Effect of psychosocial interventions on social functioning in depression and schizophrenia: meta-analysis
Open accessAbstract
Background: Psychosocial interventions may contribute to reducing the burden of mental disorders in low- and middle-income (LAMI) countries by improving social functioning, but the evidence has not been systematically reviewed. Aims: Systematic review and meta-analysis of the effect of psychosocial interventions on social functioning in people with depression and schizophrenia in LAMI countries. Method: Studies were identified through database searching up to March 2011. Randomised controlled trials were included if they compared the intervention group with a control group receiving placebo or treatment as usual. Random effects meta-analyses were performed separately for depressive disorders and schizophrenia and for each intervention type. Results: Of the studies that met the inclusion criteria (n=24), 21 had sufficient data to include in the meta-analysis. Eleven depression trials showed good evidence for a moderate positive effect of psychosocial interventions on social functioning (standardised mean difference (SMD)=0.46, 95% CI 0.24-0.69, n=4009) and ten schizophrenia trials showed a large positive effect on social functioning (SMD = 0.84, 95% CI 0.49-1.19, n=1671), although seven of these trials were of low quality. Excluding these did not substantially affect the size or direction of effect, although the precision of the estimate was substantially reduced (SMD = 0.89, 95% CI 0.05-1.72, n=863). Conclusions: Psychosocial interventions delivered in out-patient and primary care settings are effective at improving social functioning in people with depression and should be incorporated into efforts to scale up services. For schizophrenia there is an absence of evidence from high-quality trials and the generalisabilty of the findings is limited by the over-representation of trials conducted in populations of hospital patients in China. More high-quality trials of psychosocial interventions for schizophrenia delivered in out-patient settings are needed.
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- Findingown data
The 24 included trials used 10 different scales to measure social functioning.
“The 24 included trials used 10 different scales to measure social functioning, confirming the previously reported lack of consensus on its measurement.16”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [16] Burns T Patrick D Social functioning as an outcome measure in schizophrenia studies. Acta Psychiatr Scand 2007; 116: 403– 18 17941964
Not checked in the free run.
- Findingown data
Three trials of interpersonal therapy for depression showed a large positive impact on social functioning (SMD=0.84, 95% CI 0.40-1.29, P=0.0002, I2=67%, n=360).
“There was evidence from three trials of a large, positive impact of IPT on social functioning (SMD = 0.84, 95% CI 0.40–1.29, P = 0.0002, I2 = 67%, n = 360).”
Quote in the paperSubstantial claim - Findingown data
Six trials of multicomponent interventions for depression showed a small improvement in social functioning (SMD=0.35, 95% CI 0.11-0.59, P≤0.001, I2=89%, n=3291).
“There was robust evidence from the six trials evaluating multicomponent interventions for a small improvement in social functioning (SMD = 0.35, 95% CI 0.11–0.59, P≤0.001, I2 = 89%, n = 3291).”
Quote in the paperSubstantial claim - Findingown data
No schizophrenia trials were included from Sub-Saharan Africa or South Asia.
“No trials were included from Sub-Saharan Africa or South Asia.”
Quote in the paperNot a substantial claim - Findingown data
Only a tiny fraction of trials included in those Cochrane reviews came from low- and middle-income countries.
“Only 17 of the 62 Cochrane reviews of psychosocial interventions to treat depression or schizophrenia include social functioning outcomes, with only a tiny fraction of the included trials from low- and middle-income (LAMI) countries”
Quote in the paperSubstantial claim
- Findingown data
There was not enough evidence to assess the effect of problem-solving therapy or Morita therapy for depression.
“There was not enough evidence to assess the effect of problem-solving therapy or Morita therapy as only one trial respectively assessed these interventions.”
Quote in the paperNot a substantial claim - Findingown data
Most schizophrenia trials (11 of 13) were conducted in China in hospital in-patient populations.
“In contrast to the depression trials, most (11/13) were conducted in China in hospital in-patient populations and only two used non-specialists to deliver the intervention.”
Quote in the paperNot a substantial claim - Findingnone given
All 11 depression trials were suitable for inclusion in the meta-analysis.
“All 11 depression trials were suitable for inclusion in the meta-analysis.”
Quote in the paperSubstantial claim - Findingown data
Only two schizophrenia trials used non-specialists to deliver the intervention.
“In contrast to the depression trials, most (11/13) were conducted in China in hospital in-patient populations and only two used non-specialists to deliver the intervention.”
Quote in the paperNot a substantial claim - Findingnone given
Only 17 of 62 Cochrane reviews of psychosocial interventions for depression or schizophrenia include social functioning outcomes.
“Only 17 of the 62 Cochrane reviews of psychosocial interventions to treat depression or schizophrenia include social functioning outcomes, with only a tiny fraction of the included trials from low- and middle-income (LAMI) countries”
Quote in the paperSubstantial claim - Findingown data
No included tool measured all domains of social functioning.
“Many of the tools were sophisticated in their measurement of a number of domains of social functioning, although no tool measured all domains, and had been appropriately validated in either a number of populations, or specifically in the population in which they were used.”
Quote in the paperNot a substantial claim - Findingown data
Seven schizophrenia trials were assessed as having a risk of bias.
“Seven were assessed as having a risk of bias and five had strict inclusion criteria limiting the generalisability of the results.”
Quote in the paperNot a substantial claim - Findingcitation
In two trials of community care for schizophrenia, social functioning improved despite no improvement in clinical outcomes.
“notably, the two trials assessing community care for schizophrenia demonstrated an impact on social functioning even though the intervention had no impact on clinical outcomes.41,42”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [41] Li X Li X Ma X Ni Y Effects of social rehabilitation on late-onset schizophrenia [in Chinese]. Chin Ment Health J 2002; 16: 711– 3
Not checked in the free run.
- cites [42] Pang Y Huang S Li X Hu L Lin C The effect of health education on compliance of patients with paranoid schizophrenia in their follow-up therapy [in Chinese]. Chin Ment Health J 2002; 16: 348– 50
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- Findingown data
There was not enough evidence to assess the effect of art therapy or social skills training for schizophrenia.
“There was not enough evidence to assess the effect of art therapy or social skills training as only one study respectively assessed these interventions.”
Quote in the paperNot a substantial claim - Findingcitation
A fourth trial on family psychoeducation that could not be included in the meta-analysis reported a significant positive effect on social functioning.
“A fourth trial on family psychoeducation that could not be included in the meta-analysis also reported a significant positive effect on social functioning.30”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [30] Xiang M Ran M Li S A controlled evaluation of psychoeducational family intervention in a rural Chinese community. Br J Psychiatry 1994; 165: 544– 8 7804673
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- Findingown data
In the included trials, social functioning gains persisted at follow-up beyond one year.
“A striking finding of this review is that improvements in social functioning were maintained at long follow-up periods of over a year.”
Quote in the paperSubstantial claim - Findingown data
Three poor-quality trials of psychoeducation showed a large positive effect on social functioning (SMD=1.15, 95% CI 0.06-2.25, P≤0.001, I2=95%, n=362).
“There was weak evidence from three poor-quality trials of a large positive effect of psychoeducation on social functioning (SMD = 1.15, 95% CI 0.06–2.25, P≤0.001, I2 = 95%, n = 362).”
Quote in the paperSubstantial claim - Findingnone given
Many reviewed interventions were delivered by non-specialists in collaborative or stepped-care models, often in primary care or community settings.
“Many of the interventions included in the review were delivered by non-specialists in collaborative and/or stepped-care delivery models often in primary care or community settings.”
Quote in the paperSubstantial claim - Findingown data
The psychoeducation meta-analysis was skewed by the study of individual patient psychoeducation, which had a much larger effect than the two family interventions.
“The meta-analysis was skewed by the study of individual patient psychoeducation, which had a much larger effect than the two family interventions.”
Quote in the paperNot a substantial claim - Findingown data
Four trials of multicomponent structured psychotherapies versus treatment as usual, with both groups receiving antipsychotic medication, showed large improvements in social functioning (SMD=0.93, 95% CI 0.23-1.63, P≤0.0001, I2=89%, n=893).
“There was good evidence from four trials of large improvements in social functioning due to multicomponent structured psychotherapies against TAU with both groups receiving antipsychotic medication36-39 (SMD = 0.93, 95% CI 0.23–1.63, P≤0.0001, I2 = 89%, n = 893).”
Quote in the paperSubstantial claim0 of 4 sources checked- cites [36] Chen H Chang Y Xiang Y Efficacy of the rehabilitation strategy for inpatients with schizophrenia [in Chinese]. Chin Ment Health J 2003; 17: 839– 42
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [37] Guo X Zhai J Liu Z Fang M Wang B Wang C Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia. Arch Gen Psychiatry 2010; 67: 893– 904 PMC3632506 20819983 source
Not checked in the free run.
- cites [38] Yildiz M Veznedaroglu B Eryavuz A Kayahan B Psychosocial skills training on social functioning and quality of life in the treatment of schizophrenia: a controlled study in Turkey. Int J Psychiatry Clin Pract 2004; 8: 219– 25 24930550 source
Not checked in the free run.
- cites [39] Zimmer M Duncan AV Laitano D Ferreira EE Belmonte-de-Abreu P A twelve-week randomized controlled study of the cognitive-behavioral integrated psychological therapy program: positive effect on the social functioning of schizophrenic patients. Rev Bras Psiquiatr 2007; 29: 140– 7 17650536 source
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- Findingown data
In most included trials, clinical and social functioning improved at the same time.
“Indeed, in the vast majority of included trials, concurrent improvements in both clinical and social functioning were observed.”
Quote in the paperSubstantial claim - Findingown data
No trials evaluated several psychosocial interventions shown effective in high-income countries, including wellness promotion, vocational rehabilitation, and cognitive remediation.
“Lastly, no trials were found that evaluated a number of types of psychosocial interventions shown to be effective in high-income countries, such as wellness promotion,50 vocational rehabilitation51 and cognitive remediation.52,53”
Quote in the paperSubstantial claim0 of 4 sources checked- cites [50] Chafetz L White M Collins-Bride G Cooper BA Nickens J Clinical trial of wellness training: health promotion for severely mentally ill adults. J Nerv Ment Dis 2008; 196: 475– 83 18552625 source
Not checked in the free run.
- cites [51] Marshall M Crowther R Almaraz-Serrano A Creed F Sledge W Kluiter H Systematic reviews of the effectiveness of day care for people with severe mental disorders: (1) acute day hospital versus admission; (2) vocational rehabilitation; (3) day hospital versus outpatient care. Health Technol Assess 2001; 5: 1– 75 11532238 source
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- cites [52] Nuechterlein KH Dawson ME Ventura J Gitlin M Subotnik KL Snyder KS The vulnerability/stress model of schizophrenic relapse: a longitudinal study. Acta Psychiatr Scand Suppl 1994; 382: 58– 64 8091999 source
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- cites [53] Delahunty A Morice R Rehabilitation of frontal/executive impairments in schizophrenia. Aust N Z J Psychiatry 1996; 30: 760– 7 9034464 source
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- Findingcitation
A third trial not included in the meta-analysis replicated the community-based finding, showing significant improvement in social functioning at 12- and 18-month follow-up.
“This finding was replicated in a third trial that could not be included in the meta-analysis because of a lack of data, which also showed a significant improvement in social functioning at 12- and 18-month follow-up.32”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [32] Xiong W Phillips MR Hu X Wang R Dai Q Kleinman J Family-based intervention for schizophrenic patients in China. A randomised controlled trial. Br J Psychiatry 1994; 165: 239– 47 7953039 source
Not checked in the free run.
- Interpretationown data
Five schizophrenia trials had strict inclusion criteria that limit the generalisability of the results.
“Seven were assessed as having a risk of bias and five had strict inclusion criteria limiting the generalisability of the results.”
Quote in the paperNot a substantial claim - Premisereasoning
Before this review, the effect of psychosocial interventions on social functioning in depression and schizophrenia in low- and middle-income countries had not been systematically reviewed.
“Although there have been numerous reviews of the clinical effectiveness of interventions for mental disorders,4-7 the effect of psychosocial interventions on social functioning has not been reviewed.”
Quote in the paperNot a substantial claim- Rests on an assumption: Psychosocial interventions may reduce the burden of mental disorders in low- and middle-income countries by improving social functioning.
- Rests on an assumption: Impairment of social functioning is a major reason for the high levels of stigma and disability associated with depression and schizophrenia.
- Premisecitation
Increasing evidence indicates service users value social functioning improvements more than clinical status improvements.
“First, there is increasing evidence that service users place greater value on improvements in social functioning than improvements in clinical status54-56”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [54] Read UM Adiibokah E Nyame S Local suffering and the global discourse of mental health and human rights: an ethnographic study of responses to mental illness in rural Ghana. Glob Health 2009; 5: 13 PMC2770454 19825191 source
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- cites [55] Davidson L White W The concept of recovery as an organising principle for integrating mental health and addiction services. J Behav Health Serv Res 2007; 34: 104– 20 17351758 source
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- cites [56] Mental Health Gap Action Programme Scaling Up Care for Mental, Neurological, and Substance Use Disorders. World Health Organization, 2008 26290926
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationown data
Risk of bias associated with seven of ten schizophrenia studies limits the strength of evidence from the meta-analysis.
“However, the risk of bias associated with seven of these ten studies limits the strength of the evidence from this meta-analysis.”
Quote in the paperSubstantial claim - Interpretationcitation
An intervention that improves social functioning does not necessarily improve clinical symptoms.
“However, an intervention that improves social functioning may not necessarily have an impact on clinical symptoms”
Quote in the paperSubstantial claim - Interpretationown data
The generalisability of the schizophrenia findings is restricted by the predominance of trials of hospital in-patients in China.
“The generalisability of these findings is also restricted by the predominance of trials of hospital in-patients in China.”
Quote in the paperSubstantial claim - Study design and conductnone given
All but one of the depression meta-analysis trials were methodologically strong.
“In contrast, all but one of the trials included in the depression meta-analysis were methodologically strong.”
Quote in the paperNot a substantial claim - Study design and conductnone given
For schizophrenia, high-quality trial evidence was absent.
“For schizophrenia there was an absence of evidence from high-quality trials”
Quote in the paperSubstantial claim - Interpretationown data
Different types of psychosocial interventions are effective at improving social functioning in people with depression and schizophrenia in low- and middle-income countries.
“Overall, the results show that different types of psychosocial interventions are effective at improving social functioning in people with depression and schizophrenia in LAMI countries.”
Quote in the paperSubstantial claim- Rests on an assumption: Psychosocial interventions may reduce the burden of mental disorders in low- and middle-income countries by improving social functioning.
- Interpretationreasoning
Patients whose symptoms remit can be expected to show improvement in social functioning.
“and that patients who recover symptomatically can be expected to experience a positive change in social functioning.”
Quote in the paperSubstantial claim - Interpretationown data
There is good evidence from three high-quality trials that a combination of structured psychological therapies, such as psychoeducation, social skills training and interpersonal therapy, delivered with antipsychotic medication leads to large improvements in patient social functioning compared with medication alone.
“However, there was good evidence from three high-quality trials that a combination of structured psychological therapies (for example psychoeducation, social skills training and IPT), delivered in combination with antipsychotic medication, leads to large improvements in patient social functioning compared with medication alone.”
Quote in the paperSubstantial claim - Interpretationreasoning
The review provides weaker evidence for schizophrenia supporting use of various psychosocial interventions, with or without concurrent medication, in LAMI countries.
“This review provides strong evidence for depression and weaker evidence for schizophrenia in support of the use of a range of psychosocial interventions, with or without concurrent pharmacological interventions5,6 in LAMI countries.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [5] Patel V Simon G Chowdhary N Kaaya S Araya R Packages of care for depression in low- and middle-income countries. PLoS Med 2009; 6: e1000159 19806179 PMC2747016 source
Not checked in the free run.
- cites [6] Mari J Razzouk D Thara R Eaton J Thornicroft G Packages of care for schizophrenia in low- and middle-income countries. PLoS Med 2009; 6: e1000165 19841735 PMC2758997 source
Not checked in the free run.
- Rests on an assumption: The social functioning outcome measures used across the included trials are sufficiently comparable to be combined in a meta-analysis.
- Rests on an assumption: The results from the included trials are generalisable to LAMI countries.
- Study design and conductown data
The schizophrenia findings' generalisability is limited by over-representation of trials from China with hospital patient populations.
“and the generalisabilty of the findings is limited by the over-representation of trials from China conducted in populations of hospital patients.”
Quote in the paperNot a substantial claim - Premisecitation
Social functioning impairments are often a key reason individuals seek care.
“and that impairments in social functioning are often a key factor in an individual's decision to seek care.3”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [3] Hirschfeld RM Montgomery SA Keller MB Kasper S Schatzberg AF Moller HJ Social functioning in depression: a review. J Clin Psychiatry 2000; 61: 268– 75 10830147
Not checked in the free run.
- Interpretationcitation
The review provides strong evidence for depression supporting use of various psychosocial interventions, with or without concurrent medication, in LAMI countries.
“This review provides strong evidence for depression and weaker evidence for schizophrenia in support of the use of a range of psychosocial interventions, with or without concurrent pharmacological interventions5,6 in LAMI countries.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [5] Patel V Simon G Chowdhary N Kaaya S Araya R Packages of care for depression in low- and middle-income countries. PLoS Med 2009; 6: e1000159 19806179 PMC2747016 source
Not checked in the free run.
- cites [6] Mari J Razzouk D Thara R Eaton J Thornicroft G Packages of care for schizophrenia in low- and middle-income countries. PLoS Med 2009; 6: e1000165 19841735 PMC2758997 source
Not checked in the free run.
- Rests on an assumption: The social functioning outcome measures used across the included trials are sufficiently comparable to be combined in a meta-analysis.
- Rests on an assumption: The results from the included trials are generalisable to LAMI countries.
- Study design and conductcitation
There is a risk that contextually relevant outcomes, which may most reduce stigma, were not captured.
“and there is a risk that contextually relevant outcomes, which may have the biggest impact on reducing stigma49 were not captured.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [49] Patel V Farooq S Thara R What is the best approach to treating schizophrenia in developing countries? PLoS Med 2007; 4: e159 17579508 PMC1892038
Not checked in the free run.
- Study design and conductcitation
Few of the social functioning measurement tools were developed or validated for the setting where they were used.
“Furthermore, few of the tools to measure social functioning were developed or validated for the setting in which they were used, with some exceptions18”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [18] Bass J Neugebauer R Clougherty KF Verdeli H Wickramaratne P Ndogoni L Group interpersonal psychotherapy for depression in rural Uganda: 6-month outcomes. Randomised controlled trial. Br J Psychiatry 2006; 188: 567– 73 16738348 source
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- Study design and conductcitation
Limitations in the evidence reviewed affect the strength of conclusions and generalisability, especially for scaling up services in LAMI countries.
“We note some of the limitations of the evidence included in this review that affect the strength of conclusions and generalisability of the results, particularly to efforts to scale up services for people with mental disorders in LAMI countries.45”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [45] Chisholm D Flisher AJ Lund C Patel V Saxena S Thornicroft G Scale up services for mental disorders: a call for action. Lancet 2007; 370: 1241– 52 17804059 source
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- Premisecitation
Specialist human resources are scarce in these settings.
“The scarcity of specialist human resources in these settings60”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [60] Kakuma R Minas H van Ginneken N Dal Poz MR Desiraju K Morris JE Human resources for mental health care: current situation and strategies for action. Lancet 2011; 378: 1654– 63 22008420
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- Study design and conductown data
Most scales used by the included trials omit some social functioning domains listed in online Table DS2, especially parental functioning.
“Most of the scales used by the included trials do not include the full range of social functioning domains listed in online Table DS2, in particular parental functioning.”
Quote in the paperNot a substantial claim - Study design and conductown data
The precision of the sustained-effect estimate is reduced by the small number of trials in the meta-analysis.
“the precision of this estimate is reduced by the smaller number of trials included in this meta-analysis.”
Quote in the paperNot a substantial claim- Rests on an assumption: The social functioning outcome measures used across the included trials are sufficiently comparable to be combined in a meta-analysis.
- Interpretationown data
For depression, there is strong evidence that stepped collaborative care interventions, often delivered by non-specialists and comprising structured pharmacotherapy, psychoeducation, adherence support and sometimes structured psychotherapy, have moderate effects on improving patient social functioning up to 12 months from start of treatment.
“For depression, there is strong evidence that stepped collaborative care interventions, often delivered by non-specialists and comprising structured pharmacotherapy, psychoeducation, adherence support and in some cases structured psychotherapy have moderate effects on improving patient social functioning up to 12 months from start of treatment.”
Quote in the paperSubstantial claim - Study design and conductreasoning
The social functioning measures used by the trials may have influenced the review's results.
“Also, the measures of social functioning used by the trials may have affected the results of the review.”
Quote in the paperNot a substantial claim - Interpretationown data
There is some evidence that interpersonal therapy, often delivered by non-specialists, is effective at improving social functioning over a 12-month period in depression.
“There was also some evidence that IPT, often delivered by non-specialists, is effective at improving social functioning over a 12-month period.”
Quote in the paperSubstantial claim - Interpretationreasoning
The absence of clinical impact in the community care trials may be because those interventions shifted care to the community to promote re-integration after hospital admission rather than targeting clinical symptoms.
“This may be because these interventions involved shifting the locus of care to the community to promote re-integration following a hospital admission, rather than specific treatments for clinical symptoms.”
Quote in the paperNot a substantial claim
- Classified as probably not a substantial claim. 17
- May combine two claims. 25
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataFour depression trials were from Chile, three from China, and the remainder from India, Brazil and Uganda.
“Four of the trials were from Chile, three from China, and the remainder from India, Brazil and Uganda.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataExcluding the one depression trial with risk of bias did not affect the conclusion, and the magnitude of effect was the same for short- and long-term follow-up.
“Excluding the one trial with a risk of bias did not affect this conclusion, and the magnitude of effect was the same for both short- and long-term follow-up.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIn the depression trials, the pooled standardised mean difference for all psychosocial interventions was 0.46 (95% CI 0.24-0.69, P≤0.001, I2=90%, n=4009), indicating small to moderate improvements in social functioning.
“The combined SMD for all interventions was 0.46 (95% CI 0.24–0.69, P≤0.001, I2 = 90%, n = 4009), indicating small to moderate improvements in social functioning based on the rule of thumb interpretation of SMDs whereby 0.2 represents a small effect, 0.5 a moderate effect and 0.8 a large effect.29”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [29] Cohen J Statistical Power Analysis in the Behavioral Sciences (2nd edn). Lawrence Erlbaum Associates, 1988
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe majority of depression trials were set in out-patient, primary care or community settings.
“The majority of trials were set in out-patient, primary care or community settings.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataFive depression trials used non-mental health specialists to deliver the intervention through task-sharing.
“Five of the trials used non-mental health specialists to deliver the intervention through task-sharing.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThree schizophrenia trials did not contain sufficient data for meta-analysis and were included in the qualitative synthesis only.
“Three trials did not contain sufficient data to be included in the meta-analysis,30-32 and as we were unable to obtain this information from the authors, these trials are included in the qualitative synthesis of results only.”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [30] Xiang M Ran M Li S A controlled evaluation of psychoeducational family intervention in a rural Chinese community. Br J Psychiatry 1994; 165: 544– 8 7804673 source
Not checked in the free run.
- cites [31] Cui Y Yang W Weng Y Effectiveness of social skills training in patients with chronic schizophrenia [in Chinese]. Chin Ment Health J 2004; 18: 799– 805
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites [32] Xiong W Phillips MR Hu X Wang R Dai Q Kleinman J Family-based intervention for schizophrenic patients in China. A randomised controlled trial. Br J Psychiatry 1994; 165: 239– 47 7953039 source
Not checked in the free run.
May combine two claims.
Findingown dataEleven depression trials assessed interventions: six multicomponent collaborative care, three interpersonal therapy, one problem-solving therapy, and one Morita therapy.
“In total 11 trials assessed the effect of interventions to treat depression, 6 assessed multicomponent collaborative care interventions, three interpersonal therapy (IPT), 1 problem-solving therapy, and 1 Morita therapy.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThirteen schizophrenia trials assessed interventions: three family psychoeducation, one patient psychoeducation, one social skills training, one art therapy, four multicomponent structured psychotherapies, and three community-based care interventions.
“Thirteen trials assessed the effect of interventions to treat schizophrenia: 3 trials assessed the effect of family psychoeducation, 1 patient psychoeducation, 1 social skills training, 1 art therapy, 4 multicomponent structured psychotherapies and 3 community-based care interventions.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataA total of 9592 unique records were obtained, and 24 trials met the inclusion criteria.
“A total of 9592 unique records were obtained, of which 24 trials met the inclusion criteria.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOnly one depression trial was assessed as having overall risk of bias, and nine had long-term follow-up of more than six months.
“Only one trial was assessed as having an overall risk of bias and nine had long-term follow-up of more than 6 months.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataExcluding the seven schizophrenia trials with risk of bias did not substantially affect the size or direction of effect, but precision was substantially reduced (SMD=0.89, 95% CI 0.05-1.72, P≤0.001, I2=91%, n=863).
“Excluding the seven trials with a risk of bias did not substantially affect the size or direction of effect, although the precision of the estimate was substantially reduced due to the smaller pooled sample sizes (SMD = 0.89, 95% CI 0.05–1.72, P≤0.001, I2 = 91%, n = 863).”
Quote in the paperSubstantial claimMay combine two claims.
FindingcitationSome included trials showed social functioning improvements only at later stages, while clinical improvements often appeared early.
“In contrast to clinical improvements that are often observed early in the intervention, improvements in social functioning were sometimes only evident at later stages (for example Li & Arthur33 and Pang et al42).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Li & Arthur33
Not checked in the free run.
- cites Pang et al42
Not checked in the free run.
May combine two claims.
FindingreasoningThe search identified a substantial body of previously largely uncited Chinese work that adds significantly to knowledge, especially on schizophrenia intervention effectiveness.
“This resulted in the identification of a substantial body of previously largely uncited work from China that significantly adds to the body of knowledge particularly on the effectiveness of schizophrenia interventions.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe depression and schizophrenia reviews found intervention effects sustained beyond 6 and 12 months, respectively.
“Although both the depression and the schizophrenia reviews show that intervention effects were sustained over greater than a 6- or 12-month period respectively”
Quote in the paperNot a substantial claim- Rests on an assumption: The social functioning outcome measures used across the included trials are sufficiently comparable to be combined in a meta-analysis.
May combine two claims.
Findingown dataThree of these four trials had low risk of bias, and a sensitivity analysis restricted to these trials did not affect the finding.
“Three of these trials had a low risk of bias and a sensitivity analysis restricted to these trials did not affect this finding.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataEleven depression trials from five countries and thirteen schizophrenia trials from three countries were included.
“A total of 11 depression trials from 5 countries and 13 schizophrenia trials from 3 countries were included in this review.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe combined standardised mean difference for all schizophrenia interventions was 0.84 (95% CI 0.49-1.19, P≤0.001, I2=89%, n=1671), indicating large improvements in social functioning.
“The combined SMD for all interventions was 0.84 (95% CI 0.49–1.19, P≤0.001, I2 = 89%, n = 1671), indicating large improvements in social functioning.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe effect of schizophrenia interventions on social functioning increased over time: moderate at less than 12 months (SMD=0.71, 95% CI 0.36-1.06, P≤0.001, I2=88%, n=1718) and large at more than 12 months (SMD=0.93, 95% CI 0.37-1.49, P≤0.001, I2=95%, n=1409).
“The effect of the interventions on social functioning increased over time, with moderate effect sizes at less than 12 months' follow-up (SMD = 0.71, 95% CI 0.36–1.06, P≤0.001, I2 = 88%, n = 1718), increasing to a large effect on social functioning at more than 12 months' follow-up (SMD = 0.93, 95% CI 0.37–1.49, P≤0.001, I2 = 95%, n = 1409).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataTwo high-risk trials of community-based interventions showed a small increase in social functioning (SMD=0.33, 95% CI 0.10-0.55, P=0.004, I2=88%, n=316), despite neither trial showing an effect on clinical outcomes.
“There was weak evidence from two trials with a high risk of bias41,42 of a small increase in social functioning as a result of community-based interventions (SMD = 0.33, 95% CI 0.10–0.55, P = 0.004, I2 = 88%, n = 316), despite neither trial showing an effect on clinical outcomes.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [41] Li X Li X Ma X Ni Y Effects of social rehabilitation on late-onset schizophrenia [in Chinese]. Chin Ment Health J 2002; 16: 711– 3
Not checked in the free run.
- cites [42] Pang Y Huang S Li X Hu L Lin C The effect of health education on compliance of patients with paranoid schizophrenia in their follow-up therapy [in Chinese]. Chin Ment Health J 2002; 16: 348– 50
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataRisk of bias was assessed at both the study level and the outcome level.
“Risk of bias was assessed both at the study level (for example sequence generation and allocation concealment) and at the outcome level (for example losses to follow-up for the social functioning outcome).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationThe review's methods and results are reported according to the PRISMA statement for systematic reviews.
“The methods and results in this paper are presented according to the PRISMA statement for reporting systematic reviews.8”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [8] Moher D Liberati A Tetzlaff J Altman DG Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097 19621072 PMC2707599 source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe quality of included studies was assessed with the Cochrane risk of bias tool by two authors.
“The quality of included studies was assessed using the Cochrane risk of bias tool14 by two authors.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [14] Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011
Not checked in the free run.
Classified as probably not a substantial claim.
Study design and conductreasoningTo control for study quality, trials with risk of bias for allocation concealment, or unassessable allocation concealment plus risk of bias for sequence generation and/or masking, were excluded from the meta-analysis.
“To control for study quality, trials that had a risk of bias for allocation concealment, or for whom allocation concealment could not be assessed but who had a risk of bias for sequence generation and/or masking of outcome assessment, were excluded from the meta-analysis.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenData for the meta-analyses were extracted by H.L.L. and double checked by M.J.D.S.
“Data for the meta-analyses were extracted by H.L.L. and double checked by M.J.D.S.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataFunnel plots were generated to assess possible publication bias.
“Lastly, funnel plots for the primary meta-analyses were generated to assess possible publication bias.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataData were extracted by two authors using a standard data extraction form.
“Data were extracted by two authors using a standard data extraction form including inclusion criteria for participants, intervention and control groups, outcome measures and effect estimates.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataThe funnel plots were somewhat asymmetrical, but this asymmetry may have been caused by heterogeneity in intervention type rather than publication bias, as indicated by the large I2.
“Although a visual inspection of the plots shows them to be somewhat asymmetrical, this asymmetry may have been caused by heterogeneity in intervention type rather than publication bias, as indicated by the large I2 for the combined effect estimates.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataFor schizophrenia, interventions demonstrated a strong effect, but interpretation is tempered by risk of bias associated with seven of ten trials.
“For schizophrenia, interventions demonstrated a strong effect, but the interpretation of these findings is tempered by the risk of bias associated with seven of the ten trials.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductown dataThe review used a wide-ranging search with no restrictions on date, publication type, or language.
“We used a wide-ranging search strategy with no limitations set on date, publication type or language.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningSocial functioning improvements tend to occur more slowly and after clinical improvements.
“It is likely that improvements in social functioning happen more slowly and subsequently to clinical improvements”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing). May combine two claims.
InterpretationreasoningInterventions improving patient social functioning will reduce mental disorder burden by enabling productive social roles and may be the most effective way to combat stigma.
“Providing interventions that improve patient social functioning will not only reduce the burden of mental disorders by enabling people to fulfil a productive social role, but may also be the most effective way to combat stigma.”
Quote in the paperNot a substantial claim- Rests on an assumption: The results from the included trials are generalisable to LAMI countries.
Classified as probably not a substantial claim. May combine two claims.
Study design and conductown dataThe review meta-analysed similar trials with outcomes at similar time points and comparable control groups to test effect size on social functioning, and examined heterogeneity by study quality.
“We conducted a meta-analysis of similar trials, using outcomes measured at similar time points and with comparable control groups to test the size of the effect of the interventions on social functioning, and examined heterogeneity by study quality.”
Quote in the paperSubstantial claim- Rests on an assumption: The social functioning outcome measures used across the included trials are sufficiently comparable to be combined in a meta-analysis.
Probably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationSome asymmetry may have been caused by the tendency for poorer quality trials to show larger effects.
“Some asymmetry may also have been caused by the tendency in this review for the poorer quality trials to show larger effects, as documented elsewhere.44”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [44] Schulz KF Chalmers I Hayes RJ Altman DG Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995; 273: 408– 12 7823387 source
Not checked in the free run.
May combine two claims.
Study design and conductown dataParental functioning was measured in only two of the ten scales used by the included trials, which may underestimate intervention effects on social functioning.
“Parental functioning was only measured in two of the ten scales used by the included trials, leading to potential underestimates of the effect of the intervention on social functioning in these trials.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningA third of included trials had short follow-up, which may have prevented detection of functioning improvements in the intervention group.
“Additional limitations of the evidence included in this review include the short follow-up in a third of trials, potentially not allowing sufficient time to detect improvements in functioning in the intervention group.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationMaternal depression has been shown to affect child health and growth.
“but maternal depression has been shown to affect child health47 and growth.48”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [47] Rahman A Malik A Sikander S Roberts C Creed F Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial. Lancet 2008; 372: 902– 9 18790313 PMC2603063 source
Not checked in the free run.
- cites [48] Surkan PJ Kennedy CE Hurley KM Black MM Maternal depression and early childhood growth in developing countries: systematic review and meta-analysis. Bull World Health Organ 2011; 89: 608– 15 21836759 PMC3150769 source
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
Study design and conductreasoningThe review's methods were strong.
“On the other hand, the methods used for this review were strong.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataFour trials were assessed as having high overall risk of bias, so the level of evidence for psychoeducation is currently weak.
“As four trials were assessed as having a high overall risk of bias (two because the risk of bias was unknown due to lack of information in the published paper), the level of evidence for psychoeducation is currently weak.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationWomen have a higher risk of depression.
“as not only are they at a higher risk for depression,5”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [5] Patel V Simon G Chowdhary N Kaaya S Araya R Packages of care for depression in low- and middle-income countries. PLoS Med 2009; 6: e1000159 19806179 PMC2747016 source
Not checked in the free run.
The paper relies on this without support.
Psychosocial interventions may reduce the burden of mental disorders in low- and middle-income countries by improving social functioning.
“Psychosocial interventions may contribute to reducing the burden of mental disorders in low- and middle-income (LAMI) countries by improving social functioning”
The paper relies on this without support.
Impairment of social functioning is a major reason for the high levels of stigma and disability associated with depression and schizophrenia.
“Impairment of social functioning, defined as ‘an individual's ability to perform and fulfil normal social roles’,3 is a major reason for the high levels of stigma and disability associated with these mental disorders.”
The paper relies on this without support.
The social functioning outcome measures used across the included trials are sufficiently comparable to be combined in a meta-analysis.
“We conducted a meta-analysis of similar trials, using outcomes measured at similar time points and with comparable control groups to test the size of the effect of the interventions on social functioning”
The paper relies on this without support.
The results from the included trials are generalisable to LAMI countries.
“This review provides strong evidence for depression and weaker evidence for schizophrenia in support of the use of a range of psychosocial interventions, with or without concurrent pharmacological interventions5,6 in LAMI countries.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most psychotherapy and pharmacotherapy trials in depression have focussed on the reduction of depressive symptoms, rather than improvement of social functioning.
“However, most psychotherapy and pharmacotherapy trials in depression have focussed on the reduction of depressive symptoms, rather than improvement of social functioning (Silva et al., 2013).”
From Social functioning in major depressive disorder (2016) · cites this paper as Silva et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
The paper both denies and identifies high-quality schizophrenia trials
MajorThe conclusion says there is no evidence from high-quality schizophrenia trials, but the discussion identifies three such trials as providing good evidence for a treatment effect.
“For schizophrenia there is an absence of evidence from high-quality trials”
“However, there was good evidence from three high-quality trials that a combination of structured psychological therapies (for example psychoeducation, social skills training and IPT), delivered in combination with antipsychotic medication, leads to large improvements in patient social functioning compared with medication alone.”
The stated count of Chinese in-patient trials exceeds the total in-patient count
MinorThe statement places 11 schizophrenia trials in Chinese hospital in-patient populations, whereas the table lists only seven hospital in-patient schizophrenia trials across all countries.
“most (11/13) were conducted in China in hospital in-patient populations”
“| Hospital in-patient | 2 | 7 | 9 |”
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Cited by
Sorted by citations
Social functioning in major depressive disorder
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Barbui, C., Purgato, M., Abdulmalik, J., Acarturk, C., Eaton, J., Gastaldon, C., Gureje, O., Hanlon, C., Jordans, M., Lund, C., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30511-5 · Cited by 349 · see citing works
Self-citationKohrt, B. A., Asher, L., Bhardwaj, A., Fazel, M. S., Jordans, M. J. D., Mutamba, B. B., Nadkarni, A., Pedersen, G. A., Singla, D. R., & Patel, V. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15061279 · Cited by 363 · see citing works
Self-citationKoutsouleris, N., Kambeitz-Ilankovic, L., Ruhrmann, S., Rosen, M., Ruef, A., Dwyer, D. B., Paolini, M., Chisholm, K., Kambeitz, J., Haidl, T., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2165 · Cited by 341 · see citing works
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- Authors
- De Silva, M. J., Cooper, S., Li, H. L., Lund, C., & Patel, V.
- Affiliations
- University of Cape Town (ZA)
- London School of Hygiene & Tropical Medicine (GB)
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-04
- Volume
- 202
- Issue
- 4
- Pages
- 253-260
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC3613719
- OpenAlex
- W2107904541
- Semantic Scholar
- e65e7f3bd43af038ab3888f1ff9076d3bc74d1c5
- Cited by
- 125
- References
- 59
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 23 · 2020: 13 · 2019: 11 · 2018: 9 · 2017: 4 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Funders
- Wellcome Trust (091834)
- Department for International Development (HRPC10)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- psychosocial interventions, social functioning, depression, schizophrenia, low- and middle-income countries, outpatient mental health services, primary care, mental health service delivery
- MeSH terms
- Depression, Humans, Poverty, Psychotherapy, Schizophrenia, Schizophrenic Psychology, Social Behavior, Publication Bias
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-04.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-04.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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