eutopic endometrium, microRNA regulation, endometriosis progression, endometriosis pathogenesis
- MeSH terms
- Adult, Endometriosis, Female, Humans, Disease Progression, MicroRNAs, Proto-Oncogene Proteins c-crk
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review