Metabolic syndrome and shift work: a systematic review
Abstract
The aim of this systematic review was to examine the association between shift work and metabolic syndrome (MetS) as well as the potential confounders investigated. A systematic search was conducted with the aim of finding original articles on the association between shift work and MetS. The included articles were chosen based on established inclusion criteria; their methodological quality was assessed using a validated quality checklist. A total of 10 articles were included in this review. The majority of the studies were classified as having a low risk of bias. The definitions of MetS and shift work varied between studies. Among the ten studies, eight found a positive association between shift work and MetS after controlling for socio-demographic and behavioral factors. Only three studies included sleep duration as a confounder, and these studies presented discordant results. We conclude that there was insufficient evidence regarding the association between shift work and prevalent MetS when the confounders are taken into account.
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Shift workers working during their circadian night are more likely to develop metabolic disturbances.
“Most of this evidence is derived from studies on different models of shift work, which found that shift workers working during their circadian night are more likely to develop metabolic disturbances (109).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [109]
Eating late may negatively impact the success of weight loss in a cohort of 420 participants.
“Recent work by Garaulet et al. investigated the link between the timing of food intake during weight loss studies and found that eating late may negatively impact the success of weight loss in a cohort of 420 participants (49•5 % female, aged 42 (SD 11) years, BMI 31•4 (SD 5•4) kg/m 2 ).”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [54]
The CLOCK rs4580704 was associated with the timing of the main meal, with a higher frequency of minor allele C carriers among late eaters.
“They also included a SNP of CLOCK in their investigations and found that the CLOCK rs4580704 was associated with the timing of the main meal, with a higher frequency of minor allele C carriers among late eaters.”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [54]
The CLOCK SNP, sleep duration or chrono-type (morningness/eveningness) was not associated with weight loss.
“However, this CLOCK SNP, sleep duration or chrono-type (morningness/eveningness) was not associated with weight loss (54) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [54]
Cites
Downs, S. H., & Black, N. (1998) · Journal of Epidemiology and Community Health · doi:10.1136/jech.52.6.377 · Cited by 8,252 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Modern Epidemiology 3rd edition
Rothman, K. J., Lash, T. L., & Greenland, S. (1986) · Cited by 1,736 · see citing works
Short Sleep Duration and Weight Gain: A Systematic Review
Patel, S. R., & Hu, F. B. (2008) · Obesity · doi:10.1038/oby.2007.118 · Cited by 1,505 · see citing works
Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2006) · Hypertension · doi:10.1161/01.hyp.0000217362.34748.e0 · Cited by 1,284 · see citing works
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195 · see citing works
Carcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082 · see citing works
American College of Endocrinology Position Statement on the Insulin Resistance Syndrome
Einhorn, D. (2003) · Endocrine Practice · doi:10.4158/ep.9.s2.5 · Cited by 1,066 · see citing works
Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924 · see citing works
Rapid growth in infancy and childhood and obesity in later life – a systematic review
Monteiro, P. O. A., & Victora, C. G. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00183.x · Cited by 911 · see citing works
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883 · see citing works
Sleep duration as a risk factor for the development of type 2 diabetes
Yaggi, H. K., Araujo, A. B., & McKinlay, J. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-0879 · Cited by 790 · see citing works
Shift work and chronic disease: the epidemiological evidence
Wang, X.-S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr001 · Cited by 640 · see citing works
Effects of Sleep Fragmentation on Glucose Metabolism in Normal Subjects
Stamatakis, K. A., & Punjabi, N. M. (2010) · Chest · doi:10.1378/chest.09-0791 · Cited by 614 · see citing works
Shift work and occupational medicine: an overview
Costa, G. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg045 · Cited by 556 · see citing works
Balkau, B., Charles, M.-A. A., Drivsholm, T., Borch‐Johnsen, K., Wareham, N. J., Yudkin, J. S., Morris, R. W., Zavaroni, I., van Dam, R. M., Feskins, E., et al. (2002) · PubMed · Cited by 525 · see citing works
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455 · see citing works
Shift work, sleep, and sleepiness – differences between shift schedules and systems
Sallinen, M., & Kecklund, G. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2900 · Cited by 412 · see citing works
Rotating shift work and the metabolic syndrome: a prospective study
De Bacquer, D., Van Risseghem, M., Clays, E., Kittel, F., De Backer, G., & Braeckman, L. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyn360 · Cited by 394 · see citing works
Shift and night work and long working hours – a systematic review of safety implications
Wagstaff, A. S., & Sigstad Lie, J.-A. (2011) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.3146 · Cited by 367 · see citing works
Di Lorenzo, L., De Pergola, G., Zocchetti, C., L'Abbate, N., Basso, A., Pannacciulli, N., Cignarelli, M., Giorgino, R., & Soleo, L. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802419 · Cited by 346 · see citing works
Esquirol, Y., Bongard, V., Mabile, L., Jonnier, B., Soulat, J., & Perret, B. (2009) · Chronobiology International · doi:10.1080/07420520902821176 · Cited by 324 · see citing works
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323 · see citing works
Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Alvarez, A., González, C. D., & Pirola, C. J. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01766.x · Cited by 315 · see citing works
Incidence of metabolic syndrome among night-shift healthcare workers
Pietroiusti, A., Neri, A., Somma, G., Coppeta, L., Iavicoli, I., BERGAMASCHI, A., & Magrini, A. (2009) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.046797 · Cited by 301 · see citing works
A longitudinal study on the effect of shift work on weight gain in male Japanese workers.
Suwazono, Y., Dochi, M., Sakata, K., Okubo, Y., Oishi, M., Tanaka, K., Kobayashi, E., Kido, T., & Nogawa, K. (2008) · Obesity · doi:10.1038/oby.2008.298 · Cited by 259 · see citing works
Metabolic syndrome and all-cause mortality: a meta-analysis of prospective cohort studies
Wu, S., Liu, Z., & Ho, S. C. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9459-z · Cited by 244 · see citing works
Ogawa, Y., Kanbayashi, T., Saito, Y., Takahashi, Y., Kitajima, T., Takahashi, K., Hishikawa, Y., & Shimizu, T. (2003) · SLEEP · doi:10.1093/sleep/26.8.986 · Cited by 235 · see citing works
Metabolic Syndrome in Permanent Night Workers
Biggi, N., Consonni, D., Galluzzo, V., Sogliani, M., & Costa, G. (2008) · Chronobiology International · doi:10.1080/07420520802114193 · Cited by 213 · see citing works
Exercise, Abdominal Obesity, Skeletal Muscle, and Metabolic Risk: Evidence for a Dose Response
Slentz, C. A., Houmard, J. A., & Kraus, W. E. (2009) · Obesity · doi:10.1038/oby.2009.385 · Cited by 202 · see citing works
Education and the metabolic syndrome in women.
Wamala, S. P., Lynch, J. B., Horsten, M., Mittleman, M. A., Schenck-Gustafsson, K. G., & Orth‐Gomér, K. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1999 · Cited by 199 · see citing works
Household Income Is Associated With the Risk of Metabolic Syndrome in a Sex-Specific Manner
Dallongeville, J., Cottel, D., Ferrières, J., Arveiler, D., Bingham, A., Ruidavets, J. B., Haas, B., Ducimetière, P., & Amouyel, P. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.409 · Cited by 199 · see citing works
Alkerwi, A., Boutsen, M., Vaillant, M., Barré, J., Lair, M., Albert, A., Guillaume, M., & Dramaix, M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.10.036 · Cited by 198 · see citing works
The effects of shift work on body weight change − a systematic review of longitudinal studies
van Drongelen, A., Boot, C., Merkus, S., Smid, T., & Beek, A. J. (2011) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.3143 · Cited by 197 · see citing works
Atkinson, G., Edwards, B., Reilly, T., & Waterhouse, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0361-z · Cited by 167 · see citing works
Mabry, R., Reeves, M. M., Eakin, E., & Owen, N. G. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.02998.x · Cited by 164 · see citing works
Lin, Y.-C., Hsiao, T.-J., & Chen, P. (2009) · Chronobiology International · doi:10.1080/07420520902929029 · Cited by 156 · see citing works
Atypical Work Hours and Metabolic Syndrome Among Police Officers
Violanti, J. M., Burchfiel, C. M., Hartley, T. A., Mnatsakanova, A., Fekedulegn, D. B., Andrew, M. E., Charles, L. E., & Vila, B. J. (2009) · Archives of Environmental & Occupational Health · doi:10.1080/19338240903241259 · Cited by 150 · see citing works
Shift Related Dietary Intake in Day and Shift Workers
LENNERNÄS, M., HAMBRAEUS, L., & ÅKERSTEDT, T. (1995) · Appetite · doi:10.1006/appe.1995.0060 · Cited by 136 · see citing works
Circadian Aspects of Postprandial Metabolism
Morgan, L., Hampton, S. M., Gibbs, M. A., & Arendt, J. (2003) · Chronobiology International · doi:10.1081/cbi-120024218 · Cited by 129 · see citing works
Nocturnal eating and serum cholesterol of three-shift workers.
Lennernäs, M. A. ‐., Åkerstedt, T., & Hambræus, L. (1994) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1381 · Cited by 96 · see citing works
Cigarette Smoking and the Risk of the Metabolic Syndrome in Middle-Aged Japanese Male Office Workers
Nakanishi, N., Takatorige, T., & Suzuki, K. S. (2005) · Industrial Health · doi:10.2486/indhealth.43.295 · Cited by 96 · see citing works
Prince, C. T., Secrest, A. M., Mackey, R. H., Arena, V. C., Kingsley, L., & Orchard, T. J. (2009) · Diabetes Care · doi:10.2337/dc09-1936 · Cited by 89 · see citing works
Nutrient intake among female shift workers in a computer factory in Japan
N. Sudo, R. O. (2001) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480120057530 · Cited by 85 · see citing works
Meals, snacks and food choices in Brazilian shift workers with high energy expenditure
de Assis, M. A. A., Nahas, M. V., Bellisle, F., & Kupek, E. J. (2003) · Journal of Human Nutrition and Dietetics · doi:10.1046/j.1365-277x.2003.00448.x · Cited by 85 · see citing works
Folkard, S. (2008) · Chronobiology International · doi:10.1080/07420520802106694 · Cited by 78 · see citing works
Relationship between Metabolic Syndrome and Cigarette Smoking in the Japanese Population
Miyatake, N., Wada, J., Kawasaki, Y., Nishii, K., Makino, H., & Numata, T. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1850 · Cited by 72 · see citing works
Assessment of cardiovascular risk in shift healthcare workers
Copertaro, A., Bracci, M., Barbaresi, M., & Santarelli, L. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f364c0 · Cited by 65 · see citing works
Reinberg, A., Migraine, C., Apfelbaum, M., et al. (1979) · PubMed · Cited by 61 · see citing works
Shift Work and the Risk of Metabolic Syndrome: A Nested Case-Control Study
Li, Y., Sato, Y., & Yamaguchi, N. (2011) · International Journal of Occupational and Environmental Health · doi:10.1179/107735211799030960 · Cited by 58 · see citing works
Park, S., Yoon, Y. S., & Oh, S. W. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.11.010 · Cited by 47 · see citing works
Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT
Lin, Y.-C., Hsiao, T.-J., & Chen, P. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5654 · Cited by 38 · see citing works
A cross-sectional study on the shift work and metabolic syndrome in Japanese male workers
Kawada, T., Otsuka, T., Inagaki, H., Wakayama, Y., Katsumata, M., Li, Q., & Li, Y. (2010) · The Aging Male · doi:10.3109/13685530903536692 · Cited by 33 · see citing works
Relationship between sleep duration and clustering of metabolic syndrome diagnostic components
Nakamura, Y., Katano, Nakamura, Murakami, Y., Tanaka, T., Takebayashi, T., Okayama, A., Miura, K., Okamura, & Ueshima, H. (2011) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s16147 · Cited by 30 · see citing works
Shift work aggravates metabolic syndrome development among early-middle-aged males with elevated ALT
Yucheng, Lin, Tun-Jen, Hsiao, F., Pau-Chung, & Chen (2009) · World Journal of Gastroenterology · Cited by 27 · see citing works
Association of metabolic syndrome with smoking and alcohol intake in Japanese men
Takeuchi, T., Nakao, M., Nomura, K., et al. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp106 · Cited by 26 · see citing works
Shift Work and the Risk of Metabolic Syndrome: A Nested Case-Control Study
Li, Y., Sato, Y., & Yamaguchi, N. (2011) · International Journal of Occupational and Environmental Health · doi:10.1179/oeh.2011.17.2.154 · Cited by 23 · see citing works
Smoking habits and lipoproteins in British women
Razay, G., & Heaton, K. W. (1995) · QJM · doi:10.1093/oxfordjournals.qjmed.a069093 · Cited by 19 · see citing works
Morshead, D. M. (2002) · PubMed · Cited by 13 · see citing works
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7
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McHill, A. W., Melanson, E. L., Higgins, J., Connick, E., Moehlman, T. M., Stothard, E. R., & Wright, K. P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412021111 · Cited by 349 · see citing works
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Wang, F., Zhang, L., Zhang, Y., Zhang, B., He, Y., Xie, S., Li, M., Miao, X., Chan, E. Y. Y., Tang, J. L., et al. (2014) · Obesity Reviews · doi:10.1111/obr.12194 · Cited by 302 · see citing works
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Lin, X., Chen, W., Wei, F., Ying, M., Wei, W., & Xie, X. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.543 · Cited by 163 · see citing works
Pot, G. K., Almoosawi, S., & Stephen, A. M. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s0029665116000239 · Cited by 134 · see citing works
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- Authors
- Canuto, R., Garcez, A. S., & Olinto, M. T. A.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Corresponding author
- Olinto, Maria T.A.
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 17
- Issue
- 6
- Pages
- 425-431
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2157940848
- Cited by
- 130
- References
- 60
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 9 · 2023: 3 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 9 · 2017: 7 · 2016: 12 · 2015: 15 · 2014: 6 · 2013: 3
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (304793/2010-8)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Keywords
- shift work, metabolic syndrome, sleep duration, confounding factors, circadian rhythm disruption, occupational health
- MeSH terms
- Humans, Risk Factors, Work Schedule Tolerance, Sleep Disorders, Circadian Rhythm, Metabolic Syndrome
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