Cited by 27Schizophrenia research and treatmentPhysical Activity and HealthAutism Spectrum Disorder Research

Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia

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Kimhy, D., Tay, C., Vakhrusheva, J., Beck-Felts, K., Ospina, L. H., Ifrah, C., Parvaz, M., Gross, J. J. +1 more·2021·European Archives of Psychiatry and Clinical Neuroscience

Abstract

Individuals with schizophrenia display substantial deficits in social functioning (SF), characterized by chronic, lifelong presentations. Yet, at present there are few effective interventions to enhance SF in this population. Emerging evidence from studies of clinical populations that display similar SF deficits suggests that aerobic exercise (AE) may improve social skills. However, this putative impact has not been investigated in schizophrenia. Employing a single-blind, randomized clinical trial design, 33 individuals with schizophrenia were randomized to receive 12 weeks of Treatment-As-Usual (TAU; n = 17) or TAU + AE (n = 16) utilizing active-play video games (Xbox 360 Kinect) and traditional AE equipment. Participants completed an evaluation of aerobic fitness (VO 2 max) as well as self-, informant-, and clinician-reported SF measures at baseline and after 12 weeks. Twenty-six participants completed the study (79%; TAU = 13; AE = 13). At follow-up, the AE participants improved their VO 2 max by 18.0% versus - 0.5% in the controls (group x time interaction, F 1,24 = 12.88; p = .002). Hierarchical stepwise regression analyses indicated improvements in VO 2 max significantly predicted enhancement in SF as indexed by self-, informant-, and clinician-reported measures, predicting 47%, 33%, and 25% of the variance, respectively (controlling for baseline demographics, medications, mood symptoms, and social networks). Compared to the TAU group, AE participants reported significant improvement in SF (23.0% vs. - 4.2%; group × time interaction, F 1,24 = 7.48, p = .012). The results indicate that VO 2 max enhancement leads to improvements in SF in people with schizophrenia. Furthermore, low VO 2 max represents a modifiable risk factor of SF in people with schizophrenia, for which AE training offers a safe, non-stigmatizing, and nearly side-effect-free intervention.

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  • Physical exercise interventions that demonstrated significant social functioning outcomes ranged from 10 weeks to 3 months with 60-120 min of weekly sessions.

    “Interventions that demonstrated statistically significant social functioning outcomes ranged from 10 weeks to 3 months with 60–120 min of weekly sessions (Dubreucq et al. 2020; Firth et al. 2018; Kimhy et al. 2021; Şenormancı et al. 2021).”

    From Social Functioning Interventions in Psychosis: A Systematic Review. (2025) · cites this paper as Kimhy et al. 2021

    The Methods (Measures; page unavailable) describe a 12-week aerobic-exercise intervention, and the Results report a statistically significant social-functioning difference on one measure among study completers. But the prescribed schedule was three 1-hour sessions per week—180 minutes, not 60–120. The Results also report an average of 2.4 sessions attended per week, equivalent to about 144 session minutes. (LLM, conf=0.90)

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  • Physical exercise interventions improved social functioning in psychosis compared to treatment-as-usual.

    “Four studies found statistically significant improvements in social functioning in psychosis compared to the treatment‐as‐usual (TAU) group (Dubreucq et al. 2020; Firth et al. 2018; Kimhy et al. 2021; Şenormancı et al. 2021).”

    From Social Functioning Interventions in Psychosis: A Systematic Review. (2025) · cites this paper as Kimhy et al. 2021

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Authors
Kimhy, D., Tay, C., Vakhrusheva, J., Beck-Felts, K., Ospina, L. H., Ifrah, C., Parvaz, M., Gross, J. J., & Bartels, M. N.
Affiliations
  • James J. Peters VA Medical Center (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • Columbia University (US)
  • Stanford University (US)
  • Albert Einstein College of Medicine (US)
Corresponding author
Kimhy, D.
Venue
European Archives of Psychiatry and Clinical Neuroscience
Published
2021-01-03
Volume
271
Issue
2
Pages
367-376
ISSN
  • 0003-9373 (ISSN-L)
  • 0940-1334
  • 1433-8491
OpenAlex
W3119334866
Cited by
27
References
64
Citations by year
2026: 4 · 2025: 7 · 2024: 1 · 2023: 9 · 2022: 4 · 2021: 2
FWCI
2.87
Type
journal article
Language
en
Open access
Locations
  • European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R21 MH096132)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
schizophrenia, social functioning, aerobic exercise, cardiorespiratory fitness, VO2max, Kinect sensor, exercise intervention, social skills
MeSH terms
Psychiatric Rehabilitation, Social Interaction, Adolescent, Adult, Exercise Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Physical Fitness, Pilot Projects, Schizophrenia, Exercise, Single-Blind Method, Outcome Assessment, Health Care, Young Adult

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