Cited by 121Autophagy in Disease and TherapyExercise and Physiological ResponsesCardiovascular and exercise physiology

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Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

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Jamart, Cécile, Benoit, Nicolas, Raymackers, Jean-Marc, Kim, Hyo Jeong, Kim, Chang Keun, Francaux, Marc·2012·European Journal of Applied Physiology

DOI 10.1007/s00421-011-2287-3

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Abstract

The purpose of this study was to evaluate whether ultra endurance exercise changes the mRNA levels of the autophagy-related and autophagy-regulatory genes. Eight men (44 ± 1 years, range: 38-50 years) took part in a 200-km running race. The average running time was 28 h 03 min ± 2 h 01 min (range: 22 h 15 min-35 h 04 min). A muscle sample was taken from the vastus lateralis 2 weeks prior to the race and 3 h after arrival. Gene expression was assessed by RT-qPCR. Transcript levels of autophagy-related genes were increased by 49% for ATG4b (P = 0.025), 57% for ATG12 (P = 0.013), 286% for Gabarapl1 (P = 0.008) and 103% for LC3b (P = 0.011). The lysosomal enzyme cathepsin L mRNA was upregulated by 123% (P = 0.003). Similarly, transcript levels of the autophagy-regulatory genes BNIP3 and BNIP3l were both increased by 113% (P = 0.031 and P = 0.007, respectively). Since upregulation of these genes has been related with an increased autophagic flux in various models, our results strongly suggest that autophagy is activated in response to ultra endurance exercise.

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Authors: Jamart, C., Benoit, N., Raymackers, J.-M., Kim, H. J., Kim, C. K., & Francaux, M.
Affiliations: UCLouvain (BE)
Korea National Sport University (KR)
Corresponding author: Francaux, Marc
ORCID: Raymackers, Jean-Marc
Kim, Hyo Jeong
Kim, Chang Keun
Francaux, Marc
Venue: European Journal of Applied Physiology
Publisher: Springer Science and Business Media LLC
Published: 2011-12-23
Volume: 112
Issue: 8
Pages: 3173-3177
ISSN: 0020-9376 (ISSN-L)
1439-6319
1439-6327
DOI: 10.1007/s00421-011-2287-3
OpenAlex: W2009618449
Cited by: 121
References: 26
Citations by year: 2026: 2 · 2025: 7 · 2024: 8 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 16 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 6 · 2012: 4
FWCI: 5.28
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: European Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: autophagy, skeletal muscle, gene expression, ATG4B, ATG12, GABARAPL1, LC3B, cathepsin L, BNIP3, BNIP3L, autophagic flux, vastus lateralis, endurance running
MeSH terms: Autophagy-Related Proteins, Autophagy-Related Protein 12, Adult, Autophagy, Biopsy, Cysteine Endopeptidases, Genetic Markers, Humans, Male, Membrane Proteins, Microtubule-Associated Proteins, Middle Aged, Muscle Contraction, Physical Endurance, Proto-Oncogene Proteins, RNA, Messenger, Running, Time Factors, Transcription, Genetic, Up-Regulation, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Small Ubiquitin-Related Modifier Proteins, Adaptor Proteins, Signal Transducing, Quadriceps Muscle, Cathepsin L, Real-Time Polymerase Chain Reaction

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Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

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