Comparative study between VEGF-A and CA-125 in diagnosis and follow-up of advanced endometriosis after conservative laparoscopic surgery
Abstract
Objective To evaluate the role of serum level of VEGF-A in comparison to CA-125 in diagnosis and follow-up of patients with advanced endometriosis after conservative laparoscopic surgery.Methods A prospective randomized case-control study was performed on patients referred for laparoscopy complaining of unexplained primary infertility with or without chronic pelvic pain. Thirty patients with advanced endometriosis; stage III-IV were included (study group), another 30 women without endometriosis or any other medical conditions were settled as a control group. Pre-operative blood samples were collected from study and control cases. Post-operative blood samples were collected from 25 treated patients in the follicular phase of the third menstrual cycle; 5 cases were drop-outs. Serum level of cancer antigen-125 (CA-125) and vascular endothelial growth factor (VEGF-A) were assayed by using enzyme linked immunosorbent assay (ELISA) kit.Results There was a statistically significant difference in serum CA-125 and VEGF-A level in patients with advanced endometriosis before conservative laparoscopic surgery and those without endometriosis (p < 0.001) and after conservative laparoscopic surgery (p < 0.001). High sensitivity (93.3 %), specificity (96.7 %) and accuracy (95.0 %) of VEGF-A assay than in CA-125 distinguishing between patients with endometriosis from those without endometriosis; CA-125 has 70.0 %sensitivity, 90.0 % specificity and 85.0 % accuracy. Percentage of decrease of VEGF-A level after operation was higher than that of CA-125 (45.9 vs. 25.8 %) p < 0.001, respectively.Conclusion The use of VEGF-A for diagnosis of advanced endometriosis at cut-off 680 pg/ml and for follow-up is better than CA-125.
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Follow-up of patients with advanced endometriosis showed reduced VEGF-A levels after laparoscopic excision of the lesions.
“Follow-up of patients with advanced endometriosis showed reduced VEGF-A levels after laparoscopic excision of the lesions [68, 69].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [68]
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- Authors
- Mohamed, M. L., El Behery, M. M., & Mansour, S. A. E.-A.
- Affiliations
- Zagazig University (EG)
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2012-08-29
- Volume
- 287
- Issue
- 1
- Pages
- 77-82
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2094889223
- Cited by
- 35
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- advanced endometriosis, VEGF-A, CA125, serum biomarkers, laparoscopic conservative surgery, postoperative follow-up, diagnostic accuracy, primary infertility, chronic pelvic pain
- MeSH terms
- Adolescent, Adult, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Follicular Phase, Humans, Laparoscopy, Prospective Studies, Sensitivity and Specificity, Case-Control Studies, Pelvic Pain, CA-125 Antigen, Vascular Endothelial Growth Factor A
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