Exercise as a synchroniser of human circadian rhythms: an update and discussion of the methodological problems
Abstract
We review the literature on whether exercise is a synchroniser of human circadian rhythms, and highlight the specific methodological problems that are associated with this topic. In applied research, exercise has been investigated as a treatment for jet lag and shift-work problems. In these studies, there have been difficulties in controlling the characteristics of the exercise bout, the athletic status of research participants and exposure to other confounding synchronisers. Therefore, it is unclear at present whether exercise can help mitigate the problems associated with transmeridian travel and shift-work. In laboratory-based experiments, participants have exercised at various times of the day and the change in phase of various circadian rhythms has been measured. Although it is difficult to control for the considerable masking effects of exercise on these estimates of circadian timing, it is clear that nocturnal exercise can induce phase delays in the onset of melatonin. Reports of exercise-induced phase advances of the melatonin rhythm are rarer, as are any phase-shifting effects at all on the body temperature rhythm. In practical terms, the substantial levels of activity needed to obtain phase shifts may not be attainable by the majority of people. In mechanistic terms, the lack of agreement with the phase-shifting effects of bright light suggests that exercise is not exerting its effects via photic entrainment pathways. An alternative explanation may involve exercise-induced hyperthermia. Moreover, it is perplexing why exercise should have a different phase response curve to light, given that humans are diurnally active.
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Exercise may act as a zeitgeber, entraining the circadian rhythm by producing either phase advances or phase delays depending on the timing.
“Exercise may also act as a zeitgeber, i.e., it can entrain the circadian rhythm by producing either phase advances or phase delays depending on the timing [102, 103].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [102]
Cites
Physical Activity and the Incidence of Coronary Heart Disease
Powell, K. E., Thompson, P. D., Caspersen, C. J., & Kendrick, J. S. (1987) · Annual Review of Public Health · doi:10.1146/annurev.pu.08.050187.001345 · Cited by 1,457 · cited 2× · see citing works
“The undertaking of moderate and regular levels of exercise is known to impact on many physiological systems designed to maintain homeostasis, as well as to help reduce risk factors for many conditions, including coronary artery (Powell et al. 1987)”
BackgroundBright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker
Czeisler, C. A., Kronauer, R. E., Allan, J. S., Duffy, J. F., Jewett, M. E., Brown, E. N., & Ronda, J. M. (1989) · Science · doi:10.1126/science.2734611 · Cited by 946 · see citing works
Psychology of physical activity: determinants, well-being and interventions
(2015) · Choice Reviews Online · doi:10.5860/choice.192092 · Cited by 863 · see citing works
The circadian rhythm of body temperature
Refinetti, R., & Menaker, M. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90188-8 · Cited by 735 · see citing works
A human phase-response curve to light
Minors, D. S., Waterhouse, J. M., & Wirz‐Justice, A. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90051-t · Cited by 640 · see citing works
Self-citationDose-response relationships for resetting of human circadian clock by light
Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1996) · Nature · doi:10.1038/379540a0 · Cited by 559 · see citing works
Aschoff, J., & Wever, R. (1981) · Springer eBooks · doi:10.1007/978-1-4615-6552-9_17 · Cited by 533 · see citing works
Physical activity and risk of stroke in women
Hu, F. B. (2000) · JAMA · doi:10.1001/jama.283.22.2961 · Cited by 531 · see citing works
Psychology of Physical Activity: Determinants, Well-being, and Interventions
Etnier, J. L. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200110000-00030 · Cited by 466 · see citing works
Physical activity and cancer prevention: from observational to intervention research.
Friedenreich, C. M. (2001) · PubMed · Cited by 360 · see citing works
Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase
Buxton, O. M., Lee, C. W., L’Hermite‐Balériaux, M., Turek, F. W., & Cauter, E. V. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00355.2002 · Cited by 327 · see citing works
The Circadian Rhythm of Core Temperature: Origin and some Implications for Exercise Performance
Waterhouse, J. M., Drust, B., Weinert, D., Edwards, B., Gregson, W. A., Atkinson, G., Kao, S., Aizawa, S., & Reilly, T. P. (2005) · Chronobiology International · doi:10.1081/cbi-200053477 · Cited by 308 · see citing works
Self-citationNonphotic Entrainment in Humans?
Mistlberger, R. E., & Skene, D. J. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277982 · Cited by 267 · see citing works
Physical Activity and Health: The Evidence Explained
Hardman, A. E., & Stensel, D. J. (2009) · Cited by 256 · see citing works
A behavioural method for accelerating re-entrainment of rhythms to new light—dark cycles
Mrosovsky, N., & Salmon, P. A. (1987) · Nature · doi:10.1038/330372a0 · Cited by 241 · see citing works
Reeth, O. V., Sturis, J., Byrne, M. M., Blackman, J. D., L’Hermite‐Balériaux, M., Leproult, R., Oliner, C. M., Refetoff, S., Turek, F. W., & Cauter, E. V. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.6.e964 · Cited by 231 · see citing works
Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
Barger, L. K., Wright, K. P., Hughes, R. J., & Czeisler, C. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00397.2003 · Cited by 218 · see citing works
1 Prevention and Treatment of Non-Insulin-Dependent Diabetes Mellitus
Ivy, J. L., Zderic, T. W., & Fogt, D. L. (1999) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199900270-00003 · Cited by 198 · see citing works
Buxton, O. M., Frank, S. A., L’Hermite‐Balériaux, M., Leproult, R., Turek, F. W., & Cauter, E. V. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.3.e536 · Cited by 167 · see citing works
A human phase response curve for bright light pulses
Honma, K. (1988) · Medical Entomology and Zoology · Cited by 160 · see citing works
Diurnal variation in cycling performance: Influence of warm-up
Atkinson, G., Todd, C., Reilly, T. P., & Waterhouse, J. M. (2005) · Journal of Sports Sciences · doi:10.1080/02640410410001729919 · Cited by 156 · see citing works
Self-citationAtkinson, G., COLDWELLS, A., Reilly, T. P., & Waterhouse, J. M. (1993) · Ergonomics · doi:10.1080/00140139308967882 · Cited by 142 · see citing works
Self-citationCircadian phase-shifting effects of nocturnal exercise in older compared with young adults
Baehr, E. K., Eastman, C. I., Revelle, W., Olson, S. H. L., Wolfe, L. F., & Zee, P. C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00761.2002 · Cited by 141 · see citing works
Phase-shifting human circadian rhythms with exercise during the night shift
Eastman, C. I. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)02031-4 · Cited by 140 · see citing works
Long-Term Fitness Training Improves the Circadian Rest-Activity Rhythm in Healthy Elderly Males
Someren, E. J. W. V., Lijzenga, C., Mirmiran, M., & Swaab, D. F. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200206 · Cited by 140 · see citing works
Sleep EEG effects of exercise with and without additional body cooling
Horne, J. A., & Moore, V. J. (1985) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(85)90948-4 · Cited by 139 · see citing works
The Relevance of Melatonin to Sports Medicine and Science
Atkinson, G., Drust, B., Reilly, T. P., & Waterhouse, J. M. (2003) · Sports Medicine · doi:10.2165/00007256-200333110-00003 · Cited by 136 · see citing works
Self-citationHärmä, M., Ilmarinen, J., Knauth, P., Rutenfranz, J., & Hänninen, O. (1988) · Ergonomics · doi:10.1080/00140138808966647 · Cited by 124 · see citing works
PLASMA MELATONIN INCREASES DURING EXERCISE IN WOMEN
Carr, D. B., Reppert, S. M., Bullen, B. A., Skrinar, G. S., Beitins, I. Z., ARNOLD, M., Rosenblatt, M., Martin, J. B., & McArthur, J. W. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-223 · Cited by 118 · see citing works
Chronobiology and Chronomedicine
Gonçalves, C. F., & Meng, Q. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781839167553 · Cited by 118 · see citing works
Monteleone, P., Maj, M., Fusco, M., Orazzo, C., & KEMALI, D. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90432-q · Cited by 95 · see citing works
Sensitivity of the Human Circadian Pacemaker to Moderately Bright Light
Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1994) · Journal of Biological Rhythms · doi:10.1177/074873049400900311 · Cited by 91 · see citing works
Reexamination of tympanic membrane temperature as a core temperature
Sato, K. T., Kane, N. L., Soos, G., GISOLFI, C. V., Kondo, N., & Sato, K. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.4.1233 · Cited by 87 · see citing works
Pupil size regulation of threshold of light-induced melatonin suppression.
Gaddy, J. R., Rollag, M. D., & Brainard, G. C. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.5.8077340 · Cited by 87 · see citing works
Reilly, T. P. (2001) · International Journal of Sports Medicine · doi:10.1055/s-2001-16379 · Cited by 85 · see citing works
Self-citationDo subjective symptoms predict our perception of jet-lag?
Waterhouse, J. M., Edwards, B., Nevill, A. M., Atkinson, G., Reilly, T. P., Davies, P., & Godfrey, R. (2000) · Ergonomics · doi:10.1080/001401300750003943 · Cited by 80 · see citing works
Self-citationNight and shiftwork: Longterm effects and their prevention
(1988) · Applied Ergonomics · doi:10.1016/0003-6870(88)90243-8 · Cited by 80 · see citing works
Circadian clock resetting by arousal in Syrian hamsters: the role of stress and activity
Mistlberger, R. E., Antle, M. C., Webb, I. C., Jones, M., Weinberg, J., & Pollock, M. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00222.2003 · Cited by 79 · see citing works
Härmä, M., Ilmarinen, J., Knauth, P., Rutenfranz, J., & Hänninen, O. (1988) · Ergonomics · doi:10.1080/00140138808966648 · Cited by 76 · see citing works
Melatonin, pituitary function and stress in humans
Vaughan, G. M., McDonald, S. D., Jordan, R. M., Allen, J. P., BELL, R. D., & Stevens, E. A. (1979) · Psychoneuroendocrinology · doi:10.1016/0306-4530(79)90018-0 · Cited by 71 · see citing works
Circadian phase-delaying effects of bright light alone and combined with exercise in humans
Youngstedt, S. D., Kripke, D. F., & Elliott, J. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00473.2001 · Cited by 69 · see citing works
Light of domestic intensity produces phase shifts of the circadian oscillator in humans
Waterhouse, J. M., Minors, D. S., Folkard, S., Owens, D. S., Atkinson, G., Macdonald, I., Reilly, T. P., Sytnik, N., & Tucker, P. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00174-8 · Cited by 63 · see citing works
Self-citationMinors, D. S., & Waterhouse, J. M. (1992) · Chronobiology International · doi:10.3109/07420529209064516 · Cited by 57 · see citing works
Self-citationKlerman, E. B., Lee, Y., Czeisler, C. A., & Kronauer, R. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000678 · Cited by 53 · see citing works
Methodological Issues in Studies of Rhythms in Human Performance
Reilly, T., & Bambaeichi, E. (2003) · Biological Rhythm Research · doi:10.1076/brhm.34.4.321.26229 · Cited by 52 · see citing works
Self-citationEdwards, B., Waterhouse, J. M., Atkinson, G., & Reilly, T. P. (2001) · Journal of Sports Sciences · doi:10.1080/026404102320219437 · Cited by 52 · see citing works
Self-citationStrassman, R. J., Appenzeller, O., Lewy, A. J., Qualls, C., & Peake, G. T. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-3-540 · Cited by 51 · see citing works
Exercise and Human Circadian Rhythms: What we Know and What we Need to Know
Redlin, U., & Mrosovsky, N. (1997) · Chronobiology International · doi:10.3109/07420529709001157 · Cited by 50 · see citing works
Methodological and Statistical Considerations for Exercise-Related Hormone Evaluations
Tremblay, M. S., Chu, S. Y., & Mureika, R. A. (1995) · Sports Medicine · doi:10.2165/00007256-199520020-00004 · Cited by 49 · see citing works
Influences of Melatonin on Human Orcadian Rhythms
Cagnacci, A. (1997) · Chronobiology International · doi:10.3109/07420529709001156 · Cited by 48 · see citing works
A COMPARISON OF SOME DIFFERENT METHODS FOR PURIFYING CORE TEMPERATURE DATA FROM HUMANS
Waterhouse, J. M., Weinert, D., Minors, D. S., Folkard, S., Owens, D. S., Atkinson, G., Macdonald, I., Sytnik, N., Tucker, P., & Reilly, T. (2000) · Chronobiology International · doi:10.1081/cbi-100101063 · Cited by 48 · see citing works
Self-citationThermosensitivity of the circadian timing system
VAN SOMEREN, E. J. (2003) · Sleep and Biological Rhythms · doi:10.1046/j.1446-9235.2003.00002.x · Cited by 47 · see citing works
Ftaiti, F., Duflot, J., Nicol, C., & Grélot, L. (2001) · Ergonomics · doi:10.1080/00140130118503 · Cited by 30 · see citing works
Using outdoor exercise to decrease jet lag in airline crewmembers.
SHIOTA, M., Sudou, M., & Ohshima, M. (1996) · PubMed · Cited by 30 · see citing works
Callard, D., Davenne, D., Lagarde, D., Meney, I., Gentil, C., & Hoecke, J. V. (2001) · International Journal of Sports Medicine · doi:10.1055/s-2001-18524 · Cited by 28 · see citing works
Circadian variation of physiological functions in physically average and very fit dayworkers.
Härmä, M. I., Ilmarinen, J., & Yletyinen, I. (1982) · PubMed · Cited by 28 · see citing works
Evaluation of oculomotor response in relationship to sports performance
Harbin, G., DURST, L., & HARBIN, D. (1989) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198906000-00005 · Cited by 26 · see citing works
Different Effects of Intensity and Duration of Locomotor Activity on Circadian Period
Koteja, P., Swallow, J. G., Carter, P. A., & Garland, T. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403256998 · Cited by 25 · see citing works
Effects of exercise on aspects of visual function
Woods, R. L. (1995) · Ophthalmic and Physiological Optics · doi:10.1016/0275-5408(95)92786-e · Cited by 24 · see citing works
Change of pupil size as a function of exercise.
Ishigaki, H., Miyao, M., & Ishihara, S. (1991) · PubMed · Cited by 23 · see citing works
Effects of exercise on aspects of visual function
Woods, R. L., & Thomson, W. D. (1995) · Ophthalmic and Physiological Optics · doi:10.1046/j.1475-1313.1995.9592786.x · Cited by 23 · see citing works
Malin, J. I., Chen, A. C., Bonkowski, J. E., Baker, J. E., Cheng, K. Y., & Hsieh, K. C. (1996) · Journal of Applied Physics · doi:10.1063/1.362860 · Cited by 22 · see citing works
&NA; (1999) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199900270-00002 · Cited by 21 · see citing works
Waterhouse, J. M., Kao, S., Weinert, D., Edwards, B., Atkinson, G., & Reilly, T. P. (2005) · Chronobiology International · doi:10.1080/07420520500263375 · Cited by 18 · see citing works
Self-citationThe prediction of the adaptation of circadian rhythms to rapid time zone changes
SUVANTO, S., Härmä, M., & LAJTINEN, J. T. (1993) · Ergonomics · doi:10.1080/00140139308967861 · Cited by 15 · see citing works
RELATIONSHIP BETWEEN HELMET TEMPERATURE AND TYMPANIC TEMPERATURE DURING AMERICAN FOOTBALL PRACTICE
Ishigaki, T., Fujishiro, H., Tsujita, J., En, Y., Yamato, M., Nakano, S., & Hori, S. (2001) · 体力科學 · doi:10.7600/jspfsm1949.50.333 · Cited by 12 · see citing works
Locomotor activity accelerates the adjustment of the temperature rhythm in shiftwork
Schmidt, K. P., KOEHLER, W. K., Fleissner, G., & Pflug, B. (1990) · Journal of Interdisiplinary Cycle Research · doi:10.1080/09291019009360079 · Cited by 11 · see citing works
Yeo, S., & Scarbough, M. (1996) · Journal of Nursing Measurement · doi:10.1891/1061-3749.4.2.143 · Cited by 10 · see citing works
Aoki, K., Kondo, N., Shimomura, Y., Iwanaga, K., Harada, H., & Katsuura, T. (2002) · European Journal of Applied Physiology · doi:10.1007/s00421-001-0566-0 · Cited by 8 · see citing works
Day-time plasma melatonin response to physical exercise in humans
Theintz, G. E., Lang, U., Dériaz, O., Ceretelli, P., & Sizonenko, P. C. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90625-3 · Cited by 8 · see citing works
Tipton, C. M. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200112000-00001 · Cited by 6 · see citing works
Tau and Phase Response Curves for Non-photic Stimuli in Blinded Rats
Canal-Corretger, M. M., Cambras, T., & Dı́ez-Noguera, A. (2003) · Biological Rhythm Research · doi:10.1076/brhm.34.1.91.14080 · Cited by 4 · see citing works
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Sorted by citations
Kline, C. E. (2014) · American Journal of Lifestyle Medicine · doi:10.1177/1559827614544437 · Cited by 364 · see citing works
Fatigue Countermeasures in Aviation
Caldwell, J. A., Mallis, M. M., Caldwell, J. L., Paul, M. A., Miller, J. C., & Neri, D. F. (2009) · Aviation, Space, and Environmental Medicine · doi:10.3357/asem.2435.2009 · Cited by 295 · see citing works
The genetics of circadian rhythms, sleep and health
Jagannath, A., Taylor, L., Wakaf, Z., Vasudevan, S. R., & Foster, F. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx240 · Cited by 258 · see citing works
Exercise, Energy Balance and the Shift Worker
Atkinson, G., Fullick, S., Grindey, C., & MacLaren, D. P. M. (2008) · Sports Medicine · doi:10.2165/00007256-200838080-00005 · Cited by 250 · see citing works
Self-citationSchroeder, A., & Colwell, C. S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.002 · Cited by 190 · see citing works
The night‐eating syndrome and obesity
Gallant, A. R., Lundgren, J., & Drapeau, V. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00975.x · Cited by 182 · see citing works
Circadian and sleep dysfunction in Alzheimer’s disease
Uddin, M. S., Tewari, D., Mamun, A. A., Kabir, M. T., Niaz, K., Wahed, M. I. I., Barreto, G. E., & Ashraf, G. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101046 · Cited by 180 · see citing works
Exercise and melatonin in humans: reciprocal benefits
Escames, G., Öztürk, G., Baño‐Otálora, B., Pozo, M. J., Madrid, J. A., Reiter, R. J., Serrano, E. R., Concepción‐Huertas, M., & Acuña-Castroviejo, D. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00924.x · Cited by 155 · see citing works
Live to the rhythm, slave to the rhythm
Someren, E. J. W. V., & der Lek, R. F. R. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.003 · Cited by 151 · see citing works
Neurobiology of Circadian Systems
Schulz, P., & Steimer, T. J. (2009) · CNS Drugs · doi:10.2165/11318620-000000000-00000 · Cited by 137 · see citing works
Metabolic syndrome and shift work: a systematic review
Canuto, R., Garcez, A. S., & Olinto, M. T. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.10.004 · Cited by 130 · see citing works
Effects of exercise on circadian rhythms in humans
Shen, B., Ma, C., Wu, G., Liu, H., Chen, L., & Yang, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1282357 · Cited by 125 · see citing works
Circadian Rhythm and Alzheimer’s Disease
Homolak, J., Mudrovčić, M., Vukić, B., & Toljan, K. (2018) · Medical Sciences · doi:10.3390/medsci6030052 · Cited by 115 · see citing works
Alertness management strategies for operational contexts
Caldwell, J. A., Caldwell, J. L., & Schmidt, R. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.01.002 · Cited by 111 · see citing works
Amplitude of the SCN Clock Enhanced by the Behavioral Activity Rhythm
van Oosterhout, F., Lucassen, E. A., Houben, T., vanderLeest, H. T., Antle, M. C., & Meijer, J. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039693 · Cited by 105 · see citing works
Circadian Disruption and Remedial Interventions
Forbes-Robertson, S., Dudley, E., Vadgama, P. M., Cook, C. J., Drawer, S., & Kilduff, L. P. (2012) · Sports Medicine · doi:10.2165/11596850-000000000-00000 · Cited by 108 · see citing works
Irregular 24-hour activity rhythms and the metabolic syndrome in older adults
Sohail, S., Yu, L., Bennett, D. A., Buchman, A. S., & Lim, A. S. P. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1041597 · Cited by 102 · see citing works
Delirium: A disturbance of circadian integrity?
Fitzgerald, J., Adamis, D., Trzepacz, P. T., O’Regan, N., Timmons, S., Dunne, C. P., & Meagher, D. J. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.06.032 · Cited by 100 · see citing works
Feedback actions of locomotor activity to the circadian clock
Hughes, A. T. L., & Piggins, H. D. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00018-6 · Cited by 99 · see citing works
Effects of Ramadan on physical performance: chronobiological considerations
Waterhouse, J. M. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.071712 · Cited by 97 · see citing works
Self-citationMcGivney, B. A., McGettigan, P., Browne, J. A., Evans, A. C. O., Fonseca, R. G., Loftus, B., Lohan, A. J., MacHugh, D. E., Murphy, B. A., Katz, L. M., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-398 · Cited by 95 · see citing works
Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs
Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2007.12.002 · Cited by 93 · see citing works
Crosstalk Between Environmental Light and Internal Time in Humans
Martínez-Nicolás, A., Ortiz‐Tudela, E., Madrid, J. A., & Rol, M. A. (2011) · Chronobiology International · doi:10.3109/07420528.2011.593278 · Cited by 85 · see citing works
Imeraj, L., Sonuga-Barke, E. J. S., Antrop, I., Roeyers, H., Wiersema, R., Bal, S., & Deboutte, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.04.007 · Cited by 84 · see citing works
Effects of competition on the sleep patterns of elite rugby union players
Shearer, D. A., Jones, R. M., Kilduff, L. P., & Cook, C. J. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2015.1053419 · Cited by 76 · see citing works
Effects of exercise on sleep in neurodegenerative disease
Memon, A., Coleman, J., & Amara, A. W. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104859 · Cited by 76 · see citing works
Rao, R., & Androulakis, I. P. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.02.018 · Cited by 73 · see citing works
Zeitgebers and their association with rest-activity patterns
Quante, M., Mariani, S., Weng, J. F., Marinac, C. R., Kaplan, E. R., Rueschman, M., Mitchell, J. A., James, P., Hipp, J. A., Feliciano, E. M. C., et al. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1527347 · Cited by 70 · see citing works
Jet lag syndrome: circadian organization, pathophysiology, and management strategies
Avidan, A. Y., & Colwell, C. S. (2010) · Nature and Science of Sleep · doi:10.2147/nss.s6683 · Cited by 67 · see citing works
The circadian typology: the role of physical activity and melatonin
Montaruli, A., Galasso, L., Caumo, A., Cè, E., Pesenti, C., Roveda, E., & Esposito, F. (2017) · Sport Sciences for Health · doi:10.1007/s11332-017-0389-y · Cited by 66 · see citing works
Day–night contrast as source of health for the human circadian system
Martínez-Nicolás, A., Madrid, J. A., & Rol, M. A. (2013) · Chronobiology International · doi:10.3109/07420528.2013.861845 · Cited by 65 · see citing works
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58 · see citing works
“…potential candidates include temperature (Buhr et al., 2010; Glaser and Stanewsky, 2007), food availability (Carneiro and Araujo, 2012), exercise (Atkinson et al., 2007; Edgar and Dement, 1991; Miyazaki et al., 2001) and social interactions (Hastings et al., 1998; Levine et al., 2002b;…”
BackgroundLeiper, J., Junge, A., Maughan, R., Zerguini, Y., & Dvořák, J. (2008) · Jurnal sport science · doi:10.1080/02640410802538176 · Cited by 62 · see citing works
Approaches to the Pharmacological Management of Jet Lag
Arendt, J. (2018) · Drugs · doi:10.1007/s40265-018-0973-8 · Cited by 57 · see citing works
Chronotherapies for Parkinson’s disease
Fifel, K., & Videnović, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.002 · Cited by 58 · see citing works
Effects of exercise on sleep, melatonin level, and behavioral functioning in children with autism
Tse, A. C. Y., Lee, P. H., Zhang, J., Chan, R., Ho, A. W., & Lai, E. W. (2022) · Autism · doi:10.1177/13623613211062952 · Cited by 55 · see citing works
Blood Metabolites During Basketball Competitions
Abdelkrim, N. B., Castagna, C., Fazâa, S. E., Tabka, Z., & Ati, J. E. (2009) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181a2d8fc · Cited by 55 · see citing works
Melatonin and its relevance to jet lag
Brown, G. M., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2008.09.004 · Cited by 54 · see citing works
Methodological Issues for Studying the Rest–Activity Cycle and Sleep Disturbances
Calogiuri, G., Weydahl, A., & Carandente, F. (2011) · Biological Research For Nursing · doi:10.1177/1099800411416224 · Cited by 53 · see citing works
Poor Sleep Quality’s Association With Soccer Injuries: Preliminary Data
Silva, A., Narciso, F. V., Soalheiro, I., Viegas, F., Freitas, L., de Lima, A. D. A., Leite, B. A., Aleixo, H. C., Duffield, R., & de Mello, M. T. (2019) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2019-0185 · Cited by 52 · see citing works
Timing is everything: Circadian rhythms and their role in the control of sleep
Pandi-Perumal, S. R., Cardinali, D. P., Zaki, N. F. W., Ramanujam, K., Spence, D. W., Reiter, R. J., & Brown, G. M. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100978 · Cited by 50 · see citing works
Ramadan and Sport: Minimizing Effects Upon the Observant Athlete
Shephard, R. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0080-7 · Cited by 48 · see citing works
Some chronobiological and physiological problems associated with long-distance journeys
Reilly, T., Waterhouse, J. M., & Edwards, B. (2008) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2008.05.002 · Cited by 46 · see citing works
Self-citationChowdhury, I., Sengupta, A., & Maitra, S. K. (2008) · PubMed · Cited by 44 · see citing works
Circadian Disruption Leads to Loss of Homeostasis and Disease
Escobar, C., Salgado‐Delgado, R., Guerra, E. G., Osorio, A. T., Castellanos, A., & Buijs, R. M. (2011) · Sleep Disorders · doi:10.1155/2011/964510 · Cited by 45 · see citing works
Circadian regulation of locomotor activity and skeletal muscle gene expression in the horse
Martin, A.-M., Elliott, J. A., Duffy, P., Blake, C. M., Attia, S. B., Katz, L. M., Browne, J. A., Gath, V., McGivney, B. A., Hill, E. W., et al. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01327.2009 · Cited by 44 · see citing works
School Schedules Affect Sleep Timing in Children and Contribute to Partial Sleep Deprivation
Anacleto, T. S., Adamowicz, T., Pinto, L. S. D. C., & Louzada, F. M. (2014) · Mind Brain and Education · doi:10.1111/mbe.12057 · Cited by 43 · see citing works
Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington's disease
Cuesta, M., Aungier, J., & Morton, A. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.008 · Cited by 43 · see citing works
Castellanos, A., Amaya, J. M., Salgado‐Delgado, R., Buijs, R. M., & Escobar, C. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411409715 · Cited by 42 · see citing works
Sleep habits and strategies of ultramarathon runners
Martin, T., Arnal, P. J., Hoffman, M. D., & Millet, G. Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194705 · Cited by 47 · see citing works
Vitale, J. A., Lombardi, G., Weydahl, A., & Banfi, G. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1475395 · Cited by 42 · see citing works
Investigating Two Different Training Time Frames during Ramadan Fasting
Kordi, R., Abdollahi, M. R., Memari, A. H., & Najafabadi, M. G. (2011) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.34774 · Cited by 39 · see citing works
Richardson, C. E., Gradisar, M., Short, M. A., & Lang, C. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.010 · Cited by 38 · see citing works
Influence of Exercise Time of Day on Salivary Melatonin Responses
Carlson, L. A., Pobocik, K. M., Lawrence, M. A., Brazeau, D. A., & Koch, A. J. (2018) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2018-0073 · Cited by 36 · see citing works
Yamanaka, Y., Honma, S., & Honma, K. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00389.2013 · Cited by 35 · see citing works
Galbete, C., Contreras, R., Martínez, J. A., Martínez‐González, M. Á., Guillén‐Grima, F., & Martí, A. (2012) · Chronobiology International · doi:10.3109/07420528.2012.728657 · Cited by 35 · see citing works
Edwards, B. J., Reilly, T., & Waterhouse, J. (2009) · Biological Rhythm Research · doi:10.1080/09291010802067072 · Cited by 31 · see citing works
Self-citationThe clock is ticking. Ageing of the circadian system: From physiology to cell cycle
Terzibasi-Tozzini, E., Martínez-Nicolás, A., & Lucas-Sánchez, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.06.011 · Cited by 32 · see citing works
Exercise influences circadian gene expression in equine skeletal muscle
Murphy, B. A., Wagner, A. L., McGlynn, O. F., Kharazyan, F., Browne, J. A., & Elliott, J. A. (2014) · The Veterinary Journal · doi:10.1016/j.tvjl.2014.03.028 · Cited by 30 · see citing works
Frange, C., Franco, A. M., Brasil, E. L., Hirata, R. P., Lino, J. A., Mortari, D. M., Ykeda, D. S., Leocádio-Miguel, M. A., D’Aurea, C. V. R., Silva, L. O. E., et al. (2022) · Sleep Science · doi:10.5935/1984-0063.20220083 · Cited by 30 · see citing works
Effects of sports training on sleep characteristics of Asian adolescent athletes
Suppiah, H. T., Low, C. Y., & Chia, M. (2015) · Biological Rhythm Research · doi:10.1080/09291016.2015.1026673 · Cited by 29 · see citing works
Chronobiology and the horse: Recent revelations and future directions
Murphy, B. A. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.04.013 · Cited by 28 · see citing works
Okamoto, A., Yamamoto, T., Matsumura, R., Node, K., & Akashi, M. (2013) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-11-10 · Cited by 27 · see citing works
Sleep and Athletic Performance
Kutscher, S. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00064-7 · Cited by 26 · see citing works
Does Ramadan Fasting Adversely Affect Cognitive Function in Young Females?
Najafabadi, M. G., Nikoukar, L. R., Memari, A. H., Ekhtiari, H., & Beygi, S. (2015) · Scientifica · doi:10.1155/2015/432428 · Cited by 25 · see citing works
Dashti, H. S., Jansen, E. C., Zuraikat, F. M., Dixit, S., Brown, M. K., Laposky, A. D., Broussard, J. L., Butler, M. P., Creasy, S. A., Crispim, C. A., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039373 · Cited by 31 · see citing works
Physical activity, and not fat mass is a primary predictor of circadian parameters in young men
Tranel, H. R., Schroder, E. A., England, J., Black, W. S., Bush, H., Hughes, M. E., Esser, K. A., & Clasey, J. L. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1043011 · Cited by 22 · see citing works
Liu, W., Huang, Z., Xia, J., Cui, Z., Li, L., Qi, Z., & Liu, W. (2022) · Bioscience Reports · doi:10.1042/bsr20220800 · Cited by 24 · see citing works
Marqueze, E. C., Ulhôa, M. A., & Moreno, C. R. D. C. (2013) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-013-0850-4 · Cited by 23 · see citing works
Marrin, K., Drust, B., Gregson, W. A., Morris, C. J., Chester, N., & Atkinson, G. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1890-7 · Cited by 24 · see citing works
Self-citationEnhancing the metabolic benefits of exercise: Is timing the key?
Bennett, S. E., & Sato, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.987208 · Cited by 22 · see citing works
Piccione, G. G., Giannetto, C., Assenza, A., Casella, S., & CAOLA, G. (2009) · Chronobiology International · doi:10.1080/07420520802689772 · Cited by 22 · see citing works
Paradoxical post-exercise responses of acylated ghrelin and leptin during a simulated night shift
Morris, C. J., Fullick, S., Gregson, W., Clarke, N., Doran, D., MacLaren, D., & Atkinson, G. (2010) · Chronobiology International · doi:10.3109/07420521003663819 · Cited by 21 · see citing works
Self-citationAnxiety and sleep hygiene among college students, a moderated mediating model
Peng, J., Liu, M., Wang, Z., Xiang, L., & Liu, Y. (2025) · BMC Public Health · doi:10.1186/s12889-025-24441-1 · Cited by 21 · see citing works
Fatigue and Its Management in the Aviation Industry, with Special Reference to Pilots
Olaganathan, R., Holt, T. B. O., Luedtke, J., & Bowen, B. D. (2021) · Journal of Aviation Technology and Engineering · doi:10.7771/2159-6670.1208 · Cited by 23 · see citing works
The clockwork of champions: Influence of circadian biology on exercise performance
Hesketh, S. J., & Esser, K. A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.020 · Cited by 22 · see citing works
Pelvic floor muscle exercises may improve female sexual function
Ma, Y., & Qin, H. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.09.026 · Cited by 20 · see citing works
Circadian variation and soccer performance: Implications for training and match-play during Ramadan
Drust, B., Ahmed, Q. A., & Roky, R. (2012) · Journal of Sports Sciences · doi:10.1080/02640414.2012.703784 · Cited by 21 · see citing works
From animal cage to aircraft cabin: an overview of evidence translation in jet lag research
Atkinson, G., Batterham, A. M., Dowdall, N. P., Thompson, A. R., & van Drongelen, A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-3026-3 · Cited by 19 · see citing works
Self-citationHOW CAN TRAVELLING ATHLETES DEAL WITH JET-LAG?
Reilly, T. P. (2009) · Hrčak Portal of scientific journals of Croatia (University Computing Centre) · Cited by 19 · see citing works
Self-citationProcopio, S. B., & Esser, K. A. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.11.011 · Cited by 17 · see citing works
Steidle‐Kloc, E., Schönfelder, M., Müller, E., Sixt, S., Schuler, G. C., Patsch, W., & Niebauer, J. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316639682 · Cited by 18 · see citing works
Seasonal affective disorder and exercise treatment: a review
Peiser, B. (2008) · Biological Rhythm Research · doi:10.1080/09291010802067171 · Cited by 18 · see citing works
Effects of Shift Work in a Sample of Italian Nurses: Analysis of Rest-Activity Circadian Rhythm
Galasso, L., Mulè, A., Castelli, L., Cè, E., Condemi, V., Banfi, G., Roveda, E., Montaruli, A., & Esposito, F. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18168378 · Cited by 18 · see citing works
Machado, F. S. M., Rodovalho, G. V., & Coimbra, C. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.069 · Cited by 18 · see citing works
Silva, R., Paiva, T., & Silva, H.-H. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.18.08894-1 · Cited by 18 · see citing works
Garcêz, A., Canuto, R., Paniz, V. M. V., Olinto, B. A., Macagnan, J. B. A., Henn, R. L., Pattussi, M. P., & Olinto, M. T. A. (2015) · PubMed · doi:10.3305/nh.2015.31.5.8628 · Cited by 18 · see citing works
Exploring the nexus: Sleep disorders, circadian dysregulation, and Alzheimer’s disease
Khandayataray, P., & Murthy, M. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.066 · Cited by 18 · see citing works
Plano, S. A., Agostino, P. V., de la Iglesia, H. O., & Golombek, D. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037121 · Cited by 17 · see citing works
Impact of Circadian Rhythms on the Development and Clinical Management of Genitourinary Cancers
Kaur, P., Mohamed, N., Archer, M., Figueiro, M. G., & Kyprianou, N. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.759153 · Cited by 17 · see citing works
Field trial of timed bright light exposure for jet lag among airline cabin crew
Lahti, T. A., Terttunen, J., Leppämäki, S., Lönnqvist, J. K., & Partonen, T. (2007) · International Journal of Circumpolar Health · doi:10.3402/ijch.v66i4.18280 · Cited by 17 · see citing works
Christian, K. H., Petitti, C. S., Oretga-Schwartz, K., Mulder, E. R., Noppe, A., von der Wiesche, M., Stern, C., Young, M., Macias, B. R., Laurie, S. S., et al. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00211.2023 · Cited by 16 · see citing works
Medications for Sleep Schedule Adjustments in Athletes
Baird, M. B., & Asif, I. M. (2017) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738117743205 · Cited by 16 · see citing works
Manno, F. A. M., An, Z., Kumar, R., Su, J., Liu, J., Wu, E. X., He, J., Feng, Y., & Lau, C. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119016 · Cited by 15 · see citing works
The nutritional status of nurses working shifts: A pilot study in Turkey
Varlı, S. N., & Bilici, S. (2016) · Revista de Nutrição · doi:10.1590/1678-98652016000400013 · Cited by 15 · see citing works
Circadian rhythms in the blind
Allen, A. E. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.06.003 · Cited by 16 · see citing works
Machado, F. S. M., Fóscolo, D. R. C., Poletini, M. O., & Coimbra, C. C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00464 · Cited by 15 · see citing works
Tse, A. C. Y., Lee, P. H., Zhang, J., & Lai, E. W. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020944 · Cited by 16 · see citing works
Smithies, T. D., Eastwood, P. R., Walsh, J. H., Murray, K., Markwick, W., & Dunican, I. C. (2021) · Journal of Sports Sciences · doi:10.1080/02640414.2021.1947617 · Cited by 14 · see citing works
Hannemann, J., Laing, A., Glismann, K., Skene, D. J., Middleton, B., Staels, B., Marx, N., Grant, P. J., Federici, M., Niebauer, J., et al. (2020) · Diabetes and Vascular Disease Research · doi:10.1177/1479164120950616 · Cited by 14 · see citing works
- Authors
- Atkinson, G., Edwards, B., Reilly, T., & Waterhouse, J.
- Affiliations
- Liverpool John Moores University (GB)
- Corresponding author
- Atkinson, Greg
- Venue
- European Journal of Applied Physiology
- Published
- 2006-12-13
- Volume
- 99
- Issue
- 4
- Pages
- 331-341
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W2044407327
- Cited by
- 167
- References
- 71
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 14 · 2014: 8 · 2013: 14 · 2012: 11
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- TeesRep (Teesside University) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- physical activity, circadian rhythm, phase shifting, melatonin onset, body temperature rhythm, jet lag, shift work, exercise-induced hyperthermia, light entrainment, phase response curve
- MeSH terms
- Biological Clocks, Circadian Rhythm, Physical Exertion, Humans, Melatonin, Models, Biological, Oscillometry, Exercise
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