Cited by 35Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Comparative study between VEGF-A and CA-125 in diagnosis and follow-up of advanced endometriosis after conservative laparoscopic surgery

Mohamed, Mohamed L., El Behery, Manal M., Mansour, Shymaa A. E.-A.·2013·Archives of Gynecology and Obstetrics

Abstract

Objective To evaluate the role of serum level of VEGF-A in comparison to CA-125 in diagnosis and follow-up of patients with advanced endometriosis after conservative laparoscopic surgery.Methods A prospective randomized case-control study was performed on patients referred for laparoscopy complaining of unexplained primary infertility with or without chronic pelvic pain. Thirty patients with advanced endometriosis; stage III-IV were included (study group), another 30 women without endometriosis or any other medical conditions were settled as a control group. Pre-operative blood samples were collected from study and control cases. Post-operative blood samples were collected from 25 treated patients in the follicular phase of the third menstrual cycle; 5 cases were drop-outs. Serum level of cancer antigen-125 (CA-125) and vascular endothelial growth factor (VEGF-A) were assayed by using enzyme linked immunosorbent assay (ELISA) kit.Results There was a statistically significant difference in serum CA-125 and VEGF-A level in patients with advanced endometriosis before conservative laparoscopic surgery and those without endometriosis (p < 0.001) and after conservative laparoscopic surgery (p < 0.001). High sensitivity (93.3 %), specificity (96.7 %) and accuracy (95.0 %) of VEGF-A assay than in CA-125 distinguishing between patients with endometriosis from those without endometriosis; CA-125 has 70.0 %sensitivity, 90.0 % specificity and 85.0 % accuracy. Percentage of decrease of VEGF-A level after operation was higher than that of CA-125 (45.9 vs. 25.8 %) p < 0.001, respectively.Conclusion The use of VEGF-A for diagnosis of advanced endometriosis at cut-off 680 pg/ml and for follow-up is better than CA-125.

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Crossref · 10.1007/s00404-012-2539-4

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  • Follow-up of patients with advanced endometriosis showed reduced VEGF-A levels after laparoscopic excision of the lesions.

    “Follow-up of patients with advanced endometriosis showed reduced VEGF-A levels after laparoscopic excision of the lesions [68, 69].”

    From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [68]

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Authors
Mohamed, M. L., El Behery, M. M., & Mansour, S. A. E.-A.
Affiliations
Zagazig University (EG)
Venue
Archives of Gynecology and Obstetrics
Published
2012-08-29
Volume
287
Issue
1
Pages
77-82
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
OpenAlex
W2094889223
Cited by
35
References
42
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 1
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
advanced endometriosis, VEGF-A, CA125, serum biomarkers, laparoscopic conservative surgery, postoperative follow-up, diagnostic accuracy, primary infertility, chronic pelvic pain
MeSH terms
Adolescent, Adult, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Follicular Phase, Humans, Laparoscopy, Prospective Studies, Sensitivity and Specificity, Case-Control Studies, Pelvic Pain, CA-125 Antigen, Vascular Endothelial Growth Factor A

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